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      • KCI등재

        『동의보감(東醫寶鑑)』에 수록된 파킨슨병 치료 처방(處方) 후보군 선별 연구

        황민섭,박혜진,김시원,백진웅,Hwang, Min-Seob,Park, Hye-Jin,Kim, Si-Won,Baek, Jin-Ung 대한한의학방제학회 2018 大韓韓醫學方劑學會誌 Vol.26 No.1

        Objectives : This study aims to sort out prescription candidates for four major symptoms of Parkinson's disease from Korean traditional medical publication, "Dongeuibogam". Methods : Medical terms related to four major symptoms of Parkinson's disease were primarily selected from "Dongeuibogam". Prescriptions that include at least one or more medical terms which are selected above were classified by the four major symptoms of Parkinson's disease, and finally analyzed to sort the most effective candidates. Results & Conclusions : 1. There are 18 medical terms in efficacy ($ch{\grave{i}}$ $z{\grave{o}}ng$, $j{\bar{u}}$ $lu{\acute{a}}n$, $j{\bar{i}}ng$${\check{u}}$ $ju{\check{a}}n$($ju{\check{a}}n$, $qu{\acute{a}}n$) $lu{\acute{a}}n$, $j{\bar{i}}ng$${\check{u}}$ $lu{\acute{a}}n$($lu{\acute{a}}n$) $t{\grave{o}}ng$, $j{\bar{i}}n$ $lu{\acute{a}}n$, $j{\bar{i}}n$ $t{\grave{i}}$, $sh{\check{o}}u$ $zh{\grave{e}}n$, $y{\acute{a}}ng$ $sh{\check{o}}u$, $lu{\acute{a}}n$ $j{\acute{i}}$, $lu{\acute{a}}n$ $b{\grave{i}}$, $r{\grave{o}}u$ $r{\acute{u}}n$, $zh{\grave{a}}n$ $di{\grave{a}}o$, $zh{\grave{a}}n$ $y{\acute{a}}o$, $zh{\grave{i}}$ $z{\acute{u}}$, $ch{\grave{e}}$ $t{\grave{o}}ng$, $ch{\bar{o}u}$ $ch{\grave{e}}$, $f{\bar{e}}ng$ $ch{\grave{u}}$, $ch{\grave{u}}$ $nu{\grave{o}}$) related to tremor, one of four major symptoms of Parkinson's disease. 2. There are 9 medical terms in efficacy ($qi{\acute{a}}ng$ $j{\acute{i}}$, $qi{\acute{a}}ng$ $zh{\acute{i}}$, $qi{\acute{a}}ng$ $t{\grave{o}}ng$, $j{\bar{u}}$ $j{\acute{i}}$, $j{\bar{i}}n$ $j{\acute{i}}$, $sh{\bar{e}}n$ $qi{\acute{a}}ng$, $lu{\acute{a}}n$ $j{\acute{i}}$, $y{\bar{a}}o$ $j{\acute{i}}$ $qi{\acute{a}}ng$, $xi{\grave{a}}ng$ $qi{\acute{a}}ng$) related to rigidity, one of four major symptoms of Parkinson's disease. 3. 38 prescription candidates (jiaweishouxingyuan, jiaweilonghusan, gehuajiexingtang, qiangfutang, qianghuoxuduantang, dawugongsan, duhuojishengtang, mahuangzuojingtang, fangfengbaizhumulitang, fangfengtongshengsan, baizhutang, buxinwan, fulingtang, binsusan, xieqingwan, sanbitang, shengdiqinliantang, shujinbaoansan, xingxiangsan, xiaotanfulingwan, shengjunwan, shenmizuojingtang, wuyaoshunqisan, yuzhenwan, wenjingyiyuantang, yiziqingjinsan, ziyinningshentang, shaoyaogancaotang, dingtongsan, zhushazhijiasan, cangzusan, chuanxiongfulingtang, tiedanyuan, choubaowan, duomingsan, xuanhusuosan, xuefengtang, huoluodan) were selected for tremor, one of the four major symptoms of Parkinson's disease. 4. 21 prescription candidates (qianghuoshengshitang, guizhiqianghuotang, guizhifuzitang, jiuweiqianghuotang(qianghuochonghetang), xiongzhixiangsusan, daqianghuotang, mahuangguizhitang, muguajian, fuzilizhongtang, shenzhusan, lianqiaobaidusan, yuzhensan, niuhuangjinhudan, renshenbaidusan, shaoyaogancaotang, jiuzhumuguazhou, cangzusan, shenxiangtianmatang, xiangjiaosan, xuefengtang, huishousan) were selected for rigidity, one of the four major symptoms of Parkinson's disease. 5. The results in this study ought to be verified by subsequent studies and clinical trials.

