Gastric stem cells and gastric cancer stem cells

한명은,오세옥 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.1

The gastric epithelium is continuously regenerated by gastric stem cells, which give rise to various kinds of daughter cells, including parietal cells, chief cells, surface mucous cells, mucous neck cells, and enteroendocrine cells. The self-renewal and differentiation of gastric stem cells need delicate regulation to maintain the normal physiology of the stomach. Recently,it was hypothesized that cancer stem cells drive the cancer growth and metastasis. In contrast to conventional clonal evolution hypothesis, only cancer stem cells can initiate tumor formation, self-renew, and differentiate into various kinds of daughter cells. Because gastric cancer can originate from gastric stem cells and their self-renewal mechanism can be used by gastric cancer stem cells, we review here how critical signaling pathways, including hedgehog, Wnt, Notch, epidermal growth factor, and bone morphogenetic protein signaling, may regulate the self-renewal and differentiation of gastric stem cells and gastric cancer stem cells. In addition, the precancerous change of the gastric epithelium and the status of isolating gastric cancer stem cells from patients are reviewed.

부모와의 상호작용과 또래애착에서 정신건강과 공동체의식의 매개효과: 고등학생을 대상으로

한명은,서은희 학습자중심교과교육학회 2024 학습자중심교과교육연구 Vol.24 No.1

Objectives This study analyzed whether the mediating effect of mental health and sense of community was significant in the relationship between parents-children interaction and peer attachment of mid. adolescents, and whether having the multiple mediating effects of parents-children interaction on peer attachment through mental health and sense of community. Methods For the purposes, 6,429 cases, taken from the 7th wave data(high school 2nd year) of KELS2013 were used. A survey of parents-children interaction, mental health, sense of community, and peer attachment was conducted. Bootstrapping analysis was performed using the SPSS Macro Process to examine the mediating effects. Results The direct effects of parents-children interaction, mental health, and sense of community on peer attachment were significant. The each mediating effect of mental health and sense of community was significant in the relationship between parents-children interaction and peer attachment. As s result of analyzing the multiple mediators of mental health and sense of community in the effect of parents-children interaction on peer attachment, a sequential multi-mediation functions appeared between the two variables. Conclusions Parents-children interaction influences mid. adolescents’s peer attachment formation through bolstering mental health and sense of community. This implies that mental health counseling and sense of community training helps the formation of the mid. adolescents’s peer attachment

경제지표를 활용한 다중선형회귀 모델 기반 국제 휘발유 가격 예측

한명은,김지연,이현희,김세인,박민서 국제문화기술진흥원 2024 The Journal of the Convergence on Culture Technolo Vol.10 No.1

The domestic petroleum market is highly sensitive to changes in international oil prices. So, it is important to identify and respond to those changes. In particular, it is necessary to clearly understand the factors causing the price fluctuations of gasoline, which exhibits high consumption. International gasoline prices are influenced by global factors such as gasoline supplies, geopolitical events, and fluctuations in the U.S. dollar. However, previous studies have only focused on gasoline supplies. In this study, we explore the causal relationship between economic indicators and international gasoline prices using various machine learning-based regression models. First, we collect data on various global economic indicators. Second, we perform data preprocessing. Third, we model using Multiple linear regression, Ridge regression, and Lasso(Least Absolute Shrinkage and Selection Operator) regression. The multiple linear regression model showed the highest accuracy at 96.73% in test sets. As a result, Our Multiple linear regression model showed the highest accuracy at 96.73% in test sets. We will expect that our proposed model will be helpful for domestic economic stability and energy policy decisions.

노인환자에서 대뇌질환에 의해 나타나는 섬망

한명일(Myeong Il Han) 대한노인정신의학회 2008 노인정신의학 Vol.12 No.2

There are well known predisposing and precipitating factors for delirium in elderly patients. Although cerebral disease is a major precipitating factor for delirium, the concept of cerebral disease is not clear. Stroke is a typical condition reflecting intracranial change. There are not many studies about delirium post stroke. This paper reviewed delirium post stroke, instead of cerebral disease induced delirium as a whole. The etiology of delirium post stroke is not well established. The neuroanatomical site and the extent of stroke are important risk factors for the development of delirium. In spite of many limitations CAM, DRS, and MMSE are useful evaluating tools for delirium. In some cases of post stroke delirium, it was developed directly by stroke without any additional cause. In other cases there were also medical complications. And in the rest of the cases, there were multiple potential causes for delirium. Although there are not specific preventive interventions for delirium post-stroke, identifying and correcting the underlying stroke, as well as preventing secondary medical complications are important. Multicomponent non-pharmacological interventions are helpful to prevent delirium, and pharmacological methods for treating behavioral symptoms are sometimes necessary. There should be more studies about cerebral disease induced delirium.

