유방의 침윤성 미세유두암종의 세침흡인 세포검사

최현주,정지한,신정하,민기옥,강석진,이교영,유진영,Choi, Hyun-Joo,Jung, Ji-Han,Shin, Jung-Ha,Min, Ki-Ouk,Kang, Seok-Jin,Lee, Kyo-Young,Yoo, Jin-Young 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.1

Invasive micropapillary carcinoma (IMPC) of the breast is recently described rare variant of invasive ductal carcinoma. This variant has a distinctive histological features and aggressive biological behavior. We reviewed the cytologic features of eight cases of IMPC. The cytologic smears showed moderate to high cellularity and the tumor tissue was composed of atypical, angulated, cohesive clusters of neoplastic cells with a papillary to tubuloalveolar architecture, and a morular growth pattern without fibrovascular cores was seen on the histopathology. IMPC of the breast has distinctive cytologic features and it is important to make an early diagnosis via fine needle aspiration cytology due to this tumor's aggressive behavior.

하악에 발생된 결체조직성 섬유종

최현주,박영희,최갑식,Choi Hyun-Ju,Park Young-Hee,Choi Karp-Shik 대한영상치의학회 1999 Imaging Science in Dentistry Vol.29 No.1

Desmoplastic fibroma is a rare. benign intraosseous fibroblastic tumor. which is locally aggressive. It is osseous counterpart of soft tissue fibromatosis. The authors experienced the patient who complained persistent mouth opening limitation with mild swelling on the left mandibular angle area. After careful analysis of clinical. radiological and histopathological findings. we diagnosed as desmoplastic fibroma of the mandible. The results were as follows: 1. Main clinical symptoms were mouth opening limitation which had been persistent for 9 months and mild swelling on the left mandibular angle area. 2. Radiographs showed the radiolucent lesion and expansion of lingual cortex. CT finding is homogeneous soft tissue mass with expansion of left mandibular ramus. Destruction of medial wall of ramus and invasion to adjacent soft tissue is also seen. 3. Histopathologically, plump spindle shaped fibroblasts arranged in bundles or fascicles are observed. The cells of tumor are infiltrating into muscle fiber with destruction of bony trabeculae and merged with surrounding salivary gland.

진료재료대 수가누락방지 및 비용절감 개선활동

최현주,Choi, Hyun-ju 한국의료질향상학회 2015 한국의료질향상학회지 Vol.21 No.1

Objectives: Because recently hospital had to faced with financial hardship, we have to have more effective hospital management. The purpose of this study was to reduce loss costs of the hospital through the systematic management of medical supplies and increase operational efficiency. Methods: The team was composed of outpatient nursing staff, medical record administrator, nurses in medical insurance, medical computer center, dermatologists for this study. We surveyed for 114 people including outpatient nursing staff, nurse aids, medical assistant, physician assistant. Pre-survey period was 2013.03.11 ~ 03.30(2 weeks), and post-survey period was 2013.09.03 ~ 09.17(2 weeks). Result: We improved this way through the computational improvement, conservation campaigns, inventory management, staff training, replaced by low-cost medical supplies. The finding of this study were as follows: Comparing before and after the activity of outpatient nursing staff's degree of knowledge, performance, economic consciousness, the degree of knowledge, performance was increased, but there was no significant change in economic consciousness. Performance of Married person is higher than the unmarried, In addition, the high-position people were more the degree of knowleage, economic consciousness. After activity, correlation of goods and treatment, examinations is increasing, but statistically there was no mean. Conclusion: This study revealed that knowledge in a short period of activity, but also can improve, perform the same change in behavior is not easy. This one shows the intensive training required to sustained and systematic behavioral changes, such as changes in behavior, perform rituals to help the economy. Expensive medical supplies to replace a similar effect as the cost of materials just to have a lot of cost savings. Therefore, more medical supplies change is necessary to develop alternative treatment and cost cutting.

타액선의 다형성 선종에서 발견한 암종의 세침흡인 세포학적 소견 -5 예 보고-

최현주,김활웅,함의근,박인애,Choi, Hyun-Joo,Kim, Hwal-Woong,Ham, Eui-Keun,Park, In-Ae 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.2

Carcinoma ex pleomorphic adenoma(CXPA) is a rare malignant tumor of the salivary gland, fine needle aspiration cytology(FNAC) of which are rarely reported. We retrospectively reviewed FNAC of five cases of histologically proven CXPA of the salivary glands diagnosed in Seoul National University Hospital to evaluate their cytologic characteristics. Histologically, the carcinoma components were low-grade in three cases and high-grade in two cases. The cytologic diagnosis were malignancy in two cases(40%), suspicious for malignancy in one(20%), and benign(pleomorphic adenoma) in two(40%). All of the high-grade carcinomas were correctly diagnosed by FNAC, however, 2 cases of low-grade carcinomas were diagnosed as benign by FNAC. The low sensitivity in cytologic diagnosis is due to interpretative difficulties in low-grade tumors. The characteristic cytologic features of CXPA were high cellularity, necrotic, bloody, and inflammatory background, marked nuclear overlapping, coarsely granular chromatin, prominent macronucleoli, and atypical mitosis in epithelial component in addition to the typical biphasic pattern of pleomorphic adenoma consisting of epithelial cells admired with spindle-shaped cells and chondromyxoid stroma. Even though low-grade tumors show mild pleomorphism, the cytologic findings of necrotic background, moderate to high cellularity, and nuclear overlapping could lead to an accurate cytodiagnosis of CXPA.

