인진삼물탕(茵蔯三物湯) 약침처리(藥針處理)가 백서(白鼠)의 간손상(肝損傷) 회부(回復)에 미치는 영향(影響)

최성훈,박희수,Choi, Sung-Hoon,Park, Hee-Soo 대한약침학회 1999 Journal of pharmacopuncture Vol.2 No.1

These studies were carried out to investigate the effect of Herbal-acupuncture with Inzinsammultang extract on the recovery from liver injury of rats. The liver injury of rats induced with 0.3ml/ea carbon tetrachloride. The Herbal-acupunture with Inzinsam multang extract solution inserted into corresponding focus of Kansu(BL18) in rats. In this study, SD-Rats(Sprague-Dawley) were divided into 4 groups ; Normal group (None treated group), Control-group(The group not treated after $CCI_4$-intoxication), Treated group; Example I-group(Saline-injected groups after $CCl_4$-intoxication) and Example II-group(Inzinsammultang-injected groups after $CCl_4$-intoxication). Through histological observation, Example II-group sho-ws that liver injury is weaker than Control group.(p<0.05) Biochemical assays for each serum enzyme activities of AST, ALT and LDH, levels of albumin, ${\gamma}$-GT, TG, total cholesterol were performed. The results were summarized as follows 1. AST(Aspartate aminotransferase) activity in serum significantly decreased in the Inzinsammultang-injected groups after $CCl_4$-intoxication. Inzinsammultang-injected groups after $CCl_4$-intoxication showed significantly higher AST activities, compared with the Saline-injected groups after $CCl_4$-intoxication.(p<0.05) 2. ALT(Alanine aminotransferase) activity in serum significantly decreased in the Inzinsammultang-injected groups after $CCl_4$-intoxication. The Inzinsammultang-injected groups after $CCl_4$-intoxication showed significantly higher AST activities, compared with the Saline-injected groups after $CCl_4$-intoxication(p<0.05) 3. Level of Albumin in serum significantly increased in the Inzinsarnmultang-injected groups after $CCl_4$-intoxication. 4. LDH(Lactate dehydrogenase) activities in serum significantly decreased in the Inzinsammultang-injected groups after $CCl_4$-intoxication.(p<0.05) 5. ${\gamma}$-GT(Glutamyl transferase) in serum significantly decreased in the Inzinsammultang-injected groups after $CCl_4$-intoxication(p<0.05) 6. As for the TG(Triglyceride) levels in serum, Inzinsammultang-injected groups after $CCl_4$-intoxication is no significant differences compared with the Saline-injected groups after $CCl_4$-intoxication.(p<0.05) 7. Total cholesterol in serum significantly increased in the Inzinsarnmultang-injected groups after $CCl_4$-intoxication.(p<0.05) Those results indicate that the Inzinsammultang Herbal-acupuncture have significant effects on the liver injury induced by $CCl_4$. So it is expected that the Inzinsammultang Herbal-acupuncture can be used to cure inflammations and recover the functions of damaged liver cells.