중국 3~6세기 출토 청동 조명도구 연구

韓茗 충남대학교 백제연구소 2021 百濟硏究 Vol.74 No.-

This paper collects the data of bronze lamps unearthed from the 3rd to 6th century in Chinese mainland. According to the difference from the perspective of form, they are divided into eight types: vertical handle lamp, branches-shaped lamp, horizontal handle lamp, pendant lamps, clamshell-shaped lamp, vessel-shaped lamp, candle tray and candle socket, based on which we trying to summarize the evolution of bronze lamps between the end of Han Dynasty to Sui Dynasty. We investigate the general appearance of lamps in the Six Dynasties taking ceramic lamps from the same period as comparison. Although the production of bronze lamps declined after the Han Dynasty, under the background of the rise of porcelain manufacturing industry, lamp decoration showed a strong artistic expression and the influence of foreign culture, especially the rise of lamps for candle, which made the lamps more decorative and full of the new fashion of the times. The wide use of candles promoted the change of lighting fuel, which was the most important reason for the change of the forms of lamps after Han Dynasty. It was the Six Dynasties that was the transition period of ancient Chinese lamps. Starting from the particularity of the lamps from the Six Dynasties, based on the aboved iscussion, this paper discusses the judgment and classification standards of lamps and lanterns in the Han-to-Tang Dynasties period, and points out the complexityof lamp typology and that there remains much to be further explored. 본고는 중국대륙에서 출토된 3~6세기 청동 조명도구를 체계적으로 수집하고 정리하였다. 형태의 차이에 따라 수병등(豎柄燈), 연지등(連枝燈), 횡병등(橫柄燈), 제등(提燈), 녹로등(轆轤燈), 치등(卮燈), 촉반(燭盤), 촉삽좌(燭插座)의 8가지 형식으로 나눌 수 있으며, 이를 통해 한나라 이후부터 수나라 이전까지의 청동 조명도구의 변천양상을 파악해보았다. 또, 동시대의 도자기 조명도구의 형태와 비교하여 육조시대 조명도구의 전체적인 모습을 살펴보았다. 비록 한나라 이후 청동 조명도구 제작이 쇠퇴하였지만, 도자기 수공업이 발달하면서 조명도구 장식에높은 예술적 표현력과 역외(域外) 문화의 영향을 보여준다. 특히 촉삽좌 같은 조명도구의 발전으로 같은시기의 조명도구 장식을 풍부하게 하고 새로운 시대적인 특징도 더하였다. 초(燭)의 보급으로 조명연료가 변하게 된 것은 한나라 이후 조명도구의 형태변화의 가장 중요한 계기이며, 육조시대는 중국 고대 조명도구의 전환기로 되었다. 본고에서는 한당시대(漢唐時代) 조명도구의 연구과 분류기준을 참고하여 육조시대 조명도구의 특별한 성격에 알아보았다. 또한, 현재 조명도구의 형식학적 연구에 대해 복잡한 분류와 자료의 부족에서 문제가 있음을 제시하였다.

알츠하이머 치매의 행동심리증상에서 비정형 항정신병약물

한명일(Myeong-Il Han),황태영(Tae-Young Hwang),이지은(Jieun Lee) 대한노인정신의학회 2015 노인정신의학 Vol.19 No.2

