Dipalmitoyl Phosphatidyl Choline Vesicle 촉매에 의한 para-Nitrophenyl Palmitate의 가수분해 반응

최창진,이후설 圓光大學校 基礎自然科學硏究所 1987 基礎科學硏究誌 Vol.6 No.2

Dipalmitoyl phosphatidyl choline and p-nitrophenyl palmitate were directly sonicated in acidic water for 6 min to give clear stock solutions. The catalytic hydrolysis of p-nitropheny palmitate was studied at 30-55℃ in the presence of unilamellar vesicle and mixture of uni- and multilamellar aggregates. The difference of rate between uni- and mixture reaction was observed, where unilamellar reaction was more catalytic effect. The phase transition temperature of vesicle was 37-44℃.

파이브로넥틴 유래 올리고펩타이드의 적용방법에 따른 조골양세포의 이동 양상에 관한 연구

최창진,김윤정,김정훈,구영 한국생체재료학회 2012 생체재료학회지 Vol.16 No.2

Almost all the researches on synthetic oligopeptides had been carried out by the carrier-related method (pre-coating to the well before cell seeding) rather than the liquid-related method (releasing after cell seeding) until now. The purpose of this study was to evaluate the migratory behaviors of the osteoblast-like cells in each applied method. Synthetic oligopeptides derived from fibronectin were applied to the cell before and after seeding cells. The cells were fixed and stained each for 0, 6, 12 and 18 hours. After that, we investigated the cell’s migratory behaviors by counting the number of the cells showing migratory behaviors, and calculating the space which these cells occupy. As with the liquidrelated method in comparison with the carrier-related method, the number of the cells was highly enhanced at 12hours and the space which these cells occupy was highly enhanced at 12, 18 hours. Within the limit of this study,the fibrin binding oligopeptides in the liquid-related method may play a significant role in the bone regeneration and wound healing process during the early period by promoting the cell's migratory behaviors.

Plastic 難燃化에 대한 小考

崔昌鎭 西原大學校 1977 西原大學 論文集 Vol.6 No.-

The present intermational situation of plastic, its prospect of domesticdemands, its merits and demerits, and the needs of retardation of it. ⅰ) The structure of plastic, its chemical and physical properties(The characteristics of thermal decompostition, product gas, altenation, etc.) ⅱ) Moding of plastic and resin reforming ⅲ) Reguirements as fire retardant, its prospect, and its sorts. ⅳ) Adding of powder or solution in molding. ⅴ) (The method of retardation) The principle and guality of fire retardant Centering on the method of retardation plastic. ⅵ) Result.

건강한 젊은 성인에서 안지오텐신 전환효소 유전자다형성과 심박동수 변이의 연관성

최창진,김경수,변광호,이강건,채설아,이일규,나현오 대한임상건강증진학회 2005 Korean Journal of Health Promotion Vol.5 No.3