제강.연주 공장 설계와 운영을 위한 시뮬레이터

최성훈,Choi, Seong-Hoon 한국시뮬레이션학회 2011 한국시뮬레이션학회 논문지 Vol.20 No.2

치열한 경쟁과 원자재 가격 급등은 시행착오를 최소화 하면서 제철소를 최적으로 설계하여 운영할 것을 한층 더 강력하게 요구하고 있다. 컴퓨터 시뮬레이션은 이 요구에 부합되는 방법론을 제공할 수 있다. 본 논문의 목적은 제강 연주 공장의 설계와 운영을 지원하기 위한 시뮬레이터를 제안하는 것이다. 본 연구에서 제안하는 시뮬레이터는 유지보수와 확장에 용이하도록 널리 알려진 Arena로 개발되었으며 사용의 편의성을 위하여 엑셀 기반으로 입출력 인터페이스를 설계하였다. 또한 운반 대차와 천정 크레인으로 구성되는 복잡한 운반 모듈을 포함하여 모델의 정확도를 높였다. 시뮬레이터는 생산량 분석과 물류 분석을 통하여 제강 연주 공장 설계안의 적정성을 평가하는데 유용하게 사용될 수 있다. 그리고 다양한 상황별로 최적의 제품 조합을 도출하는데 적용될 수 있으며, 공정별 설비별로 작업을 배정하는 조업 운영 패턴을 평가하고 정확도를 향상시키는 도구로써 활용이 가능하다. Stiff competition and skyrocketing prices of raw materials are increasingly demanding the optimal design and operation of iron and steel mills minimizing trial and error. Computer simulation can provide the methodology in accordance with requirements. The purpose of this paper is to suggest a simulator for the design and operation of the steelmaking and continuous casting mill. The simulator was developed using Arena, popular simulation software and input and output interface based on MS Excel. It allows easy access for the maintenance and extension of the model. One of distinct features of the proposed simulator is the inclusion of complex transportation modules composed of transfer cars and overhead cranes. The simulator can be used for evaluating various alternative designs of a projected mill via throughput analysis and material flow analysis. Also, one can utilize it effectively to search for the best product mix suitable for many types of situations. It could be an invaluable tool evaluating the performance of operation patterns and improving the accuracy.

피질하 혈관성치매의 진단, 치료 및 예방 : 1례 보고와 함께

최성훈,구세광,전우현,백경민,한창현,전원경,이영준,Choi, Seong-Hun,Ku, Sae-Kwang,Cheon, Woo-Hyun,Baek, Kyung-Min,Han, Chang-Hyun,Kyung, Jeon-Won,Lee, Young-Joon 대한예방한의학회 2010 대한예방한의학회지 Vol.14 No.3

Vascular dementia(VaD) is currently considered to be the second most common type of dementia. VaD is not a single diagnostic entity, but a heterogeneous syndrome which encompasses several clinicopathological forms of dementia resulting from cerebrovascular diseases. A common form of VaD is subcortical VaD which is characterized by lacunar infarcts and deep white matter changes, leading to a progressive decline in memory and cognitive function. The neuropsychological and cognitive profiles of subcortical VaD have been reported relatively homogeneous. At present, subcortical vascular dementia is regarded as the most important subtype of VaD with getting the attention of vascular dementia. The aims of this study are to discuss the concept of subcortical VaD and its importance focusing on diagnosis, prevention and treatment with a case report.

The Trinitarian Principles of Christian Education: Based on the Reaction of Neo-Orthodox Theology against Postmodern Challenges

최성훈,Choi, Seong-Hun The Korean Society of Christian Religious Educatio 2020 기독교교육논총 Vol.0 No.61

