Cytomegalic Inclusion Disease의 2부검례

한운섭,서정훈,노재윤,김지환 中央醫學社 1971 中央醫學 Vol.21 No.3

Two cases of cytomegalic inclusion disease observed from autopsy are reported as its rare disease in this country. The first case was 23-day-old male infant who had complained of jaundice from 2 days ago without fever. It was found that he had yellowish discoloration of the skin, icteric sclera, anemic conjunctiva, and palpable liver and spleen. But he was dead in six hours of admission in spite of treatment without studying of the routine laboratory tests except blood culture, which revealed no growth during 48 hours. The gross findings at autopsy performed 44 hours after expire were yellowish skin discoloration, severe dehydration, subarachnoid hemorrhage in brain, small multiple subcapsular petechiae in thymus and bilateral cortical hemorrhagic spots of the both kidney. The liver showed dark greenish black, but the surface was smooth. The microscopic observation showed characteristic inclusion-bearing giant cells in the pituitary gland, thyroid, liver, kidney, lungs, pancreas, and adrenal glands. The second case was 76-day-old male patient complained of jaundice, acholic stool since birth and respiratory distress with cyanotic attacks. He expired with respiratory distress accompanying frequent cyanotic attacks. The gross findings of the autopsy were not significant, and then microscopic feature showed that the cytomegalovirus infection involved the lung without other visceral involvement. A brief review of the literature was also made.

비 특이성 양성 임파절 병변의 병리조직학적 및 면역조직학적 연구

한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1988 EMJ (Ewha medical journal) Vol.11 No.4

This study was undertaken in an attempt to identify histopathologic and immunohistologic findings of non-specific benign lymphnode hyperplasia. The materials used in this suty consist of 169 cases of benign lymphnode hyperplasia in the lymphnode specimen dissected due to mass during the period of 6 years and 10 months in the department of pathology. The following results were obtained. 1) The ratio male to female was 1:1.2. The frequency was most common between 20 to 29 years old age with the percents of 24. 2) The most common type of benign lymphnode hyperplasia was diffuse hyperplasia(54 cases, 32%). The follicular hyperplasia was noted in 40 cases(24%), sinus histiocytosis in 36 cases(21%) and mixed pattern in 39 cases(23%). 3) The degree of diffuse hyperplasia, sinus histocytosis and mixed pattern was mild to moderate, while the severe degree was common in follicular hyperplasia. 4) The histopathologic findings associated with benign hyperplasia were necrosis, abscess and granulomas. 5) The immunohistologic stainings showed more frequent positive cells for IgG and IgA than positive cells for IgM. The frequency of positive cells for IgG and IgA was mild to moderate in follicular hyperplasia, diffuse hyperplasia and mixed pattern of lymphnode hyperplasia. IgM positive cells was mild in degree of frequency in diffuse hyperplasia, sinus histocytosis and mixed patterns.

제 24 차 학술대회 : 73. 원발성 담낭악성종양 ( 15예의 분석보고 )

한운섭,윤세옥 대한외과학회 1972 대한외과학회 학술대회자료집 Vol.- No.-

폐 소형세포암의 광학 및 전자현미경적 연구

한운섭,등영건,최인준,이유복,김동식 최신의학사 1975 最新醫學 Vol.18 No.7

Eight cases of oat-cell carcinoma of the lung were studied histochemically and- ultrastructurally. Neurosecretory-type cytoplasmic granules were found in six cases of oat-cell carcinoma, but were not numerous. The argyrophilic granules, however,were not simply identified histochemically and, the symptoms suggesting hormonal.aecretion were not recognized clinically. Both tumors, Carcinoid and oat-cell carcinoma, show the appearance-of neurosecretory-type granules in their cytoplasm which are considered as a lowgrade malignant. in the former and a highly malignant variant. in the latter arising from Kulchitsky-type cells of Ironchi.

위 용종과 위 선암 조직내 Carcinoembryonic Antigen에 대한 면역화학적 비교 연구

한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1985 EMJ (Ewha medical journal) Vol.8 No.4

For the study of relationship between gastric polyps and gastric carcinoma, the tissue carcinoembryonic antigen, so called tumor marker, was investigated by immunoperoxidase method with paraffin embedded block in the gastric epithelial polyps and adenocarcinoma. The representative lesions of the hyperplastic polyps(6 cases), adenomatous polyps(5 cases), and adenocarcinoma(6 cases) consisting of pyloreocardiac cell type, intestinal cell type and mucous cell type, were selected. The following results were obtained. 1) The reactions of tissue CEA in the adenocarcinoma were more strong than those of gastric hyperplastic and adenomatous polyps. 2) The CEA of adenomatous polyps was demonstrated within the cytoplasm of glands and along the glandular luminal border, while the hyperplastic polyps showed CEA only along the luminal border of the gland in weak positive reaction. 3) The adenocarcinoma showed the CEA in the stroma around the cancer cells and within the glandular lumens of the cancer tissue as well as the cytoplasm of the cancer cells and glandular luminal border. 4) Among the adenocarcinomas of the stomach, the pyloro-cardiac cell and mucous cell types demonstrated more strong positive reaction for CEA than that of intestinal cell type.

