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폐경후 여성에서 호르몬 치료에 따른 골 생화학 표지자들의 양상에 관한 연구
추형식(Hyung Sik Chu),채희동(Hee Dong Chae),김정훈(Chung Hoon Kim),장윤석(Yoon Seok Chang),목정은(Jung Eun Mok),강병문(Byung Moon Kang),장영우(Young Woo Chang),강은희(Eun Hee Kang) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.2
N/A Objectives: To investigate the patterns of biochemical bone markers, such as urinary deoxypyridinoline (DPD), N-telopeptide of type I collagen (NTX), and serum osteocalcin (OC), bone-specific alkaline pbosphatase (BSAP) in postmenopansal women with hormone replacement therapy (HRT). Materials and Method: From July 1997 to January 1998, total 239 postmenopausal women were emolled in the present study, and 198 healthy premenopausal women with regular menstruation were served as control. The postmenopausal women were pouped into the HRT group and the non-HRT group. The women in the HRT poup have received estrogen with continuous or cyclic progestin therapy far more tban 6 months. The biochemical bone markers of all women were assayed. Results were analysed with Students t-test. Results: The urinary DPD of the non-HRT group was sigaificantly higher than both the HRT poup and the premenopausal group(5.51 +- 2.47 vs. 3.36 +- 1.02 and 4.01 +- 3.86 nM/mM, p < 0.05, repectively). The urinary NTX of the non-HRT group was also higher in comparison to the HRT group and the premenopausal group(48.71 +- 11.54 vs. 33.70 +- 17.43 and 33.70 +- 17.43 nM BCE/mmol, p < 0.05, repectively). However, there were no significant differences in the concentrations of serum BSAP and OC among the three poups. Conclusion: The urinary DPD and NTX were more sensitive indicators of bone metabolism tban serum BSAP and OC in postmenopausal women undergoing HRT.
폐경 전후 여성에서 생화학적 골대사지표들의 폐경기간에 따른 변화 양상에 관한 연구
추형식(Hyung Sik Chu),채희동(Hee Dong Chae),김정훈(Chung Hoon Kim),장윤석(Yoon Seok Chang),목정은(Jung Eun Mok),강병문(Byung Moon Kang),조준식(Jun Sik Jo),강은희(Eun Hee Kang) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12
N/A Changes of bone turnover with aging are responsible for bone loss and play a major role in osteoporosis. Among the early postmenopausal women, as are known by previous study, there are about 35% fast bone losers and bone turnover is more uncoupled in osteoporotic group than in normal control. So, early detection of such fast losers and women who have high turnover rate is important to prevent postmenopausal osteoporosis and spontaneous fracture. Dual-energy X-Ray absorptiometry (DEXA), however, cannot reflect current bone loss because changes in bone mineral density (BMD) are only seen after 1 or more years of bone densities declining. In this study, we have measured a battery of new sensitive and specific markers of bone turnover which reflect current bone loss. To investigate the changing pattern of those markers, 674 healthy women including 451 postmenopausal women were classified, according to their menopausal period (less than 5 years, 5-10 years, more than 10 years). Bone formation was assessed by serum osteocalcin (OC), bone-specific alkaline phosphatase (BSAP) and bone resorption by the urinary excretion of deoxypyridinoline (DPD), cross-linked N-telopeptide of type I collagen (NTX). All Biochemical markers, except OC, significantly increased after menopause (p < 0.05). NTX and BSAP remained elevated after 10 years of menopause. These data indicated that the overall rates of both bone formation and bone tesorption increased after menopause and remained high in elderly women.
추형식(Hyung Sik Chu),채희동(Hee Dong Chae),김정훈(Chung Hoon Kim),장윤석(Yoon Seok Chang),이종표(Jong Pyo Lee),강은희(Eun Hee Kang),강병문(Byung Moon Kang) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3
Congenital diaphragmatic hernia (CDH) is caused by a failure of fusion of the muscular diaphragm and results in herniation of abdominal viscera into the thorax, It occurs in appoximately 1 in 2,200 to 5,000 live births, and most cases are probably multifactorial, but they can be also associated with chromosomal abenation. Due to the improvement of sonography, it can be diagnosed more accurately. However, the mortality associated with CDH is extremely high. It is well known that the incidence of congenital anomaly in infants after in vitro fertilization and embryo transfer (IVF-ET) is not increased copared with that of general population, and CDH that occurred following IVF-ET has not been reported. A case of CDH that occurred following IVF-ET is presented with brief review of literatures.
