삶의 부침과 생애사 연구: 새롭게 생각해 보는 한국 교사의 활력(vitality)의 원천들

차헌주 한국초등교육학회 2007 학술대회 Vol.2007 No.1

AHP 방법론에 의한 건축물 해체공사의 안전관리 개선사항 평가

차헌주,최종수,Cha, Hun-Ju,Choi, Jong-Soo 한국건축시공학회 2007 한국건축시공학회지 Vol.7 No.3

Current domestic safety training in building demolition works are heavily relies on the limited number of experienced people and thus, it implies the demand of preparing the systematic program and stricter yardstick is soaring. Questionnaire survey and in-depth interview results with demolition engineers were analyzed adopting AHP methodology. Analysis results reveal that the most urgent items which required improving current safety training system are to increase investment level, prepare more structured training system and secure experts, and so on. In addition, field labors and managers strongly requested the improvement of environment-related safety matters. Based on the evaluation results, guidelines were suggested for the improvement of safety training system in building demolition works.

노출배관(교량첨가/공동구) 상시 모니터링 시스템

차헌주(Cha Hunjoo),송경석(Song Kyungsuk),박찬영(Park Chanyoung),조성용(Cho Sungyong) 한국가스학회 2020 한국가스학회 학술대회논문집 Vol.2020 No.10

오디오/비디오 스트리밍을 지원하는 분산 객체 프레임워크 설계 및 구현

차신(Shin Cha),반덕훈(Duk-Hoon Bahn),김동성(Dong-Sung Kim),박연상(Yeon-Sang Park),이헌주(Huen-Joo Lee) 한국정보과학회 1999 정보과학회 컴퓨팅의 실제 논문지 Vol.5 No.4

본 논문은 객체지향형 분산처리 환경 하에서 오디오나 비디오 등과 같은 실시간(real-time) 스트림(stream) 데이타를 처리하는 데 필요한 소프트웨어 기반구조를 설계하고 구현한 내용을 기술한다. 본 논문에서는 제시한 DAViS(Distributed Object Framework supporting Audio/Video Streaming)는, 오디오/비디오 데이타의 처리와 관련된 여러 소프트웨어 구성요소들을 분산객체로 추상화하고, 그 객체들간의 제어정보 교환경로와 오디오/비디오 데이타 전송경로를 서로 분리하여 처리한다. 분산응용프로그램 작성자는 DAViS에서 제공하는 서비스들을 이용하여, 기존의 분산프로그래밍 환경이 제공하는 것과 동일한 수준에서 오디오/비디오 데이타에 대한 처리를 표현할 수 있다. DAViS는, 새로운 형식의 오디오/비디오 데이타를 처리하는 부분을 손쉽게 통합하고, 하부 네트워크의 전송기술이나 컴퓨터시스템 관련 기술의 진보를 신속하고 자연스럽게 수용할 수 있도록 하는 유연한 구조를 가지고 있다. This paper describes the design and implementation of software framework which supports the processing of real-time stream data like audio and video In distributed object-oriented computing environment. DAViS(Distributed Object Framework supporting Audio/Video Streaming), proposed in this paper, abstracts software components concerning the processing of audio/video data as distributed objects and separates the transmission path of data between them from that of control information. Based on DAViS, distributed applications can be written in the same abstract level as is provided by the existing distributed environment in handling audio/video data. DAViS has a flexible internal structure enough to easily incorporate new types of audio/video data and to rapidly accommodate the progress of underlying network and computer system technology with very little modifications.

OLETF쥐에서 Amlodipine, Losartan과 비교한 Lithospermic Acid B의 당뇨병성 신증 예방효과

강은석,하헌주,허규연,차봉수,김범석,김철훈,안철우,이현철,서기호,한승진,전성완,정만길 대한당뇨병학회 2008 Diabetes and Metabolism Journal Vol.32 No.1

Background: Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. Methods: LAB (20 mg/kg), amlodipine (10 mg/kg), or losartan (10 mg/kg) was given orally once daily to 10-week-old male OLETF rats for 28 weeks. Results: None of LAB, losartan, and amlodipine exhibited effects on blood glucose levels. Treatment with amlodipine or losartan resulted in similar reductions in blood pressure; however, LAB was less effective in lowering blood pressure. Albuminuria was markedly suppressed by losartan and LAB, but not by amlodipine. LAB treatment decreased levels of renal lipid peroxidation, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-β1 (TGF-β1). Conclusion: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (J Kor Diabetes Assoc 32:10~20, 2008) Background: Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. Methods: LAB (20 mg/kg), amlodipine (10 mg/kg), or losartan (10 mg/kg) was given orally once daily to 10-week-old male OLETF rats for 28 weeks. Results: None of LAB, losartan, and amlodipine exhibited effects on blood glucose levels. Treatment with amlodipine or losartan resulted in similar reductions in blood pressure; however, LAB was less effective in lowering blood pressure. Albuminuria was markedly suppressed by losartan and LAB, but not by amlodipine. LAB treatment decreased levels of renal lipid peroxidation, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-β1 (TGF-β1). Conclusion: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (J Kor Diabetes Assoc 32:10~20, 2008)

