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하수정,이성철,박소정,전형준,이연월,조종관,유화승,Ha, Su-jeong,Lee, Sung-cheol,Park, So-jung,Jeon, Hyung-joon,Lee, Yeon-Weol,Cho, Chong-kwan,Yoo, Hwa-seung 대한암한의학회 2019 大韓癌韓醫學會誌 Vol.24 No.1
Objective : The purpose of this study is to report and observe effects of Integrative Cancer Treatment (ICT) on metastatic breast cancer patient. Method : A left breast cancer patient diagnosed with recurrence on liver and bones April 2018. The patient had received paclitaxel chemotherapy for two months and discontinued it because of tumor progression and side effects. The patient has been treated with ICT since March 2018 and has been taking capecitabine since October 2018. The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA15-3). The clinical outcomes were measured by computed tomography, laboratory findings including tumor markers (CEA, CA15-3), liver function test (AST, ALT), Eastern Cooperative Oncology Group performance status (ECOG PS), and numeric rating scales (NRS). Results : After the ICT, tumor size was partially decreased accompanying by reducing the levels of tumor markers. Major clinical symptoms induced by paclitaxel chemotherapy were improved. There were no severe adverse events induced by ICT based on National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0. Conclusion : This case suggests that ICT may have synergistic effect for the treatment of metastatic breast cancer patient in conjunction with capecitabine.
Stainless steel에 접종된 식중독 미생물에 대한 천연항균제 및 유기산 분무 살균효과
하수정,오세욱,양승국,박현주,김충환 한국식품위생안전성학회 2011 한국식품위생안전성학회지 Vol.26 No.4
This study was carried out to investigate efficacy of aerosol sanitizer with natural antimicrobial and organic acids against Escherichia coli O157:H7, Salmonella Typhimurium and Listeria monocytogenes. The artificially inoculated pathogens on stainless steel coupon were treated with grapefruit seed extract (GFE), acetic acid,citric acid and lactic acid in model cabinet for 5 min. The number of three foodborne pathogens with individual treatment was reduced by 0.34-3.77 log units, treatment with GEF + organic acid was reduced by 1.72-3.89 log units and treatment with GEF + organic acid + alcohol was reduced by 1.46-5.05 log units. By treatment with GEF + lactic acid + alcohol in scale-up model system for 10 min. Populations of E. coli O157:H7, S. Typhimurium and L. monocytogenes were reduced by 3.42, 2.72 and 2.30 log units from the untreated control respectively. From the above result,aerosol sanitizer with natural antimicrobial agents and organic acid can be used as an environmental sanitation method with satisfying the consumer demand on safe food.
Preventive effect of Ephedra sinica extract on UVB-induced COX- 2 and MMP-1 expression
하수정,이창주,정성근 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.4
Ultraviolet B (UVB)-induced cyclooxygenase (COX)-2 and matrix metalloproteinase (MMP)-1 are representative markers for skin inflammation and photoaging, respectively. To evaluate compounds that may counteract the effects of UVB-induced skin damage, we developed an immortalized human keratinocyte (HaCaT) cell line with an MMP-1 reporter construct. Among the 30 botanical extracts screened, we selected Ephedra sinica extract (ESE) as a promising candidate and confirmed that ESE significantly suppresses UVB-induced COX-2 and MMP-1 expression in HaCaT cells. Treatment with ESE also potently suppressed UVB-induced ERK1/2 phosphorylation, as well as UVB-induced MEK1/2 and Raf phosphorylation in HaCaT cells. These findings suggest that our MMP-1 reporter system can be used to evaluate compounds with anti-inflammatory and anti-photoaging effects. We also report that ESE has potent suppressive effects against COX-2 and MMP-1 expression, which occurs via downregulation of Raf/MEK1/2/ERK1/2 phosphorylation.
비소세포성 폐암환자의 Crizotinib과 삼칠충초정 병용투여 경과관찰 1례
하수정,송시연,박소정,전형준,이연월,조종관,유화승,Ha, Su jeong,Song, Si yeon,Park, So-jung,Jeon, Hyung-joon,Lee, Yeon-weol,Cho, Chong-kwan,Yoo, Hwa-seung 대한암한의학회 2018 大韓癌韓醫學會誌 Vol.23 No.1
Objective: The purpose of this study is to report the case of a patient with non-small cell lung adenocarcinoma (NSCLC) with anaplastic lymphoma kinase (ALK) mutation treated by Samchilchoongcho-Jung in conjunction with Crizotinib. Methods: An NSCLC patient diagnosed with multiple pleural and lymph nodes metastasis has been taking Crizotinib (500 mg/day) since January 2014. The patient has been treated with Samchilchoongcho-Jung (1,500 mg/day) since June 2014. The tumor size was measured by computed tomography (CT) and laboratory analysis was conducted. Adverse events were evaluated by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), version 5.0. Results: After combining treatment, stable disease was shown on CT. The tumor marker (CEA, Cyfra 21-1) levels were maintained. NCI-CTCAE 5.0 showed no adverse events. Conclusion: This case study suggests that Samchilchoongcho-Jung may contribute to tumor response, in conjunction with Crizotinib on the treatment of patients with NSCLC.