Angiotensin converting enzyme(ACE) gene polymorphism is known to be associated with hypertension or ischemic heartdisease. Heart rate variability(HRV) has been reported to be one of the potential useful tools for predicting cardiac risksand autonomic nervous system activity. The purpose of this study is to find out the association between ACE gene polymorphism and heart rate variability.Subjects were 81 healthy young(aged between 22 and 30 years) individuals. HRV parameters was measured for 5 minutesby SA-2000 Medicore. ACE gene polymorphism was examined by polymerase chain reaction(PCR).ACE genotype II:ID:DD were 18(22%):55(68%):8(10%), respectively. All of HRV parameters were decreased in ACE DDgenotype group, but there was no statistical significance. The mean±standard deviation of HRV parameters in ACEgenotype II, ID, DD group were SDNN 53.7±26.8, 53.4±21.5, 40.8±11.2(㎳), TP 2654.3±2857.6, 2450.1±2187.8, 1340.7±711.0(msec2), LF 703.6±849.1, 949.8±1484.5, 418.8±413.7(msec2), HF 667.1±996.1, 822.5±862.2, 460.3±302.3(msec2), respectively. Themean±SD of VLF in ACE genotype II, ID, DD group were 1283.6±1595.2, 668.7±638.4, 461.6±321.5(msec2), respectively.Only VLF among several HRV parameters showed a statistical significant difference between ACE genotype groups(P=0.040), and also showed a statistical significant difference only between ACE II and ACE ID in within group comparison(P=0.017).VLF among HRV parameters showed a statistical significant difference between ACE genotyping groups. Further studiesare required to see the potential possibility of HRV as a surrogate indicator of renin-angiotensin system activity.(Korean J Health Promot Dis Prev 2005 ; 3 :206~211) 안지오텐신 전환효소(angiotensin converting enzyme, ACE) 삽입/결손(I/D) 유전자 다형성은 고혈압 및 허혈성심질환의 병태생리 및 예후와 관련이 있다고 알려져 있다. 심혈관질환의 예후와 관련이 있는 것으로 알려진 안지오텐신 전환효소 유전자 다형성과 심박동수 변이의 관계를 조사함으로써 심박동수 변이가 레닌-안지오텐신 시스템 활성도의 간접적인 지표가 될 수 있는지 조사하였다.22세에서 30세 사이의 건강한 자원자 81명을 대상으로 하여 체질량지수와 흡연 유무를 조사하였고 심박동수 변이는 SA-2000 Medicore 분석기기를 이용하여 5분간 2회 측정하였다. 안지오텐신 전환효소 유전자 다형성은 혈액 림파구의 DNA를 추출하여 중합효소 연쇄반응 제한효소 절단 길이 다양성법(PCR_RFLP)으로 확인하였다. ACE 유전자다형성에 따른 심박동수 변이의 차이를 ANOVA test를 통해 비교하였다.대상자의 ACE 유전자다형성의 분포는 II, ID, DD 유전자형이 총 81명중 각각 18명(22%), 55명 (68%), 8명 (10%)이었다. 심박동수 변이의 지표는 ACE 유전자 II형, ID형, DD형에 따라 각각 SDNN 53.7±26.8, 53.4±21.5, 40.8±11.2(㎳), TP 2654.3±2857.6,2450.1±2187.8, 1340.7±711.0(msec2), LF 703.6±849.1, 949.8±1484.5, 418.8±413.7(msec2), HF 667.1±996.1, 822.5±862.2, 460.3±302.3(msec2)으로 DD형에서 II형이나 ID형에 비해 심박동수 변이가 감소하는 경향을 보였으나 통계적 유의성은 없었다. VLF는 ACE 유전자 II형, ID형, DD형에 따라 각각 1283.6±1595.2, 668.7±638.4, 461.6±321.5(msec2)으로 통계적으로 유의한 감소를 보였다(P=0.040).ACE I/D 유전자 다형성에 따라 심박동수 변이중 VLF가 통계적으로 의미있는 차이를 보여 심박동수 변이와 레닌-안지오텐신 시스템 활성도와의 연관성에 대한 연구가 더 필요하다(대한임상건강증진학회지 2005;3:206~211)

Changes in the Degree of Patient Expectations for Patient- Centered Care in a Primary Care Setting

최창진,Sun-Wook Hwang,김하나 대한가정의학회 2015 Korean Journal of Family Medicine Vol.36 No.2

