측두엽 간질 수술 후 인지기능의 변화: 기억력을 중심으로

진주희,강연욱,홍승봉,홍승철,박재설,서대원 한국임상심리학회 2005 Korean Journal of Clinical Psychology Vol.24 No.1

2PB-18 / The Studies on the Methanolysis of Aflatoxin G1 Epoxide in Cancer Compound

진주희,장향동,류성렬 한국공업화학회 2000 한국공업화학회 연구논문 초록집 Vol.2000 No.0

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Re-standardization of the Korean-Instrumental Activities of Daily Living (K-IADL): Clinical Usefulness for Various Neurogenerative Diseases

진주희,Jaeseol Park,Soh-Jeong Yang,염지영,Yisuh Ahn,백민재,Hui Jin Ryu,Byung Hwa Lee,Noh Eul Han,Kyung Hi Ryu,강연욱 대한치매학회 2018 Dementia and Neurocognitive Disorders Vol.17 No.1

Background and Purpose: Evaluating instrumental activities of daily living (IADL) is an important part of procedure to diagnose dementia. The Korean-Instrumental Activities of Daily Living (K-IADL) has been used extensively in Korea. However, its cut-off score has not been reformulated since 2002. The purpose of this study was to yield a new optimal cut-off score for the K-IADL and confirm the validity of this new cut-off score with various dementia groups. Methods: We retrospectively collected a total of 2,347 patients' K-IADL data from 6 general hospitals in Korea. These patients had mild cognitive impairment (MCI) or dementia with various etiologies for cognitive impairment. We also recruited a normal control group ( n =254) from the community. Korean-Mini Mental State Examination, Short version of the Geriatric Depression Scale, Clinical Dementia Rating, and Global Deterioration Scale were administered to all participants. Caregivers completed K-IADL and Barthel Index. Results: K-IADL scores were significantly different among dementia subgroups, but not significantly different among MCI subgroups. Based on internal consistency, correlations with other scales, and factor analysis, K-IADL showed excellent reliability and validity. The new optimal cut-off score to diagnose dementia was 0.40, which gave a sensitivity of 0.901 and a specificity of 0.916. Positive predictive value for dementia using the new cut-off score was 94.2% for Alzheimer's disease, 100% for vascular dementia, and 84% for Parkinson's disease. Conclusions: Our results illustrate that the new K-IADL cut-off score of 0.40 is reliable and valid for screening impairments of daily functioning resulting from various etiologies.

노인의 주관적 기억 장애의 특징 및 하위 유형

진주희,오경자,서상원,신희영,나덕렬 대한치매학회 2010 Dementia and Neurocognitive Disorders Vol.9 No.4

Background: Subjective memory impairment (SMI) refers to a condition where people complain about memory problem despite intact cognition. The aims of this study were to examine the specific characteristics of memory complaints using Multifactorial Memory Questionnaire (MMQ) and to investigate whether there were subgroups among the SMI subjects. Methods: A total of 252 subjects with SMI were recruited from a health promotion center. These subjects did not have previous history of dementia or cognitive impairment and performed normally on the Korean-Mini Mental State Examination (K-MMSE). A group of 196 individuals served as healthy controls (HC) recruited from the same center. Both SMI and HC groups underwent KMMSE, short version of Geriatric Depression Scale (S-GDS) and MMQ which consisted of 3 subscales: Memory contentment (MMQ-C), memory ability (MMQ-A) and memory strategy (MMQ-S). SMI were analyzed according to 3 subscales of MMQ. Results: SMI group showed the lower scores on the MMQ-C and MMQ-A and the higher scores on the S-GDS and MMQ-S than HC group, but no significant difference on K-MMSE scores between groups. Three clusters of SMI subjects were identified according to MMQ- A, MMQ-S and S-GDS. Cluster 1 contained subjects with lower memory contentment, more memory complaints and less use of memory strategy than HC. Cluster 2 subjects presented lower memory contentment, more memory complaints and more use of memory strategy. Subjects in cluster 3 showed prominent depression, severe discontentment about memory and memory complaints. Conclusions: Our results indicate that SMI group might be heterogeneous and could be divided into subgroups according to specific features of memory complaints. Furthermore we could suggest that memory questionnaire is useful to evaluate various features of SMI and some SMI subjects might be closely related with psychological problem such as depression.

