일제강점기 초기 도청소재지의 도시공간변화에 관한 비교연구 - 충청북도 청주(淸州)와 평안북도 의주(義州)를 중심으로 -

최지해,한동수,董健菲 한국건축역사학회 2021 한국건축역사학회 학술발표대회논문집 Vol.2021 No.05

QUESTION: What is your diagnosis?

최지해,Choe, Ji-Hae 대한수의사회 2011 대한수의사회지 Vol.47 No.4

녹용 혼합 추출물의 면역기능 조절 효과

최지해,김나영,김선영,박혜령,유광원,이현순 한국식품영양과학회 2020 한국식품영양과학회지 Vol.49 No.1

A mixture of Cervus nippon (deer antler) and ten kinds of medicinal herbs was manufactured to develop new bioactive ingredients with immunoregulatory effects. Among them, both the ethanol extract and water extract of Acanthopanax sessiliflorum showed significant nitric oxide (NO) production and did not affect the Raw 264.7 cell viability. The optimal mixing ratio of C. nippon and A. sessiliflorum was found to be 1:1. The mixture (CME-PI, C. nippon mixture extract) showed higher immunoregulatory effects on the production of NO, IL-6, and TNF-α than a single treatment. In addition, the mRNA gene expression levels of IL-6, TNF-α, iNOS, and COX2 increased significantly, as determined by real-time PCR analysis. CME-PI showed considerably high proliferation activity in splenocytes, and cytokine production, such as IL-2 and IFN-γ, at a dose of 1,000 μg/mL. In an assay of the natural killer (NK) cell activity, the intravenous administration of CME-PI stimulated significant NK cytotoxicity against Yac-1 tumor cells in a dose-dependent manner. These results showed that CME-PI has superior potential as a material in high-added functional foods. 녹용과 10종의 한약재(감초, 참당귀, 백작약, 두충, 산약, 오갈피, 백복령, 길경, 천궁, 천마)를 각각 혼합하여 Raw 264.7 cell에 대한 세포 증식능과 NO 생산능을 측정한 결과, 녹용과 오갈피를 혼합하였을 때 가장 우수한 활성을 나타내었다. 이후 녹용 및 오갈피 혼합 추출물의 비율을 녹용:오갈피=1:1, 1:2, 2:1로 하여 Raw 264.7 cell에 대한 세포 증식능과 NO 생산능을 측정한 결과 녹용 및 오갈피 혼합 추출물 비율 1:1이 가장 우수한 활성능을 보여 이후 면역조절 효과 입증을 위해 최종 시료로 사용되었다. 녹용 및 오갈피 혼합 추출물(녹용:오갈피=1:1)의 Raw 264.7 cell에 대한 TNF-α와 IL-6를 측정한 결과, 녹용 및 오갈피를 단독으로 처리하였을 때보다 우수한 cytokine 분비능을 보여주었다. Real-time PCR을 통해 TNF-α, IL-6, iNOS와 COX-2 mRNA gene expression을 확인한 결과, 녹용 및 오갈피를 단독으로 처리한 것보다 녹용 및 오갈피 혼합 추출물(녹용:오갈피=1:1)에서 우수한 mRNA 발현량을 나타내었다. 비장세포에 대한 증식능을 측정한 결과 1,000 μg/mL의 고농도에서만 우수한 증식능을 보여주었다. 추가로 IL-2 및 IFN-γ에 대한 생산능을 측정한 결과 IL-2의 경우 양성대조군 LPS 대비 약 80%의 생산능을, IFN-γ의 경우 양성대조군 LPS에 준하는 우수한 cytokine 분비능을 보여주었다. 또한 in vivo 상에서 자연살해세포에 대한 cytolytic activity를 측정한 결과 농도 의존적으로 높은 종양세포에 대한 살해능을 나타내었다. 위 결과를 모두 종합해보면 녹용 및 오갈피를 단독으로 처리한 것보다 녹용 및 오갈피 혼합 추출물에서 면역조절 효과가 우수하다고 최종 확인되었다.