Ba ckground: To date, the medical environment has been undergoing continual changes. It is thereforeimperative that clinicians recognize the changing trends in the degree of patient expectationsfor patient-centered care. We conducted this study to examine changes in the degree of patientexpectations for patient-centered care and the related socio-demographic factors in a primary caresetting over a 5-year period. Me thods: We evaluated patients’ attitudes toward patient-centered care using the Patient-PractitionerOrientation Scale, which provides ‘sharing’ and ‘caring’ scores. The study included 359 and468 patients in phase I (March–July, 2005) and II (March–July, 2010). We also examined therelationship of their changes to their socio-demographic factors. Re sults: In phase II, as compared with phase I, the ‘sharing’ score was higher (3.67 ± 0.68 vs. 3.82 ±0.44; P < 0.001) and ‘caring’ one was lower (4.01 ± 0.57 vs. 3.67 ± 0.58; P = 0.001). Further, ‘sharing’and ‘caring’ scores were associated with age, monthly income, education level, marital status, andthe functional health status of patients. Co nclusion: These results would be of help for providing patient-centered care for patients because itmakes clinicians are aware of the degree to which patients’ expect it.

가정의학 학생실습 실태 조사

최창진,김범택,박훈기,오상우,원장원,유선미 대한가정의학회 2004 Korean Journal of Family Medicine Vol.25 No.12

Background: New educational objectives and evaluation methods in Korean medical schools have been suggested recently to cope with health care related environmental changes. Current status of family medicine clinical clerkships in Korean medical schools is to be known before establishing standards. Methods: Educational Committee of Korean Academy of Family Medicine surveyed the family medicine clerkship in Korean medical school (about educational environment, subjects and evaluation methods) using structured questionnaires by e-mail and Fax from February through March in 2004. Results: Family medicine clinical clerkship was run by 25 of 41 medical schools (65.9%). Educational subject areas included communication skill, observation in hospital based ambulatory office, primary care and family medicine, medical recording, diagnosis and treatment of common problems, residential out-hospital ambulatory programs, presentation of hospital based ambulatory programs, procedure skill, lifelong heath management plan, and health promotion, in descending order. Faculties of family medicine were directly in charge of educational subjects. However, educational methods were mainly composed of lectures and indirect observation. It should be noted that concrete and precise evaluation methods in the family medicine clerkship program had been lacking due to insufficient and obscure evaluation strategies. Conclusion: Clerkship period, educational environment, and number of class were variable among medical schools in Korea. Educational format needs to be standardized in terms of common educational subjects such as communication skill education, patient education, and ambulatory care clerkship. More valid methods are to be introduced for family medicine clerkship evaluation. 연구배경: 의료 관련 상황의 변화에 부응하는 의사를 배출하기 위한 노력으로 새로운 교육목표와 새로운 평가방법이 요구되는 시점에서 한국 의과대학의 가정의학 임상실습실태를 조사하여 실습교과과정에 대한 개선점과 합의점을 모색하고자 하였다. 방법: 대한가정의학회 교육위원회에서는 2004년 2월부터 3월까지 국내 의과대학을 대상으로 가정의학과 학생임상실습에 대한 설문조사를 시행하였다. 결과: 총 41개의 의과대학 중 27개의 대학에서 가정의학 실습교육이 시행되고 있었으며(65.9%) 15개 대학(36.6%)에서는 가정의학임상실습이 필수과목으로 운영되고 있었다. 실습 기간과 실습 학생수는 다양하였다. 교육 주제는 의사소통기술, 외래 참관, 일차의료와 가정의학, 의무기록 작성, 흔한 질환의 진단과 치료, 지역사회 실습, 외래 클리닉 소개, 임상수기 실습, 평생건강관리, 건강증진 빈도 순으로 나타났다. 대부분의 교육영역에서 전임교원이 교육을 직접 담당하고 있었으며 교육방식은 강의나 참관으로 진행되는 경우가 많았다. 가정의학 임상실습 평가에서 구체적인 평가기준이 제시된 경우는 적었다. 결론: 의과대학별로 가정의학 임상실습교육 기간 및 여건이 서로 다르지만 의사소통 교육, 환자교육, 지역사회실습 등의 공통교육주제에 대한 표준화가 필요하고 평가에 있어서 구체적인 방안이 마련되어야 하겠다.

