증상 발현과 증상 심각성을 병합한 추세검정법

최세미,양수,송혜향,Choi, Se-Mi,Yang, Soo,Song, Hae-Hiang 한국통계학회 2011 응용통계연구 Vol.24 No.6

임상 연구자는 일정기간의 치료에 의해 환자에게 증상 발현 또는 증상 비발현을 관측할 뿐만 아니라 증상이 발현된 환자의 경우에는 증상 심각성 점수가 측정됨을 자주 본다. 예를 들어서 대조군을 비롯하여 치료의 정도에 차이가 있는 여러 치료군이 있을 때 발현율의 감소를 검정하는 전통적인 방법은 Cochran-Armitage 추세검정이며, 한편 비정규분포하는 연속자료의 감소를 검정하는 전통적인 방법은 Jonckheere-Terpstra 추세검정이다. 전자의 추세검정은 증상 발현의 이항자료만을 사용한 검정이 되며 한편 후자의 추세검정은 증상의 심각성 점수만을 사용한 검정이 된다. 본 논문에서는 증상 발현율과 증상의 심각성 점수로 나타나는 정보의 특성을 모두 감안한 추세검정법을 제안한다. 새로운 추세검정법을 항정신병 약제를 복용하는 정신분열증 입원환자로부터 수집된 자료에 적용하며 본 논문에서 취급하는 여러 다른 검정법과 비교한 효율성을 모의실험으로 알아본다. During clinical trials a researcher is frequently able to observe a disease symptom in a subject as well as a severity score for those who experienced a symptom after a fixed length of treatment. The traditional method to evaluate a decreasing trend in proportion, when there is an intrinsic order in the treatment groups (for example control and two or more treatment groups) is a Cochran-Armitage test, while the method to evaluate a decreasing trend in continuous non-normal data is a Jonckheere-Tersptra test. The Cochran-Armitage test emphasizes the dichotomous data of symptom occurrence and the Jonckheere-Tersptra test emphasizes the continuous non-normal data of severity symptom scores. In this paper we propose new test statistics that consider the combined evidence from a symptom occurrence and disease severity score. We illustrate these methods with example data of schizophrenic inpatients that demonstrated antipsychotic-drug induced constipation. A small-scale simulation is conducted to compare the new trend tests with other trend tests.

아파트 규모별 발코니공간의 개선방향에 관한 연구

최세미,이지순,윤정숙 한국주거학회 2001 한국주거학회 논문집 Vol.12 No.3

Even though the balcony in apartment is considered as a necessary space rather than a supplementary one nowadays, we still have many problems in balcony. The utilization of balcony space in our daily lives are as follows: Laundry, Storage, Indoor gardening, Exercise, Hobby activities etc. Despite of these various functions of balcony, balconies were designed without taking them into consideration. Therefore balcony spaces are not functional and the lines of flow get more complicated. Until now, the studies of balcony were simply done on the utilizing pattern and the satisfaction degree of residents, not on connections between balcony location and utilizing pattern. Thus, the purpose of this study is to provide improvement guidelines for the utilization of the balcony space in apartment by examining the present conditions and multiple needs.

Optimal Conditions for the Production of Gamma-aminobutyric Acid by Enterococcus casseliflavus PL05 Isolated from Oenanthe javanica

