구강내 궤양에서의 중합효소 연쇄반응을 이용한 단순포진 바이러스 DNA의 검색

최지호(Jee Ho Choi),김성범(Seong Beom Kim),이승철(Seung Chul Lee),서대헌(Dae Hun Suh),성경제(Kyung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.1

Background : The oral ulcer is a common oral disorder, but the precise etiology remains elusive despite of intensive clinical, immunological, hematological and microbiobgi,al investigations. Objective : The purpose of his study was to examine oral ulcers

한국인에서의 전염성연속종 바이러스의 분자생물학적 역학에 관한 연구

최지호(Jee Ho Choi),김규한(Kyu Han Kim),김성범(Seong Beom Kim),서정화(Jung Wha Suh),고재경(Jai Kyoung Koh),성경제(Kyung Jeh Sung) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.5

Background : Recent restriction enclonuclease analysis studies hsve revealed that MCV DNA can be classified into two major types, designated MCV-1 and MCV-2, by th:ir restriction enzyme cleavsge patterns. In earlier reports of MCV DNA analysis, MCV-2 was the main virus type found in genital lesions. However many recent studies cienied the relationship between virus type and anatomical distribution. Objective : The purpose of this study was to examine the ratio of MCV-l to MCV-2 in Korean isolates of MCV DNA and the relationship between MCV subtypes and with clinical features such as anatomical location, age, sex, numiber of lesions, and atopic dermatitis. Methads : MCV DNA extrated from 112 cases of Korean patients waa examined by restriction endonuclease analysis using Brtm HI. Results : 1. MCV-1 was found in 108 of 112 (96.4%) patients and MCV-2 in of 112 (3.6%) patients. The ratio of MCV-1 to MCV-2 wss 28:1. 2. There was no significant ciprrelation between MCV subtypes and the age, sex, number of lesions, atopic dermatitis, and anatoimic loction. 3. Lesions induced by MCV-1 MCV-2 were indistinguishable on the brsis of size and form. Conclueion : This study showis that the ratio of MCV-1 to MCV-2 was 28:1 in Korean molluscum contagiosum patients and there was no relationship between MCV subtyies and lesional morphology or snatomical distribution. (Kor J Dermatol 1994;32(5):763-769)

면역억제제 Rapamycin과 Cyclosporin A가 각질형성세포주 HaCaT 세포의 증식, 세포주기 및 Cyclin 발현에 미치는 영향

최지호 ( Jee Ho Choi ),서호석 ( Ho Seok Suh ),정성태 ( Sung Tae Chung ),서치우 ( Chi Woo Suh ),백은미 ( Eun Mi Paek ),성경제 ( Kyung Jeh Sung ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.4

건선과 소양증

최지호 ( Jee Ho Choi ) 한국피부장벽학회 2009 한국피부장벽학회지 Vol.11 No.2

Pruritus is much more commonly complained in psoriatic patients than generally expected and the significance of this complaint has often been overlooked by dermatologists. The clinical features and cause of pruritus in psoriasis are not well known. This lecture is aimed to review the prevalence and related clinical characteristics of pruritus in Korean psoriatic patients and the expression of pruritogenic factors in psoriatic lesions with or without pruritus. Questionnaire data from 152 psoriatic patients were analyzed and psoriasis severity was determined by PASI score evaluation. 112 of 152 (73.7%) psoriatic patients suffered from pruritus. The severity and extent of psoriasis in pruritic patients were significantly higher as compared to non-pruritic patients. Important factors to exacerbate pruritus were emotional stress, hot bath, sweating, and so on. There was no correlation between pruritus and sex, age, duration of disease, family history of psoriasis, smoking, and alcohol habits. The pruritus significantly affected quality of life of psoriatic patients. A skin biopsy was obtained from 10 psoriatic patients with pruritus, 10 psoriatic patients without pruritus and 10 normal controls. Immunofluorescence stainings and confocal laser scanning microscopy were performed. Keratinocytes in the psoriatic plaques of patients with pruritus showed consistently increased expression of substance P receptor (SPR), high-affinity nerve growth factor receptor (TrkA) and calcitonin gene-related peptide receptor (CGRPR). In conclusions, pruritus is a common feature in psoriasis. Considering the well-known roles of neuropeptides in pathogenesis of both psoriasis and pruritus, increased SPR, TrkA and CGRPR may be involved in the pathogenesis of pruritus in psoriasis and in the severity of psoriasis. The attempt to relieve symptom of pruritus may improve the overall quality of life of patients with psoriasis and the psoriatic lesion.

