한국인(韓國人) 구안와사(口眼喎斜) 환자(患者)의 Angiotensin Converting Enzyme 유전자(遺傳子) 다형성(多形成)에 관(關)한 임상연구(臨床硏究)

홍장무,박동석,고형균,Hong, Jang-mu,Park, Dong-suk,Koh, Hyung-kyun 대한침구의학회 2004 대한침구의학회지 Vol.21 No.2

Objective : This study was designed to investigate the relation between the angiotensin converting enzyme(ACE) gene polymorphism and Facial nerve palsy in the Korean population. Methods : This sudy was carried out on 117 Facial nerve palsy patients who were treated in the department of acupuncture & moxibustion, Hospital of Oriental medical college, Kyung-Hee University and 135 healthy control subjects. Blood samples from all subjects were obtaind for DNA extraction. The extracted DNA was amplified by polymerase chain reaction(PCR). PCR products were visualized by 2% agarose gel electrophoresis. Results : The sub-genotypes of ACE gene were II homozygotes, ID heterozygotes, DD homozygotes. While the distribution of ACE polymorphism in control subjects was 33%, 43%, 24%, the distribution of it in Facial nerve palsy patients was 32%, 50%, 18%(II, ID, DD). Thus, there was no significant different between the control and Facial nerve palsy groups. Conclusions : we conclude that there is no significant association between ACE gene polymorphism and Facial nerve palsy in Korean population. However, the findings of this study need to be confirmed in more patients and further studies. Additional epidemiologically based studies of the effects and relationship between ACE or other genes and lifestyles with regard to Facial nerve palsy is required.

韓國人 口眼喎斜 患者의 Angiotensin Converting Enzyme 遺傳子 多形成에關한 臨床硏究

홍장무,박동석,고형균 대한침구의학회 2004 대한침구의학회지 Vol.21 No.2

Objective : This study was designed to investigate the relation between the angiotensin converting enzyme(ACE) gene polymorphism and Facial nerve palsy in the Korean population. Methods : This sudy was carried out on 117 Facial nerve palsy patients who were treated in the department of acupuncture & moxibustion, Hospital of Oriental medical college, Kyung-Hee University and 135 healthy control subjects. Blood samples from all subjects were obtaind for DNA extraction. The extracted DNA was amplified by polymerase chain reaction(PCR). PCR products were visualized by 2% agarose gel electrophoresis. Results : The sub-genotypes of ACE gene were II homozygotes, ID heterozygotes, DD homozygotes. While the distribution of ACE polymorphism in control subjects was 33%, 43%, 24%, the distribution of it in Facial nerve palsy patients was 32%, 50%, 18%(II, ID, DD). Thus, there was no significant different between the control and Facial nerve palsy groups. Conclusions : we conclude that there is no significant association between ACE gene polymorphism and Facial nerve palsy in Korean population. However, the findings of this study need to be confirmed in more patients and further studies. Additional epidemiologically based studies of the effects and relationship between ACE or other genes and lifestyles with regard to Facial nerve palsy is required.

병력기간과 말초성 안면신경마비와의 상관성 연구

홍장무,신경민,서광명,최순영,배광록,박지영,백용현,남동우,이윤호 대한침구의학회 2009 대한침구의학회지 Vol.26 No.2

Objectives : This study was designed to evaluate the influence of the period of disease on Bell’s palsy patients Methods : We investigated 40 cases of patients with peripheral facial palsy who visited Yumin Oriental Hospital from 1st January to 31st August, 2008 with both oriental and western medical therapy and classified them as period of disease. The period of disease of Group A was within 3 days. The period of disease of Group B was from 4 to 10days. We evaluated the treatment effect of each group by House-Brackmann grade before treatment and 1, 2 week treatment. Results : 1. There was a statistical significant difference in period of disease between Group A and Group B. 2. After 1 week treatment, Group A showed more recovery compared with Group B. 3. After 2 week treatment, there was no statistical significant difference in House-Brackmann grade between Group A and Group B Conclusions : These results suggest that early treatment could be more effective in recovery of Bell’s palsy

