최민지, 유석화

최민지 충북연구원 2009 앞,뒤 바라보다 Vol.- No.3

Mechanoluminescent Particles for Ultrasound-Triggered Bioimaging Applications

최민지,김성종,한세광 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2

Molecular imaging has suffered from limited applications due to the short light penetration depth. Here, we developed mechanoluminescent (ML) particles that can non-invasively emit light in the deep tissue upon non-destructive ultrasound (US) stimulation. ML particles were synthesized through solid state reaction of ZnS:Ag, Co. In the photoluminescence spectra, two emission peaks were detected at 450 nm and 540 nm. ML particles, recharged with UV light, could emit concentrated light with US stimulation. Taken together, it has been demonstrated that synthesized ML particles could effectively trap light and emit intense light in response to US for molecular imaging applications.

위협인자 및 공격 패턴 기반 HWP 문서형 악성코드 탐지 시그니처 생성

최민지,정동재,조호묵,원유재 한국정보과학회 2023 정보과학회논문지 Vol.50 No.6

최근 코로나19로 재택근무가 증가함에 따라 업무에서 주로 사용되는 전자 문서에 악성코드를 삽입한 문서형 악성코드 공격이 활발하게 발생되고 있다. 문서형 악성코드는 메신저, 이메일, 웹사이트와 같은 다양한 경로에서 유입되고 있으며, 문서형 악성코드는 문서 내에 악성코드를 인코딩하거나 난독화하여 숨기기 때문에 기존의 행위 기반 보안 솔루션 및 내부 메일 모니터링 서버를 쉽게 우회할 수 있다. 따라서 본 논문에서는 HWP 문서의 포맷 구조 분석을 통해 총 5가지의 위협인자를 분류하였고 위협인자의 공격코드 패턴 분석을 통해 악성 HWP 문서를 탐지할 수 있는 시그니처를 생성하였다. 이를 통해 최신 악성 HWP 문서를 효과적으로 탐지할 수 있는 시그니처 생성 방안을 제안하며 향후에는 시그니처 생성 및 탐지에 기계학습을 적용하여 연구를 확장할 계획이다.

노인의 스마트폰 사용과 사회활동 참여가 인지기능에 미치는 영향에 대한 연구

최민지,손범수,조창익,이종석,정득 한국산학기술학회 2022 한국산학기술학회논문지 Vol.23 No.8

본 연구는 노인의 스마트폰 사용과 사회활동 참여가 인지기능에 미치는 영향을 실증적으로 분석하기 위해 한국보건사회연구원에서 수행한 「2020년 노인실태조사」 자료를 활용하였다. 65세 이상의 노인 8,247명을 대상으로 분석한 결과, 스마트폰 사용을 포함한 사회활동에 참여하는 노인이 참여하지 않는 노인보다 인지기능이 높게 나타났다. 또한, 스마트폰 사용 노인 4,224명(51.2%)과 미사용 노인 4,023명(48.8%)에 대해 치매와 관련된 지남력, 기억력 등 인지기능의 8가지 영역을 분석한 결과, 스마트폰 사용 노인이 모든 영역에서 인지기능이 유의하게 높았으며, 스마트폰을 사용하는 노인 가운데에서도 스마트폰의 다양한 기능을 활용하는 노인이 높은 인지기능을 보였다. 노인의 인지기능에 영향을 미치는 요인을 다중회귀분석으로 분석한 결과, 스마트폰 사용이 다른 사회활동 참여보다 약 2배 이상 높게 노인의 인지기능에 영향을 미쳤다. 특히 스마트폰 사용 노인의 인지기능에 긍정적인 영향을 미치는 사회활동은 동호회, 자원봉사, 노인복지회관, 여가・문화활동, 컴퓨터 활동이었다. 이와 같은 결과는 노인의 스마트폰 사용이 사회활동을 더욱 활발하게 하고 이를 통해 인지기능에 긍정적인 영향을 미치므로, 사회복지 정책적 차원에서 스마트폰 활용에 대한 다양한 프로그램을 마련하여 더욱 건강한 노년의 삶을 영위하도록 지원해야 함을 시사한다.