피부과 영역에서의 레이저

최지호 (Jee Ho Choi) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.2

레이저의 기본 개념은 1917년 아인슈타인에 의해서 처음 기술되었으며 1960년대부터 의학 분야에 치료 목적으로 이용되기 시작하여 최근에는 다양한 종류의 레이저가 개발되어 사용되고 있다. 피부과 영역에서 현재 사용되고 있는 레이저는 이산화탄소 레이저(CO_2 laser), 색소 레이저(Dye laser), 구리증기 레이저(Copper vapor laser), Nd:YAG 레이저(Neodymium:Yttrium-Aluminum-Garnet laser), Q-switched 루비 레이저(Q-switched ruby laser). 아르곤 레이저(Argon laser), 알렉산드라이트 레이저(Alexandrite laser), He-Ne 레이저(Helium-Neon laser) 등이며 피부 혈관성 병변, 색소성 피부질환, 문신 및 양성 피부 종양의 제거에 이용되고 있다. 본 종설에서는 레이저의 특징, 생체조직과의 상호작용, 피부과에서 사용되고 있는 레이저의 특성 및 각종 피부질환의 치료에 대한 레이저의 응용, 레이저 치료시의 주의사항 등에 대하여 언급하고자 한다. The basic concept of the laser was first described by Einstein in 1917. Laser is an acronym for “Light Amplification by Stimulated Emission of Radiation”. The applications of laser light to the field of medicine were begun in 1960s. Since that time there has been a great increase in the development of laser technology and in the understanding of laser-target tissue interactions. The theory of selective photothermolysis means that a chromophore can be selectively damaged with a laser light of an appropriate wavelength and of a suitably short pulse duration that is shorter than the thermal relaxation time of the chromophore. The introduction of pulsed tunable dye lasers has considerably improved the treatment of vascular lesions, particularly light pink nevus flammeus in children. The argon pumped dye laser and copper vapor laser may be better for telangiectatic and the hypertrophic nevus falmmeus often seen in adults. Since the Q-switched and pulsed green light lasers are capable of selective photothermolysis of melanosomes and tattoo dyes, their efficacy has lasers are capable of selective photothermolysis of melanosomes and tottoo dyes, their efficacy has been under investigation for the treatment of pigmented lesions. The automated delivery of laser light and the risk of scarring is reduced. Further comparative study is needed to determine which lesions respond best to each laser system, and which treatment techniques are optimal. Treatment combining more than one of these laser systems may prove superior to any of them used alone.(Korean J Dermatol 1994;32(8):205~216)

피부를 침범한 비강 원발성 CD56 양성 T/NK-세포 림프종의 임상 및 병리조직학적 고찰

최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),장성은(Sung Eun Chang),윤길숙(Ghil Suk Yoon),허주령(Joo Ryung Huh) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.6

Background:There are recently increasing reported cases of patients with malignant lymphoma with unique characteristics, designated nasal-type T/natural killer (NK) cell lymphoma (NKTL), which usually expresses the NK cell marker and shows frequent extra-nodal involvement including skin and poor prognosis. The CD56+ NKTL can be divided into nasal and non-nasal types. Nasal and non-nasal (nasal type) CD56+ NKTL share the same pathologic features such as angiocentricity and necrosis. Objective:We have studied clinicopathologic features of 5 cases of nasal CD56+ NKTL with cutaneous involvement to further elucidate the behaviour of nasal CD56+ NKTL. Results:Clinically, the cutaneous lesions were variable. Four of the five cases died with rapidly progressive disease within 25 months. Histologically, variable sized pleomorphic lymphoid cells with or without prominent angiodestruction were observed. Severe necrosis was consistent features. The results of immunophenotypes(both CD56+ and CD3+) and TCR gene rearrangement study showed these 5 cases are of NK cell origin(4 cases) or NK-like T-cell origin (1 case). A firm association with Epstein-Barr virus (EBV) infection was confirmed in our study. Conclusion:Although the prognosis of nasal CD56+ NKTL was not so bad, higher stage of nasal CD56+ NKTL with cutaneous metastasis seemed to be very fatal. The term NKTL has to be further specified according to immunophenotypes such as CD56+ or true T-cell, NK-like T cell lymphoma since biologic behaviour of each subgroup can be different. (Korean J Dermatol 2000;38(6):713~720)