AD 환자의 치료에서 BPSD를 조절하는 것은 매우 중요하다. 이를 통하여 환자의 삶의 질을 향상시키고 가족과 수발자 의 부담을 경감시키며 요양시설 등에의 입소를 지연시켜 의료비의 감소를 유도할 수 있다. AD 환자에서 빈발하는 정신증, 초조증상, 그리고 공격성 등의 BPSD 치료에 공인된 약물은 아직 없다. 다만 임상 지침서와 전문가의 의견을 토대로 AAP 가 일차적 선택 약물로 추천된다. AD 환자에서 정신증을 비롯한 BPSD의 치료에 사용되는 risperidone과 aripiprazole의 치료적 효과는 분명하지만 효 과의 정도는 크지 않다. Olanzapine의 치료 효과는 앞의 두 가지 약물에 비해 다소 부족하고, quetiapine은 고용량에서 어느 정도 효과가 있을 것이라고 기대된다. AAP의 사용과 관련하여 흔히 발현되는 부작용으로는 졸림, EPS, 말초 부종 등이 있다. AAP는 인지기능 저하, CVAEs 증가, 그리고 사망률 증가 등의 심각한 부작용을 발생시킨다. 치료 효과는 크 지 않고 부작용은 심각하기 때문에 AD 환자의 BPSD를 치료하기 위해 AAP를 사용하는 경우에는 약물 사용에 따른 편익(benefits)과 위험(harms)을 충분히 비교하면서 접근하 는 것이 중요하다. In addition to cognitive and functional decline, various behavioral and psychological symptoms in dementia (BPSD) are mani-fested in the patients with Alzheimer’s dementia (AD). Some of BPSD, especially psychosis, agitation, and aggression could be challenges to caregivers and clinicians. Atypical antipsychotic drugs (risperidone, olanzapine, quetiapine, and aripiprazole) are widely prescribed to manage complicated neuropsychiatric symptoms associated with AD. It is known that atypical antipsychotics (AAP) have modest and significant beneficial effects in the short term treatment of BPSD. However their safety of AAP has been concerned with potentially increased adverse events. This article reviewed the treatment outcomes and adverse effects of AAP when managing BPSD in the patients with AD. The effects of risperidone and aripiprazole are obvious on psychosis and aggres-sion, but with small effect size. AAP could exacerbate cognitive decline, and it could increase the rate of cerebrovascular accidents and mortality rate in the patients with AD.

지역사회의 건강증진을 위한 금연사업의 개선방안

한명이,김노마,Mehta Jaydip Chandrkant 한국디지털정책학회 2012 디지털융복합연구 Vol.10 No.4

노인 환자에서 나타나는 섬망의 임상적 접근

한명일(Myeong Il Han) 대한노인정신의학회 2004 노인정신의학 Vol.8 No.2

Delirium is not uncommon and is a devastating clinical syndrome. Elderly patients are vulnerable to delirium, especially demented or/and medically-surgically ill patients. Old age, comorbid psychiatric, medical and/or neurological diseases, medications, changed pharmacodynamics, sensory impairment and psychosocial stresses contribute to the development of delirium. Delirium in elderly patients is somewhat different from delirium in younger patients, sometimes under detected and/or poorly managed. This review discusses the diagnosis, classification, etiology and treatment, and presents 3 clinical cases of delirium in elderly patients. This review also focuses on a practical approach in assessing and managing delirium in elderly patients. The management of delirium consists of identifying and correcting the underlying problems, including prescribing suitable medication.

서울시 노인돌봄종사자의 직업만족도 연구

한명이 한국노인복지학회 2023 한국노인복지학회 학술발표논문집 Vol.2023 No.5

고혈압의 응급치료로서 刺針이 혈압에 미치는 영향

한명아,김동웅 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.4

It was recognized in the previous studies that electric muscular stimulation or electric acupuncture affected on the sympathetic nerve activities, and especially blood pressure was decreased to statistically significant value in the hypertension patients. But those electric acupuncture effect was controversial in other studies. In this study, we investigated the effects of systemic acupuncture and ear acupuncture combined with systemic acupuncture on blood pressure. When patients first visited to emergency room(ER) of Oriental Medicine Hospital of Wonkwang Oriental Medical School, blood pressure was checked. Then systolic pressure was more than 180mmHg and diastolic blood pressure was more than 90mmHg, the patient was included into Systemic acupuncture group. During admission day, if the same patient was checked again high blood pressure(borderline was same to ER), then included into ear acupuncture combined systemic acupuncture group. And same patient was checked again high blood pressure(borderline was same to ER), then included into control group. In this way fifteen patients was included into this study. In systemic acupuncture group, ear acupuncture combined with systemic acupuncture group and control group, systemic blood pressure was commonly decreased at 50minutes, 60minutes, 120minutes after the baseline in statistical significance value. But diastolic blood pressure was not changed in statistical significance. Compared to control group, systemic acupuncture group or ear acupuncture combined with systemic acupuncture group had not revealed more significant change in blood pressure. There was no therapeutic superiority of systemic or ear acupuncture on high blood pressure control to non-acupuncture group.