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인체 흑색종 세포(SK-MEL-28 Cell Line)에서 Cisplatin, Heptaplatin, 그리고 Sunpla에 의한 Apoptosis의 유도
최수라,명평근 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8
A wide variety of cancer chemotherapeutic agents have been shown to induce programmed cell death (PCD, APOPTOSIS) in variou s tumor cell lines in vitro. cis-Malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isoprpopyl-1,3-dioxolane] platinum(Ⅱ) (heptaplatin), which is a new drug approved by KFDA in a novel platinum-based antitumor agent with clinical potential against stomach cancer and the 3rd generation of the cisplatin. This study was performed to know how heptaplatin and cisplatin and sunpla (mixture of heptaplatin and mannitol) affect on SK-MEL-28 cell line, and hour they induce the apoptosis. At EM analysis, the morphology of the cell was changed by treatment of the cisplatin, heptaplatin and sunpla. Apoptotic body formed around plasma membrane, and chromatin condensation represented in nucleus. This phenomenon is one of the characteristic of the apoptosis. The DNA of SK-MEL-28 cell line truncated by cisplatin and sunpla treatment was identified on 2% agarose gel electrophoresis. TUNEL assay was performed to know whether SK-MEL-28 cell die as apoptosis or necrosis by cisplatin, heptaplatin and sunpla. At this result, fluorescence intensity increased according to increase of time and concentration. Therefore, it was identified that cislatin, heptaplatin and sunpla induced apoptosis. Fas expressed on SK-MEL-28 cell membrane by cisplatin, heptaplatin and sunpla was identified by using flow cytometer and the expression of bcl-2(anti-apoptotic gene) decreased according to increase of concentration of the cisplation, heptaplatin and sunpla. Cisplatin, heptaplatin and sunpla induced apoptosis against 나-MEL-28 cell line, and the apoptotic mechanism was identified as Fas-mediated apoptosis and decreased bcl-2 expression.
동역학 해석을 통한 자동화 수동 변속기(AMT) 기어 액추에이터의 설계 검증
최수길(Sugil Choi),조태영(Taeyoung Cho),이한구(Hangu Lee),최세빈(Sebin Choi) 한국자동차공학회 2013 한국자동차공학회 부문종합 학술대회 Vol.2013 No.5
In this paper, shift performance of a pneumatic gear actuator is investigate. To obtain the shift force, dynamic model of the pneumatic gear actuator is constructed by using RecurDyn. The prototype of pneumatic gear actuator system is designed and implemented systematically, which is composed of an control valve, cylinder, double slide mechanism. As a result, the design of pneumatic gear actuator was verified through dynamic analysis result. Were obtained through Dynamic Analysis model the base model, optimization, and solve technical problems in future design changes or development designs.
자동화 수동 변속기(AMT) 기어 액추에이터의 설계 검증
최수길(Sugil Choi),조태영(Taeyoung Cho),최세빈(Sebin Choi) 한국자동차공학회 2014 한국자동차공학회 학술대회 및 전시회 Vol.2014 No.11
In this paper, shift performance of a pneumatic gear actuator is investigate. To obtain the shift force, dynamic model of the pneumatic gear actuator is constructed by using RecurDyn. The prototype of pneumatic gear actuator system is designed and implemented systematically, which is composed of an control valve, cylinder, double slide mechanism. As a result, the design of pneumatic gear actuator was verified through dynamic analysis result. Were obtained through Dynamic Analysis model the base model, optimization, and solve technical problems in future design changes or development designs.
최수길(Sugil Choi) 한국자동차공학회 2019 한국자동차공학회 학술대회 및 전시회 Vol.2019 No.11
This paper is about optimization design and analysis verification of automotive electronic actuators. An electronic actuator for a vehicle is composed of a motor, a reducer, and a controller for controlling the motor. In recent years, metal gears have been replaced by plastic gears. Plastic gears have advantages in cost, weight, noise reduction, etc., but the size increase and durability of steel gears are reduced. Therefore, it is necessary to optimize the design in order to minimize the disadvantages of the plastic gear, and to ensure structural safety. Structural analysis was performed on design parameters such as material, module, and thickness of plastic gears to select the optimal parameters, and plastic gears were optimized for design. In addition, a prototype was developed to compare the test results with the analysis results to ensure the correlation between the analysis models and to build an analysis model that can efficiently design and verify according to specification changes.