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13. 한국산 고등균류의 성분연구 (33) : 간버섯의 항암성분 Antitumor Components of Trametes sanguinea (L. ex Fr.) Lloyd .
최응칠,정경수,강창율,홍화봉,김병각 한국균학회 1982 韓國菌學會誌 Vol.10 No.1
For the purpose of finding out the stronger antitumor compounds with the lower toxicity from the natural resources, the antitumor activity test of the water extract of the carpophores of Trametes sanguinea (L. ex Fr.) Lloyd, was undertaken. The carpophores of T. sanguinea, a high fungi, were collected in Gyeong Gi Province and extracted with hot water. The extract was purified by dialyzing through Visking tube and a polysaccharide fraction was obtained. The antitumor activity of the fraction was tested against sarcoma 180 implanted in mice. The tumor inhibition ratio of the polysaccharide fraction against the tumor was 72.4% in the doses of 10㎎/㎏/day for the period of ten days. The tumor in two of the 8 mice was completely regressed. The components of this aqueous extract were found to be a polysaccharide and a protein by color reactions including Anthrone and Lowry-Folin tests. The chemical analysis of the polysaccharide fraction was also undertaken.
세균의 항생물질 내성에 관한 연구 Macrolide계 항생물질에 대한 유도 내성 Bacillus속 세균
최응칠,김병각,심미자,정경수,김혜령,이종길 대한약학회 1982 약학회지 Vol.26 No.3
Several strains of bacteria having resistance to macrolide antibiotics were isolated. EMR-1, one of them, exhibited the induced resistance to macrolide antibiotics and this microorganism was identified as a bacterium belong to Bacillus species. The subinhibitory concentration of erythromycin or oleandomycin induced strong resistance to both erythromycin and oleandomycin themselves and to other macrolide antibiotics such as leucomycin, spiramycin and josamycin. The effective concentration of inducer, erythromycin was $0.0016-0.2\mu$g/ml. The inactivating enzyme of these antibiotics was not produced by EMR-1.
Bacillus licheniformis EMR-1에서의 MLS 유도내성 기전 -erm K의 크로닝-
최응칠,곽진환,B.와이스브럼,Choi, Eung-Chil,Kwak, Jin-Hwan,Weisblum, Bernard 대한약학회 1988 약학회지 Vol.32 No.4
Inducible MLS resistance gene of Bacillus licheniformis specified by erm K was subcloned in Bacillus subtilis and the DNA sequence corresponding to its control region was determined. The determinant erm K was in Pvu II=Hind III fragment, which was 1.3 kb. The leader region is capable of forming a complex series of inverted complementary repeat sequences (ICRS) centering on at least six axes of symmetry, some of them mutually exclusive, in a way that resulted ultimately in post-transcriptional unmasking of the ribosome loading site for methylase synthesis.
Mycobacterium smegmatis를 이용한 Viomycin의 내성 및 작용 기전에 관한 연구
최응칠 대한약학회 1980 약학회지 Vol.24 No.1
Viomycin inhibited polypeptide biosynthesis, initiation complex formation and translocation of peptidyl-tRNA on ribosomes derived from a sensitive strain of Mycobacterium smegmatis (R-15), but not significantly on ribosomes from viomycin-resistant mutants(R-31 and R-43). The inhibition of translocation was stronger than that of initiation complex formation in the sensitive strain. The binding of [$^{14}C$] tuberactinomycin O, a viomycin analog, to ribosomal particles was studied by Millipore filter method. The sensitive ribosome exhibited higher affinity for the antibiotic than the resistant ribosomes. The resistance was localized on the large ribosomal subunit in a mutant(R-31), and on the small subunit in another mutant(R-43). The binding of the drug to the sensitive ribosomal subunit was markedly reduced by combination with the resistant pair subunit, and the entire ribosome became resistant to the antibiotic.
a possible combined attenuation control of the inducible MLS resistance
최응칠,Weisblum, B. 한국미생물학회 1987 微生物과 産業 Vol.13 No.2
이글에서는 항생물질 내성의 생화학적 기전, MLS계 항생물질 내성기전, Post-transcriptional attenuation control, MLS계 항생물질 내성기전 연구방향, erm K의 cloning: transcriptional attenuation control의 가능성에 대해 논하였다.
최응칠 생화학분자생물학회 1986 BMB Reports Vol.13 No.4
Viomycin inhibited polypeptide biosynthesis, initiation complex formation and translocation of peptidyl-tRNA on ribosomes derived from a sensitive strain of Mycobacterium smegmatis (R-15), but not significantly on ribosomes from viomycin-resistant mutants (R-31 and R-43). The inhibition of translocation was stronger than that of initiation complex formation in the sensitive strain. The binding of [^(14)C] tuberactinomycin O, a viomycin analog, to ribosomal particles was studied by Millipore filter method, The sensitive ribosome exhibited higher affinity for the antibiotic than the resistant ribosomes, The resistance was localized on the largeribosomal subunit in a mutant (R-31), and on the small subunit in another mutant (R-43). The binding of the drub; to the sensitive ribsomal subunit was markedly reduced by combination with the resistant pair subunit, and the entire ribosome became resistant to the antibiotic.