The Development of “Welfare Medical Service Network Model” for Community Care - Focusing on a Customized Integrated Care Model for Patriots and Veterans Welfare Services

최민지 한국보훈학회 2019 한국보훈논총 Vol.18 No.4

This study aims to develop a customized integrated care model for patriots and veterans welfare services following the legislation review of the fundamental laws of local community integrated care implemented as Korean style community care policies. Therefore, the study analyzed current patriots and veterans welfare delivery systems and sought out the creation of local community safety nets and patriots and veterans welfare governance tasks that can support the integrated services of patriots and veterans welfare and medical domains for patriots and veterans who need the care of their local communities for the rest of their lives. A customized integrated care model of patriots and veterans welfare services was drawn as a “welfare medical service network model” and in addition to local community welfare services, networks, voluntary services, and citizen participation plans of public medical care and patriots and veterans welfare related organizations that need connections were searched for. Therefore, as patriots and veterans welfare governance tasks for the settlement of a "welfare medical service network model", proposals were made for the integrated management of local community integrated care service delivery systems such as patriots and veterans welfare and welfare medical sector networks, patriots and veterans welfare related organization care culture, and sanctioned patriots and veterans welfare service expansions.

우리나라 노인의 가구형태와 주관적 건강상태의 관련성: 2017년 노인실태조사 자료를 이용하여

최민지,주혜진,김태현,백상숙,정우진 한국보건행정학회 2022 보건행정학회지 Vol.32 No.2

Background: In Korea, the population is rapidly aging, and the types of households for the elderly are also diversifying. The self-ratedhealth of the elderly is a valuable health indicator that can comprehensively represent the overall quality of life along with physical,mental, and functional health. On the other hand, studies on the association between household type and self-rated health of theelderly are still insufficient. Thus, this study analyzed the association between household type and self-rated health by gender inKorean older adults. Methods: Using data from the analysis of the National Survey of Older Koreans 2017, 10,299 elderly people aged 65 and over weretargeted. For the accuracy of the analysis data, 9,910 people were selected as the study sample by excluding proxy responses, thosediagnosed with dementia, and non-response. And technical analysis, univariate analysis using the Rao-Scott chi-square test, andlogical regression analysis involving survey characteristics were conducted by gender. Results: According to the adjusted model with all variables, in both men and women, the odds ratio of self-rated health ‘bad’ in‘couple (with ill spouse)’ was significantly higher than ‘couple (with spouse)’. It was 2.54 (95% confidence interval [CI], 2.05–3.15) formen and 2.11 (95% CI, 1.70–2.62) for women. In addition, the odds ratio of self-rated health ‘bad’ in ‘living with adult children’ was1.43 (95% CI, 1.09–1.87) for men and 1.42 (95% CI, 1.15–1.75) for women, which was more significant in women than men. Conclusion: This study states that there is an association between gender, household type, and self-rated health of the elderly, andthe health of a spouse and cohabitation with children have a significant effect on self-rated health. As a result, in order to improvethe health status of the elderly, health promotion and health care policies involving the characteristics of the elderly’s gender andhousehold type are needed.

두레 공동체문화의 현재성과 대안 가치 입론

최민지 실천민속학회 2022 실천민속학연구 Vol.39 No.-

두레는 농작업을 위한 노동공동체이자, 연희문화의 연행주체이기도 했으며, 공동체의 위기 국면에서 정치적 결사체가 되기도 했다. 이는 이전에는 없던 새로움이었으며, ‘두레’라는 사건공동체의 문화적 특이성이다. 사건적인 관점 속에서 두레는 격절되는 것으로, 즉 새로운 국면과 조응하며 달리 존재하는 것으로 사유될 수 있다. 두레를 고정된 형태로 인식하지 않고 전승 환경에 따라 다른 모습과 형태로 변환되고 있는 실천으로 본다면, 그 현재성에 주목할 수 있다. 이 연구를 통해 말하고자 하는 두레는 원형이나 변질․소멸된 형태에 대한 서술보다는, 사건공동체로서 그 현재성을 어떻게 논의할 수 있을까 하는 관심에 있다. 이러한 관심 아래, 본 글에서는 입론의 차원에서 가능할 두레 연구의 실천 지형을 나타내고, 잠정적인 사례를 통해 논의의 구체성을 확보하고자 했다. 관광두레사업, 통두레 운동, 촛불행동이라는 세 가지 사례를 대상으로 하여 두레의 현재성과 대안 가치에 대한 논의를 수행했다. 이 사례 검토는 두레의 현재성과 대안 가치를 특정하려는 것이 아니다. 사실상 소멸된 것으로 여겨질 수밖에 없는 두레를, 그것이 가졌던 민속문화의 공동체성이 특정한 계기에 발현되는 양상을 두레의 지속으로 읽고자 하는 하나의 시도이다.