다낭성난소증후군 환자들에게서 배란유도시 성장억제호르몬 유사체가 난소반응에 미치는 영향
추형식(Hyung Sik Chu),채희동(Hee Dong Chae),김정훈(Chung Hoon Kim),강병문(Byung Moon Kang),장윤석(Yoon Seok Chang),강은희(Eun Hee Kang) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.3
N/A Objective: To determine whether the somatostatin analogue, octreotide, given concunently with human menopausal gonadotropin (HMG) affects ovarian response, ovulation induction outcome, and serum levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) in infertile patients with polycystic ovarian syndrome (PCOS) resistant to clomiphene citrate (CC). Methods: From August 1996 to June 1998, 42 infertile patients with PCOS urresponsive to CC were enrolled in the present study. Women who had other infertility factors were excluded from this study. Patients were randomly allocated either to combined HMG and octreotide treatment (treatment group) (n 21) or HMG alone (control group) (n=21). In the treatment group, 100 micrograms of octreotide were administered daily concomitantly with HMG from the 3rd day of menstrual cycle to the preceding day of human chorionic gonadotropin (HCG) injection. Results: Patient's characteristics were comparable in both groups. One cycle in the control group was abandoned because of excessive follicular development. However, none of the cycles in the treatment group was abandoned. There were no differences in the number of HMG ampules required and the duration of HMG administration between the two groups. The number of follicles > 14mm diameter on the day of HCG injection was significantly less in the treatment group than that in the control group (p<0.01). The serum estradiol level on the day of HCG injection was also significantly lower in the treatment group, with 1391.0 +- 695.5 pg/ml compared with 2217.5 +- 811.6pg/ml in the control group (p<0.001). The incidence of severe ovarian hyperstimulation syndrome seemed to be lower in the treatment group, but the difference did not achieve significance (4.9% vs 23.8%). There were no differences in the clinical pregnancy rate, miscarriage rate and multiple pregnancy rate between the two groups. Although serum GH levels were comparable between the two groups, serum IGF-1 level on the day of HCG injection was significantly higher in the treatment gmup than that in the control group (p<0.001). Conclusion: This study suggests that the combined octreotide and HMG treatment could improve hormonal milieu and folliculogenesis compared to HMG alone, and therefore may be effective in ovulation induction for patients with PCOS resistant to CC.
녹색경제와 지속가능발전을 위한 환경정책 뉴 패러다임 개발
추장민 ( Jangmin Chu ),주현수,강형식,황상일,이현우,조지혜,한진석,신동원,윤경준,홍종호,윤순진,최선미,임혜숙,홍현정,서은주,정아영,박종문,김지혜,최종민,손민지,예민지 한국환경연구원 2017 수시연구보고서 Vol.2017 No.-
The purpose of this study is to develop a new environmental policy paradigm for green economy and sustainable development and to develop major policy tasks in each field based on the analysis of internal and external environmental changes and current and future environmental issues. Changes in population structure such as aging population and low fertility, personalization and localization, urbanization and depletion of resources, international power movement and New Normal, new technologies such as Big Data in accordance with the 4th Industrial Revolution are demanding fundamental change of development paradigm such as green economy for development. Along with such changes, new changes in environmental administration and governance systems are required, including integrated response systems for cross cutting across ministries such as fine dust, biocide, climate change, and environmental disaster. In addition, it is necessary to effectively reorganize the environmental finance and tax system to solve the environmental finance pressure due to the rapid increase in public demand for health, safety and environmental services. As a major policy agenda in the field of environment, it is necessary to realize the environmental rights of the people, to coordinate and restructure the environmental governance, to establish sustainable smart-city environment management, to establish a system to cope with global fine dust, improvement of environment of 4 rivers and unification of water management, and response to integrated climate change - establishment of environmental disaster response system. The following are specific policy tasks for each sector to realize this policy agenda. Major policy tasks in the atmosphere sector have been proposed such as integrated management of fine dust, enhancement of effectiveness of fine dust management in transport sector, and improvement of management system in atmospheric environment information. Second, major policy tasks in the field of water environment are improvement of sustainability in water infrastructure, improvement of water cycle, development of water industry. Third, in the field of natural resources conservation, main streaming nature conservation and wise use of natural benefits have been proposed as major policy tasks. Fourth, in the field of resource recycling, realization of landfill zeroing through resource virtuous cycle, management of cyclic resource whole cycle and improvement of resource efficiency, proper management of waste due to complex disasters and nuclear dismantlement, and waste resource management for coping with future social change are major policy tasks . The main policy tasks for environmental governance will be to consider integration between relevant sectors. Regarding the rationalization of the distribution of the central-local environmental affairs, it can be achieved through the introduction of a differential decentralization system and strengthening cooperation between central and local governments. In order to reorganize and stabilize the financial system of the environment sector, two ways have been largely derived. First, the following two improvement measures were proposed in the traffic·energy and environmental tax sectors. The first is to impose the carbon tax, energy tax and environmental tax on all energy sources without extending the sunset. The second is to extend the deadline of the traffic, energy and environmental tax law and coordinate the price, and annual expenditure ratio in relative price of oil type. Next, in the charge of the Ministry of Environment, the measures to consolidate the transportation energy environment tax after the abolition of the charge, or to transfer the local area were suggested.
용해된 Matrigel 첨가 배지에서 착상전 생쥐 배아의 발생
정병목,추형식,강병문,계명찬,Chung, Byung-Mok,Choo, Hyung-Sik,Kang, Byung-Moon,Gye, Myung-Chan 대한생식의학회 2000 Clinical and Experimental Reproductive Medicine Vol.27 No.4
Objective: To verify the effect of two forms (growth factor and growthfactor-reduced) of solubilized Matrigel on the development in mouse preimplantation embryos. Methods: Late 2-cell stage eggs were cultured through the blastocyst stage in the presence of GF- or GFR-Matrigel (0.5%, v/v). Morphological development, cell number and % apoptotic nuclei of blastocyst were measured by Roecst staining and TUNEL of nuclei. Results: Morphological development, number of cells per embryo was significantly increased in the presence of GF- or GFR-Matrigel. Culture of the embryos in the GF-Matrigel gave the best result. Conclusion: Low concentration of solubilized Matrigel improved development of mouse embryos regardless of growth factor content of the Matrigel. Growth factors and extracellular matrix protein included in the Matrigel synergistically potentiated the development of mouse embryos.