Sweet 증후군 24예에 대한 임상적 고찰

최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),안세진(Se Jin Ahn),장경애(Kyoung Ae Jang),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.2

N/A Background:Sweet's syndrome is a neutrophilic dermatosis that has various clinical characteristics and is often associated with inflammatory, malignant or autoimmune diseases, so the viral or bacterial antigens and tumor antigens are suspected to play a role in the pathogenesis of Sweet's syndrome. Objective:This study was conducted to obtain a better understanding of the clinical features of Sweet's syndrome and estimate the prevalence of malignant associated Sweet's syndrome in Korea. Methods:Clinical manifestations and histopathologic features of 24 Sweet's syndrome patients were evaluated. Results:The age was varied from 24 to 85 years, averaging 49.3 years. The male to female ratio was 1:2.4 . The site of predilection was the extremities, and the most common involved site was the upper extremities. The associated clinical symptoms were fever, arthralgia, myalgia, and oral ulcer in varying frequencies. In laboratory examinations, there were increased ESR, leukocytosis, and neutrophilia in part of the patients. The associated systemic diseases were found in 58.3% of the patients and hematologic malignancies were the most common with prominent AML-association. The majority of the patients were treated with oral or topical steroids and the recurrences were reported in 50%. Conclusion:The associated systemic diseases were presented in 58.3% of 24 Sweet's syndrome patients. And there was high association of Sweet's syndrome and hematologic malignancies, especially AML, as previously reported, which implies the importance of thorough investigation for underlying diseases in the Sweet's syndrome patients. (Korean J Dermatol 2000;38(2):163~169)

Th17 immune response (초)

최지호 ( Jee Ho Choi ) 대한피부과학회 2009 초록집 Vol.47 No.20

p70 Ribosomal Protein S6 Kinase is Activated In Psoriasis

최지호 ( Jee Ho Choi ) 대한피부과학회 1996 초록집 Vol.34 No.20

육아종성 피부질환의 면역조직화학적 연구

최지호(Jee Ho Choi),조광현(Kwang Hyun Cho),류병직(byung Jick Ryu),성경제(Kyoung Jeh Sung),고재경(Jai Kyoung Koh) 대한피부과학회 1993 大韓皮膚科學會誌 Vol.31 No.5

Background : A definition of granuloma is a focal chronic inflammatory response to tissue injury evolved by a poorly soluble substwice characterized by the accumulation and proliferation of the mono-nuclear histiocytic cells. The accuracy with which rnononuclear cells may be identified in skir. is much improved by the use of both heteroantisera and monoclonal antibodies directed against selected cellular antigens, Objective : Our purpose was to examine the staining patterns of anti-lysozyme, anti-a-1-antitrypsin, anti-S-100 protein antibodies, and MAC-387 monoclonal anibody in granulomatous skin diseases. Method : We performed imminoperoxidase staining(the labelled str prvidin-biotin peroxidase complex method on the formalin-fixed, paraffin-embedded tissue specimens of granulomatous skin diseases. Results : S-100 protein positive dendritic cells were demonstrated in the granulomatous infiltrates as scattered pattern and MAC-387 positive cells were predominantly found in the center of granulomas, The staining pattern and percentage of positively stained cells of a--antitrypsin were similar to those of lysozyme. A1Pha-1-antitrypsin and lysozyme positive cells w re present in the center as well as lymphohistiocytic infiltrates of granulomas. Conclusion : These data sugget that histiocytes are composed of heter igeneous groups of cells such as the mononuclear-phagocyte system and dendritic cell system. (Kor J Dermatol 1993;31(5):702-712)