당뇨병 신증을 동반한 환자에서 단핵구 내 NF-κB 및 AP-1의 활성화

남지선,하헌주,이근택,강은석,임승길,이현철,이유미,안철우,차봉수,이은직,김경래,박종숙,조민호,김혜진 대한당뇨병학회 2007 Diabetes and Metabolism Journal Vol.31 No.3

Background: We evaluated the role of oxidative stress in diabetic nephropathy by measuring intracellular reactive oxygen species (ROS) and redox-sensitive transcription factors in isolated peripheral mononuclear cells (PBMC). Methods: From 66 diabetic patients with or without diabetic nephropathy (Group III and II, respectively) and 49 normal control subjects (Group I), spontaneous and stimulated ROS levels, activities of nuclear factor-kappa B (NF-κB), activator protein-1 (AP-1), and specificity protein1 (Sp1) in PBMC, urinary and PBMC TGF-β1 (transforming growth factor-β1), and 24-hour urinary albumin excretion (UAE) were measured.Results: Spontaneous ROS was significantly higher in group III and II than group I (60.7 ± 3.3 vs. 60.0 ± 3.0 vs. 41.1 ± 2.4%, respectively), and stimulated ROS were significantly higher in Group III compared to Group II (Increment of H2O2-induced ROS production: 21.8 ± 2.2 vs. 11.1 ± 2.0%, respectively; increment of PMA-induced ROS production 23.5 ± 4.5 vs. 21.6 ± 2.2%, respectively). The activities of NF-κB and AP-1, but not of Sp1, were significantly higher in Group III than in Group II (2.53 vs. 2.0 vs. 1.43-fold, respectively). Both PBMC- and urinary TGF-β1 levels were higher in Group III than Group II (3.23 ± 0.39 vs. 1.99 ± 0.68 ng/mg in PBMCs, 16.88 ± 6.84 vs. 5.61 ± 1.57 ng/mL in urine, both respectively), and they were significantly correlated with activities of NF-κB and AP-1 and 24-hour UAE. Conclusions: Increased intracellular ROS generation in PBMCs of diabetic patients is involved in the pathogenesis of diabetic nephropathy through activation of NF-κB and AP-1, but not Sp1, and increased expression of TGF-β1. (J Kor Diabetes Assoc 31:261~273, 2007) 연구배경: 본 연구는 당뇨병환자에서 세포 내 반응성 산소족 스트레스를 정량화 하고, PBMC 내 NF-κB, AP-1 및 Sp1 등 산화환원반응에 관여하는 여러 전사인자의 활성도를 측정하여 산화 스트레스가 신손상에 미치는 영향을 알아보고자 하였다. 또 산화 스트레스와 연관 있다고 알려진 TGF-β1을 PBMC와 소변에서 측정하여 24시간 UAE와 앞의 전사인자들과 분석하여 당뇨병 신증에서 TGF-β1의 역할에 대해서도 알아보고자 하였다. 방법: 66명의 제2형 당뇨병환자와 연령, 성별에 맞춘 정상 대조군 49명을 24시간 소변 내 알부민 배설량에 따라 세 군으로 나누었다. Dichlorodifluorescein (DCF)와 형광분광광도계를 사용하여 세포 내 반응성 산소족의 활성도를 측정하였고, PBMC 내 NF-κB, AP-1 및 Sp1의 활성도는 EMSA를 이용하여 측정하였으며, PBMC와 소변 내 TGF-β1는 quantitative sandwich enzyme immunoassay로 정량화하였다. 결과: 임의의 반응성 세포족은 당뇨병환자군(II군, III군) 에서 정상군(I군)에 비해 높게 측정되었다(60.7 ± 3.3 vs. 60.0 ± 3.0 vs. 41.1 ± 2.4, %, 순서대로, P < 0.05). H2O2 와 PMA로 자극시킨 반응성 세포족은 III군에서 I군뿐 아니라 II군보다도 의미있게 높게 측정되었다(H202에 의해 자극된 후 증가율: 21.8 ± 2.2 vs. 9.1 ± 4.0 vs. 11.1 ± 2.0, III, II, I군 순서; PMA에 의해 자극된 후 증가율이 23.5 ± 4.5 vs. 12.1 ± 3.0 vs. 21.6 ± 2.2%, III, II, I군 순서). PBMC 내 Sp1을 제외하고 NF-κB, AP-1은 III군에서 II에 비해 의미있게 증가하였다(2.53 vs. 2.0 vs. 1.43배, NF-κB, AP-1, Sp1 순서). 그리고 PBMC 및 소변 내 TGF-β1 역시 III군에서 II에 비해 높게 측정되었고(PBMC에서 3.23 ± 0.39 vs. 1.99 ± 0.68 ng/mg; 소변에서 16.88 ± 6.84 vs. 5.61 ± 1.57 ng/mL, 순서대로), 이들은 NF-κB 및 AP-1의 활성도와 24시간 UAE와 상관관계에 있었다.