      • KCI등재

        『東醫寶鑑』에 수록된 파킨슨병 치료 處方 후보군 선별 연구

        황민섭,박혜진,김시원,백진웅 대한한의학방제학회 2018 大韓韓醫學方劑學會誌 Vol.26 No.1

        Objectives : This study aims to sort out prescription candidates for four major symptoms of Parkinson's disease from Korean traditional medical publication,『Dongeuibogam』. Methods : Medical terms related to four major symptoms of Parkinson's disease were primarily selected from 『Dongeuibogam』. Prescriptions that include at least one or more medical terms which are selected above were classified by the four major symptoms of Parkinson's disease, and finally analyzed to sort the most effective candidates. Results & Conclusions : 1. There are 18 medical terms in efficacy (chì zòng, jū luán, jīngǔ juǎn(juǎn, quán) luán, jīngǔ luán(luán) tòng, jīn luán, jīn tì, shǒu zhèn, yáng shǒu, luán jí, luán bì, ròu rún, zhàn diào, zhàn yáo, zhì zú, chè tòng, chōu chè, fēng chù, chù nuò) related to tremor, one of four major symptoms of Parkinson’s disease. 2. There are 9 medical terms in efficacy (qiáng jí, qiáng zhí, qiáng tòng, jū jí, jīn jí, shēn qiáng, luán jí, yāo jí qiáng, xiàng qiáng) related to rigidity, one of four major symptoms of Parkinson's disease. 3. 38 prescription candidates (jiaweishouxingyuan, jiaweilonghusan, gehuajiexingtang, qiangfutang, qianghuoxuduantang, dawugongsan, duhuojishengtang, mahuangzuojingtang, fangfengbaizhumulitang, fangfengtongshengsan, baizhutang, buxinwan, fulingtang, binsusan, xieqingwan, sanbitang, shengdiqinliantang, shujinbaoansan, xingxiangsan, xiaotanfulingwan, shengjunwan, shenmizuojingtang, wuyaoshunqisan, yuzhenwan, wenjingyiyuantang, yiziqingjinsan, ziyinningshentang, shaoyaogancaotang, dingtongsan, zhushazhijiasan, cangzusan, chuanxiongfulingtang, tiedanyuan, choubaowan, duomingsan, xuanhusuosan, xuefengtang, huoluodan) were selected for tremor, one of the four major symptoms of Parkinson’s disease. 4. 21 prescription candidates (qianghuoshengshitang, guizhiqianghuotang, guizhifuzitang, jiuweiqianghuotang(qianghuochonghetang), xiongzhixiangsusan, daqianghuotang, mahuangguizhitang, muguajian, fuzilizhongtang, shenzhusan, lianqiaobaidusan, yuzhensan, niuhuangjinhudan, renshenbaidusan, shaoyaogancaotang, jiuzhumuguazhou, cangzusan, shenxiangtianmatang, xiangjiaosan, xuefengtang, huishousan) were selected for rigidity, one of the four major symptoms of Parkinson’s disease. 5. The results in this study ought to be verified by subsequent studies and clinical trials.

      • KCI등재
      • KCI등재

        經筋理論에 대한 硏究

        황민섭,윤종화 대한침구의학회 2005 대한침구의학회지 Vol.21 No.1

        Object : This study was performed to understand about the concept of Meridian muscle which is the method explaining the muscular system in the Oriental Medicine. Materials and Methods : To reveal the concept and the course of formation of Meridian muscle, we have compared the route and symptoms of meridian muscle with the Meridian route and Symptoms of 《Zu bi shi yi mai jiu jing(足臂十一脈灸經)》, 《Yin yang shi yi mai jiu jing(陰陽十一脈灸經)》 and 《Jing Mai(經脈)》. Results & conclusion : 1. The concept of "Keun(筋)" reported in the 《Huangdi-Naijing(黃帝內經)》 include muscle, tendon, superficial vein and nerve. and in the 《Kyung keun(經筋)》, it means muscle and tendon. 2. The route of the Meridian muscle is facing toward the heart or head from the limbs, and the symptoms is mostly muscle spasm or pain according to the route, therefore the symptoms of the Meridian muscle are similar to the meridian symptoms of 《Zu bi shi yi mai jiu jing(足臂十一脈灸經)》. 3. The twelve-Meridian muscle had been made by classifying the whole muscle into twelve sections with making reference to the Meridian system.