This study analyzes the Trinitarian principles of Christian education through the neo-orthodox theology of Karl Barth, Reinhold Niebuhr, and Paul Tillich in the current era of postmodernism. Both neo-orthodoxy and postmodernism react against the epistemological ideals of modernity. Postmodernism is based on a limited human point of view, and thus becomes a captive to its own subjectivity, producing two main characteristics - pluralism and relativism. Since neo-orthodoxy appeared as a reaction against human-centered modernity, critical analysis of neo-orthodox theology can give insights to cope with the challenges of postmodernism in Christian education today. Thus, this study bases its argument critically on the thoughts of neo-orthodox theologians such as Karl Barth, Reinhold Niebuhr, and Paul Tillich, since they responded to the challenges of enlightenment through rediscovering fundamental theological principles. First of all, this study examined the meaning of God's creation and the fall and provided the principle of theistic relativism. Secondly, this study explored educational insights from Jesus' crucifixion, through His work of redemption, liberation, and restoration and suggests an incarnated relationship building. Thirdly, the study analyzed the caring and comforting work of the Holy Spirit and emphasized the power of the Holy Spirit that heals corrupted human reason and enables loving relationships. 본 연구는 포스트모던 시대의 기독교교육의 삼위일체적 원리를 칼 바르트, 라인홀드 니버, 폴 틸리히의 신정통주의 신학을 통해 조명하였다. 신정통주의와 포스트모더니즘 양자는 모두 모더니즘의 인식론적 인식에 대항하였다. 포스트모더니즘이 인간의 유한한 관점에 기반함으로써 자신의 주관성에 갇혀서 다원주의와 상대주의를 양산한 데 비하여 신정통주의는 인간중심의 모더니즘에 대항하여 일어났기 때문에 오늘날 기독교교육이 기반으로 삼아야 할 원리에 시사하는 바가 크다. 따라서 본 연구는 그 논점을 칼 바르트, 라인홀드 니버, 폴 틸리히 등 기본적인 신학적 원리를 통해 모더니즘에 대항한 신정통주의 신학자들의 의견을 비판적으로 조명하는 데에 두었다. 첫째, 본 연구는 하나님의 창조와 인간의 타락 사건을 유신론적 상대주의의 관점에서 조명하였고, 둘째, 예수 그리스도의 십자가 대속을 구속, 해방, 회복의 관점에서 조명하여 교육의 실천에 있어서 성육화된 관계 형성으로 연계하였으며, 셋째, 성령의 돌봄과 위로 사역을 통해 인간 이성의 한계를 극복(치유)하고 사랑의 관계를 수립하는 가교로서 조명하였다.

온실가스 감축목표에 따른 고속도로 구간 배출량 변화 연구

최성훈,장현호,윤병조,Choi, Seonghun,Chang, Hyunho,Yoon, Byungjo 한국재난정보학회 2020 한국재난정보학회 논문집 Vol.16 No.4

연구목적: 온실가스는 전 세계적인 재난인 지구 온난화의 주요 원인 중 하나이다. 수송부문에서 펼쳐지고 있는 지구온난화의 주요 원인인 온실가스 저감 정책이 고속도로에서 얼마나 효과가 있었는지와 온실가스 배출량 산정 방법의 개선하는 목적을 가진다. 연구방법: DSRC 원시자료를 사용해 거시적 방법(기존)과 미시적 방법(개별차량) 두 가지 방법으로 2017년부터 2019년까지의 남해고속도로(영암-순천) 배출량 산정을 진행한다. 연구결과: 고속도로의 배출량을 산정한 결과 예측하고 있던 배출량을 훨씬 넘어선 결과가 나왔으며 개별차량별로 산정을 진행할 때 20%이상 과소추정되고 있었다는 결과가 나왔다. 결론: 현재 수송부문에서 예상하고 있던 온실가스 배출량보다 더 많은 배출량이 지속적으로 배출될 경우 현 상태에서 온실가스 감축목표를 달성하기 위해서는 추가적인 배출량 저감정책이 필요하다. 또 한 이 정책의 기본이 되는 배출량 산정에서 현재 DSRC 원시자료를 통해 개별차량별로 분석을 진행하였지만 이후 GPS를 활용하면 좀 더 미시적인 분석을 통해 정밀한 배출량 산정이 가능할 것이다. Purpose: Greenhouse gases are one of the major causes of global warming, a global disaster. It aims to improve how effective the GHG reduction policy, which is the main cause of global warming in the transportation sector, has been effective on the highway and how to calculate GHG emissions. Method: Using the DSRC raw data, we estimate the emissions of Namhae Expressway (Yeongam-Suncheon) from 2017 to 2019 in two ways, a macro method (conventional) and a micro method (individual vehicle). Result: As a result of calculating the emission of the highway, the result was far exceeding the estimated emission, and it was found that when the calculation was performed for each vehicle, it was underestimated by more than 20%. Conclusion: If more emissions are continuously emitted than expected in the current transportation sector, additional emission reduction policies are needed to achieve the current greenhouse gas reduction targets. In addition, in the calculation of emissions, which is the basis of this policy, analysis was conducted for each individual vehicle using the current DSRC raw data, but using GPS afterwards will enable precise emission calculation through a more microscopic analysis.

