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Effects of Cricket Extract on Lipid Metabolism and Body Fat Content in High-Fat Diet Fed Rats
황석연,박종배,한직현,서동환,고상균,김윤배,윤치영 한국곤충학회 2004 Entomological Research Vol.34 No.4
The effect of cricket extract on high-fat diet fed rat was observed. It was shownthat cricket extract prevented the increment of body weight by high-fat diet. The extract alsodecreased the value of AST in liver. The most significant effect of the extract was shown on lipidmetabolism. The contents of total lipid and total cholesterol in liver and feces were reduced by theextract on dose-dependent. These statistically significant results were clear in 3% extract treatedgroup (HFD3) while were slight in 1% extract treated group (HFD1). The same result was alsoshown in body fat content.
자근으로부터 acetylshikonin의 분리 및 함량분석
황석연,황방연,강삼식,김창민,박정일,배기환,손건호,이승호,장승엽,강신정,노재섭,이경순 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Lithospermi Radix has been used in traditional medicine for antimicrobial, antiinflammatory, immunostimulating, antitumor and wound-healing activities. For the quality control of this drug, acetylshikonin was isolated from the hexane extract of Lithospermum erythrorhizon(Boraginaceae) and identified by the spectroscopic evidences. A quantitative analysis of acetylshikonin using HPLC method showed that the average contents were 0.084±0.026% in 31 samples collected throughout the various regions of Korea.
기니피그에서 홍삼 사포닌의 2,3,7,8-TCDD 독성 방어 효과
황석연,이찬용,Hwang, Seock-Yeon,Lee, Chan-Yong 한국환경보건학회 2009 한국환경보건학회지 Vol.35 No.4
This study was carried out to investigate the protective effect of Red Ginseng Saponins on 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced toxicities in guinea pigs ($200{\pm}10$ g). Normal control (NC) group guinea pigs ($200{\pm}10$ g) received vehicle and saline, while the TCDD-treated (TT) group was given water-extract (WE), saponin fraction (SF) and non-saponin fraction (NSF). Korean red ginseng fractions were administered from 1 week before TCDD-exposure for 4 weeks. Body weight loss and deteriorated clinical parameters related to sugar metabolism and liver function such as lipase and AST, respectively, these were significantly reduced by both saponin and non-saponin fractions. However, increase of lipase was attenuated by the saponin fraction in a dose-dependent manner. Only AST was affected by the saponin fraction. The results suggest that saponins are active substances in the Korean red ginseng water extract against TCDD induced toxicities in Guinea pigs.