Necrotizing Lymphadenitis에 대한 병리조직학적 검색

한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1984 EMJ (Ewha medical journal) Vol.7 No.2

Since 1972, the necrotizing lymphadenitis, histiocytic necrotizing lymphadenitis without granulocytic infiltration etc. Seven cases of necrotizing lymphadenitis has presented in this study. Most of them were young men cha-racterized by persistent lymphadenopathy with or without fever. The histopathologic features of lymphnodes showed focal or diffuse well cir-cumscribed paracortical necrotizing lesion , abundant karyorrhectic debris and aggregates of large mononuclear cells. However, there were no infiltrates of pla-sma cells and neutrophils. The remaining areas of lymphnodes showed severe degree of paracortical hyperplasia without significant hyperplasia of lymphoid follicles in the cortex.

난소 및 충수돌기의 원발성 경계성 점액성 종양이 병발된 복막 위점액종 1 예

한운섭,김승철,김연정,김희옥,정경아,이민진 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.11

Pseudomyxoma peritonei is a poorly understood condition characterized by mucinous ascites and multifocal peritoneal mucinous tumors. Pseudomyxoma peritonei is most commonly associated with mucinous tumors of the ovary and appendix. When two lesions are morphologically similar, it is difficult to determine whether one reflects a metastasis or whether the tumors are independent. Many studies concluded that most cases in which both the appendix and ovary were involved were primary appendiceal tumor with secondary involvement of the ovary, but we have experienced one case of pseudomyxoma peritonei originated from independent primary borderline mucinous tumors of the ovary and appendix. So we report this case with the brief review of literatures

불임증 자궁내막의 병리조직학적 및 조직화학적 연구

한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.4

One hundred and twenty cases of endometrial tissue curettaged from the patients of primary and secondary sterility were studied by the methods of histopathologic and histochemical examination. The following results were obtained: 1) The cases aged from 25 to 29 were most frequent. 2) The pathologic lesions of the endometrium were present in 12 cases. The cases of chronic endometritis were most common and were 6(5.0%). There were 2 cases of cystic hyperplasia and 2 cases of atrophy. Each one case of tuberculosis and endometrial polyp was also present. 3) Most cases among 108 cases after excluding 12 cases of pathologic lesions showed mild degree of glandular tortuosity and secretory activity with mild to moderate degree of predecidual change of stromal cells. 4) The glandular secretion of PAS positive material was mild in many cases of endometrium. However, there were many cases of absence of PAS positive material. The stromal cells showed negative or mild positive PAS staining in almost all cases. 5) The alcian blue staining revealed positivity in the glandular cytoplasm of all cases and positivity in the luminal secretion of many cases. 6) The differences of histopathology and histochemical reaction between primary and secondary sterility were not significant.

肺炎樣疾患의 剖檢 및 死後檢針組織檢査

韓雲燮,金東武 대한의학협회 1976 대한의학협회지 Vol.19 No.4

기능성 자궁출혈 환자의 자궁내막에 대한 병리조직학적 연구 : 병리조직학적 분류 및 화생변화에 관하여 Histopathologic Classification and Metaplastic Changes

한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1982 EMJ (Ewha medical journal) Vol.5 No.4

The histopathologic study of the curettaged endometrial tissue taken from the patient with the clinical impression of dysfunctional uterine bleeding was performed. The total 221 cases of this study were classified as 76 cases of proliferative phase, 46 cases of secretory phase, 25 cases of menstrual phase, 25 cases of hyperplasia, 18 cases of chronic inflammation, 11 cases of irregular shedding, etc. Even age distributions were present in the patient of proliferative, secretory and menstrual phases. However, most cases of hyperplasia, irregular shedding, atrophy and adenocarcinoma of the endometrium were found at the age of more than 40. The metaplastic changes of endometrial tissue were present in about 1/3 of total cases. Almost all of these metaplastic changes were epithelial metaplasia. The most common type of epithelial metaplasia was tubal metaplasia which was observed mostly in the hyperplasia including cystic and adenomatous hyperplasia. The varieties of metaplastic changes occurred in the proliferative phase, secretory phase, chronic endometritis and menstrual phase in order. There were only 2 cases of mesenchymal metaplasia which was osseous and smooth muscle metaplasia.