Ar/N₂ 2단계 플라즈마 처리에 따른 저온 Cu-Cu 직접 접합부의 정량적 계면접착에너지 평가 및 분석

최성훈,김가희,서한결,김사라은경,박영배,Choi, Seonghun,Kim, Gahui,Seo, Hankyeol,Kim, Sarah Eunkyung,Park, Young-Bae 한국마이크로전자및패키징학회 2021 마이크로전자 및 패키징학회지 Vol.28 No.2

3 차원 패키징을 위한 저온 Cu-Cu직접 접합부의 계면접착에너지를 향상시키기 위해 Cu박막 표면에 대한 Ar/N₂ 2단계 플라즈마 처리 전, 후 Cu표면 및 접합계면에 대한 화학결합을 X-선 광전자 분광법(X-ray photoelectron spectroscopy)을 통해 정량화한 결과, 2단계 플라즈마 처리로 인해 Cu표면에 Cu₄N이 형성되어 Cu산화를 효과적으로 억제하는 것을 확인하였다. 2단계 플라즈마 처리하지 않은 Cu-Cu시편은 표면 산화막의 영향으로 접합이 제대로 되지 않았으나 2단계 플라즈마 처리한 시편은 효과적인 표면 산화방지효과로 인해 양호한 Cu-Cu접합을 형성하였다. Cu-Cu직접접합 계면의 정량적 계면접착에너지를 double cantilever beam 시험방법 및 4점 굽힘(4-point bending, 4-PB) 시험방법을 통해 비교한 결과, 각각 1.63±0.24, 2.33±0.67 J/m²으로 4-PB 시험의 계면접착에너지가 더 크게 측정되었다. 이는 계면파괴역학의 위상각(phase angle)에 따른 계면접착에너지 증가 거동으로 설명할 수 있는데 즉, 4-PB의 계면균열선단 전단응력성분 증가로 인한 계면거칠기의 효과에 기인한 것으로 판단된다. The effect of Ar/N₂ two-step plasma treatment on the quantitative interfacial adhesion energy of low temperature Cu-Cu bonding interface were systematically investigated. X-ray photoelectron spectroscopy analysis showed that Ar/N₂ 2-step plasma treatment has less copper oxide due to the formation of an effective Cu4N passivation layer. Quantitative measurements of interfacial adhesion energy of Cu-Cu bonding interface with Ar/N₂ 2-step plasma treatment were performed using a double cantilever beam (DCB) and 4-point bending (4-PB) test, where the measured values were 1.63±0.24 J/m² and 2.33±0.67 J/m², respectively. This can be explained by the increased interfacial adhesion energy according phase angle due to the effect of the higher interface roughness of 4-PB test than that of DCB test.

경도인지 장애 평가 및 분석 시스템

최성훈,주문일,양영애,김희철,Choi, Sung-Hoon,Joo, Moon-Il,Yang, Yeong-Ae,Kim, Hee-Cheol 한국정보통신학회 2016 한국정보통신학회논문지 Vol.20 No.11