      • KCI등재

        환도(GB30) 및 족삼리(ST36) 건강약침이 신경병증성 통증 유발 흰쥐에 미치는 영향

        황민섭 경락경혈학회 2019 Korean Journal of Acupuncture Vol.36 No.1

        Objectives : The objective of this study was to investigate the effects of Zingiberis Rhizoma Pharmacopuncture(ZP) at GB30 and ST36 in neuropathic pain induced SD rats by the block of Transient Receptor Potential Vanilloid 1(TRPV1). Methods : Neuropathic pain in rats was induced by tibial and common peroneal nerve transection of right leg. The rat subjects were divided into 6 groups : normal(Nor, n=5), control(Con, n=5), neuropathic pain plus 2 mg/kg ZP injection at GB30 and ST36(ZP-A, n=5), 10 mg/kg ZP(ZP-B, n=5), 20 mg/kg ZP(ZP-C, n=5) and 0.45 mg/kg Tramadol(Tra, n=5). Three days after the surgery, injections were administered once a day for 17 days. Withdrawal response of neuropathic rats’ legs were measured by stimulating the paw of Right leg with von frey filament, acetone and radient heat on day 3, 7, 11, 15, 19 after surgery. After all treatments were completed, c-Fos in the midbrain central gray and TRPV1 & TRPA1 of DRG(L5) were analyzed. Results : Groups ZP-B and ZP-C showed a meaningful decrease in the withdrawal response of mechanical allodynia, thermal hyperalgesia and cold allodynia compared to the control group(p<0.05, p<0.01, p<0.001). Groups ZP-B and ZP-C showed a meaningful decrease in the expression of c-fos and TRPV1 protein level compared to the control group(p<0.05, p<0.01, p<0.001). Conclusions : These results suggest that Zingiberis Rhizoma Pharmacopuncture at GB30 and ST36 could decrease mechanical & cold allodynia and thermal hyperalgesia by block the TRPV1 on the model of neuropathic pain.

      • KCI등재

        초미세버블이 종자발아에 미치는 영향

        황민섭,오승훈,이정일,한정우,김종민 한국자원식물학회 2016 한국자원식물학회지 Vol.29 No.5

        For the last few decades, much research has been tried to improve crop’s characteristics such as crop yield, quality, seeding period and environmental adaptability. In this paper, the effect of nanobubbles on the germination rate of barley seed is experimentally investigated. The air nanobubble was generated in water by gas-liquid mixing method. The results were shown that the mean diameter and concentration of nanobubble fabricated in DI water are 133 ㎚ and 8.59✕108 particles/㎖, respectively. Also, the seed germination rate for the nanobubble water was approximately 40 % higher than that of pure water.

      • KCI등재
      • KCI등재

        경근이론(頸筋理論)에 대한 연구(硏究)

        황민섭,윤종화,Hwang, Min-sub,Yoon, Jong-hwa 대한침구의학회 2005 대한침구의학회지 Vol.22 No.1

        Objective : This study was performed to understand about the concept of Meridian muscle which is the method explaining the muscular system in the Oriental Medicine. Methods : To reveal the concept and the course of formation of Meridian muscle, we have compared the route and symptoms of meridian muscle with the Meridian route and Symptoms of <<Zubi shi yi mai jiu jing(足臂十一脈灸經)>>, <<Yin yang shi yl mai jiu jing(陰陽十一脈灸經)>> and <<Jing Mai(經脈)>>. Results & Conclusion : 1. The concept of "Keun(筋)" reported in the <<Huangdi-Naijing(黃帝內經)>> include muscle, tendon, superficial vein and nerve. and in the <<Kyung keun(經筋)>>, it means muscle and tendon. 2. The route of the Meridian muscle is facing toward the heart or head from the limbs, and the symptoms is mostly muscle spasm or pain according to the route, therefore the symptoms of the Meridian muscle are similar to the meridian symptoms of <<Zu hi shi yi mai jiu jing(足臂十一脈灸經)>>. 3. The twelve-Meridian muscle had been made by classifying the whole muscle into twelve sections with making reference to the Meridian system.

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