침구과에 입원한 뇌졸중 환자의 최근 역학적 동향

홍장무,강미경,김종덕,인창식,강중원,박상민,서병관,정인태,고형균 대한침구의학회 2004 대한침구의학회지 Vol.17 No.2

Objectives: The purpose of this study is to present the epidemiological data on patients with a stroke admitted to Department of Acupuncture & Moxibustion, Oriental Medical Hospital Kyung Hee University and to investigate the difference between preceding diseases of stroke. Methods: We reviewed medical records of 700 patients with a stroke admitted to Department of Acupuncture & Moxibustion, Oriental Medical Hospital, Kyung Hee University Results: The incidence of cerebral infarction was 6.7 times that of cerebral hemorrhage. The incidence in males was 1.28 times of that in females. The incidence of stroke increased with aging and more cerebral hemorrhage occured in lower age group than cerebral infarction. There was higher morbidity in October, during the changing of the seasons , than any other months. Hypertension was the most common preceding disease followed by diabetis mellitus, heart disease, hyperlipidemia, and according to Odds's ratio for Male/Female, the probability of having preceding diseases was higher in females than males. In cerebral infarction, MCA territory was the most frequent lesion sites. Of the cerebral hemorrhage, basal ganglia (60%) was the most commonly involved site which was followed by thalamus(33.3%), cortex (3.3%) and subcortex (2.2%). The most common symptom accompanied by stroke was motor dysfunction which was followed by verbal disturbance, urination disorder and dysphagia. Conclusion: This study showed the trends of stroke in Oriental medical center. We expects that Multicenter cooperative and prospective study including Oriental Medicine will be inspired by this study for establishing more accurate chacteristics of stroke in Korea in the future.

침구과에 입원한 뇌졸중 환자의 최근 역학적 동향

홍장무,강미경,김종덕,인창식,강중원,박상민,서병관,정인태,고형균,Hong, Jang-mu,Kang, Mi-kyeong,Kim, Jong-deog,Yin, Chang-sik,Kang, Jung-won,Park, Sang-min,Seo, Byung-kwan,Chung, In-tae,Koh, Hyung-kyun 대한침구의학회 2004 대한침구의학회지 Vol.21 No.4

Objective : The purpose of this study is to present the epidemiological data on patients with a stroke admitted to Department of Acupuncture & Moxibustion, Oriental Medical Hospital Kyung Hee University and to investigate the difference between preceding diseases of stroke. Methods : We reviewed medical records of 700 patients with a stroke admitted to Department of Acupuncture & Moxibustion, Oriental Medical Hospital, Kyung Hee University. Results: The incidence of cerebral infarction was 6.7 times that of cerebral hemorrhage. The incidence in males was 1.28 times of that in females. The incidence of stroke increased with aging and more cerebral hemorrhage occured in lower age group than cerebral infarction. There was higher morbidity in October, during the changing of the seasons, than any other months. Hypertension was the most common preceding disease followed by diabetis mellitus, heart disease, hyperlipidemia, and according to Odds's ratio for Male/Female, the probability of having preceding diseases was higher in females than males. In cerebral infarction, MCA territory was the most frequent lesion sites. Of the cerebral hemorrhage, basal ganglia (60%) was the most commonly involved site which was followed by thalamus(33.3%), cortex (3.3%) and subcortex (2.2%). The most common symptom accompanied by stroke was motor dysfunction which was followed by verbal disturbance, urination disorder and dysphagia. Conclusion : This study showed the trends of stroke in Oriental medical center. We expects that Multicenter cooperative and prospective study including Oriental Medicine will be inspired by this study for establishing more accurate chacteristics of stroke in Korea in the future.

특발성 파킨슨병 환자의 전침치료 효과

강미경,이상훈,홍장무,박상민,강중원,박히준,임사비나,장대일,이윤호,Kang, Mi-kyung,Lee, Sang-hoon,Hong, Jang-moo,Park, Sang-min,Kang, Jung-won,Park, Hi-joon,Lim, Sabina,Chang, Dae-il,Lee, Yun-ho 대한침구의학회 2004 대한침구의학회지 Vol.21 No.5

Objective : This study was designed to evaluate the effect of electroacupuncture with various scales on symptoms of idiopathic Parkinson's disease. Methods : Subjects were voluntarily recruited by newspapers and internet. All the subjects are confirmed as idiopathic parkinson's disease by a neurologist. The acupuncture therapy was performed twice a week for 8 weeks. Acupuncture points for EA group were GB34, and LR3, electrical stimulation frequency was 120Hz, duration 15 minutes, and intensity is up to pain threshold according to patients. The patient's symptoms were assessed before, after 4 weeks and after 8 weeks treatments by unified Parkinson's disease rating scale(UPDRS), modified Hoehn-Yahr(H-Y) stage, Schwab & England activity of daily living and freezing of gait questionnaire(FOGQ). Results : UPDRS I, II, III, IV and total UPDRS scores were significantly improved after 4 weeks(p<0.05) and after 8 weeks(p<0.05) compared to the pre-treatment. The scores of ADL were significantly improved after 4 weeks(p<0.05) and after 8 weeks(p<0.05). There were significant changes in H-Y stage after 4 weeks(p<0.05), but There were no significant changes in H-Y stage after 8 weeks. There were significant changes in FOGQ scale after 4 weeks(p<0.05) and after 8 weeks(p<0.05). Conclusion : This study suggests that electroacupuncutre treatments can be applicable to improve symptoms in the patients with idiopathic Parkinson's disease.