자궁경부 Adenoma Malignum의 세포학적 소견 - 1예 보고 -

최현주,김영신,이교영,강창석,심상인,Choi, Hyun-Joo,Kim, Young-Shin,Lee, Kyo-Young,Kang, Chang-Suk,Shim, Sang-In 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2

Adenoma malignum is an extremely well-differentiated variant of cervical adenocarcinoma in which the cells composing the tumor lack the typical cytological features of malignancy. The prognosis of this rare tumor is poor in spite of high degree of differentiation. The cytologic characteristics are extremely bland so frequently make a confusion of adenoma mailgnum with endocervical glandular hyperplasia. We report a case of adenoma malignum in a 35-year-old woman who complained of mucoid vaginal discharge and vaginal bleeding. The cervicovaginal smear showed endocervical cells exhibiting a spectrum of atypical chances. The cells were arranged in multilayered strips and monolayered sheets. Individual cells ranged from cuboidal to columnar; typically the columnar cells had abundant lacy or vacuolated cytoplasm. The smear showed the majority of only atypical cells and small numbers of frankly malignant cells.

자궁경부 세포도말 검사에시 미세침윤성 편평세포암종의 세포학적 분석

최현주,박인애,Choi, Hyun-Joo,Park, In-Ae 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1

Whlie cytologic characteristics of squamous dysplasia, carcinoma in situ, and invasive squamous cell carcinoma of the uterine cervix are well documented, relatively few studios have dealt with the cellular features of microinvasive carcinoma. In order to describe the cellular characteristics of microinvasive squamous cell carcinoma, we retrospectively reviewed 45 cervovaginal smears(15 carcinoma in situ, 15 microinvasive cancer, 15 invasive cancer) which were confirmed by histologic examination of specimens obtained by hysterectomy at the Seoul National University Hospital during S years from 1995 to 1999. The cytologic features about tumor diathesis, inflammatory background, ceil arrangement, anisonucleosis, nuclear membrane irregularity, nuclear chromatin pattern, and nucleoli were observed. The cytologlc characteristics of microinvasive squamous cell carcinoma of the uterine cervix are syncytial pattern, mild tumor diathesis, the irregularity of nuclear membrane, irregularly distributed nuclear chromatin, and occurrence of micronucleoli. But, correlation between the depth of Invasion and the cytologic feature had limited value.

지루 피부염 환자의 피지 조성에 관한 연구

최현주,임성빈,이승헌 ( Hyun Joo Choi,Sung Bin Lim,Seung Hun Lee ) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.6

N/A We attempted to examine the compositions of seborrheic lipids from the scalp of the human adult males and the patints who have the seborrheic dermatitis by the ?hin layer chromatography(TLC) and the photodensitometer. The human skin surface lipids are composed of the seborrheic lipids from the sebaceous glands and epidermal lipids from the ediermis. The sebaceous lipids were known that they played the role to protect the skin and they had the pathophysiologic role in the seborrheic dermatitis and the ance. We observed that the sebacous lipids were composed of squalene, ??olestrol ester, wax ester, triglyceride, free fatty acid, and saturated hydrocabon in both the control group and the patient group. In the mean values of the ratio of the seborrheic lipids composition, the ratio of squalene and cholesterol eater were higher, and the ratio of free fatty acid and triglyceride were lower in the patient group than in the control group, and the ratio of wax ??ster which was originated from sebaceous glands was no difference between two groups. Thus, n?the seborrheic dermatitis, there was no change in the sebum secertion rate, but the lipid compositions were changed.

Surface Modification of Poly(dimethylsiloxane) Microchip by Using Cetyltrimethylammonium Bromide (CTAB)

최현주,이경복,Kuk Ro Yoon,최인성,우성일,Kyungseong Choi,Sang Chun Lee 대한화학회 2004 Bulletin of the Korean Chemical Society Vol.25 No.4

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집합 결합과 신경망을 이용한 복합질환의 예측

최현주,김승현,위규범,Choi, Hyun-Joo,Kim, Seung-Hyun,Wee, Kyu-Bum 한국정보처리학회 2008 정보처리학회논문지B Vol.15 No.4