하드웨어-인-더-루프 기반의 배관 평가 시뮬레이터의 개발

김영진,허남수,차헌주,최재붕,표창률,Kim, Yeong-Jin,Heo, Nam-Su,Cha, Heon-Ju,Choe, Jae-Bung,Pyo, Chang-Ryul 대한기계학회 2001 大韓機械學會論文集A Vol.25 No.7

In order to verify the analytical methods predicting failure behavior of cracked piping, full-scale pipe tests are crucial in nuclear power plant piping. For this reason, series of international test programs have been conducted. However, full-scale pipe tests require expensive testing equipment and long period of testing time. The objective of this paper is to develop a test system which can economically simulate the full-scale pipe test regarding the integrity evaluation. This system provides the failure behavior of cracked pipe by testing a wide-plate specimen. The system provides the failure behavior of cracked pipe by testing a wide-plate specimen. The system was developed for the integrity evaluation of nuclear piping based on the methodology of hardware-in-the-loop (HiL) simulation. Using this simulator, the piping integrity can be evaluated based on the elastic-plastic behavior of full-scale pipe, and the high cost full-scale pipe test may be replaced with this economical system.

상수도 관망 데이터의 사용목적에 관한 수집 주기 연구

이경환,서정철,차헌주,송교신,최준모 대한상하수도학회 2013 상하수도학회지 Vol.27 No.2

Sampling rate of Hydraulic pressure data, depending on the intended use of the water distribution system is an important factor. If sampling interval of hydraulic data is short, that will be more useful but it demand a lot of expense for maintenance. In this study, based on simulation of water distribution system 2 khz data, statistical techniques of student t distribution, non-exceedance probability using the optimal sampling rate for research.

CMOS 를 이용한 Digital-Analog 변환기 설계에 관한 연구 ( A study on design Digital to Analog Converter using the CMOS )

이주환,강희조,홍성찬,차헌주,최승철 대한전자공학회 1988 대한전자공학회 학술대회 Vol.1988 No.1

제2형 당뇨병환자에서 Pioglitazone이 뇌혈류 개선에 미치는 영향

박종숙,김형진,곽혜선,임승길,차봉수,김경래,이현철,이유정,안철우,원영준,하헌주,김혜진,박진아,이경열,김철식 대한당뇨병학회 2006 Diabetes and Metabolism Journal Vol.30 No.2

-Background: Atherosclerosis is one of the major causes of morbidity and mortality in patients with type 2 diabetes and pioglitazone has been reported to have antiatherogenic effect. The aim of this study was to investigate whether pioglitazone affects carotid intima-media thickness (IMT) and pulsatility index (PI) in type 2 diabetic patients. Methods: A total of 40 type 2 diabetic patients were included and divided into two groups: the pioglitazone-treated group (pioglitazone 15 mg/day with gliclazide 80~320 mg/day for 12 weeks) (n = 20) and control group (gliclazide 80~320 mg/day for 12 weeks) (n = 20). The changes in lipid profile, insulin resistance, IMT, and PI were monitored to determine that pioglitazone improves cerebrovascular blood flow. Results: The pioglitazone treatment significantly increased HDL-C, reduced triglyceride, insulin resistance and PI. IMT tended to decrease but the change was not significant. This study revealed that treatment with pioglitazone was associated with the improvement of cerebrovascular blood flow. Conclusions: Pioglitazone appears to be effective for the improvement of cerebrovascular blood flow in type 2 diabetic patients (J Kor Diabetes Assoc 30:96~103, 2006). 연구배경: 죽상경화증은 제2형 당뇨병환자의 주요한 사망 원인이며 pioglitazone은 항죽상경화 효과가 있는 것으로 알려져 있다. 본 연구의 목적은 제2형 당뇨병환자를 대상으로 pioglitazone을 투여한 후 경동맥 초음파 및 경두개 초음파 혈류 검사를 통해 경동맥 내중막 두께 및 박동성 지수의 변화를 측정하여 뇌혈관에 미치는 효과를 평가하고자 하였다 방법: 40명의 제2형 당뇨병환자를 20명씩 pioglitazone 투여군 (pioglitazone 15mg/day with gliclazide 80~320 mg/day)과 대조군 (gliclazide 80~320 mg/day)으로 나누어 12주간 약제를 투여하였고 약제 투여 전후의 혈당 및 당화혈색소 변화, 지질, 인슐린 저항성, 경동맥 내중막 두께 및 박동성 지수의 변화를 측정하였다.결과: pioglitazone 투여군은 대조군에 비해 HDL 콜레스테롤이 증가하고 중성지방, 유리지방산이 감소하였으며 인슐린 저항성, 박동성 지수가 감소하였다.