최근 인구 고령화가 급속히 진행되면서 치매인구가 빠른 속도로 증가하고 있다. 치매는 완벽한 치료법이 없기 때문에 경도인지 장애 평가를 통해 조기 발견하여 예방 훈련하는 것이 중요하다. 기존의 경도인지 장애 평가는 수기형태로 이루어지며, 피검자와 검사자의 1:1 대면 평가가 원칙이다. 이는 검사자의 피로도 증가와 이로 인한 평가오류의 가능성을 증가시킨다. 또한 도출된 데이터도 수기 형태이기에 다양한 방식으로 분석 및 활용하기에는 한계가 있다. 따라서 기존 방식의 제한점을 극복 수 있는 시스템화가 가능한 어플리케이션을 활용하여 평가하고, 그 결과를 저장 및 분석할 수 있는 시스템 개발이 필요하다. 본 논문은 경도인지 장애를 평가할 수 있는 피검자와 검사자용 어플리케이션과 평가 데이터를 저장 및 분석할 수 있는 시스템을 개발하고자 한다. As the aging society is accelerated, the population with dementia grows significantly faster. Because there is no complete cure of dementia, it is of great importance to detect the disease at a very early stage and prevent its fast aggravation through evaluation of MCI(Mild Cognitive Impairment) which happens before dementia. The current assessment of MCI conducts only in the form of hand-written data and by 1:1 face to face communication between the subjects and the examiners. Due to this, both examiners' fatigue rate and evaluation error rate increase. Further, there are some limitations in utilizing and analyzing data collected. Against the problems, therefore, there is a need to develop a computerized system by which MCI is assessed, and the results are saved and analyzed. This paper presents the development of such a system enabling MCI evaluation, its related data collection and analysis.

Halcyon^TM 선형가속기 6MV-FFF 에너지의 표재 선량에 대한 고찰: Phantom Study

최성훈,엄기천,유순미,박제완,송흥권,윤인하,Choi, Seong Hoon,Um, Ki Cheon,Yoo, Soon Mi,Park, Je Wan,Song, Heung Kwon,Yoon, In Ha 대한방사선치료학회 2020 대한방사선치료학회지 Vol.32 No.-

목 적: 본 연구는 HalcyonTM과 TrueBeamTM에서 사용하는 6MV-FFF(Flattening Filter Free) 에너지를 이용하여 전산화치료계획시스템(Treatment Planning System, TPS)에서 계산된 선량과 광자극형광선량계(Optically Stimulated Luminescence Dosimeter, OSLD)로 측정된 표재 선량(Superficial dose)을 비교하고자 한다. 재료 및 방법: 팬텀연구를 위해 인체모형 팬텀(Human Phantom)의 CT 영상을 이용하여 치료계획시스템에서 성문암(Glottic cancer)과 유사한 치료계획용적(Planning Target Volume, PTV)과 두경부위의 등 중심점(Iso-center) 위치에 측정을 위한 Point(M), Point(R), Point(L)의 구조물을 설정하고 체표윤곽(Body contour)에 5mm Bolus를 적용하였다. 그 후 전산화치료계획은 HalcyonTM과 TrueBeamTM의 6MV-FFF 에너지를 이용하여 정적(Static) 세기변조방사선치료(Intensity Modulated Radiation Therapy, IMRT)와 용적변조회전치료(Volumetric Modulated Arc Therapy, VMAT)계획을 각각 수립하였다. 전산화치료계획과 동일하게 재현하기 위해 OSLD를 등 중심점에 위치시키고 5mm Bolus를 적용하여 선량 전달 후 오차율을 비교하였다. 결 과: 인체모형 팬텀을 사용한 실험 결과 HalcyonTM의 전산화치료계획시스템에서의 점 선량과 OSLD를 이용한 선량 측정의 오차율의 절댓값의 평균은 VMAT, IMRT 각각 1.7±1.2%, 4.0±2.8%로 확인되었으며, TrueBeamTM의 오차율의 절댓값의 평균은 VMAT, IMRT 각각 2.4±0.4%, 8.6±1.8%로 확인되었다. 결 론: 실험결과 HalcyonTM을 기준으로 TrueBeamTM에서 VMAT과 IMRT 각각 2.4배, 3.6배 더 큰 오차가 발생하는 것을 확인할 수 있었다. 따라서 본 연구의 결과를 토대로 표재 선량에 대한 정확한 선량평가가 이루어져야 하는 경우, TrueBeamTM보다 HalcyonTM에서 정확한 선량 평가가 이루어질 수 있을 것으로 사료된다. Purpose: The aims of this study were to compare the superficial dose with Optically Stimulated Luminescence Dosimeter(OSLD) measurement and Treatment Planning System(TPS) calculation for 6MV-Flattening Filter Free(FFF) energy using HalcyonTM and TrueBeamTM. Materials and methods: Phantom study was performed using the CT images of human phantom. In the treatment planning system, the Planning Target Volume(PTV) was contoured which is similar to Glottic cancer. Furthermore, Point(M), Point(R), and Point(L) were contoured at the iso-center of head and neck region and 5mm bolus was applied to the body contour. Each treatment plans using 6MV-FFF energy from HalcyonTM and TrueBeamTM with static Intensity Modulated Radiation Therapy(IMRT) and Volumetric Modulated Arc Therapy(VMAT) were established with eclipse. To reproduce the same position as the TPS, OSLDs were placed at the iso-center point and 5mm bolus was applied to compare the error rate after the dose delivery. Result: The results of the study using human phantom are as follows. In case of HalcyonTM, the mean absolute error rates of the point dose using the treatment planning system and the dose measured by OSLD were 1.7%±1.2% for VMAT and 4.0±2.8% for IMRT. Also TrueBeamTM was identified as 2.4±0.4% and 8.6±1.8% respectively for VMAT and IMRT. Conclusion: Through the results of this study, TrueBeamTM confirmed that the average error rate was 2.4 times higher for VMAT and 3.6 times higher for IMRT than HalcyonTM. Therefore, based on the results of this study, If we need a more accurate dose assessment for the superficial dose, It is expected that using HalcyonTM would be better than TrueBeamTM.

