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베체트병과 동반된 Immunoglobulin A 신증에서 발생한 흉선암 1예
박세희 ( Se Hee Park ),김정호 ( Jung Ho Kim ),이정연 ( Jung Yoen Lee ),신석균 ( Sug Kyun Shin ),홍용국 ( Yong Kook Hong ),기정혜 ( Jeong Hae Kie ),강두영 ( Du Yong Kang ),이찬희 ( Chan Hee Lee ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.2
Behcet`s disease is a systemic inflammatory disorder of unknown etiology, characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. Renal involvement is rare in patients with Behcet`s disease particularly immunoglobulin A (IgA) nephropathy. Other autoimmune diseases have been associated with increased risk of malignancy, but not Behcet`s disease. Some cases of Behcet`s disease accompanied by bladder cancer, thyroid cancer, stomach cancer, or hematologic malignancies have been reported. However, to the best of our knowledge, co-occurrence of Behcet`s diseases with thymic carcinoma has not yet been reported. We experienced a 49-year-old male patient who had been treated for Behcet disease and IgA nephropathy, who presented with a large mediastinal mass on chest x-ray. After thymectomy, he was diagnosed with thymic carcinoma with complete resection. (J Rheum Dis 2015;22:118-122)
폐 장외 증상을 동반한 크론병의 성공적인 아달리무맙 치료 증례
신동열 ( Dongyeol Shin ),박병규 ( Byung Kyu Park ),서정훈 ( Jeonghun Seo ),원선영 ( Sun Young Won ),이미경 ( Mi Kyoung Lee ),홍용국 ( Yong Kook Hong ),조용석 ( Yong Suk Cho ) 대한소화기학회 2018 대한소화기학회지 Vol.72 No.3
Pulmonary extraintestinal manifestation is rare in Crohn’s disease and has been reported in only a few cases. Despite the presence of pulmonary abnormalities in a significant proportion of patients with inflammatory bowel disease, there are only few case reports, due to complicated diagnosis and low recognition by clinicians. Currently, treatment guidelines for pulmonary Crohn's disease have not been established. There are some case reports of pulmonary Crohn’s disease that achieved remission after infliximab treatment. Clinical and radiological remission of pulmonary extraintestinal involvement in Crohn's disease after adalimumab therapy has not been reported yet. Here, we report one case of lung involvement of Crohn’s disease, which shows radiological and clinical remission after adalimumab treatment. (Korean J Gastroenterol 2018;72:141-145)
정재헌 ( Jae Heon Jeong ),신상윤 ( Sang Yun Shin ),손명균 ( Myoung Kyun Son ),이영주 ( Young Joo Lee ),김세현 ( Se Hyun Kim ),기정혜 ( Jeong Hae Kie ),최윤정 ( Yoon Jung Choi ),홍용국 ( Yong Kook Hong ),한창훈 ( Chang Hoon Hahn 대한결핵 및 호흡기학회 2007 Tuberculosis and Respiratory Diseases Vol.63 No.2
악성 흉수의 원인은 폐암, 유방암, 및 악성 림프종, 백혈병이 그 대부분을 차지하며 내분비 종양에 의한 악성 흉수는 매우 드물며 특히 유두상 갑상선 암에 의한 흉수는 거의 없다. 저자들은 유두상 갑상선 암이 폐 전이를 거치지 않고 유방 전이를 거쳐 흉막 전이 일으킨 것으로 보이는 1예를 경험하였기에 보고하는 바이다. 아울러 원인이 명확하지 않은 악성 흉수의 원인 감별에 유두상 갑상선 암도 고려 대상으로 할 필요가 있다고 생각한다. Lung cancer, breast cancer and lymphoma are the common oncologic causes of malignant pleural effusion, comprising more than the half of the causes. However, an endocrinologic carcinoma associated malignant effusion is very rare. Recently, we encountered a case of papillary thyroid carcinoma causing malignant effusion. An 83-year-old female patient presented with dyspnea due to massive pleural effusion in her left side. The pleural biopsy, pleural fluid cytology and breast needle aspiration biopsy results were consistent with a metastatic papillary thyroid carcinoma. Thyroid ultrasonography showed two thyroid masses, but the patient refused a thyroid biopsy. This case highlights the need for considering the possibility of papillary thyroid carcinoma when the cause of malignant pleural effusion cannot be found because one of the rare clinical manifestations of a papillary thyroid carcinoma can be dyspnea due to malignant effusion. (Tuberc Respir Dis 2007; 63: 188-193)
시상 증후군에 동반된 대뇌 피질 혈류 변화에 대한 99mTc - HMPAO Brain SPECT
이명식(Myung Sik Lee),서정호(Jung Ho Suh),김동익(Dong Ik Kim),정태섭(Tae Sub Chung),이종두(Jong Doo Lee),박창윤(Chang Yoon Park),김은경(Eun Kyung Kim),홍용국(Yong Kook Hong) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.1
N/A Spontaneous pain and painful overreaction to external stimuli resulting from lesion confined central nervous system (CNS) were named as thalamic syndrome. Thalamic lesion and decreased regional cortical perfusion thought to the pathogenesis of thalamic syndrome due to decreased regional cortical perfusion thought to the pathogenesis of thalamic syndrome due to decreased function of thalamocortical tract. We performed Tc-99m-HMPAO regional cerebral perfusion in 10 patients with clinical diagnosis of thalamic syndrome due to thalamic lesion or near the thalamic lesion at Yonsei University Hospital, from January 1989 to August 1991. In contrast to five patients with lesions near the thalamus who did not show secondarily decreased perfusion at cerebral cortex, four among the five patients with thalamic lesions revealed decreased cortical perfusion in the ipsilateral cerebral cortex on brain SPECT. These Phenomena may suggest the loss of afferent activating stimuli from the thalamus led to decreased neuronal activity and the following hypoperfusion of cerebral cortex, and might be one of the indirect signs for suggesting presence of the thalamocortical tract. A causal relationship between cortical hypoperfusion and neuropsychological deficit is strongly suggested.
간질증후군의 99mTc - HMPAO Brain SPECT ; Ictal Study
박창윤(Chang Yun Park),서정호(Jung Ho Suh),김동익(Dong Ik Kim),정태섭(Tae Sub Chung),이종두(Jong Doo Lee),홍용국(Yong Kook Hong),이병인(Byung In Lee),허균(Kyun Huh) 대한핵의학회 1992 핵의학 분자영상 Vol.26 No.2
N/A Both interictal and ictal Tc-99m-HMPAO brain SPECT were performed in 22 patients with medically intractable epilepsy. Localization of epileptic foci in our patients was made by combined results of EEG and other tests, including Wada test, magnetic resonance imaging, and neuropsy- chometric test. Among them, ictal Tc-99m-HMPAO SPECT, localized epilptic foci in 20 of 22 patients and provided evidence of epileptic focus in 12 patients by demonstrating maximally increased regional cerebral perfusion (rCP) in epileptic foci during the ictal study with decreased rCP in interictal study. Ictal Tc-99m-HMPAO SPECT Was particularly useful for investigating epileptic foci, and when correlated with simultaneously recorded ictal EEG, provided further insight for localizing epileptic foci. Conclusively, Tc-99m-HMPAO SPECT is a useful, noninvasive method of localizing epileptic activity which may be particularly important for presurgical investigations, especially in those patients without large morphological lesions.