p53 Codon 72 다형성과 한국인 여성의 자궁내막증의 연관성에 관한 연구

허성은,심성신,이경순,문혜성,유한기,정혜원,Hur, Sung-Eun,Shim, Soung-Shin,Lee, Kyung-Soon,Moon, Hye-Sung,Yu, Han-Ki,Chung, Hye-Won 대한생식의학회 2002 Clinical and Experimental Reproductive Medicine Vol.29 No.4

Objective: The present study was performed to evaluate the association o f p53 codon 72 polymorphism and endometriosis. Materials and Methods: We investigate 74 women who were operated for endometriosis and 93 women who had no endometriotic lesion proved by operation. Polymerase chain reaction was used to detect p53 codon polymorphisms. Result: We have found no significant difference between endometriosis and control group in the p53 codon polymorphism. The respective proportion of arginine homozygotes, heterozygotes and proline homozygotes in endometriosis group were 18.9%, 62.2% and 18.9%, respectively, and were 12.9%, 75.2% and 11.9%, respective in the group without endometriosis. Conclusion: Endometriosis is not associated with p53 polymorphism in Korean endometriosis patients.

중증 자궁내막증 환자의 내막에서 thrombospondin-1과 -2의 mRNA의 발현에 관한 연구

허성은,이지영,문혜성,정혜원,Hur, Sung Eun,Lee, Ji Young,Moon, Hye-Sung,Chung, Hye Won 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.3

Objective: We investigated the expression of TSP-1 and -2 in eutopic endometrium of advanced endometriosis and control patients. Methods: The 33 endometriosis patients and 32 controls were enrolled. Endometrial samples were obtained from 65 premenopausal women aged 29-44 years, undergoing laparoscopic surgery or hysterectomy for non-malignant lesions. Sufficient samples were collected from 33 patients with endometriosis stage III and IV and 32 controls without endometriosis confirmed by laparoscopic surgery. The mRNA expression from eutopic endometrium for TSP-1 and -2 were analyzed by RT-QC PCR. Results: The mRNAs of TSP-1 and -2 were expressed in eutopic endometrium from endometriosis and normal controls throughout the menstrual cycle. There were no significant differences in expression of TSP-1 and TSP-2 in eutopic endometrium between controls and endometriosis patients. Conclusion: Our results indicated that TSP-1 and -2 had no crucial role compared to other molecules in the regulation of angiogenesis. These findings also suggest that dysregulation of other angiogenic regulators would be concerned in pathophysiologic role in endometriosis development.

대학생의 사회봉사활동 경험특성에 따른 전공만족도 및 학업성취도에 관한 융합연구

허성은 한국융합학회 2016 한국융합학회논문지 Vol.7 No.4

본 연구는 대학생의 전공만족도 및 학업성취수준을 봉사활동 특성과 융합적으로 규명하여 대학의 사회봉 사활동의 올바른 정착과 함께 전공학문과의 연계에 필요한 프로그램의 운영 및 개발에 필요한 기초자료를 제공하 고자 한다. 연구방법은 2014년 12월 1일부터 2015년 2월1일까지 부산·경남지역에 거주하는 대학생들을 대상으로 온라인 설문 패널을 이용하여 자율적으로 연구에 참여한 대학생 401명을 대상으로 설문조사를 실시하여 최종분석 에 사용하였고 다음과 같은 결과를 얻었다. 봉사활동 경험이 있을수록 봉사활동 참여도가 높을수록 전공만족도와 학업성취수준이 높았고, 특히 봉사활동이 전공과 관련성이 있는 경우 전공만족도가 높았다. 또한 봉사활동 만족도가 높을수록 봉사활동 필요성이 높을수록 전공만족도가 높았고, 보건계열이 비 보건계열에 비하여 전공만족도가 높았 다. 따라서 전공 관련된 체계적인 봉사활동을 경험 할 수 있는 기회를 제공하여 봉사활동의 필요성과 참여도를 높이 고 봉사활동이 보다 지속적으로 활성화될 수 있는 효과적인 프로그램 개발이 필요할 것으로 판단된다. This study aimed to provide basic data required for operation and development of a program that is necessary for linkage with the major as well as proper settlement of community service of the university by identifying university students' major satisfaction and academic achievement level in relation with the characteristics of community service. A survey was conducted in 401 university students who voluntarily participated in this study using the online survey panel targeting university students who reside in Busan and South Gyeongsang Province from December 1, 2014 to February 1, 2015. The results are as follows. Students who had a community service experience and had higher participation in community service showed higher major satisfaction and academic achievement. Particularly, when community service was related to the major, major satisfaction was higher. In addition, the higher the satisfaction with community service was and the higher the need of community service was, the higher the major satisfaction was. Students with health major showed higher major satisfaction than students with non-health major. Therefore, development of an effective program will be necessary to increase the need and participation of community service and revitalize community service more continuously.

