장거리 달리기가 소화관 호르몬에 미치는 영향

최석준 ( Suck Jun Choi ),채정룡 ( Jeong Ryong Chae ),문용식 ( Yong Shig Moon ),최태석 ( Tae Suck Choi ),심미령 ( Mi Ryeong Sim ),최석채 ( Suck Chei Choi ) 한국운동영양학회 2004 Physical Activity and Nutrition (Phys Act Nutr) Vol.8 No.2

The purpose of this study was to determine the effect of long distance running on the level of gastrointestinal hormones such as gastrin which stimulates the secretion of gastric acid, insulin and glucagon which affect glucose metabolism as well as the level of glucose. Method: Twenty four long distance runners (male 16, female 8) participated in this study. Studies were performed after an overnight fasting. The levels of gastrin, insulin, glucagon, and glucose in blood were measured at 30min before and after exercise, and then they were measured again at 24 hr after 10 km race. Result: Plasma gastrin level was increased immediately after exercise (p<0.05), while no significant changes were observed before and after 24 hours of exercise. Plasma insulin level was decreased immediately after exercise (p<0.05). Plasma glucagon level was elevated immediately after exercise (p<0.05). However, there was no significant difference in the level of plasma glucose level during the study period. Conclusion: These results indicate that the elevated level of gastrin in long distance runner may be involved in acid-related gastrointestinal disease. The changes of insulin and glucagon levels may represent the constant blood glucose level and further imply the fine regulatory mechanism of glucose homeostasis in blood during short time exercise in long distance runners.

복합훈련이 안지오텐신 전환효소 유전자의 다형성에 따라 체력에 미치는 관련성

최석준 ( Suck Jun Choi ) 한국스포츠정책과학원(구 한국스포츠개발원) 2002 체육과학연구 Vol.13 No.1

본 연구의 목적은 한국인의 성별 ACE 유전자형의 빈도와 복합훈련에 의한 체력향상이 ACE 유전자형에 따라서 어떠한 차이가 있는지를 규명하는데 있다. 이를 위하여 남학생 500명, 여학생 500명 총 1,000명의 중학생을 대상으로 ACE 유전자형의 빈도를 분석한 후, 이들 중 Ⅱ형 20명, ID형 20명, DD형 20명 총 60명의 자발적인 지원자를 대상으로 복합운동을 주 5회(월, 화, 목, 금, 토)의 빈도로 1일 40~50분씩 12주간 실시하여 체력요소의 변화를 측정 분석한 결과 다음과 같은 결론을 얻었다. 한국인의 성별 ACE 유전자형은 남자의 경우는 ID형 47.8%, Ⅱ형 37.0%, DD형 15.2%의 순이고, 여자의 경우는 ID형 51.6%, Ⅱ형 34.0%, DD형 14.4%의 순으로 나타났다. 그리고 체력의 요소 중 근 지구력은 모든 ACE 유전자형 집단에서 훈련 6주 후부터 증가되는 경향을 보였으나 Ⅱ형, ID형에서만 유의한 차이를 보였고(p<0.05), DD형 집단이 Ⅱ형, ID형 집단에 비해 유의하게 낮은 수치를 보였다(p<0.05, p<0.01). 평형성은 모든 ACE 유전자형 집단에서 훈련 6주 후부터 증가되는 경향을 보이고 있으나 Ⅱ형에서 만 유의한 차이를 나타냈다(p<0.05). 근력, 유연성, 민첩성, 순발력은 모든 ACE 유전자형 집단에서 훈련 6주 후부터 증가되는 경향을 보였으나 유의한 변화는 없었다. 이러한 결과들은 Ⅰ대립 인자가 근지구력에 영향을 미치고 있다는 것을 알 수가 있어 선수 선발 시 Ⅰ대립인자를 가지고 있는 자를 선발하는 것이 경기력 향상에 도움이 될 수 있을 것이다. The aim of this study was to investigate the distribution of ACE genotype in Korean population and to evaluate the association on angiotensin-converting enzyme gene polymorphism with change in physical fitness in response to combined training. One thousand middle students (500 male and 500 female) were selected as the experimental objects for ACE genotype in Korean. The experimental subjects, 60 female middle students volunteered (II type; 20, ID type; 20, DD type; 20) in this study. Subjects participated in 12 weeks of combined both aerobic and resistance training to five times per week for 40~50minites. The ACE polymorphism was genotyped by PCR amplication of the 64, 86 and 490bp alleles. The results of this study were as following; The first, the frequencies of male and female of ACE genotype were ID(47.8%, 51.6%), II(37.0%, 34.0%) and DD(l5.0%, 14.4%) respectively. The second, muscle endurance showed a case of increasing after 6 weeks at all ACE genotype, but there was significantly difference at 12 weeks in II and ID genotype. Also, DD genotype was lower significantly than both II and ID genotype at all the blood sampling time(exercise time). The third, balance was showed a case of increasing after 6 weeks at all ACE genotype, but there was significantly difference at both 6 weeks and 12 weeks in II genotype. The fourth, muscle strength, agility, flexibility and power were increased after 6 weeks at all ACE genotype, but there was no significant difference. These data suggest that ACE genotype associations with physical performance in highly selected situations.