國産 Rhodochrosite로부터 黃酸망간 浸出時 不純物 除去에 關한 硏究(제1보)

崔昌鎭,金城權,金英玉 圓光大學校 基礎自然科學硏究所 1986 基礎科學硏究誌 Vol.5 No.2

The purpose of this investigation is to study efficiency of the impurities removal and leaching efficiency of manganese(Ⅱ) sulfate on the pH when we make pure manganese(Ⅱ) sulfate by leaching from the medium-grade domestic rhodochrosite ore under the best conditions. Leaching process is carried out by treating the sample with sulfuric acid to extract out the manganese(Ⅱ) sulfate, thereafter to experimentally obtain the content of each component in leached solution. The leaching efficiency-pH relations of manganese(Ⅱ) sulfate was measured in MnSO_4 solutions as function of pH with NH_4 OH -BaS and CaO-BaS. The removal efficiency-pH relations of iron was measured in MnSO_4 solutions as function of pH with NH_4 OH or CaO The best pH-response of the efficiency of iron removal was obtained as above 94.5%, 95.1% in NH_4 OH or CaO solutions in the pH range 5.0. With the intention of obtain the best conditions of impurities-pH relations, leached substances were investigated by means of I.C.A.P analysis, atomic absorption spectra, X-ray diffraction, infrared spectra and chemical analysis.

만경강의 수질 오염도 조사연구

최창진,유일수,황은희 圓光大學校 基礎自然科學硏究所 1986 基礎科學硏究誌 Vol.5 No.1

上關 저수지로부터 흘러 내려오는 맑은 물이 完山橋와 西新橋(〔A〕지점)를 지나면서 전주시민의 생활하수에 의하여 오염되어 흐르다가 전주 공업단지 폐수에 의하여 오염이 증가 되었다. 그러한 결과로 全州川과 전주 공업단지 폐수가 合流되는 〔D〕지점부터 全州川과 高山川이 合流되는 〔E〕지점 사이에서 水質汚染이 심하게 나타나고 있다. 全州川과 高山川의 맑은 물이 合流되는 〔E〕지점에서부터 水質汚染이 급격히 低下되고 있으며 만경강과 이리 공업단지 폐수가 合流되는 〔G〕와 〔H〕지점에서 수질오염은 加重되어 西海로 흘러가게 된다. 이와같은 결과로 볼때 만경강 수질오염의 主要因인 전주 공업단지 폐수와 이리 공업단지 폐수에 의하여 날로 오염이 심화되는 것을 알 수 있었다. An investigation on the water quality of the Mankyung river was carried out from March to september in 1984. The pollution levels of metals such as Pb, Cu and Cd were remarkably indicated high values at sites 〔C〕and 〔G〕. The values of BOD and COD were 30.1-468.4 ppm, 28.1-617.0 ppm, respectively and were serious. It is found that pH, SS, DO and Fe values of the river are 6.9-7.3ppm, 353-1322ppm, 2.8-6.7ppm and 1.29-9.226ppm, respectively. Those values were higher than values permitted by the environmental standards of the government. In conclusion that Mankyung river was being contaminated mainly by the waste water from the plants located at Jeon-ju Industrial Area and at Iri Industrial Area.

