비선형 반군(非線型半群)과 축소작용소(縮小作用素)

한창우 한국수학교육학회 1976 수학교육 Vol.15 No.1

本論文에서는 Banach 空間에서의 非線形 縮小作用素의 半群에 대하여 조사하고 非線形 半群에서의 生成作用素의 生成을 論하였다.

청간해주탕(淸肝解酒湯)이 kupffer cell의 $NF{\kappa}B$ 활성화 및 세포사멸에 미치는 영향

한창우,김영철,우홍정,이장훈,Han Chang-Woo,Kim Young-Chul,Woo Hong-Jung,Lee Jang-Hoon 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.1

Objectives : Previous studies showed that treatment with Chungganhaeju-tang prevents hepatic inflammation and apoptosis in alcoholic liver disease. The purpose of our study is to determine if any relations exsists between the transcription factor $NF{\kappa}B$, an orchestrating expression of a large number of genes and inhibitory effects of Chungganhaeju-tang on ethanol induced apoptosis. Materials and Methods : To assess the role of $NF{\kappa}B$, we blocked NFkB activation by delivering to the kupffer cells $I{\kappa}B{\Delta}N$, a dominant negative $NF{\kappa}B$ inhibitor, and investigated if Chungganhaeju-tang still prevented apoptosis. Results : When $NF{\kappa}B$ activation was blocked, there was no inhibitory effect of Chungganhaeju-tang on ethanol induced apoptosis of kupffer cells. Conclusion : This result suggests that Chungganhaeju-tang protects the liver from ethanol induced apoptosis by activating the $NF{\kappa}B$ that plays a key role in porotecting mechanism and reducing inflammatory cytokine gene expression.

대면적 TET-LCD 유리기판 이송용 복합재료 로봇 손 개발에 관한 연구

한창우,최기한,이상룡 대한기계학회 2002 大韓機械學會論文集A Vol.26 No.7

Clean Stocker내 새로운 방식의 기류제어에 관한 해석

한창우,최기한,이상룡 대한기계학회 2002 大韓機械學會論文集A Vol.26 No.1

Spatial and Temporal Trends of Number of Deaths Attributable to Ambient PM2.5 in the Korea

한창우,김순태,임연희,배현주,홍윤철 대한의학회 2018 Journal of Korean medical science Vol.33 No.30

Background: We aimed to evaluate the spatial and temporal trends of the health burden attributable to particulate matter less than 2.5 µm in diameter (PM2.5) in the metropolitan cities and provinces of the Korea. Methods: We used modeled PM2.5 concentration data for the basic administrative levels, comprising the cities and the provinces of Korea, the corresponding annual population census data for each level, and the age and cause specific mortality data. We applied cause- specific integrated exposure-response functions to calculate the premature mortality attributable to ambient PM2.5 for four disease end points (ischemic heart disease [IHD], chronic obstructive pulmonary disease [COPD], lung cancer [LC], and cerebrovascular disease [stroke]) for the year 2015. Moreover, the temporal trends of the health burden from 2006 to 2015 were assessed. Results: The annual average PM2.5 concentration for Korea was 24.4 μg/m3 , and 11,924 premature deaths were attributable to PM2.5 exposure in 2015. By simulating the reduction in the annual mean values of PM2.5 to 10 µg/m3 , about 8,539 premature deaths were preventable. There was spatial variation in mortality burden attributable to PM2.5 across the sub-national regions of Korea. In particular, the high burden was concentrated at Seoul and Gyeonggi province due to the high population density. However, decreasing trends were noted for most of the metropolitan cities and provinces of Korea since 2006. Conclusion: Our findings show that further actions to improve air quality in Korea would substantially improve the health burden due to particulate matter.

The Ratio of 2nd to 4th Digit Length in Korean Alcohol-dependent Patients

한창우,Hwallip Bae,이유상,원성두,김대진 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.2

Objective: The ratio of 2nd to 4th digit length (2D:4D) is a sexually dimorphic trait. Men have a relatively shorter second digit than fourth digit. This ratio is thought to be influenced by higher prenatal testosterone level or greater sensitivity to androgen. The purpose of this study is to investigate the relationship between alcohol dependence and 2D:4D in a Korean sample and whether 2D:4D can be a biologic marker in alcohol dependence. Methods: In this study, we recruited 87 male patients with alcohol dependence from the alcohol center of one psychiatric hospital and 52 healthy male volunteers who were all employees in the same hospital as controls. We captured images of the right and left hands of patients and controls using a scanner and extracted data with a graphics program. We measured the 2D:4D of each hand and compared the alcohol dependence group with the control group. We analyzed these ratios using an independent-samples t-test. Results: The mean 2D:4D of patients was 0.934 (right hand) and 0.942 (left hand), while the mean 2D:4D of controls was 0.956 (right hand) and 0.958 (left hand). Values for both hands were significantly lower for patients than controls (p<0.001, right hand; p=0.004, left hand). Conclusion: Patients who are alcohol dependent have a significantly lower 2D:4D than controls, similar to the results of previous studies, which suggest that a higher prenatal testosterone level in the gonadal period is related to alcoholism. Furthermore, 2D:4D is a possible predictive marker of alcohol dependence.