복합질환은 다수의 유전자들이 상호작용하여 유발되는 질병으로서, 여러 유전자들이 관여한다는 복잡성 때문에 전통적인 분석 방법을 적용하는데 한계가 있다. 최근에는 기계학습 기법을 이용한 새로운 분석 방법들이 제안되고 있다. 신경망은 이처럼 복잡한 데이터에서 일정한 패턴을 찾아 이를 분류하는데 적합한 모델이다. 그러나 다량의 데이터가 입력으로 들어오는 경우에 학습에 오랜 시간이 걸리고 패턴을 찾기가 어려워지는 단점이 있다. 본 연구에서는 다량의 SNP 데이터로부터 질병에 연관된 소수의 중요 SNP을 찾기 위한 통계학적인 방법인 집합결합(set association)과 신경망을 결합한 모델을 제시한다. 이 모델을 천식 관련 SNP 데이터에 적용하여 천식 발병 여부를 예측한 결과, 신경망만 사용했을 때보다 실행 시간도 빠르고 예측 정확도도 높았다. 이 모델은 다른 복합질환의 예측에도 효과적으로 사용할 수 있을 것으로 기대한다. Since complex diseases are caused by interactions of multiple genes, traditional statistical methods are limited in its power to predict the onset of a complex disease. Recently new approaches using machine learning techniques are introduced. Neural nets are a suitable model to find patterns in complex data. When large amount of data are fed into a neural net, however, it takes a long time for learning and finding patterns. In this study we suggest a new model that combines the set association, which is a statistical technique to find important SNPs associated with complex diseases, and neural network. We experiment with SNP data related to asthma to test the effectiveness of our model. Our model shows higher prediction accuracy and shorter execution time than neural net only. We expect our model can be used effectively to predict the onset of other complex diseases.

만삭아에서 발생한 상부위장관 출혈에 대한 임상적 고찰

최현주,김재선,윤혜선,배선환,Choi, Hyon Ju,Kim, Jae Seon,Yoon, Hye Sun,Bae, Sun Hwan 대한소아소화기영양학회 2005 Pediatric gastroenterology, hepatology & nutrition Vol.8 No.2

Purpose: The aim of this study was to evaluate the clinical characteristics, endoscopic findings and risk factors related to the upper gastrointestinal bleeding (UGIB) seen in full-term infants. Methods: A clinical analysis for 9 cases with UGIB confirmed by endoscopy was carried out retrospectively. Patients were admitted to the Department of Pediatrics, Eulji Hospital, from January to December 2003. Results: UGIB from gastric or duodenal mucosal lesions has been seen in 0.13% in newborns infants. All patients were full-term AGA neonates without asphyxic findings at birth. Hematemesis, melena or recurrent vomiting developed within $4.4{\pm}3.8days$ after birth. Vital sign and laboratory test was normal on admission. Endoscopic findings showed hemorrhagic gastritis in 6 cases and peptic ulcers in 3 cases. All patients were successfully managed by medical treatment for $18.6{\pm}5.0days$. On treatment, clinical symptoms improved within $0.9{\pm}0.3days$. Follow-up endoscopy was not performed because there was no recurrence of symptoms in all patients. Case mothers had no history of gastritis, ulcer or anti-ulcer medications before and during pregnancy. Conclusion: If the healthy full-term infants express UGIB within a few days after birth, it is necessary to take careful history of family, mother and delivery process and to practice endoscopy for mucosal lesions of the patients. A follow-up endoscopy dose not seem to be necessary if the infant is clinically well. 목 적: 건강한 만삭아로 출생한 신생아에서 상부위장관 출혈의 임상적 특징, 위내시경 소견, 연관된 위험요소 등을 알아보고자 하였다. 방 법: 2002년 1월부터 2003년 12월까지 을지의과대학교 을지병원 신생아 중환자실에 토혈 혹은 혈변을 주소로 입원하여 위내시경상 출혈성 위염 또는 궤양으로 진단된 9명의 환아들을 대상으로 산전인자, 모체인자, 분만소견, 내시경 소견, 예후 등을 후향적으로 조사하였다. 결 과: 1) 9명의 환아 중 원내 출생아는 5명(5명/3,734명)으로 발생률은 0.13%였고, 모두 적정체중 만삭아로 출생 시 가사소견은 없었다. 2) 산모들의 병력상 산전에 위염, 소화성 궤양, 제산제 복용 등의 기왕력, 위장관 질환의 가족력은 없었고, 분만과정 중 특이소견 없었다. 3) 토혈, 혈변, 반복되는 구토가 주증상이었으며, 출생 후 $4.4{\pm}3.8$일에 발생하였고, 입원 시 활력증후는 양호하였고, 혈액검사소견도 정상이었다. 내시경 검사상 출혈성 위염이 6예, 위궤양이 3예였다. 4) 모든 환아는 $H_2$ 수용체 차단제 치료와 보존적 치료을 실시하였고, 치료 시작 후 $0.9{\pm}0.3$일 이내에 임상증상은 호전되었다. $H_2$ 수용체 차단제는 $18.6{\pm}5.0$일 치료하였으며 추적관찰상 증상이 재발된 환아는 없어서 추적 내시경은 실시하지 않았다. 결 론: 만삭아에서 출혈을 동반한 상부위장관 점막질환은 대부분 예후가 양호하여 임상증상이 호전된 경우에는 추적 위내시경 검사는 불필요한 것으로 사료된다.