최세미,김정아,김근수,권도영,김상구,이상윤,이강욱 한국식품위생안전성학회 2022 한국식품위생안전성학회지 Vol.37 No.1

In this study, a new lactic acid bacterium (LAB) that could produce gamma-aminobutyric acid(GABA) was isolated from Oenanthe javanica (water celery) and identified as an Enteroccoccus casseliflavus strain. Until recently, there have been many studies on the gamma-aminobutyric acid producing lactic acid bacterium, as wellas on some lactic acid bacterium in Enteroococcs genus, but none on the species E. casseliflavus. Therefore, in thepurpose of finding the optimal conditions for GABA production of E. casseliflavus PL05, the effects of several conditionsincluding the type of mediums, growth temperatures, initial pH, growth time, L-mono sodium glutamate(MSG) concentration, and carbon source were tested. The study revealed that the PL05 strain grew better in the BrainHeart Infusion (BHI) medium than in the Man, Rogosa, and Sharpe (MRS) or Tryptic Soy Broth (TSB) medium. Also,similar results were obtained with GABA production conditions. As a result of analysis on the GABA productionyield by concentration of MSG, a GABA substrate, the highest production was found at 7% of MSG concentration. However, since similar level of production was found at 5%, it is considered to be more efficient to use 5% MSGconcentration. The analysis on the growth and GABA production yield by carbon sources showed the highest resultswhen maltose was used. From the final test under the optimal conditions found, 140.06±0.71 mM of GABA was producedover 24 hours with the conversion rate of 78.95%. Lastly, from the sensitivity analysis on the 10 different antibiotics,including vancomycin, it was found that there were not confirmed cases of resistance.

난소에서 발생한 Hepatoid Carcinoma

최세미(Se Mi Choi),박창수(Chang Soo Park),오성희(Sung Hee Oh),김태중(Tae Joong Kim),송상용(Sang Young Song),안긍환(Geung Hwan Ahn),배덕수(Duk Soo Bae),이제호(Je Ho Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.1

Hepatoid carcinoma is a rare type of malignant tumor resembling hepatocellular carcinoma that arises in extrahepatic sites.(stomach, lung, ovary, pancreas, bladder and renal pelvis). Hepatoid carcinoma of the ovary is an extremely rare ovarian tumor, first described by Ishikura and Scully in 1987. Histologically it is important to differentiate this entity from other oxyphil tumors of the ovary as it requires aggressive treatment. We have experienced a case of hepatoid carcinoma of the ovary in 69-year-old postmenopausal woman, who has been treated with operation and adjuvant Taxol - cisplatin chemotherapy. We present this case with brief review of literatures.

난소의 악성 혼합성 뮬러리안 종양 1예

오성희,배덕수,노정수,최세미,엄상탁,박창수,이제호 대한부인종양 콜포스코피학회 1999 Journal of Gynecologic Oncology Vol.10 No.3

Malignant mixed mu¨llerian tumors(MMMTs) are uncommon neoplasms of the female genital tract that are histologically defined by the presence of malignant epithelial and stromal elements. MMMTs can arise hom the uterine body, cervix, vagina, ovary, and fallopian tube and constitute less than 1% of all overian malignancies. These tumors are usually advanced when diagnosed and follow an aggressive clinical course. We had experienced a case of MMMT of the ovary and presented with a brief review of literature.

과학기술자 블로그 운영사례 연구

윤정선(Jungsun Yoon),박보미(Bomi Park),최세미(Semi Choi),한선화(Sun-Hwa Hahn) 한국콘텐츠학회 2007 한국콘텐츠학회 종합학술대회 논문집 Vol.5 No.2_1

한민족과학기술자네트워크 KOSEN에서는 과학기술자 블로그 서비스를 시작하였다. 기존의 정형화된 서비스의 틀을 넘어 과학자 자신이 자유롭게 자신이 보유한 지식을 드러내며 자유로운 교류가 가능케 하기 위한 시도이다. 2007년 4월 처음 개설한 이래 2007년 10월 현재 251개의 블로그가 개설되어 운영중이다. 블로그를 통해 전공지식에서부터 여행, 취미까지 다양한 콘텐트들을 확보 할 수 있었으며, 블로그 서비스의 문제점도 파악할 수 있었다. 본 논문에서는 과학자 블로그 사용 실태를 분석하여 제시한다. 또한 블로그 운영의 활성화 전략을 도출하여 서비스의 나아갈 방향을 제시하고자 한다. KOSEN(KOrean Scientists and Engineers' Network) started Blog servece to encourage users' knowledge sharing and interaction between users. Since blog opened in April of 2007, 251 blogs have been made. We could collect diverse information from technical knowledge to private hobbies. We could find our blog's limitations and weakness, too. We analyze blog patterns and suggest strategies for service activation in this paper.

