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The Toxicological Studies and Autopsy Findings of Aconitine Poisoning
최화경,김이석,최인석,김장한 대한법의학회 2010 대한법의학회지 Vol.34 No.1
Background: Aconitium species have been used for a material of oriental herb medicine for analgesic and anti-inflammatory effects. But Aconitium species were known to have the potent poisons like aconitine, mesaconitine and hypaconitine which are of C19 diterpenoid alkaloids. The intoxication symptoms are nausea, vomiting, discomfort and cardiac arrhythmias which are well known as a main cause of death. Method and Materials: We obtained the specimens from the five poisoned cases and analyzed those specimens by GC/MS-SIM for 2002-2004. These cases were divided into two groups. The first group was the victims who ingested raw Aconitium roots and leaves and were all dead. The second was those who ingested processed Aconitium roots. One of them drank Aconitium root-submersed alcohol (root wine) and died. Another victim had ingested some liquid extract of herb medicine for three months but the person’s symptom was manifested by jaundice and hematuria without fatality. Results: Autopsy pathology on the cases of raw Aconitium ingestion and root wine drinking revealed similar gross and microscopic feature. The benzoylaconine analogues were detected in root wine (dead case) and hypaconitine, benzoylmesaconine and benzoylhypaconine were detected in herb liquid (living case). The aconitine analogues are hydrolyzed to make less toxic benzoylaconine analogues but the toxicity of hydrolyzed products and the methods of detoxification are still in controversy. Conclusion: We could conclude that benzoylaconine is relatively more toxic than benzoylmesaconine and benzoylhypaconitine. And the hypaconitine is relatively less toxic than aconitine and mesaconitine.
고령자 복합 만성질환에 따른 주택 개조 선호도에 관한 연구
최화경,박성준 한국문화공간건축학회 2017 한국문화공간건축학회논문집 Vol.- No.58
Korea is entering an aging society with an average life expectancy and low birth rate, and the government and society are proposing the policy and business to improve active aging of elderly. Especially, due to the desire of an aging in place, the government is enforcing various policies related to modification of residence for the elderly. However, physical housing modification items can not slow down the physical, mental and social aging of the elderly. Thus, the purpose of this study is to discuss the direction of customized house modification for the elderly by analyzing the preference of the house modification in accordance with the elderly who is suffering from multiple chronic disease. The study methods are as follows. Firstly, based on the analysis of previous studies related to the elderly, multiple chronic disease and house modification, a research tool about house modification of the elderly was developed, and conducted a survey targeting an elderly or pre-elderly with chronic disease. Secondly, the house modification preference and the chronic disease of survey subjects and the preference of house modification of chronic disease were analyzed. Finally, the house modification preference by multiple chronic disease was drawn, and proposed the planning items and details regarding the field of house modification. The results of this study are as follows: In the case of the elderly suffering from multiple chronic diseases: hypertension + chronic back pain + arthropathy, the housing modification should be considered in order of the intelligent residential service, space planning, assistive device, and materials and color scheme. The result of study is expected to be utilized as the fundamental data of house modification guideline on aging society in the future.