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차용준,김유정,이세훈,김태민,최승홍,김동완,박철기,김일한,김지현,김은희,최병세,김재용,김인아,허대석 대한암학회 2017 Cancer Research and Treatment Vol.49 No.1
Purpose Bevacizumab±irinotecan is effective for treatment of recurrent malignant gliomas. However, the optimal duration of treatment has not been established. Materials and Methods Ninety-four consecutive patients with recurrent malignant glioma who were treated with bevacizumab at our institutions were identified. Patients who continued bevacizumab until tumor progression were enrolled in a late discontinuation (LD) group, while those who stopped bevacizumab before tumor progression were enrolled in an early discontinuation (ED) group. Landmark analyses were performed at weeks 9, 18, and 26 for comparison of patient survival between the two groups. Results Among 89 assessable patients, 62 (69.7%) and 27 (30.3%) patients were categorized as the LD and ED groups, respectively. According to landmark analysis, survival times from weeks 9, 18, and 26 were not significantly different between the two groups in the overall population. However, the LD group showed a trend toward increased survival compared to the ED group among responders. In the ED group, the median time from discontinuation to disease progression was 11.4 weeks, and none of the patients showed a definite rebound phenomenon. Similar median survival times after disease progression were observed between groups (14.4 weeks vs. 15.7 weeks, p=0.251). Of 83 patients, 38 (45.8%) received further therapy at progression, and those who received further therapy showed longer survival in both the LD and ED groups. Conclusion In recurrent malignant glioma, duration of bevacizumab was not associated with survival time in the overall population. However, ED of bevacizumab in responding patients might be associated with decreased survival.
차용준,박지영,김훈,박승영,조우진,송양순,유영재 창원대학교 생활과학연구소 2000 생활과학연구 Vol.4 No.-
This study was conducted to identify irradiation-derived volatile components, having positive-correlation with irradiation doses, which may play roles as maker materials for detecting post-irradiation in pork meat. The volatile components of irradiated(0, 1, 3, 5 and 10 kGy doses) pork(Belly) meat was analyzed by liquid liquid continuous extraction(LLCE)/GC/MSD methods. By the results of linear regression analysis between irradiation doses and volatile component amounts in fresh pork, 3 compounds including γ-octalactone(r=0.82), 1-octen-3-ol(r=0.90) and butanoic acid(r=0.81) had high correlations with irradiation doses.
차용준,김경 한국장애인재활협회 2011 재활복지 Vol.15 No.3
본 연구는 성인 편마비환자를 대상으로 하여 보행보조도구로 사용되고 있는 지팡이 길이에 대 한 실태를 조사하는데 목적이 있다. 신경계 물리치료를 받고 있는 총 116명의 성인 편마비환자를 대상으로 하여 환자의 특징에 따른 지팡이 길이의 비교와 실제 사용되는 지팡이의 길이에 대한 회귀식을 산출하기 위해 빈도분석, 카이-스퀘어 검정, 위계적 회귀분석을 실시하였다. 성별, 연령, 발병 후 경과기간, 손상요인, 마비측 부위, 그리고 지팡이 종류에 따른 지팡이의 길이는 차이를 보이지 않았고, 넙다리 큰돌기 위 높이의 지팡이 길이가 가장 높은 분포를 보였다. 지팡이의 길이 (cm)는 34.986 + 0.337 × 넙다리 큰돌기 높이 + 0.174 × 팔 길이 + 0.053 × 신장으로 계산이 가능하다. 이와 같은 결과는 임상가들에게 성인 편마비환자들은 기존에 제시되고 있는 길이가 아닌 실제로 넙다리 큰돌기 높이보다 높은 지팡이를 사용하고 있는 사실에 대한 실질적인 정보 제공에 의미가 있다고 본다. The purpose of this study was to investigate the real picture of cane length to support walking of adult hemiplegia. Data were collected from 116 adult hemiplegias being treated neurorehabilitation and analyzed using the frequency analysis, chi-square test, and hierarchial regression analysis to compare the actual cane length condition regarding each character. There were not significantly difference in the cane length according to the sex, age, onset, damage factor, attack site, and cane type, the cane length of above greater trochanter was the highest distribution among the three different lengths. The cane length (L) can be determined by the formula L (cm) = 34.986 + 0.337 × GT (height of greater trochanter) + 0.174 × A (arm length) + 0.053 × H (height). This current study will help the clinician to know the fact that adult hemiplegias actually use cane to be longer than greater trochanter.
젓갈에서 分離한 蛋白質分解力이 强한 細菌 및 生成 酵素의 特性에 관한 硏究
車庸準 國立 昌原大學校 産業技術硏究所 1988 産技硏論文集 Vol.2 No.-
Fermented fish products which held more than 15% of salt contents have been consumed from old ages in Korea. However, it has been currently known that salt is one of the causative ingredients for adult diseases, diet reduced salt content is recently recommended. And fermented fish products were difficult to be industrial large scale-production because of long term by natural fermentation, also flavor and nutrition were slowly degraded after optimal fermentation day. So it is urgent that quality improvement such as sanitary processing and preservative method for stability during circulative process. In this study, actually, the strongest proteolytic bacteria, Bacillus subtilis p-4(below, B. subtilis p-4), among strains which were isolated from fermented anchovy on the marketing was selected, and its cultural character, properties of protease produced by that strain were experimented. The results obtained were as follows; B. subtilis p-4, which grow best at 40℃, pH 7.0 and 3% of salt contents, was shown 0.48hr?? of specific growth rate and 182㎍-Tyr/hr.ml of maximum proteolytic activity after 30 hrs in continuous culture. The protease produced by B. subtilis p-4 showed maximum activity at 50℃, pH 7.0, and molecular weight was estimated to be 18,000 by Sephadex G-100 filtration, Km value by equation of Lineweaver-Burk was determinded to be 0.65% for casein as a substrate. It was supposed to be a kind of metal chelator sensitive neutral protease from the result of high sensitivity against EDTA, o-phenanthroline and metal ions such as Cu²?, Ni²?, Zn²?.