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국내 염증성장질환의 약물치료 및 약제비 현황: 2010-2014 국민건강보험자료 활용 연구
하정은,장은진,임슬기,손현순 한국임상약학회 2019 한국임상약학회지 Vol.29 No.2
Backgrounds: Inflammatory bowel disease (IBD) including ulcerative colitis (UC) and Crohn’s disease (CD) increased prevalence and economic burden. Objectives: This study aimed to investigate drug use pattern in IBD patients in a real world. Methods: National Health Insurance claim data from 2010 to 2014 were used in this population-based study. All IBD patients diagnosed during study period were enrolled. IBD medications included 5-aminosalicylic acid (ASA), glucocorticoid, immunomodulator and anti-tumor necrosis factor-α agent(anti TNF-α). Growth rate of IBD prevalence, prescribed drug classes, duration of drug therapy and medication cost were analyzed. Number and percentage of patients for categorical variables, and mean and median for continuous variables were presented. Results: Total numbers of patients were 131,158 and 57,286 during 5 years, and their annual growth rate were 3.2 and 5.7% for UC and CD. UC and CD were prevalent in the 40-50 (41.2%) and 20-30 age groups (36.0%). About 60% of IBD patients was prescribed any of medications. 5-ASA was the most frequently prescribed, followed by corticosteroid and immunomodulator. Anti TNF-α use was the lowest, but 5 times higher than UC in CD. Combination therapies with different class of drugs were in 29% for UC and 62% for CD. Mean prescription days per patient per year were 306 and 378, and the median medication cost per patient per year was KRW 420,000 (USD 383) and KRW 830,000 (USD755), for UC and CD, respectively. Conclusions: Increasing prevalence of IBD requires further studies to contribute to achieve better clinical outcomes of drug therapy.
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하정은 대한통합의학회 2018 대한통합의학회지 Vol.6 No.1
Purpose : Preeclampsia(PE) is a pregnancy-specific disease which is characterized by hypertension and proteinuria. This disease occurs in about 2-8% of pregnancies in developing countries and remains among the major causes of maternal and neonatal mortality and morbidity throughout the world. Although the causes of PE are not fully understood, the infection has been considered as the main risk factor for this diseases. Periodontal disease may provide a chronic burden of endotoxin and inflammatory cytokines and the disease has been considered as risk factors of systemic illnesses including cardiovascular disease, atherosclerosis, and cerebrovascular ischemia. So, studies performed over the last 15 years have suggested that periodontal disease may be associated with adverse pregnancy outcomes such as PE. However, this association has not been found in all populations. The aim of this review article was to evaluate whether periodontal status and the presence of specific periodontal pathogens may influence the incidence of PE. Method : Many research articles searched at the electronic databases(MEDLINE; 2000 to July 2017) including search term as periodontal disease and preeclampsia. Result : There were 11 case-control studies and 5 cohort studies meeting our inclusion criteria. The results showed that maternal periodontitis (adjusted odds ratio: 1.5 to 9.3) was associated with preeclampsia in 16 epidemiological studies. Conclusion : It is clear that maternal periodontitis is a risk factor associated with preeclampsia, emphasizing the importance of periodontal care in prenatal programs. 목적: 자간전증은 임신 20주 이후에 고혈압과 함께 단백뇨가 나타나는 임신 특이성 질환으로 발병률이 약 2-8% 정도로 보고되고 있으며, 모체와 신생아의 질병 및 사망의 주요 원인 중에 하나로 꼽힌다. 자간전증 발생의 위험요인으로는 감염이 가장 주요한 원인으로 여겨지고 있어, 구강 내의 만성염증질환인 치주질환이 자간전증 발생에 영향을 미칠 수 있다는 가설이 제기되었다. 그 이후 치주질환과 자간전증 발생에 대한 연관성을 확인하기 위한 분자생물학 연구 및 역학 연구가 진행되었으나, 명확한 관련성에 대한 체계적 고찰이 보고되지 못하고 있는 실정이다. 따라서 본 연구는 임신기에 진행되어 악화될 수 있는 치주질환이 고위험 임신인 자간전증에 미치는 영향에 대한 연구 결과의 최근 동향을 알아보고자 한다. 방법: 2000년에서 2017년까지 발행된 자간전증과 치주질환간의 연관성을 확인한 역학연구를 대상으로 하였으며, “치주질환”, “자간전증”이라는 키워드로 검색하였다. 연구설계방법은 환자대조군연구와 코호트연구를 대상으로 조사하였다. 결과: 11편의 환자대조군 연구와 5편의 코호트 연구가 조사되었으며, 전체적으로 자간전증과 치주질환간의 연관성은 보정비차비가 1.5에서 9.3으로 조사되었다. 결론: 자간전증은 치주질환과의 환자-대조군 연구인 단면적 연구설계 뿐만 아니라 전향적 코호트 연구 설계에서도 연관성이 입증되는 것으로 조사되었다. 따라서 임신기에는 모체의 구강건강 뿐만 아니라 건강한 임신 및 출산을 위하여, 치주건강관리가 필수적이며, 이를 위한 여성 치주건강 프로그램의 개발 및 보급이 필요할 것이다.
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일부지역 대학생들의 이성교제 여부가 구강건강행태에 미치는 영향
하정은,김수빈,김수진,서은지,이지영,정여진,김민지,Ha, Jungeun,Kim, Subin,Kim, Sujin,Seo, Eunji,Lee, Jiyoung,Jeong, Yeojin,Kim, Minji 대한통합의학회 2017 대한통합의학회지 Vol.5 No.3
Purpose : The purpose of this study was to investigate whether or not the effects of the relationship among college students on the oral health were affected by the increased interest in the appearance. Methods : After explanation of this study, we conducted the questionnaire to those who accepted questionnaire from April 26 to May 28, 2017. In order to collect the data, Naver-form (mobile) questionnaire was distributed to the research subjects and the collected data. The analysis technique used the frequency and percentage to examine the general characteristics of the subjects and the status of the relationship. Chi-square test was used to examine the number of toothbrushes, toothbrushing time, oral health concern, regular oral examination and scaling, use of oral care products, smoking status, and bad breath. Result : Among the total of 190 research subjects, 79 (41.6 %) were male and 111 (58.4 %) were female. The presence of brushing just before going out and carrying a toothbrush were more frequent for those subjects who are in relationship (p<.001). The subjects who considered oral hygiene to be important were higher in those who were in relationship (p<.001). Conclusion : Some oral health care behaviors such as toothbrushing just before going out or carrying a toothbrush were well formed, and oral hygiene was important in those who were in relationship.
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하정은 한국병원약사회 2003 병원약사회지 Vol.20 No.1
남성형 탈모증은 유전적인 배경이 있는 사람에서 androgen의 작용으로 사춘기 이후 모발이 가늘어지고 탈모가 발생하는 질환으로 일부에서는 정상적인 노화과정으로 인식되기도 한다. 남성형 탈모증은 남성뿐만 아니라 여성에게도 발생하며 그 양상은 남성과 여성이 다르지만 기전은 동일하다.
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