쌍태임신에서 쌍태아간 출생체중 차이에 따른 주산기 예후의 비교

정재현,노정래,양순하,박선혜,서용수,최세미 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.9

저자들은 임신 25주에서 37주 미만의 쌍태임신 119예를 대상으로 쌍생아간 출생체중 차이에 따라 대상군을 네 군으로 나눈 후 각 군간의 주산기 예후를 비교함으로써 다음과 같은 결과를 얻었다. 1. 연구 대상이었던 238명의 쌍생아 중 10% 이하인 Ⅰ군은 128명(54%), 10∼20%인 Ⅱ군은 58명(24%), 20∼ 30%인 Ⅲ군은 32명(13%) 그리고 30% 초과인 Ⅳ군은 20 명(8%)이었다. 2. 각 군간 제태주령과 출생체중 간에는 유의한 차이를 보이지 않고 있으나 저출생체중아 및 신생아 호흡부전 증후군이 Ⅳ군에서 유의하게 많이 발생한 것으로 나타났다(p<0.001 and p<0.05, respectively). 신생아 사망률과 주산기 사망률은 각 군간에 유의한 차이가 없었다. 3. 신생아 중환자실에서의 집중치료가 필요했던 경우가 Ⅳ군에서 많았으나 통계적으로는 의미가 없었으며, 신생아 중환자실 재원 기간도 각 군간에 통계적인 차이가 없었다. 4. 출생체중이 큰 쌍태아와 작은 쌍태아의 주산기 예후를 비교해 보았을 때 저출생체중의 빈도를 제외하면 두 군간에 통계적으로 유의한 빈도 차이를 보이는 예후 인자는 발견되지 않았다. 5. 다른 주산기 예후의 예측인자들과 같이 multiple logi stic regression analysis를 시행한 결과 출생체중의 차이는 불량한 주산기 예후의 독립적 예측인자로 생각되지 않았다. 결론적으로 쌍태임신에서 쌍태아간의 출생체중 차이 그 자체는 주산기 예후의 독립적 예후인자가 되지 않는 것으로 생각되며 이 결과는 쌍생아간 체중불일치의 정의를 보다 엄격히 정함으로써 쌍태임신의 산전관리 및 신생아 처치에 오류를 범하지 않아야함을 시사한다. 이의 증명을 위하여는 향후 보다 많은 수의 쌍태임신을 대상으로 하여 전향적 연구를 시행하여야 한다고 사료된다. Objective: The purpose of this study was to determine the effect of discordant fetal growth on subsequent perinatal and neonatal outcome for different degrees of birth weight discordance in twin gestations. Study design: One hundred nineteen sets of twins delivered between 25 and 37 weeks` gestation were studied. They were stratified into four categories according to the percent difference in infant birth weight: ≤10%, 10% to 20%, 20% to 30%, and >30%, which was defined as ([Birth weight of larger twin - Birth weight of smaller twin]/Birth weight of larger twin)×100. The relationship between different birth weight categories and the perinatal and neonatal outcome and the difference in outcome between the large and small infants were evaluated. Multiple logistic regression analysis was used to determine the relationship between the poor perinatal outcome and independent variables. Results: Twin gestations with >30% birth weight discordance were associated with a higher incidence of small-for-gestational-age (SGA) infants and respiratory distress syndrome of neonates (p<0.001 and p<0.05, respectively). Outcome of the large and small twins showed no significant difference except incidence of SGA infants. Multiple logistic regression analysis revealed that birth weight discordance >30% was not an independent predictor for perinatal outcome. Conclusion: In twin gestations the use of a 30% birth weight difference to define twin discordance seems to be most clinically relevant in identifying those infants at risk for adverse perinatal outcome. However, birth weight discordane is not an independent risk factor for perinatal mortality and morbidity. It suggests that the estimated fetal weight discordance by prenatal ultrasonography is not an indication of preterm delivery.

국내외 유행색의 특성비교에 따른 유행색과 유행테마의 관련성

국지인,김경은,이현주,차성희,차정은,최세미 연세대학교 생활과학대학 1998 생활과학 Vol.- No.31