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차미선,소원욱,박인준,이수복 한국공업화학회 2004 응용화학 Vol.8 No.1
We describe the synthesis and characterization of amphoteric poly(acrylate), consisting of the F-marcromer and a 2-(dimethyl amino)ethyl methacrylate (2-DMAEMS) The amphoteric polymer were prepared by marcromonomer technique and radical copolymerization. After copolymerization, the resultant rection solution was purified by silica column. In this study, separation of resultant reaction sloution was purified by silica column. In this study, separation of amphoteric poly(acrylate)s and characterization by InfraRed Spectroscopy, Gel Permeation Charomatography. The IR traces showed that the amphoteric poly(acrylate) was separated successfully polymr of p(2-DMAEMA). The amphoteric poly(acrylate) have number average molecular weights(Mw) about 38,000 by GPC.
차미선,소원욱,박인준,김동권,이수복,ShiYuan, Cheng 한국공업화학회 2003 응용화학 Vol.7 No.2
The graft copolymer, consisting of a flurorinated macromer(F-macromer) and a 2-(dimethyl amino)ethyl methacrylate, were prepared by marcromonomer technique and radical copolymerization. In this study, the surface propeties of the graft copolymer and its additive effect on the surface energy of polymer film were compared with the random copolymer of poly(perfluoroalkyl ethyl acrylate)-r-poly(2-dimethylamino ethyl methacrylate)(PFA-r-P(2-DMAEMA)). The contact angles of the surface modified by the graft copolymer is large than that of random copolymer with similar FA monomer content, and surface free energy of the substrate containing 0.01wt% of the graft copolymer is similar with that of 0.1wt% random copolymer surface. That is, The low-energy modification effect of the graft copolymer is better than that of the random copolymer.
차미선,소원욱,박인준,이수복 한국공업화학회 2003 응용화학 Vol.7 No.1
We describe the synthesis and characterization of amphoteric poly(acrylate), consisting of a F-marcromer and a 2-(dimethyl amino)ethyl methacrylate (2-DMAEMA). The amphoteric polymer were prepared by marcromonomer technique and radical copolymerization. After copolymerization, the resultant reaction solution was purified by silica column. In this study, separation of amphoteric poly(acrylate)s and characterization by InfraRed Spectroscopy, Gel Permeation Chromatography, Polarized Optical Microscopy, and Differential Scanning Calorimeter were described. The IR traces showed that the amphoteric poly(acrylate) was separated successfully and the characterisitic peaks of both hydrophobic F-macromer and hydrophilic polymer of p(2-DMAEMA). The amphoteric poly(acrylate) have number average molecular weights(Mw) about 38.000 by GPC.
차미선,하종욱,박인준,소원욱,이수복,( Cheng Shiyuan ) 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1
불소함유 그라프트 공중합체는 매크로 단량체인 F-macromer와 (2-dimethylamino)ethyl methacrylate DMAEMA)를 개시제인 2,2``-azobisisobutyronitrile (AIBN)을 사용하여 라디칼 용액중합하여 합성하였다. 합성한 그라프트 공중합체의 bulk 및 표면특성은 FT-IR, 1H-NMR, DSC, GPC, Particle analyzer, SEM을 사용하여 관찰하였다. 공중합체의 표면특성은 접촉각을 측정하여 관찰하였으며, 표면자유에너지는 기하평균식(geometric approximation mean method)을 사용하여 산출하였다. 그라프트 공중합체를 황산용액으로 에멀젼시켰을 때 불소함량이 5%일 때 입자크기는 170nm였다. 공중합체의 평균 도메인 크기는 15nm였다. 그라프트 공중합체의 불소함량이 5%에서 표면자유에너지는 12.5dyn/cm로 저 표면에너지를 갖는 것을 알 수 있었다.
차미선,이경미,이재협 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.4
BACKGROUND: Recent evidence from in vitro and in vivo studies indicates that bisphosphonates may promote osteoblastic bone formation and potently inhibit osteoclast activity. However, little is known about the potential effect of bisphosphonates on the recruitment of osteoblastic precursors from patient-derived bone marrow stromal cells due to difficulties in accessing human bone marrow from healthy and disease subjects. METHODS: In this study, we evaluated the potential of using FDA-approved and clinically utilized bisphosphonates such as alendronate, ibandronate, and zoledronate to enhance the development of bone forming osteoblasts from osteoporosis patient- and healthy-person derived hBMSCs (op-MSCs and hp-MSCs, respectively). hBMSCs were obtained from postmenopausal women without endocrine diseases or receiving hormone replacement therapy. Cells were treated with or without a bisphosphonate (alendronate, ibandronate, and zoledronate) and analyzed over 21 days of culture. RESULTS: hBMSC from osteoporosis-patient with bisphosphonates treatment demonstrated a significant increase in Alizarin red staining after 7 days compared to that from healthy-person. Calcium contents and alkaline phosphatase (ALP) enzyme activity also demonstrated an increased propensity in hMSCs from osteoporosis-patient compared to those from healthy-person, although there were inter-individual variations.Gene expression levels varied among different donors. There were no significant differences in the effect on the osteoblastic differentiation of hBMSCs among alendronate, ibandronate, and zoledronate. Statistical significance in the osteoblastic differentiation of hBMSCs between the positive control group cultured in osteogenic mediumalone and groups cultured in osteogenic mediumsupplemented with bisphosphonate was not shown either.These results might be due to various cell types of hBMSCs from individual clinical patients and concentrations of bisphosphonate used. CONCLUSION: Our study using a clinically relevant in vitro model suggests that bisphosphonate treatment is more effective for patients with osteoporosis than its preventive effect for healthy person. In addition, patient-specific responses to bisphosphonates should be considered rather than bisphosphonate type prior to prescription. Further investigations are needed to determine how bisphosphonates influence hBMSCs function to mediate bone quality and turnover in osteoporotic patients. Such studies can generate novel approaches to treat age-related osteoporotic bone loss.
차미선,김세미,주민혁,정종국 한국공업화학회 2014 한국공업화학회 연구논문 초록집 Vol.2014 No.1
PFPE(Perfluoropolyether)는 slip성 및 광학적 특성이 우수한 소재로 다양한 산업용도로 사용되고 있다. PFPE 합성물은 반응모노머로 HFPO(Hexafluoropropylene oxide), 촉매로 CsF(Caesium fluoride), 용매인 TG(Tetraethylene glycol dimethyl ether)를 사용하여 합성할 수 있다. 본 연구에서는 HFPO의 투입속도와 반응온도조건을 변화시켜 다양한 분자량 분포를 갖는 PFPE를 합성하였으며, 합성여부는 GC(Gas chromatography), GPC(Gel permeation chromatography), NMR(Nuclear magnetic resonance), IR(Infrared spectroscopy) 분석 등을 통해 확인하였다. 이렇게 합성된 PFPE-COF의 COF 작용기를 에스테르화 반응, 알코올 반응하여 광경화형 지문방지제의 원료가 되는 PFPE-OH를 합성하였다. 그러나 에스테르화 반응 시 반응 용매 중 포함된 수분 등의 영향으로 산(-COOH)등의 불순물이 일부 발생하면서 최종 생성물의 반응성, 표면특성 등에 영향을 주는 것으로 나타났다. 따라서 합성 중 생성되는 이러한 불순물을 제거하기 위해 흡착제를 사용하였으며, 제거여부는 GC분석을 통해 확인하였다.