카지노 딜러의 감성지능이 고객지향성에 미치는 영향

최은애(Choi, Eun-Ae) 한국서비스산업학회 2014 서비스산업연구 Vol.11 No.1

photon빔 조사 후 AuNPs 입자의 방사선 감수성 향상에 관한 생물물리학적 평가

최은애(Eun ae Choi),손재만(Jae man Son) 한국방사선학회 2016 한국방사선학회 논문지 Vol.10 No.7

이 연구는 γ선 및 x선 조사 시 AuNPs 입자의 방사선감수성의 향상을 생물물리학적으로 평가하기 위해 두 가지 실험을 시행하였다. 생물학적 방사선 감수성의 평가에 앞서 6시간, 12시간, 18시간, 24시간 incubation한 후 세포생존율(surviving Fraction, SF)값을 비교하여 AuNPs 입자의 독성 여부와 세포질에 입자의 균일된 분포 여부를 확인 해 보았다. incubation time에 따라 세포생존율(surviving Fraction, SF)이 낮아지지 않음을 확인한 다음 γ선 및 x선 조사 후 Clonogenic assay 실시하고 세포생존율(surviving Fraction, SF)을 구하여 방사선 감수성을 비교 평가하였다. 방사선량 증가 시 세포생존율(surviving Fraction, SF)이 계속해서 낮아졌고 8Gy 조사 시 최대치로 약 30%의 차이가 있음을 확인하였다. 또한 Gate v6.1을 사용하여 몬테카를로 시뮬레이션 후 percent depth dose(PDD)를 구한 뒤 선량 평가하여 약 40% Dose Enhancement가 있음을 확인하였다. 두 가지 실험에 따라 생물물리학적으로 AuNPs 입자는 방사선 감수성이 향상되도록 하며 이는 nanop article을 이용한 방사선 병합 치료 시 치료 성적 향상에 큰 도움이 될 것으로 보인다. The purpose of this study is to investigate whether gold nanoparticles had radiosensitization when combined with gamma and x ray beam. Cytotoxicity was mearsured with comparing survival fraction after incubated time 6,12,18 and 24 hours. Clonogenic assay was employed to assess survival fraction of cells with and without gold nanoparticles treatment following gamma ray irradiation. The most of gold nanoparticles were distributed in the cytoplasm. And the toxicity of gold nanoparticles used this study were found to be non-cytotoxic. And we also observed enhancement by about 40% in RBE value for gamma ray irradiation of cells treated with gold nanoparticles. Dose reduction of about half for gamma ray irradiation is demonstrated for gold nanoparticles treated cells as compared to untreated cells. In cells with exposed to gamma ray, DNA damage was increased when compared to only radiation exposed cells. The study revealed a significant reduction in radiation dose for killing the cells with internalized gold nanoparticles as compared to the cells without gold nanoparticles. The gold nanoparticles treatment resulted in enhancement of radiation effect as evident from increase in relative biological effectiveness values for photon irradiated cells.

양성자빔 조사에 따른 MRC-5와 SK-N-SH의 DNA 손상 후 회복 특성

최은애(Eun-Ae Choi),이봉수(Bong-Soo Lee),조영호(Young-Ho Cho) 대한방사선과학회 2011 방사선기술과학 Vol.34 No.4