극저탄소강의 Mash Seam TB 용접성 평가에 관한 연구

한창우,이창희,이명호 대한용접접합학회 2002 대한용접·접합학회지 Vol.20 No.4

M/S TB(Mash Seam Tailored Blank) is a production method for blanks by welding together blanks of different material, thickness and coating, and is an attractive method for manufacturing car body because it makes parts lighter and can save the cost and time to manufacture. However, there have not been quantified criteria to evaluate the quality of TB weld. This study introduced FHR (failure height ratio) in order to assess formability or/and weldability of the M/S welds and the applicability of FHR was confirmed by actual auto body forming and FLD tests. Furthermore, a new parameter, HN(heat number) based on the heat input of "$Q=I^2Rt$" was proposed and assessed. It was found that the concept of HN could be utilized to evaluate the soundness of M/S welds without any destructive tests.ive tests.

태아수종 및 선천성 심장병에 동반된 난치성 상심실성 빈맥을 보이는 미숙아에서 Amiodarone및 Digoxin 병합 치료 1례

한창우,유하양,신정은,은호선,이순민,박민수,남궁란,이철,박국인 대한신생아학회 2014 Neonatal medicine Vol.21 No.1

Fetal tachycardia is at risk for developing low cardiac output, non-immune hydrops fetalis and ultimately fetal death. Spontaneous resolution of supraventricular tachycardia (SVT) is common during the first year of age, but some infants need long-term antiarrhythmic therapy. In almost neonatal tachyarrhythmia including SVT, adenosine is the drug of the first choice. Digoxin is used to treat the SVT which is not controlled with adenosine. Class Ic and III antiarrhythmic drugs are additionally recommended for the disease unresponsive to digoxin. Intravenous amiodarone is highly effective and safe in an infant with refractory or life threatening tachycardia. Some cases have been reported that amiodarone combined with digoxin therapy is effective for treating tachycardia. We herein report a case of a preterm infant–born at 32 weeks of gestational age–with hydrops fetalis and life-threatening refractory SVT accompanied by multiple congenital heart diseases. SVT was initially not responsive to adenosine therapy, however, it was then successfully controlled with combination therapies of amiodarone and digoxin. 태아 부정맥(fetal arrhythmia)은 비면역학적 이상으로 인한 태아수종 (hydrops fetalis)을 유발하는 대표적인 원인중의 하나로, 궁극적으로 태아의 사망에 이를 수 있다. 상심실성 빈맥(supraventricular tachycardia)은 대부분 1세이전에 자연 소실 되나, 일부에서 장기간 항부간정맥(antiarrhythmic drugs)치료를 필요로 한다. 상심실성 빈맥을포함한 대부분의 신생아 빈맥에서 아데노신(adenosine)은 첫 번째로 사용되는 약물이다. 아데노신으로 조절되지않는 상심실성 빈맥의 경우 디곡신(digoxin)을 사용하여 조절 한다. 디곡신에 반응 하지 않는 경우 제 1 c 군과 제3군 항부정맥제의 사용이 추천된다. 아미오다론 (amiodarone)은 난치성 혹은 생명을 위협하는 빈맥을 보이는 영아에서 좋은 치료 효과를 보이나, 일부에서는 디곡신과의 병합요법을 통해 더 높은 치료 성적을 보고 하였다. 본증례는 태아빈맥, 태아-수종 및 선천성 심장병이 동반된 재태연령 32주 미숙아로 출생한 환아에서, 출생 후 계속하여 상심실성 빈맥을 보여 아데노신을 투여 하였으나 조절되지 않아, amiodarone과 digoxin을 병합 투여하여 빈맥이 치료되어 보고하는 바이다.

Entecavir와 한의약 치료를 병행한 후 HBV-DNA가 음전된 만성 B형 간염 환자 증례 보고

한창우,Han, Chang-woo 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.2

The patient presented to the clinic with the complaint of severe fatigue. The patient had been diagnosed with chronic hepatitis B a number of years earlier. Although he had used entecavir, an antiviral agent, for over two years, his HBV-DNA level had not dropped below undetectable levels. The fatigue seemed to be associated with chronic hepatitis B. Traditional Korean medicine (TKM) therapy for chronic hepatitis B was administered in conjunction with entecavir and at the same dose. The excessive fatigue gradually decreased following the treatment. On the 28th day, laboratory tests revealed that the patient's bilirubin level was slightly lower and that his HBV-DNA level had dropped below undetectable levels. The addition of TKM therapy may have contributed to the HBV-DNA clearance. No similar cases have been reported in Korea. Herein, we summarize the patient's progress.

모듈 분리형 가이드 레일의 안정성 해석

한창우,손재환,장원석,김철홍 한국자동차공학회 2016 한국자동차공학회 지부 학술대회 논문집 Vol.2016 No.10