노르딕 누아르(Nordic Noir) 속 여성의 역할 변화: 로재나에서 리스베트 살란데르를 거쳐 말린까지
하수정 한국 스칸디나비아학회 2023 스칸디나비아 연구 Vol.31 No.-
Scandinavian crime fiction has gained immense popularity since the 1990s, becoming a global phenomenon in the 2000s. Known for its unpretentious narrative style, authentic dark atmosphere, and complex characterization, Nordic Noir stands apart from its predecessors by featuring ordinary police stations and their everyday problems reflecting reality. This paper explores the origins of the term “Nordic Noir” and delves into its defining features. The novel “Roseanna,” written by Maj Sjöwall and Per Wahlöö in 1965, played a pivotal role in shaping the future of Nordic Noir and influencing subsequent writers. The study focuses on the winners of the Glass Key Award, an annual literature award given to a Nordic crime novel, compiling statistics on the gender of narrators, assailants, and victims. A character tree is used to analyze the relationships among the characters. Traditionally portrayed as victims, female characters have now become more diverse in terms of their professions and roles within Nordic Noir narratives. In the 2000s, stories led by female protagonists became increasingly common, while minors, immigrants, and LGBTQ+ characters also started appearing as victims. However, male characters still dominate the role of assailants. Notably, every male victim has a connection to their assailant, providing a motive for their elimination. In contrast, female victims are often targeted by strangers or passersby encountered during their daily routines. The evolution of female characters in Nordic Noir, from the silent “Roseanna” to the resilient Lisbeth Salander and beyond, not only reflects the contemporary Nordic society but also spearheads the changing landscape of crime fiction. While female characters were initially limited to victim roles, they have now gained more agency and representation, showcasing a broader range of experiences and occupations. However, the prevalence of male assailants highlights persistent gender imbalances. Understanding these shifts and trends allows for a deeper exploration of the complexities within Nordic Noir and its impact on contemporary crime literature. 1990년대부터 시작된 북유럽 범죄소설의 인기는 2000년대 들어 세계적 현상이 되었다. 비현실적으로 뛰어난 탐정이 사건을 해결하는 추리소설과 달리 인물 중심 구조에 사회비판적 성격을 띤 북유럽 범죄소설은‘노르딕 누아르’라는 별칭으로 분류되었다. 이 글은 노르딕 누아르의 기원과 특징을 살피고, 현실 반영에 충실한 노르딕 누아르 속 여성 인물이시대에 따라 어떻게 변했는지 분석하는 것을 목적으로 한다. 노르딕 누아르의 시초로 불리는 마이 셰발과 페르 발뢰의 로재나를포함해, 매년 북유럽 범죄소설 중 가장 뛰어난 작품에 수여하는 유리열쇠상 수상작 중 1993년부터 2020년까지 수상작 중에 한국어로 출판된모든 작품을 분석 대상으로 삼았다. 수상 작가의 성별, 각 작품의 화자/ 가해자/피해자의 수와 성비를 집계하고 벡델 테스트를 적용했다. 등장인물의 성비와 역할이 어떻게 변하는지 통계를 활용해 확인하였으며, 마인드맵으로 각 작품의 인물 관계도를 그렸다. 역할 변화에 이정표가 되는 주요 인물의 경우 묘사를 따로 분석해 정성적 측면을 보강했다. 초창기 주로 피해자로만 그려지던 여성의 역할이 최근 들어 다양해지고 주도적인 인물, 남성으로 바꿔도 어색하지 않은 성중립적 인물이 늘었다. 2000년대 들어 피해자에 어린이, 청소년, 성소수자, 이민자 등 사회적 약자가 등장하는 것을 확인할 수 있었다. 남성 피해자의 경우 가해자와 모두 아는 사이였던 것과 달리 여성 피해자는 가해자와 일면식도 없거나 일상에서 우연히 마주친 후 범죄의 타깃이 되는 경우가 많았다. 북유럽 사회 곳곳에 여성 진출이 늘고 평등이 확장된 지난 30여 년간 노르딕 누아르 속 여성 인물도 많은 변화를 겪었다. 수동적 존재(주로 피해자)에서 적극적인 주체(가해자, 해결자)로의 변화뿐 아니라 늘어난 여성의 직업군, 가정과 조직 내의 역할과 문제해결 방식 등 사회상을 충실히 반영하는 노르딕 누아르 속 여성의 역할도 북유럽 사회와 함께 진화했다.