식후 달리기운동이 식도운동과 위산역류에 미치는 영향

최석준(Suck Jun Choi),김동희(Dong Hee Kim),최석채(Suck Chei Choi),김태현(Tae Hyeon Kim),나용호(Yong Ho Nah) 한국사회체육학회 1998 한국사회체육학회지 Vol.10 No.-

4주간 달리기 운동이 흰쥐의 전경골근에서 ERK 및 JNK의 활성화에 미치는 영향

최석준(Suck Jun Choi),신병철(Byung-Cheul Shin),박한수(Han Su Park),김모경(Mo Kyung Kim),신철호(Chul Ho Shin),김민선(Min Sun Kim) 한의병리학회 2007 동의생리병리학회지 Vol.21 No.1

녹차(-)-Epigallocatechin-3-gallate 섭취가 고강도 운동시 흰쥐의 대장에서 HO-1발현에 미치는 영향

최석준 ( Suck Jun Choi ),이경완 ( Gyoung Wan Lee ) 대한스포츠의학회 2010 대한스포츠의학회지 Vol.28 No.1

The purpose of this study was to investigate effects of combined treatment with high intensity exercise and (-) epigallocatechin-3 gallate (EGCG), a potent free radical scavenger on a transcriptional level of hemoxygenase-1 gene in the large intestine. Sprague-Dawley rats were randomly divided into control group (CON, n=7), high intensity exercise group (HIE, n=7), EGCG group (EGCG, n=7), and EGCG plus high intensity exercise group (HIE+EGCG, n=7). Animals were given an intraperitoneal injection of EGCG with 50 mg of dosage per kg for four weeks 30 minutes before exercise. In order to induce HIE animals were allowed to ran on a treadmill with 0 degree of slope at speed of 28 m/min for 30 minutes. The exercise was performed four times a week for four week. The results of this study were as following; The expression level of hemoxygenase-1 mRNA of the high intensity exercise group was 15.21 times higher than that of the control group. The EGCG plus high intensity exercise group showed 5.98 times increased expression level of hemoxygenase-1 mRNA than control group. These results suggest that treatment of EGCG decrease the expression level of HO-1 mRNA through the removal of oxygen radicals produced by a high intensity exercise.

운동이 흰쥐의 대장에서 종양억제 유전자 발현

최석준 ( Suck Jun Choi ) 대한스포츠의학회 2009 대한스포츠의학회지 Vol.27 No.1

The purpose of this study was to investigate a member of tumor suppressing genes in intestine according to different intensity of treadmill exercise with Sprague Dawley Rats. Assigned groups of the rats were as followings: control group (no exercise), low-intensity exercise group (8 m/min of treadmill) and high-intensity exercise group (28 m/min of treadmill). The exercise groups ran for 30 min/day in a frequency of 4 days/week for 4 weeks on treadmill. As results, there were 7 genes were constructed. Only Rhos (rashemoglog gene family memberh) showed decreased in the low-intensity exercise group and increased in the high-intensity exercise group. It was decreased 10 times in the low intensity exercise group and increased 3.1 times in the high intensity exercise group. Additionally there were 5 genes which were decreased in both low intensity and high intensity exercise groups. Namely, Vldlr (very low density lipoprotein receptor) was decreased 1.2 times and 11.3 times in the low intensity exercise group and high intensity exercise groups respectively. Tiam 2 (T-cell lymphoma invasion and metastasis 2) was decreased 8.8 times in the low intensity exercise group and 19.1 times at high intensity exercise group. Lcn 2 (lipocalin 2) was increased in both low-intensity exercise and high intensity exercise groups. It showed 17.09 times and 99.67 times increase in the low-intensity exercise group and high intensity exercise group. Dmbt 1 (deleted in malignant brain tumors) showed 9.1 times increase in the low-intensity exercise group and 10.5 times in the high intensity exercise group.

운동이 흰쥐의 대장과 비장에서 IL-10 mRNA 발현에 미치는 영향

최석준 ( Suck Jun Choi ) 대한스포츠의학회 2007 대한스포츠의학회지 Vol.25 No.2

흰쥐의 급성 발목삠에서 테이핑요법이 cFos 단백의 발현과 통증억제에 미치는 영향

최석준 ( Suck-jun Choi ),변신규 ( Sin-kyu Byun ),이경완 ( Gyoung-wan Lee ),김재효 ( Jae-hyo Kim ),양승범 ( Seung-bum Yang ) 대한경락경혈학회 2017 Korean Journal of Acupuncture Vol.34 No.1