자하거 약침의 천식 환자에 대한 연속증례보고

이소열,신경민,홍장무,최순영,배광록,김한겸,Lee, So-Yol,Shin, Kyung-Min,Hong, Jang-Mu,Choi, Soon-Young,Bae, Kwang-Rok,Kim, Han-Kyum 대한약침학회 2008 Journal of pharmacopuncture Vol.11 No.4

Objectives The purpose of this study is to report the effect of Hominis Placenta Pharmacopuncture(HPP) for patients with asthma. Methods We treated three patients who have asthma with HPP. To check the effect of HPP we used CAMSOM-V. To check the satisfaction of HPP we used Five-point Likert scale. Results After treatment symptoms were improved. CAMSOM-V decreased in all cases. The Likert scale points were checked 5 and 4 and 4. Conclusions In this study, we have found the meaning of the research that HPP, in the future will be efficacious against asthma.

구안와사 후유증의 분포와 인식도에 대한 단면조사

인창식,강미경,김종덕,홍장무,서동민,우현수,이현종,하지영,강중원,박상민,서병관,정인태,이상훈,고형균,Yin, Chang-shik,Kang, Mi-kyeong,Kim, Jong-deok,Hong, Jang-mu,Seo, Dong-min,Woo, Hyun-su,Lee, Hyun-jong,Ha, Ji-young,Kang, Jung-won,Park, Sang-mi 대한침구의학회 2003 대한침구의학회지 Vol.20 No.3

Background : Sequelae symptoms of peripheral facial palsy include not only partial recovery of the paretic muscles but contracture, spasm, synkinesis and atrophy which cause significant functional, esthetic, and psychosocial disturbances to the lives of patients. Objective : This study is to investigate the prevalence, time of onset, patient's self assessment on the degree of understanding of the sequelae and the association of the degree of palsy with the appearance of sequelae. Methods : 106 patients with peripheral facial palsy were sequentially interviewed and examined. Results : 29 patients(27.4%) of 106 patients showed sequelae symptoms, of whom 19 patients(65.5%) showed sequelae symptoms during 4 to 6 months after the onset of palsy. The degree of understanding on the sequelae at the time of interview showed improvement compared to that at the time of first consultation to any physician but not to reach an sufficient understanding. No relation between the degree of palsy and the appearance of sequelae was observed.

PubMed에서 acupuncture와 tension-type headache and migrain로 검색한 최근 연구경향

김경민,변임정,우현수,이현종,하지영,김종덕,홍장무,이재동,이윤호,최도영,Kim, Kyung-min,Byun, Im-jeung,Woo, Hyun-su,Lee, Hyun-Jong,Ha, Ji-young,Kim, Jong-deog,Hong, Jang-mu,Lee, Jae-dong,Lee, Yun-ho,Choi, Do-young 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective : To research the trends of study related to tension-type headache and migrain with acupuncture in PubMed, and to establish the hereafter direction of acupuncture. for tension-type headache and migrain. Methods : We searched in PubMed, with tension-type headache, migrain and acupuncture limitted by abstract and enterz data 10 years. Results : 1. The pattern of the study was as follows: Review article(18), Clinical Trials(23), meta analysis(2) and rondomized controlled trials(16). We further estimated 23 articles. 2. Many of these studies provide equivocal results because of designs, sample size and the others, but in the majority of the trials were concludes that acupuncture offers benefits in the treatment of headache. 3. Acupuncture methods need individualization, a carefully selected placebo and cross-over design must have adequate time between the two treatment periods.

혈우병 소견을 가진 뇌출혈 환자 치험(治驗) 1례(例)

정인태,서병관,이현종,하지영,강미경,홍장무,백용현,박동석,최도영,Jung, In-tae,Seo, Byung-kwan,Lee, Hyun-jong,Ha, Ji-young,Kang, Mi-kyeong,Hong, Jang-moo,Baek, Yong-hyeon,Park, Dong-suk,Choi, Do-young 대한침구의학회 2003 대한침구의학회지 Vol.20 No.4

Objective : Hemophilia, a genetically determined disorder, is characterized by abnormality of the coagulation mechanism due to functional deficiency of a specific factor, namely VIII or IX. In this study, the effect of Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was evaluated. Methods : We treated him with acupuncture by stimulating Dong-Si acupuncture point(Yuk Wan) and assessed the effect by using manual dynamic evaluation of MRC(Medical Research Council) and Modified Barthel Index. Results : After treatment, the bleeding tendency was grossly reduced and bleeding lesion was absorbed gradually. And manual dynamic evaluation of the upper extremity increased from 4 grade to 5 grade. Conclusions : This result suggest that Dong-Si acupuncture therapy on the cerebral hemorrhage patient with hemophilia was effective. And futher studies are required to concretely prove the effectiveness of Dong-Si acupuncture therapy for treating hemorrhagic diseases.