성인의 주관적 구강 건강 상태와 건강 실천행위가 구강 건강 관련 자기효능감에 미치는 영향

허성은 중소기업융합학회 2020 융합정보논문지 Vol.10 No.5

In order to investigate the effects of subjective oral health status and health practice behavior on oral health-related self-efficacy in adults, a survey was conducted in adults living in Busan and analyzed using the SPSS 21.0 program. The better the subjective oral health status, brushing-related self-efficacy and oral health management self-efficacy were significantly higher. The better the health practice behavior, brushing-related self-efficacy and oral health management self-efficacy were significantly higher. The better the subjective oral health status, the more positively it affected oral health-related self-efficacy. The implementation of health practice behavior in order of exercise, health responsibility implementation, and smoking showed a positive effect on oral health-related self-efficacy. Therefore, we hope that the results of this study are used as fundamental data for development of continued oral health programs converging systemic and oral health and contribute to the promotion of comprehensive and oral health in adults. 본 연구는 성인의 주관적 구강 건강상태와 건강 실천행위가 구강 건강 관련 자기효능감에 미치는 영향을 파악하고자 부산광역시에 거주하는 성인을 대상으로 설문 조사를 시행한 후, SPSS 21.0 프로그램을 사용하여 분석하였다. 주관적 구강 건강 상태가 좋을수록 칫솔질 관련 자기효능감(p<.001)과 구강 건강관리 자기효능감(p<.01)이 유의하게 높게 나타났고, 건강 실천 행위를 이행할수록 칫솔질 관련 자기효능감(p<.001)과 구강 건강관리 자기효능감(p<.001)이 유의하게 높게 나타났다. 주관적 구강 건강상태가 좋을수록 구강 건강 관련 자기효능감에 긍정적 영향을 미치며(p<.001), 운동, 건강 책임이행, 흡연 순으로 건강 실천 행위를 이행할수록 구강 건강 관련 자기효능감에 긍정적 영향을 미치는 것으로 나타났다(p<.05). 따라서 전신건강과 구강건강의 상호 융합적 계속 구강 보건 프로그램 개발의 기초 자료로 활용되어 성인의 포괄적 건강 및 구강건강 증진에 기여하고자한다.

한국인 태아의 인체측정

허성은,이지영,김철중,정언석,임현균,이성기 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-

직장인의 직무 스트레스와 구강 자각증상의 융합적 관련성

허성은 중소기업융합학회 2020 융합정보논문지 Vol.10 No.4

본 연구는 직장인의 직무 스트레스가 구강 자각증상에 미치는 영향을 파악하고자 경기도 일부 지역 내 직장인을 대상으로 설문 조사를 시행하였다. 수집된 자료는 SPSS 21.0 프로그램으로 분석하였으며 그 결과, 직무 스트레스 하위 요인 중 직무 불안정은(p<.01)저작 장애에, 직무 요구는(p<.01)잇몸 출혈 및 잇몸질환에, 긍정적 조 직체계는 구취와(p<.05)잇몸 출혈 및 잇몸질환에(p<.01)유의한 영향을 미치는 것으로 나타났다. 따라서 직장인의 직무 스트레스에 대한 효율적인 관리 방안을 마련하고, 직무 스트레스와 관련된 구강 자각증상을 예측한다면 직장 인의 계속 구강 건강관리는 물론 성인 구강 건강증진에 도움이 될 것으로 판단된다. This study was conducted to investigate the effect of job stress on oral subjective symptoms observed in office workers. A survey of office workers in the Gyeonggi-do area was conducted and data collected was analyzed using SPSS 21.0 program. The results showed that among the sub-scales of job stress, job insecurity, job demand, and positive organizational system had significant effects on dysmasesis (p<.01), gum bleeding and gum disease (p<.01), and halitosis (p<.05) as well as gum disease (p<.01), respectively. Therefore, it is considered that making an effective job stress management plan and predicting related oral subjective symptoms in office workers will help improve the oral health management of office workers and adult oral health management in general.