The purpose of this study was to evaluate effects of taping therapy on recovery of behavioral symptoms and neural excitability of the lumbar spinal cord in rat model for ankle sprain. Methods : Adult Sprague-Dawley rats was used and divided into 3 experimental groups: normal group(n=6), ankle sprain(n=6), and ankle sprain with taping treatment(n=6). In order to induce ankle sprain the right ankle joint was injured with 4∼5 repetitive over-flexions and over-extensions manually. The severity of joint pain was evaluated by measuring foot weight bearing force ratio(FWBRF) of the hind limb and the injury-induced edema formation by diameter of the joint following ankle sprain. The changes of neural excitability in the lumbar spinal cord was tested by observation of cFos protein expression, a metabolic marker for neural excitation. Results : Severity of ankle injury induced in this experiment coincided with Grade 1 ankle sprain. Compared with ankle sprain group, ankle sprain+taping showed a significant reductions of joint pain as well as of edema formation at the ankle joint following ankle sprain. There was significant upregulation of cFos-immunoreactive neurons in the lumbar spinal cord 24 hours after ankle sprain. In contrast, taping therapy resulted in significant inhibition of cFos-immunoreactive neurons in the lumbar spinal cord. Conclusions : Collectively, these results suggest that taping therapy may be an alternative therapeutic intervention for symptom recovery of the mild ankle sprain.

장거리 달리기 선수의 빈혈과 헬리코박터 파이로리의 관련성에 관한 연구

최석준 ( Suck Jun Choi ),신철호 ( Chul Ho Shin ),김선호 ( Sun Ho Kim ),김태현 ( Tae Hyeon Kim ),박무림 ( Moo Rim Park ),나용호 ( Yong Ho Nah ),최석채 ( Suck Chei Choi ) 한국스포츠정책과학원(구 한국스포츠개발원) 2003 체육과학연구 Vol.14 No.2

본 연구의 목적은 고등부 남자 장거리 달리기 선수들을 대상으로 10㎞ 달리기 전ㆍ후 빈혈관련 혈액학적 변인(혈색소, 헤마토크리트, 혈청 철, 페르틴, 혈청 철 결합력, 적혈구)들과 헬리코박터 파이로리와(이하 HP)의 연관성을 규명하는데 있다. 이를 위하여 1일 20㎞ 이상의 거리를 주 5회 이상 달리는 고등학교 남자 장거리 선수 16명(나이; 18.2±1.5세, 신장 ; 170.38±5.21Cm, 체중 ; 55.13±6.67㎏, 경력 ; 4.31±0.89년)을 대상으로 10㎞를 완주했던 기록에 준하는 속도로 400m 트랙을 25바퀴(10㎞) 달리도록 하였으며, 이 때의 평균속도는 5.35m/sec-5.65m/sec, 평균시간은 28-31분 소요되었다. 10㎞ 달리기 전·후 빈혈관련 혈액학적 변인들의 변화를 측정 분석한 결과 다음과 같은 결론을 얻었다. HP 감염 여부와 관계없이 혈색소, 헤마토크리트, 적혈구는 운동 전·후에 변화를 보이지 않았지만 혈청 철과 페리틴은 달리기 후에 감소를, 혈청 철 결합력은 증가를 보였으며, 적혈구 형태 변화도 운동 후에 나타났다. 그리고, HP 감염 집단에서 빈혈은 없었지만 HP 비감염 집단에 비해 달리기 전에 페리틴과 철 결합력이 낮게 나타나 장거리 달리기 운동이 빈혈 발생을 유발될 가능성이 높거나, HP 균의 감염이 밀접한 연관성이 있음을 알 수 있었다. 따라서 경기력 향상의 저하 및 빈혈의 증상이 발생되면 원인 인자에 따른 치료가 필요하고, 철분 부족에 의한 빈혈 시에는 철분제 투여를 고려 해 볼 수 있다. 그러나 이러한 치료에도 증상의 호전이 없을 경우에는 HP와 관련성 여부를 확인하고 이에 대한 조치도 고려되어져야 할 것이다. Several reports have demonstrated that Helicobacter pylori(HP) gastric infection has emerged as a new cause of refractory iron deficiency anemia which is unresponsive to iron therapy and not attributed to usual causes such as intestinal losses, poor intake, malabsorption or diversion of iron in the reticulo-endothelial system. The objective was to investigate the role of Helicobacter pylori infection in anemia of long distance runners. Methods : Sixteen male long distance runners(age; 18.2±1.5 years) participated in this study. They trained 200 km running for a week and they participated three running competitions every 3 months for a year. All participants completed a rapid urease test(CLO) for HP detection and anemia study(Hemoglobin; Hb, hematocrit; Hct, serum iron, ferritin, total iron binding capacity; TIBC) with peripheral blood smear before 30 minute and after running. Results : There were significant changes in the following hematological parameters : iron(decreased, p<.05), ferritin(decreased, p<.05), TIBC(increased, p<.01) after race. Eight out of the 16 participants had change of red blood cell morphology after running. The level of ferritin(p<.0l) and TIBC(p<.01) were significantly decreased in the runners of HP exhibited group after race. Conclusions: Our results suggest that HP may have a role in causing anemia in long distance runners. Screening for HP should be extended to cover the patients had refractory anemia.

마이크로어레이 분석을 통한 운동이 대장의 면역체계 유전자 발현 변화

최석준 ( Suck Jun Choi ) 한국운동영양학회 2008 Physical Activity and Nutrition (Phys Act Nutr) Vol.12 No.2