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조현병 유전적 고위험군, 초발 정신증 환자군, 건강 대조군에서의 Five Factor 성격 및 정서 특성의 다면적 비교
한재욱,김성년,박진우,윤제연,신나영,허지원,김승원,권준수 대한조현병학회 2012 대한조현병학회지 Vol.15 No.2
Objectives : Previous studies have suggested that some personality characteristics are associated with the onset, prognosis and social function in schizophrenia patients. However few is known about the personality and affective characteristic of genetic high risk group (GHR) for schizophrenia. This study aimed to investigate the personality and the affective characteristic of GHR group for schizophrenia. Methods : Participants were 54 healthy controls (HC), 26 subjects with GHR for schizophrenia and 28 subjects with first episode psychosis (FEP). We performed three self-report questionnaires; NEO-Personality Inventory-Revised, State and Anger Expression Inventory and Positive Affect and Negative Affect Schedule. Results : The GHR group showed higher score in agreeableness item than the HC (p=0.028). In extraversion item, the FEP group showed significantly lower scores than the HC (p=0.001). The GHR group showed lower scores in neuroticism item compared with FEP group in trend level. The FEP group showed higher trait-anger, lower positive affect and higher negative affect compared with the others. Conclusion : The GHR group seem to share certain vulnerable personality and affective characteristics for schizophrenia with the FEP group. On the other hands, the GHR group appeared to be more agreeable than the other groups, which might act as the compensation for other impaired functions.
80세 이상 고령에서 시행한 특발망막앞막제거술의 임상결과
한재욱,김종우,김철구,이동원,유수진,최문정,유영주,김형석,조한주,김주연,김재휘 대한안과학회 2020 대한안과학회지 Vol.61 No.2
Purpose: To evaluate clinical outcomes of idiopathic epiretinal membrane removal in patients ≥ 80 years of age. Methods: A retrospective review of medical records was performed with 56 patients who underwent vitrectomy and removal of idiopathic epiretinal membrane. In the ≥ 80 years of age group (n = 28), the best-corrected visual acuity (BCVA) and central macular thickness (CMT) before surgery were compared with those at the final follow-up. The amount of change in the BCVA after surgery was also compared between the ≥ 80 years of age group and the < 80 years of age group (n = 28). Results: In the ≥ 80 years of age group, the mean follow-up period was 19.1 ± 17.0 months. Before surgery, 11 eyes were pseudophakic and 17 eyes were phakic. Combined cataract surgery was performed with epiretinal membrane removal in all 17 phakic eyes. The mean logarithm of the minimal angle of resolution BCVA was 0.75 ± 0.30 before surgery, which improved to 0.50 ± 0.30 at the final follow-up (p < 0.001). The CMT was 458.0 ± 79.7 μm before surgery, which decreased to 367.2 ± 83.4 μm at the final follow-up (p < 0.001). There was no significant difference in the amount of change in the BCVA after the surgery between the ≥ 80 years of age group and the < 80 years of age group (p = 0.547). Conclusions: In patients with idiopathic epiretinal membrane who were ≥ 80 years of age, the visual acuity was improved or maintained, and was accompanied with anatomical improvement after epiretinal membrane removal with or without cataract surgery. These results suggest the usefulness of epiretinal membrane removal in older patients. 목적: 80세 이상 초고령 환자에서 특발망막앞막제거술의 임상성적을 보고하고자 한다. 대상과 방법: 특발망막앞막으로 유리체절제술 및 망막앞막제거술을 시행 받은 56명을 대상으로 후향적 연구를 시행하였다. 80세 이상군(n=28)에서 수술 전 측정된 시력과 중심망막두께를 최종 추적 관찰 시의 값과 서로 비교하였다. 80세 이상 군과 80세 미만 군(n=28)에서의 수술 후 시력 변화 정도를 추가적으로 비교하였다. 결과: 80세 이상 군에서 평균 추적 관찰기간은 수술 후 19.1 ± 17.0개월이었다. 수술 전 11안은 위수정체, 17안은 유수정체였으며, 유수정체였던 17안 모두에서 망막앞막제거술 시 백내장수술을 함께 시행하였다. 수술 관련 합병증은 관찰되지 않았다. 수술 전 측정된 평균 logarithm of minimal angle of resolution (logMAR) 시력은 0.75 ± 0.30이었으며, 최종 추적 관찰 시 0.50 ± 0.30으로 호전되었다(p<0.001). 중심망막두께는 수술 전 458.0 ± 79.7 μm였으며, 최종 추적 관찰 시 367.2 ± 83.4 μm로 감소하였다(p<0.001). 80세 이상 군과 80세 미만 군 사이에 수술 후 시력의 변화 정도는 유의한 차이가 없었다(p=0.547). 결론: 80세 이상 고령의 특발망막앞막환자에서 망막앞막제거술 단독 혹은 백내장수술과의 병합수술 결과 해부학적 호전과 함께 시력이 유지 혹은 회복되었다. 이러한 결과는 고령에서도 망막앞막제거술이 유용할 수 있음을 시사한다.
