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Microfluidic Systems for High Throughput Screening
홍종인 한국바이오칩학회 2008 BioChip Journal Vol.2 No.1
High-throughput screening (HTS) is a method of scientific experimentation widely used in drug discovery and relevant to the fields of biology and chemistry. Microfluidic systems manipulate or process tiny volumes of fluids in channel with dimensions of tens to hundreds of micrometers and are well suited for HTS due to their small size, which allows massively parallel experimentation. The unique feature of fluids within microfluidic networks can give an insight on new way to resolve the current challenges of HTS and to revolutionize all stages in drug discovery. Herein, recent progress in both microarraying strategies based on microfluidics and novel microfluidic devices with high throughput rates will be discussed.
Interfacial Tension-Mediated Droplet Fusion in Rectangular Microchannels
홍종인,최민석,Joshua B. Edel,Andrew J. deMello 한국바이오칩학회 2009 BioChip Journal Vol.3 No.3
We successfully demonstrate the merging of aqueous droplets within a microfluidic channel mediated by a difference in interfacial tension. Interfacial tension is shown to have a significant influence on the hydrodynamic forces associated with a segmented flow in a rectangular microchannel and results in the possibility of merging multiple droplets in a simple fashion. This facility is important in allowing droplet-based microfluidic systems to be used as synthetic tools in complex reaction processing.