구안와사(口眼渦斜) 환자(患者)의 Matrix Metalloprotease-l (MMP-l)의 유전자(遺傳子) 다형성(多形性)에 대한 연구(硏究)

최성훈,이경민,이봉효,임성철,정태영,서정철,Choi, Sung-Hun,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한침구의학회 2007 Korean Journal of Acupuncture Vol.24 No.2

Objectives : This study was designed to investigate the relation between the matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. Methods : This study was carried out on 102 facial nerve palsy patients who were treated with oriental medicine therapy at the department of acupuncture & moxibustion, hospital of Oriental medical college, Daegu Hanny University and 104 healthy control subjects. Blood samples from all subjects were obtained for DNA extraction. We have investigated the genotyping of matrix metalloprotease-1 by using Pyrosequencing. Results : The genotypes of matrix metalloprotease-l gene were G/G homozygotes, A/G heterozygotes and A/A homozygotes. There was no significant difference between the control and facial nerve palsy groups. Conclusion: We concluded that there was no significant association between matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. However, the findings of this study need to be confirmed in more patients and further studies.

구안와사(口眼渦斜) 환자(患者)의 Matrix Metalloprotease-l (MMP-l)의 유전자(遺傳子) 다형성(多形性)에 대한 연구(硏究)

최성훈,이경민,이봉효,임성철,정태영,서정철,Choi, Sung-Hun,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한침구의학회 2007 대한침구의학회지 Vol.24 No.2

Objectives : This study was designed to investigate the relation between the matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. Methods : This study was carried out on 102 facial nerve palsy patients who were treated with oriental medicine therapy at the department of acupuncture & moxibustion, hospital of Oriental medical college, Daegu Hanny University and 104 healthy control subjects. Blood samples from all subjects were obtained for DNA extraction. We have investigated the genotyping of matrix metalloprotease-1 by using Pyrosequencing. Results : The genotypes of matrix metalloprotease-l gene were G/G homozygotes, A/G heterozygotes and A/A homozygotes. There was no significant difference between the control and facial nerve palsy groups. Conclusion: We concluded that there was no significant association between matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. However, the findings of this study need to be confirmed in more patients and further studies.