양성자 빔의 조사선량에 따라 정상섬유모세포인 MRC-5와 신경모세포종세포인 SK-N-SH의 DNA 손상도를 확인하고 시간 흐름에 따른 회복률을 비교 분석하였다. 두 가지의 세포에 2Gy, 5Gy, 8Gy의 양성자 빔을 각각 조사한 후 Alkaline comet assay를 실시하였다. Tail moment를 측정하여 DNA의 손상도를 비교하였고 일정시간이 지난 후 재 측정을 하여 두 가지 세포의 회복가능성을 비교하였다. 세가지 선량으로 양성자 빔을 조사하였을 때 전체적으로 SK-N-SH에 비해 MRC-5의 DNA 손상도는 낮았지만 8Gy 조사하였을 때 MRC-5의 Tail moment값은 50.3202±23.17155로 위험수준의 손상이 발생함을 알 수 있었다. 또한 2Gy와 5Gy 조사하였을 때 두 세포 모두 25시간 안에 거의 회복되는 반면 8Gy 조사시 두 세포 모두 회복률이 낮아졌으며 MRC-5의 경우 25시간 후 측정시 Tail moment값은 18.1536±4.42849로 선량 증가에 크게 반응하여 회복률이 낮아짐을 확인하였다. 양성자 빔의 SOBP 중 다른 지점에 비해 distal declining edge에서 LET가 더 높으며 선량을 높이면 그 차이는 월등히 커진다. 이러한 특징과 더불어 본 연구에서 확인한 고선량 조사시 정상섬유모세포의 회복률이 낮아져 지속적인 손상으로 이어진다는 점은 양성자 치료시 주의하여야 한다. 종양조직에 해당하는 SOBP 중심부에 조사되는 조건 뿐 아니라 더 높은 RBE의 주변 정상조직에 적용되는 조사조건을 확인하여야 부작용을 막을 수 있다. The purpose of this study is to compare DNA repair characteristics of normal fibroblast cell (MRC-5) and neuroblastoma cell (SK-N-SH) induced by proton beam. Cells were irradiated with 2Gy, 5Gy and 8Gy proton beam. The rate of DNA rejoining was measured by alkaline version of the comet assay. After a repair time, tail moment was measured again. The tail moment of MRC-5 was lower than SK-N-SH. However, after 8Gy of exposure, the tail moment of MRC-5 was measured as 50.320223.17155 which represents dangerous level of DNA damage. The cells were repaired practically within 25 hours after 2 and 5Gy of exposure while they were not fully recovered after 8Gy of exposure. Especially, tail moment of MRC-5 after 25 hours was 18.15364.42849. In the distal declining edge of SOBP, the RBE value is increased by high LET. The RBE differences of SOBP in high-dose were greater than low-dose. After the high-dose exposure, MRC-5 of normal fibroblast cell could lead to lasting DNA damage as shown in this study. In conclusion, we has to pay special attention when the region of the treatment volume is close to sensitive tissues.

연구논문(硏究論文) : 카지노 딜러가 인식하는 감정노동이 리더의 감성지능의 수준에 의한 고객 지향성에 미치는 영향에 관한 연구

최은애 ( Eun Ae Choi ) 한국관광산업학회 2011 Tourism Research Vol.32 No.-

This study aimed at inquiring into the effect of the emotional labor of casino dealers` perception on customer orientation, and catching the moderating role by the level of leader`s emotional intelligence as the mechanism, which can ease this relation. A survey was made on casino dealers at Kangwon Land through questionnaires. The factors composition, which releases in the existing precedent studies, was almost supported by measuring the emotional labor and customer orientation with casino dealers on the basis of the existing precedent studies. The well-timed application of the emotional application, emotional regulation and emotional perception of leader for efficient organization management in casino corporations could contribute to efforts for the inspiration and raise of dealers` customer-oriented mind.

야구장 소음이 주민 생활에 미치는 영향에 관한 연구

최은애(Eun Ae Choi),송국곤(Guk Gon Song),강종구(Jong Ku Kang),이태강(Tai Kang Lee),김선우(Sun-Woo Kim) 한국소음진동공학회 2011 한국소음진동공학회 학술대회논문집 Vol.2011 No.10

나노 섬유간 간격조절을 위한 물리적 전계가변 콜렉터

이준희(Lee Jun Hee),이현지(Hyeon JI Lee),박지수(Jeesoo Park),은다희(Da hui Eun),최은애(Choi Eun Ae),김철생(Cheol Sang Kim),박찬희(Chan Hee Park) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11

알코올 금단 증상의 치료에서 Topiramate의 효과 및 안정성

최은애,기선완,김성은,김지웅,박진균 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : Benzodiazepines are most often used for the treatment of alcohol withdrawal, but they also may result in several adverse consequencies such as sedation, respiratory depression, cognitive impairment, disinhibition, and abuse. New anticonvulsants, topiramate may have a potential to treat alcohol withdrawal effectively. This study compared the therapeutic responses of a benzodiazepine, lorazepam, and an anticonvulsant, topiramate, for the treatment of alcohol withdrawal. Methods : Fifty-two hospitalized patients with the diagnosis of DSM-IV Alcohol dependence, after obtaining written informed consent, were randomely divided into the either lorazepam (N=27) or the topiramate (N=25) groups. Subjects were assessed with CIWA-Ar scores at the time of baseline, 1, 3, 5 day after the last alcohol drinking. Lorazepam was given 4 mg divided by 4 on day 1, tapering to 2 mg divided by 2, and topiramate was given fixed single dose of 50 mg a day. Results : There were no significant differences between two groups in demographic or clinical characteristics except marital status and s-ALT level. Two groups had similar ADS scores and baseline withdrawal severity. There were no significant differences by treatment group in CIWA-Ar scores over time (F=0.883, P>0.05). Conclusion : Efficacy and safety were not different between the two groups. Therefore our results suggest that topiramate is a Promising alternative agent to benzodiazepine for treating alcohol withdrawal.