오전과 오후에 측정한 심박동수변이의 변화

최창진,최환석,김경수 대한가정의학회 2008 Korean Journal of Family Medicine Vol.29 No.8

Background: Short-term measurement of heart rate variability is known to be a non-invasive technique to examine autonomic nerve system. Heart rate variability exhibits circadian rhythm according to work/sleep cycle and biological clock. In primary practice, short-term measurement of heart rate variability is usually used during the day. Therefore the aims of this study were to investigate the possibility of differences in heart rate variability between morning and afternoon and also to examine the relationship among associated factors. Methods: Sixty-eight healthy volunteers underwent short- term measurement of heart rate variability on two occasions: in the morning (08:30∼11:00) and in the afternoon (13:30∼16:00). A structured questionnaire was used to access general characteristics, emotion, fatigue and sleeping hours. Results: The mean heart rate was significantly increased and SDNN, RMSSD, TP, HF and VLF were significantly decreased in the afternoon compared to the morning. LF and LF/HF were not changed. The anxiety group, the depression group and the fatigue group showed significantly greater reduction in TP and RMDDS than the control group. Conclusion: In the afternoon, parasympathetic activity and total power were decreased significantly compared to the morning. Short-term heart rate variability should be measured in the same time zone and need to consider food intake effect. Those who complained of anxiety, depression or fatigue were related to much decrease in TP and RMSSD in the afternoon. 연구배경: 심박동수변이(heart rate variability)의 단기측정은 자율신경계를 평가하는 비침습적인 방법이다. 심박동수변이는 24시간 생체주기와 수면/활동 여부에 따라 하루주기를 보인다. 일차진료영역에서는 단기 심박동수변이 분석을 주로 낮 동안 이용하게 되므로 동일개체에서 오전과 오후에 측정한 심박동수변이에 차이가 있는지와 대상자의 불안이나 우울경향, 수면시간, 피로 정도에 따라 영향을 받는지 조사하고자 하였다. 방법: 20대의 건강한 성인 68명을 대상으로 오전 8시 30분∼11시와 익일 오후 1시 30분∼4시에 심박동수변이를 측정하였고, 설문을 통해 대상자의 우울, 불안, 피로, 수면시간, 건강상태, 생활습관 등을 조사하였다. 결과: 오전에 비해 오후에는 심박수가 유의하게 상승하였고, SDNN (standard deviation of normal to normal interval), RMSSD (root-mean-square of successive differences), TP (total power), HF (high frequency), VLF (very low frequency)가 유의하게 감소하였다. LF (low frequency), LF/HF는 유의한 변화를 보이지 않았다. 불안경향이 있는 군, 우울경향이 있는 군, 피로군은 정상군에 비해 TP와 RMSSD의 감소 정도가 유의하게 컸다. 결론: 동일한 개체에서 익일 시행된 심박동수변이의 단기 분석결과, 오전에 비해 오후에는 부교감신경과 총변이가 유의하게 감소하였으며 우울이나 피로를 호소하는 경우는 정상군에 비해 심박동수변이의 감소가 더 크게 나타났다. 이는 심박동수변이 단기측정시 일정한 시간대와 음식섭취 여부의 제한의 중요성을 시사한다.

防炎劑에 대한 小考 : 火炎의 原因과 理論, 實驗을 中心으로

崔昌鎭 西原大學校 1976 西原大學 論文集 Vol.5 No.-

이상에서 현재 국내외의 방염현황과 피처리대상물들의 물리, 화학적 성질에 따른 특성과 방염의 원리와 작용, 효과 등을 단편적으로 또는 전체적으로 종합하여 논의하고 또 실험에 대한 예와 방염제의 수종의 실례를 들어서 방염효과를 얻은 결과를 보고했다. 서두에서도 거론했지만 아직도 우리 현실에서 이것을 광범위하게 연구하고 또 실험장치와 그에 소요된 중요약품 등의 제조나 또는 수입 등은 너무나 어려움이 많았다. 더욱이 공업용약품은 순도면에서도 그렇지만 일정한 기준제품이 특속적으로 생산되지 못한데다가 수요자가 극소하고 또 보장된 제품의 요구와 관리가 소홀하여 더욱 난맥상을 이루었다. 더욱이 방염제는 주생산품에 대한 부자재이기에 원가에 미친 영향은 생산성과 연관시킬적에 재삼재고 않을 수 없는 문제점이다. 앞으로 국내수요나 수출과도 밀접한 관계가 있기 때문에 방염제의 보다 학문적인 차원은 물론 이를 밑받침하기 위한 여러 가지 공용시설이 아쉽다고 느낀다.