65세 이상 노인의 가철성 의치만족도와 구강건강관련 삶의 질의 관련성

허성은,지재훈,이선찬,허종훈 보건의료산업학회 2016 보건의료산업학회지 Vol.10 No.3

Objectives : This study explored ways to improve the quality of life related to oral health and the oral health of senior citizens by identifying the relevance of oral health-related quality of life issues, and satisfaction with dentures in elderly 65 years of age or older. Methods : This study surveyed 220 senior citizens who are currently using dentures and 65 years of age or older living in Busan. As a result, 200 questionnaires were returned. All of these questionnaires were used in the final analysis. The method of analysis was descriptive statistics using SPSS VER. 19.0, t-test, ANOVA, Pearson correlation coefficients, and regression analysis. Results : First, when verifying the difference in the quality of the health-related life of the oral cavity in accordance with the general characteristics, only average monthly income showed a significant difference. Second, the results of the analysis for factors that affect the quality of the health -related life of the oral cavity, fixation satisfaction, and mastication satisfaction, in that order, affected the general satisfaction of the elderly. Conclusions : Dentures satisfaction and the quality of the health-related life of the oral cavity show a high correlation and causality.

Single-Particle Study: Refractive Index Sensitivity of Localized Surface Plasmon Resonance Inflection Points in Mesoporous Silica-Coated Gold Nanorods

허성은,하지원 한국바이오칩학회 2022 BioChip Journal Vol.16 No.2

Gold nanorods coated with a mesoporous silica shell (AuNRs@mSiO 2 , core@shell) have been in the employment for various bioapplications, including drug delivery and photothermal cancer therapy. Nevertheless, limited studies have been conducted on AuNRs@mSiO 2 for their biosensing applications that use a refractive index (RI)-based localized surface plasmon resonance (LSPR). In this study, the LSPR detection sensitivity of individual AuNRs@mSiO 2 with two distinctive core sizes, but the same aspect ratio of 3, was presented at LSPR inflection points (IFs) according to RI variations of the surrounding environment. The RI sensitivity at the homogeneous LSPR IF located on the low-energy side was higher than the wavelength shifts in the conventional LSPR maximum peak. Moreover, single AuNRs@mSiO 2 having a smaller core size exhibited better RI sensitivity at the IFs of LSPR. Thus, we presented a better understanding of the RI-based detection sensitivity in single AuNRs@mSiO 2 at LSPR IFs for developing LSPR biosensors.

『現代漢語詞典』의 사전학적 조명

허성도(許成道) 한국사전학회 2005 한국사전학 Vol.- No.5

한국인 여성에서 중증 자궁내막증의 발생 위험도와 CYP19 유전자 다형성과의 관련성에 관한 연구

허성은,이지영,문혜성,정혜원,Hur, Sung Eun,Lee, Ji Young,Moon, Hye-Sung,Chung, Hye Won 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.2

Objective: To investigate whether polymorphism of CYP19 gene is associated with the risk of advanced endometriosis in Korean women. Methods: Blood samples were collected from 202 endometriosis patients and 221 controls. The patients with endometriosis of stages III and IV diagnosed by both pathologic and laparoscopic findings to according modified AFS classification. The women undergoing laparoscopic surgery or laparotomy for non-malignant lesions were included in the control group. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype. Results: The heterozygous allele in CYP19 gene was the most common genotypes in both endometriosis and healthy control groups (52.0% vs. 46.1%). CYP19 gene polymorphisms did not show the significant differences between the control group and endometriosis group. Conclusion: The results suggested that the CYP19 genetic polymorphism was not associated with a risk of advanced endometriosis in Korean women.