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허민석,최용범,안규중,이양원 대한피부과학회 2019 Annals of Dermatology Vol.31 No.4
Background: Although oral antihistamines (H1-histamine receptor antagonists) are the main treatment option for pruritus in general skin dermatosis, their effect in treating pruritus of atopic dermatitis (AD) has not yet been established. Objective: We conducted a systematic review and meta-analysis to evaluate the effectiveness of combined therapy of H1-antihistamines and topical steroids. Methods: We systematically searched MEDLINE, Embase, and CENTRAL databases for articles published from 1967 to 2015. We identified 1,206 studies and assessed their titles, abstract, and full-text. Random effects meta-analysis was used to calculate mean differences (MD) with 95% confidence intervals (CI). Results: Two studies satisfying the inclusion criteria of antihistamine therapy with mandatory topical steroid use were selected. Comparing antihistamine monotherapy with combination therapy, patients treated with the addition of antihistamine to topical corticosteroids showed a statistically significant clinical improvement (standard MD, −0.24; 95% CI, −0.42 to −0.05; p=0.01). Conclusion: H1-antihistamines may have a synergistic effect when combined with topical steroids by influencing various associative factors of chronic pruritus in AD.
레파지토리 및 프로세스 기반의 데이터 전환 자동화 도구
허민석,김동수,김희완 서비스사이언스학회 2020 서비스연구 Vol.10 No.2
데이터를 운영하는 운영시스템은 비지니스의 변경, 고객 요구와 IT 기술의 발달로 정보시스템 재구축 프로젝트는 주기적으로 발생하고 있다. 이 과정에서 기업의 자산인 데이터의 정합성과 무결성을 보장하는 데이터 전환은 중요하다. 데이터 전환의 목표는 현재의 데이터베이스 시스템 운영 환경을 이해하고, 사용 중인 DBMS의 특성을 파악하여, 최적의 데이터베이스 구조를 유지하며, 신 시스템이 최상의 성능을 발휘하도록 해야 한다. 기존 정보시스템에 존재하는 축적된 과거자료를 추출하여 새로운 정보시스템의 개선된 테이블로 옮기는 과정을 말한다. 데이터 전환은 사전에 설계/계획된 규칙에 따라 최종 목적 테이블로 전환하는 전체 과정이다. 따라서, 기존 정보시스템에서 사용하고 있는 데이터를 차세대 시스템 구축 사업에서도 사용할 수 있도록 데이터의 이행은 무엇보다도 중요하다. 본 논문에서는 차세대 시스템 통합 프로젝트 중 중요한 부분인 데이터 전환을 위한 자동화 도구를 설계하였다. 본 연구에서 기존 데이터 전환 방식의 문제점을 분석하여 데이터 전환을 위한 개선방안을 제시하고, 레파지토리와 프로세스 기반의 효율적인 데이터 전환 자동화 도구를 제안하고 실제 차세대 프로젝트의 적용사례를 통해 그 효율성을 검증하였다.
인공적 인접면 치아우식증의 구내방사선사진과 디지털 영상의 진단능 평가
허민석,유동수,Heo Min-Suk,You Dong-Soo 대한영상치의학회 1994 Imaging Science in Dentistry Vol.24 No.2
Recently, the digital image was introduced into radiological image. The digital image has the power of contrast enhancement, histogram control, and other digitally enhancement. At the point of the resolution, periapical radiograph is superior to the digital image, but enhanced digital procedure improves the diagnostic ability of the digital image. The purpose of this study was to evaluate the diagnostic ability of artificial proximal caries in conventional radiographs, digital radiographs and enhanced digital radiographs (histogram specification). ROC (Receiver Operating Characteristic) analysis and paired t-test were used for the evaluation of detectability, and following results were acquired: 1. The mean ROC area of conventional radiographs was 0.9274. 2. The mean ROC area of unenhanced digital image was 0.9168. 3. The mean ROC area of enhanced digital image was 0.9339. 4. The diagnostic ability of three imaging methods was not significant difference(p>0.05). So, the digital images had similar diagnostic ability of artificial proximal caries to conventional radiographs. If properly enhanced digital image, it may be superior to conventional radiographs.
허민석,신종희,최민지,박연준,이혜수,구선회,이원길,김수현,신명근,서순팔,양동욱 대한진단검사의학회 2015 Annals of Laboratory Medicine Vol.35 No.6
Background: We investigated the species distribution and amphotericin B (AMB) susceptibility of Korean clinical Aspergillus isolates by using two Etests and the CLSI broth microdilution method. Methods: A total of 136 Aspergillus isolates obtained from 11 university hospitals were identified by sequencing the internal transcribed spacer (ITS) and β-tubulin genomic regions. Minimal inhibitory concentrations (MICs) of AMB were determined in Etests using Mueller-Hinton agar (Etest-MH) and RPMI agar (Etest-RPG), and categorical agreement with the CLSI method was assessed by using epidemiological cutoff values. Results: ITS sequencing identified the following six Aspergillus species complexes: Aspergillus fumigatus (42.6% of the isolates), A. niger (23.5%), A. flavus (17.6%), A. terreus (11.0%), A. versicolor (4.4%), and A. ustus (0.7%). Cryptic species identifiable by β-tubulin sequencing accounted for 25.7% (35/136) of the isolates. Of all 136 isolates, 36 (26.5%) had AMB MICs of ≥2 μg/mL by the CLSI method. The categorical agreement of Etest-RPG with the CLSI method was 98% for the A. fumigatus, A. niger, and A. versicolor complexes, 87% for the A. terreus complex, and 37.5% for the A. flavus complex. That of Etest-MH was ≤75% for the A. niger, A. flavus, A. terreus, and A. versicolor complexes but was higher for the A. fumigatus complex (98.3%). Conclusions: Aspergillus species other than A. fumigatus constitute about 60% of clinical Aspergillus isolates, and reduced AMB susceptibility is common among clinical isolates of Aspergillus in Korea. Molecular identification and AMB susceptibility testing by Etest-RPG may be useful for characterizing Aspergillus isolates of clinical relevance.