일제강점기 초기 도청소재지로서 충청북도 청주와 평안북도 의주의 비교분석

최지해,한동수 한국문화공간건축학회 2021 한국문화공간건축학회논문집 Vol.- No.75

This study examines urban spatial changes of Cheongju and Uiju which were provincial capital cities and how to change Korean traditional buildings to Japanese buildings during the Japanese colonial period. After the establishment of the Japanese Resident-General in 1905, Japan tried to reform the Korean local government system. The construction of the railway running from Busan to Shinuiju (New Uiju) was completed in 1905. This railway system was a trigger to change the Korean local government system. Former Chungbuk and Pyeongbuk provincial governments are located inland and far from the railway stations. For economic reasons, these two provincial governments had to be relocated. So Chungbuk provincial office moved from Chungju to Cheongju and Pyeongbuk provincial office moved from Yeongbyun to Uiju that was near the borderline between China and Korea. Japan had a plan to expand its power to China, so Japan needed a strategic administrative hub to do it. Since the early Japanese colonial period, the urban space of the two cities was getting to change so fast. Cheongju faced urban changes as pulling down the city wall and constructing straighten and grid roads. the Uiju city had lots of military facilities in the city because of its borderline ** All Korean local government buildings were switched to Japanese administrative buildings with a Korean-Japanese mixed-style. Chungbuk provincial government used the building built in the 18th century but they remodeled and extended the building. Pyeongbuk provincial government used the building Korean local government's and Japan also remodeled the building and built new annexes with Japanese style. Those buildings were connected with outer aisles. ​The southern gate of the Uiju city wall turned into a Japanese industrial exhibition facility.

일제강점기 관찰부 이전(移轉) 후 관련건축물의 변화에 관한 연구 -수원과 충주를 중심으로-

최지해,한동수,Choi, Ji-Hae,Harn, Dong-Soo 한국건축역사학회 2021 건축역사연구 Vol.30 No.4

This study examines changes and features of provincial office buildings in Suwon and Chungju after relocation during Japanese occupation. Gyeonggi and Chungbuk provincial offices(Gwanchalbu) were relocated by Japan. Gyeonggi Provincial Office in Suwon used HwaseongHaenggung buildings and moved to Seoul in 1910. After relocation, most of HwaseongHaenggung buildings used for Suwon Governmental hospital(JaHye Uiwon). Suwongun Office, Suwon public elementary school, Japanese Military and Suwon Police station also used HwaseongHaenggung buildings with the Hospital. At first, Japan remodeled local government buildings for their use. Most of HwaseongHaenggung buildings had been destroyed to build new buildings since 1920s. Chungbuk Provincial office in Chungju used DongHeon building which is Chungju local government building and relocated to Cheongju in 1908. DongHeon building changed to Chungju county office after relocation. This building was renovated. Chungju county office moved to other site, this building was used for Chungju county conference room. During Japanese colonial period, Suwon local government buildings were destroyed and replaced with new Japanese style buildings. Chungju local government buildings were also renovated or destroyed.

일제강점기 부산제2공립상업학교의 건축적 특성에 관한 연구

최지해 한국건축역사학회 2022 한국건축역사학회 학술발표대회논문집 Vol.2022 No.11

Effects of Fermented Barley on Lipid and Carnitine Profiles in C57BL/6J Mice

최지해,Tae-Hee Kim,Myung-Suk Ko,차연수 한국식품과학회 2012 Food Science and Biotechnology Vol.21 No.2

The aim of the present study was to investigate the effects of fermented barley supplementation on blood lipid profiles, carnitine concentrations, and hepatic mRNA levels of enzymes involved in fatty acid metabolism. Thirtytwo C57BL/6J male mice were divided into 4 groups;normal diet control group (ND), high fat diet control group (HD), high fat diet plus barley supplemented group (BR),and high fat diet plus fermented barley supplemented group (BR-F). BR-F supplementations decreased total cholesterol (TC) and LDL-cholesterol in serum, triglyceride (TG) in liver. Serum total carnitine (TCNE) concentrations were significantly higher in the BR-F group than HD group. BR-F supplementations significantly increased hepatic lipolysis regulating gene expression such as carnitine palmitoyltransferase-I (CPT-I), peroxisome proliferatoractivated receptor-α (PPARα), whereas significantly decreased lipogenic enzyme expression such as acetyl CoA carboxylase (ACC). These results suggest that the fermented barley has anti-obesity properties.

上海의 개항초기 건물유형 및 외국인 거류지 형성과정

최지해(Choi Ji-Hae),한동수(Harn Dong-Soo) 대한건축학회 2011 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.31 No.2(계획계)

This paper aims at identifying the process to establish the British settlement and first buildings in Shanghai. The letters and writings by foreigners, lived in Chinese cities in 19th century, were used as the data. The results of this study were as follows; The first foreign settlement was not british their own thinking but the Shanghai bureaucrat(Daotai)’s idea as the traditional Chinese diplomatic policy. First buildings in Shanghai included both dwelling and office together under one roof and connected the annex where Chinese workers lived in and godowns(warehouses). The whole process of those buildings was managed by the Chinese compradore, so the style of them was called ‘Compradoric Style’.

컨베이어

최지인 푸른사상사 2021 푸른사상 Vol.38 No.-

그리고 나는 저녁이 될 때까지 계속 걸었다

최지인 한국비정규노동센터 2016 비정규 노동 Vol.117 No.-