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토끼에 대한 Sangmosu의 국소독성 (일차 피부자극) 시험
최설민,김대영,박요안,김주영,김형식,안미영,곽승준,최이선,이병무 대한약학회 1999 약학회지 Vol.43 No.4
Primary skin irritation tests for Sangmosu were performed in male New Zealand White rabbits. In primary skin irritation test, body weights were not significantly changed and Primary Irritation Index(P.I.I) was 0.25, indicating Sangmosu as barely irritating material. These results indicate that Sangmosu was not considered to be irritant in test animals.
최설민(Seul Min Choi),김대영(Dae Young Kim),박요안(Yo An Park),이미경(Mi Kyung Lee),송현수(Hyun Sue Song),권오성(Oh Sung Kwun),임승용(Seung Yong Lim),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김주영(Ju Young Kim),김형식(Hyung Sik Kim 대한약학회 1999 약학회지 Vol.43 No.3
Hair growth effects of Sangmosu have been evaluated in C57BL/6 mice. Animals were topically treated with Sangmosu (50 or 100mcl/mouse) for 40 days on the back of shaved area. Twenty days after treatment, hair growth effects were significantly observed in both female and male mice. There was no sex difference although 30 days after treatment female mice were shown to be more effective at the dose of 50mcl/mouse than males. These data demonstrate that Sangmosu is very effective in hair growth effects in animals and thus it may be applicable to humans.
김대영(Dae Young Kim),최설민(Sul Min Choi),천선아(Sun Ah Chun),박현선(Hyun Sun Park),우동준(Mi Kyung Lee),이미경(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 한국독성학회 1999 Toxicological Research Vol.15 No.3
Acute subcutaneous toxicity of Sangmosu was investigated in Sprague-Dawley rats. Seven days after administration of Sangmosu (0.078~20 ml/kg), we examined the clinical signs, mortalities, body weight changes, etc. No clinical signs and mortalities were observed in animals. Any significant change of body weights was not observed. These results suggest that LD50 value of Sangmosu was above 20 ml/kg in Sprague-Dawley rats.
이병무(Byung Mu Lee),최설민(Seul Min Choi),조현(Hyun Cho),안병옥(Byoung Ok Ahn),김원배(Won Bae Kim) 한국독성학회 2001 Toxicological Research Vol.17 No.2
The anti-emetic effect of a 5-HT₃receptor antagonist, Ondaron, was compared with that of the approved ondansetron agent, Zofran® in the ferrets. Emesis was induced by single intraperitoneal injection of cisplatin 10 mg/kg, and Ondaron or Zofran® was injected intraperitoneally in a dose of 1.0 mg/ kg, respectively. Ondaron and Zofran® effectively antagonised the emetic response for 4 hours after injection. They significantly reduced the number of vomiting and retching, and prolonged the latency to the first episode. The anti-emetic effect of Ondaron was almost the equal to that of Zofran®. These results suggest that Ondaron is an effective anti-emetic agent against cisplatin-induced emesis, and its anti-emetic potency is similar to that of 5-HT₃receptor abtagonist, ZoJran®.
천선아(Sun Ah Chun),최설민(Sul Min Choi),김대영(Dae Young Kim),박현선(Hyun Sun Park),이미경(Mi Kyung Lee),우동준(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 한국독성학회 1999 Toxicological Research Vol.15 No.3
Eye irritation of Sangmosu was evaluated in New Zealand White rabbits. In ocular irritation test, any injury on iris, conjunctival membrane, and cornea was not observed. No injuries of the ocular mucous membrane were also recorded. These results indicate that Sangmosu was not considered to be irritant in test organs of animals.
박현선(Hyun Sun Park),천선아(Sun Ah Chun),최설민(Sul Min Choi),김대영(Dae Young Kim),이미경(Mi Kyung Lee),우동준(Dong Jun Woo),배혜진(Hye Jin Pae),신동훈(Dong Hun Shin),김형식(Hyung Sik Kim),안미영(Mi Young Ahn),곽승준(Seung Jun Kwac 대한약학회 1999 약학회지 Vol.43 No.3
Subacute toxicity study was performed in Sprague-Dawley rats after daily dermal administration of Sangmosu (0.2, 1.0 and 5.0g/kg) for one month. There were no clinical signs and pathological changes compared with control group. Body weights were not significantly changed between control and Sangimosu treatment groups. In histopathological examinations, there were some pneumonia in lung tissues at all groups of Sangmosu treatment including control, but it was not considered to be caused by Sangmosu. These results suggest that Sangmosu does not induce any significant subacute dermal toxicities in Sprague-Dawley rats.
이기명(Ki Myung Lee),함기백(Ki Baik Hahm),조성원(Sung Won Cho),오태영(Tae Young Oh),최설민(Seul Min Choi),김정훈(Jung Hoon Kim),안병욱(Byoung Ok Ahn),권종원(Jong Won Kwon),김원배(Won Bae Kim) 한국응용약물학회 2002 Biomolecules & Therapeutics(구 응용약물학회지) Vol.10 No.1
N/A Silymarin and curcumin have been used for supportive treatment of liver disease of different etiology due to their hepatoprotective activities. The present study was carried out to investigate the hepatoprotective effects of silymarin and/or curcuma extract against hepatotoxins induced liver injury. To investigate hepatoprotective effects, the silymarin and/or curcuma extract were pre-treated orally to experimental animals. And thereafter a single dose of hepatotoxin, carbon tetrachloride (CCl_4) and acetaminophen were administered through oral or intraperitoneal route, respectively. Chronic liver damage was induced by subcutaneous injection of CCl_4 for 3 weeks (2 times/week). Hepatoprotective and therapeutic effects were monitored by estimating serum ALT and AST levels and by measuring hepatic glutathione (GSH) and malondialdehyde (MDA) levels. Collagen type 1 was detected with immunostaining to assess fibrosis. The results showed that the mixture of silymarin and curcuma extract significantly reduced serum biochemistry levels and MDA levels compared with those of control group in both acute and chronic animal models. In antifibrotic effect, the relative hepatic collagen content was significantly decreased by silymarin and/or curcuma extract treatment. It was concluded that the complex of silymarin and curcuma extract have a both hepatoprotective and therapeutic effect synergically in rat liver injury induced by heptotoxins.