한재욱,임혜빈,이나영,Jae Wook Han,MD,Hye Bin Yim,MD,PhD,Na Young Lee,MD,PhD 대한안과학회 2014 대한안과학회지 Vol.55 No.9
Purpose: To compare the response of dry eye treatment in patients divided by the degree of lower lid laxity. Methods: Thirty patients were classified into three groups - normal, moderate and severe, according to the degree of lower lid laxity. Tear break-up time (TBUT), Schirmer test (ST), ocular surface disease index (OSDI) scores and changes in OSDI score in each group were compared before and at 3 months after the treatment. Results: TBUT, ST and OSDI scores were not different among the three groups at baseline. TBUT improved to 6.60 ± 1.43, 6.0 ± 2.54 and 6.0 ± 1.45 sec in normal, moderate and severe lower lid laxity group, respectively at 3 months after the treatment and no difference among the groups was found. ST scores did not increase after the treatment, while OSDI scores improved to 12.20 ± 1.40, 16.10 ± 4.63 and 20.80 ± 4.52 in each group, respectively and they were significantly different (<EM>p</EM> = 0.029, 0.029, <0.001, respectively). The response to the dry eye treatment as assessed by changes in OSDI scores was poorer in patients in the severe lower lid laxity group (<EM>p</EM> = 0.019 vs. moderate laxity group, <0.01 vs. normal group). Conclusions: As the degree of lower lid laxity increases, the response to dry eye treatment becomes poorer even when TBUT increases. J Korean Ophthalmol Soc 2014;55(9):1307-1312
Composite 추진제 적용 사출용 가스발생기 성능 최적화 연구
한재욱(Jaeuk Han),이종섭(Jongseop Lee),류정헌(Junghun Ryu),김한준(Hanjun Kim),정세용(Seyoung Jung),백국현(Gookhyun Baek),이도형(Dohyung Lee) 한국추진공학회 2018 한국추진공학회 학술대회논문집 Vol.2018 No.5
유도탄 사출용 가스발생기는 일정 값 이상의 사출 종말 속도와 허용 조건 이하의 가속도를 동시에 만족시켜야 한다. 또한 발사 플랫폼 보호를 위해 일관된 성능과 안정적인 연소가 일어나야한다, 이를 위해서는 가스발생기 설계/제작 최적화가 필요하다. 본 연구에서는 가스발생기의 점화 성능에 영향을 미치는 점화기 주장약 양과 추진제 그레인의 연소속도를 변경하여 가스발생기를 제작, 시험 하였다, 점화기 주장약 양을 줄여 점화초기 압력을 낮추어 최대가속도를 저감 할수 있게 하였고 추진제 연소속도, 조성 변경을 통해 연소불안정성이 줄어든 것을 확인 하였다. Ejection gas generator for missile launching must satisfy the maximum initial acceleration of the missile and minimum missile ejection velocity at the same time. Also, to protect the launching platform, consistent performance and stable combustion are needed. To satisfy these requirements, optimization of gas generator design and manufacturing are essential. In this study, gas generator are manufactured and tested changing the igniter agent and propellant grain burning rate which influence the initial combustion performance. Reducing igniter agent makes the lower initial pressure profiler. And combustion instability is decreased by changing the propellant grain bring rate and composition.
나이관련황반변성에 대한 항혈관내피성장인자 14회 유리체내주사: 완료시기와 임상결과
한재욱(Jae Wook Han),김종우(Jong Woo Kim),김철구(Chul Gu Kim),이동원(Dong Won Lee),한정일(Jung Il Han),유영주(Young Ju Lew),김재휘(Jae Hui Kim) 대한안과학회 2017 대한안과학회지 Vol.58 No.9
Purpose: To evaluate the clinical course of patients who had completed 14 ranibizumab or aflibercept monocular treatments. Methods: Retrospective medical record analysis was performed to 24 patients who were diagnosed with monocular neovascular age-related macular degeneration and had completed 14 ranibizumab or aflibercept monocular injections, allowed by the Korean National Health Care system. Time to completion was measured along with the percentage and timing of medication switch. Best-corrected visual acuity (BCVA) was measured at the time of diagnosis, after 3-loading injections, and the time of completion. Additionally, we searched for any other factors that had influenced the time to completion. Results: The average time to completion of 14 injections was 32.3 ± 6.2 months (21–48 months). The switching was performed in 17 eyes (70.8%), and it was done after 9.4 ± 2.1 injections (4–14 injections) with prior medication. After 14 injections, the BCVA improved in 6 eyes (25.0%), unchanged in 8 eyes (33.3%), and worsened in 10 eyes (41.7%). Complete resolution of intraretinal fluid and subretinal fluid after 3 loading injections were observed in 20 eyes, and it was significantly related to time to the first recurrence and time to the completion of 14 injections (p = 0.007, r = 0.583). Conclusions: The average time to completion of 14 injections was 32.3 months, and switching of medication was performed in 70.8%. Longer time to the first recurrence was related to longer completion time. This study will provide useful facts when informing the patients their future treatment plans under the Korean Health Care system. J Korean Ophthalmol Soc 2017;58(9):1042-1049