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정용규,초재관,초영진 한국인터넷방송통신학회 2011 한국인터넷방송통신학회 논문지 Vol.11 No.4
근래에 들어 여러 교육방법에 많은 변화가 왔다. 그럼에도 불구하고 자유로운 의학 및 전문 지식을 얻을 수 있는 교육환경을 조성하는데 어려움이 따르고 있다. 본 논문에서는 의학교육의 자유로운 학습을 위한 시스템으로 매쉬업 서비스를 통한 의학교육 메타 검색 시스템을 제안한다. 이 시스템은 사용허가를 받은 검색 API와 콘텐츠 API, 데이터 API를 통하여 검색 시스템과 동영상 콘텐츠 시스템을 설계하고, 이를 바탕으로 의학교육 메타 검색 시스템을 구현한다. In recent years, several technologies have brought many changes in the field of education. Nonetheless, it is difficult to get freely medical and professional knowledge in the educational environment . In this paper, we study a free medical education system for medical education through service to the Mashup offers a meta-search system. Received permission to use the system API to retrieve the content API, data retrieval systems and video content via the API to design a system, based on this medical education, meta-search system is implemented.
5-Hydroxytryptamine Inhibits Glutamatergic Synaptic Transmission in Rat Corticostriatal Brain Slice
조형석,최세준,김기정,이현호,김성윤,초영진,성기욱 대한약리학회 2005 The Korean Journal of Physiology & Pharmacology Vol.9 No.5
Striatum is involved in the control of movement and habitual memory. It receives glutamatergic input from wide area of the cerebral cortex as well as an extensive serotonergic (5-hydroxytryptamine, 5-HT) input from the raphe nuclei. In our study, the effects of 5-HT on synaptic transmission were studied in the rat corticostriatal brain slice using in vitro whole-cell recording technique. 5-HT inhibited the amplitude as well as frequency of spontaneous excitatory postsynaptic currents (sEPSC) significantly, and neither γ-aminobutyric acid(GABA)A receptor antagonist bicuculline (BIC), nor N-methyl-D-aspartate (NMDA) receptor antagonist, DL-2-amino-5-phosphonovaleric acid (AP-V) could block the effect of 5-HT. In the presence non-NMDA receptor antagonist, 2,3-dioxo-6-nitro-1,2,3,4-tetrahydrobenxo[f] quinoxaline-7-sulfonamide (NBQX), the inhibitory effect of 5-HT was blocked. We also figured out that 5-HT change the channel kinetics of the sEPSC. There was a significant increase in the rise time during the 5-HT application. Our results suggest that 5-HT has an effect on both pre- and postsynaptic site with decreasing neurotransmitter release probability of glutamate and decreasing the sensitivity to glutamate by increasing the rise time of non-NMDA receptor mediated synaptic transmission in the