『즉석커피 품질시험』 결과

최민지 한국소비자원 2022 시험결과보고서 Vol.- No.-

Loss of ADAMTS15 Promotes Browning in 3T3-L1 White Adipocytes via Activation of β3-adrenergic Receptor

최민지,술라그나 무케르지,윤종원 한국생물공학회 2021 Biotechnology and Bioprocess Engineering Vol.26 No.2

ADAMTSs belong to the superfamily of secreted metalloendopeptidases, some of which are reported to be closely associated with obesity. However, the role of ADAMTS15 is not well characterized in adipocytes. This study investigates the effect of Adamts15 deficiency on lipid metabolism in 3T3-L1 and HIB1B adipocytes, with a focus on the role of browning of white adipocytes. Quantitative real-time PCR, immunoblot analysis, immunofluorescence, and staining methods were applied to evaluate the effects of ADAMTS15 on other target proteins and genes involved in lipid metabolism, after silencing Adamts15 by applying the siRNA technique. Our results demonstrate that ADAMTS15 is expressed in both white and brown adipocytes, and the deficiency of Adamts15 promotes browning of white adipocytes by enhancing the expression of brown adipocyte-specific genes and proteins. In addition, silencing of Adamts15 activates brown adipocytes and also upregulates lipid metabolic activity in both white and brown adipocytes, by increasing mitochondrial biogenesis as well as the levels of lipolytic and fat oxidative marker proteins, and reducing adipogenic factors. Moreover, mechanistic studies revealed that depletion of Adamts15 induces browning via activation of the β3AR-PKA-CREB signaling pathway. Taken together, our data unveiled a previously unknown mechanism of ADAMTS15 in the regulation of lipids, and the significance of this protein as a pharmacotherapeutic target to treat obesity-related metabolic disorders.

A Method to Isolate Pericytes From the Mouse Urinary Bladder for the Study of Diabetic Bladder Dysfunction

최민지,Nguyen Nhat Minh,옥지연,서준규,Guo Nan Yin,류지간 대한배뇨장애요실금학회 2020 International Neurourology Journal Vol.24 No.4

Purpose: Pericytes surround the endothelial cells in microvessels and play a distinct role in controlling vascular permeability and maturation. The loss of pericyte function is known to be associated with diabetic retinopathy and erectile dysfunction. This study aimed to establish a technique for the isolation of pericytes from the mouse urinary bladder and an in vitro model that mimics in vivo diabetic bladder dysfunction. Methods: To avoid contamination with epithelial cells, the urothelial layer was meticulously removed from the underlying submucosa and detrusor muscle layer. The tissues were cut into multiple pieces, and the fragmented tissues were settled by gravity into collagen I-coated culture plates. The cells were cultured under normal-glucose (5 mmol/L) or high-glucose (30 mmol/L) conditions, and tube formation, cell proliferation, and TUNEL assays were performed. We also performed hydroethidine staining to measure superoxide anion production. Results: We successfully isolated high-purity pericytes from the mouse urinary bladder. The cells were positively stained for platelet-derived growth factor receptor-β and NG2 and negatively stained for smooth muscle cell markers (desmin and myosin) and an endothelial cell marker (CD31). The number of tubes formed and the number of proliferating cells were significantly lower when the pericytes were exposed to high-glucose conditions compared with normal-glucose conditions. In addition, there were significant increases in superoxide anion production and the number of apoptotic cells when the pericytes were cultured under high-glucose conditions. Conclusions: To the best of our knowledge, this is the first study to isolate and culture pericytes from the mouse urinary bladder. Our model would be a useful tool for screening the efficacy of therapeutic candidates targeting pericyte function in diabetic bladder dysfunction and exploring the functional role of specific targets at the cellular level.