그림책에 대한 교사의 질문유형이 유아의 언어표현력 및 사고력에 미치는 영향

최은애,박혜경 동덕여자대학교 2003 생활과학연구 Vol.8 No.-

The purpose of this study is to testify whether divergent questions among the questioning types influence on language expression and thinking ability of young children. The subjects of study were 40 five-year-old children in Y kindergarten located in Nowon-gu, Seoul. Two groups, each of 20 children, were chosen from 40 children. One group were asked of divergent type questions as the experimental group, and the other group were asked of convergent type as the comparative group. The experiment had, been conducted as much 10 times main tests in total, twice per week. As a results, statistically, there were no meaningful difference of young children`s language expression ability and thinking ability between the experimental group and the comparative group. However, in the interaction between the teacher and the children, we could find that the children in the experimental group gradually increased the number of new words and sentences, adding a new word, and showed diverse and abundant expression in the content. They expressed divergent way of thinking and used reasoning power about a given situation improved.

노년기 주관적 기억력 감퇴의 예측인자 : 한국인의 건강과 노화에 관한 종적 연구 결과

유지민,김기웅,박준혁,이석범,최은애,최진영,정지운,도연자,노현아,박영선,이동영,우종인 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : We investigated the predictors of subjective memory complaints in the community-dwelling normal elderly. Methods : This study was conducted as a part of Korean Longitudinal Study on Health and Aging (KLoSHA). 747 non-demented community-dwelling elderly aged 65 years or older were recruited. All participants underwent clinical evaluation for dementia and psychiatric disorder conformed to the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD-K.) Clinical Assessment Battery and Korean version of Mini-Intemational Neuropsychiatric Interview, res-pectively. Word list recall test, frontal assessment battery, Mini Mental Status Examination (MMSE-KC) and Korean version of Geriatric depression scale (GDS-K) were administered to evaluate episodic memory, frontal function, global cognition and depression, respectively. Subjective memory complaint was defmed in two different ways: worse than one's past (SMC-P) and worse than others of one's age (SMC-O). Results : In highly educated elderly, minor depressive disorder (0R=7.23, 95% C.I.= 2.29-22.86) and frontal dysfunction (0R=2.48, 95% C.I.= 1.29-4.77) significantly increased the risk of SMC-O. However, they did not influence the risk of SMC-P. In low educated elderly, both the minor depressive disorder and frontal dysfunction did not influence the risk of SMC-0 as well as that of SMC-P. Conclusion : SMC-O can be a sensitive subjective recognition of mild depression and/or frontal dysfunction in highly edu-cated normal elderly.

한국어판 중증간이정신상태평가의 신뢰도와 타당도

박준혁,최진영,윤종철,이원혜,정지운,도연자,최은애,이석범,주진형,이동영,김기웅 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2

Objectives : We developed the Korean version of Severe Mini-Mental Status Examination (SMMSE-K) which is a brief cognitive test for the severely demented patients. Methods : The translation was carried out keeping the basic structure of the English version Severe Mini-Mental Status Examination (SMMSE). The SMMSE-K, Korean version of Mini Mental State Examination (MMSE-KC), and Clinical Dementia Rating (CDR) were administered to 84 Alzheimer's disease (AD) patients and 36 cognitively normal elderly subjects. For evaluating the reliability of the SMMSE-K, Cronbach alpha coefficient, inter-rater reliability, and test-retest reliability were examined. For confirming the validity of the SMMSE-K, the correlations of the SMMSE-K with MMSE-KC and CDR were examined, and factor analysis was performed using principal component analysis with Varimax rotation. Results : SMMSE-K was found to have a high internal consistency (Cronbach alpha coefficient=0.906, P<0.01), inter-rater reliability (Pearson correlation coefficient=0.980, P<0.01) and test-retest reliability (Pearson correlation coefficient= 0.940, p<0.01). Performances on the SMMSE-K and MMSE-KC were found to correlate significantly in the subjects with CDR of 2 (Pearson correlation coefficient=0.827, P<0.001) and 3 (Pearson correlation coefficient= 0.929, P<0.001). In the subjects with CDR of 3, the MMSE-KC showed a floor effect (2.93±3.21), whereas the SMMSE-K did not (11.00±8.48). Exploratoiy factor analysis yielded two factors (automatic informational processing, controlled informational processing) accounting for 76.1% of the total variance. Conclusion : The SMMSE-K was found to be a reliable and valid test for assessing the cognition of severely demented patients.