A Validation Study of the Inbrain CST: a Tablet Computer-based Cognitive Screening Test for Elderly People with Cognitive Impairment

진주희,김다은,이혜주,Yun Juoh,이병화,Park Jongha,Yeom Jiho,Shin Dae-Seock,나덕렬 대한의학회 2020 Journal of Korean medical science Vol.35 No.34

Background: Computerized versions of cognitive screening test could have advantages over pencil-and-paper versions by eliminating rater-dependent factors and saving the time required to score the tests and report the results. We developed a computerized cognitive screening test (Inbrain Cognitive Screening Test [Inbrain CST]) that takes about 30 minutes to administer on a touchscreen computer and is composed of neuropsychological tests already shown to be sensitive in detecting early cognitive decline in Alzheimer's disease (AD). The aims of this study were to 1) introduce normative data for Inbrain CST, 2) verify its reliability and validity, 3) assess clinical usefulness, and 4) identify neuroanatomical correlates of Inbrain CST. Methods: The Inbrain CST runs on the Microsoft Windows 10 operating system and comprises 7 subtests that encompass 5 cognitive domains: attention, language, visuospatial, memory, and executive functions. First, we recruited 480 cognitively normal elderly people (age 50–90) from communities nationwide to establish normative data for Inbrain CST. Second, we enrolled 97 patients from our dementia clinic (26 with subjective cognitive decline [SCD], 42 with amnestic mild cognitive impairment [aMCI], and 29 with dementia due to AD) and investigated sensitivity and specificity of Inbrain CST for discriminating cognitively impaired patients from those with SCD using receiver operating characteristic (ROC) curve analyses. Third, we compared the Inbrain CST scores with those from another neuropsychological test battery to obtain concurrent validity and assessed test–retest reliability. Finally, magnetic resonance imaging (MRI)-based cortical thickness analyses were performed to provide anatomical substrates for performances on the Inbrain CST.Results: First, in the normative sample, the total score on the Inbrain CST was significantly affected by age, years of education, and gender. Second, Inbrain CST scores among the three patient groups decreased in the order of SCD, aMCI, and AD dementia, and the ROC curve analysis revealed that Inbrain CST had good discriminative power for differentiating cognitively impaired patients from those with SCD. Third, the Inbrain CST subtests had high concurrent validity and test–retest reliability. Finally, in the cortical thickness analysis, each cognitive domain score and the total score of Inbrain CST showed distinct patterns of anatomical correlates that fit into the previously known brain–behavior relationship. Conclusion: Inbrain CST had good validity, reliability, and clinical usefulness in detecting cognitive impairment in the elderly. Furthermore, it showed neuroanatomical validity through MRI cortical thinning patterns. These results suggest that Inbrain CST is a useful cognitive screening tool with efficiency and validity to detect mild impairments in cognition in clinical settings.

COVID-19에 대한 유아의 이해와 정서

진주희,김민진 한국어린이문학교육학회 2022 어린이문학교육연구 Vol.23 No.2

본 연구는 COVID-19에 대해 유아가 무엇을 알고 있고, 어떻게 느끼고 있는지를 살펴봄으로써 감염병 재난 시 유아 지원 방안에 대한 기초자료를 제공하는 데에 목적이 있다. 이를 위해 만 4세, 만 5세, 초등학교 1학년 105명을 대상으로 그림 그리기 및 개별 면담을 실시하였다. 그 결과 첫째, 유아는 COVID-19가 무엇이며, 예방하는 방법은 무엇인지에 대해서는 잘 이해하고 있으나 전파 경로나 증상, 치료 가능성에 대해서는 이해가 부족하였다. 둘째, 유아가 COVID-19 관련 경험에 대해 나타낸 정서는 공포‧슬픔‧괴로움‧혐오‧분노 등의 부정적인 정서들이 많았으며, 그중에서도 공포와 괴로움이 가장 많았다. 이는 COVID-19 감염에 대한 걱정과 두려움, 예방 수칙을 지키는 과정에서 어려움과 관련이 있었다. 본 연구에서 제시한 결과는 감염병 재난 발생 시 안정감있게 일상을 보낼 수 있도록 지원하는 감염병 재난 교육을 위한 기초 자료로 활용될 수 있을 것이라 기대된다.

법인세 인하 효과의 문헌연구 : 기업이익조정과 공평성을 중심으로

진주희 서울시립대학교 도시과학대학 세무학과 2005 稅務學論集 Vol.18 No.2

법인세 인하 효과의 문헌연구(기업이익조정과 공평성을 중심으로)

그림책을 활용한 화법교육활동이 유아의 또래 상호작용 능력과 자기조절력에 미치는 효과

진주희(Ju-Hee Jin),김민진(Min-Jin Kim) 중앙대학교 한국교육문제연구소 2016 한국교육문제연구 Vol.34 No.1

본 연구의 목적은 그림책을 활용한 화법교육활동이 유아의 또래 상호작용 능력과 자기조절력에 미치는 효과를 알아보는데 있다. 이를 위하여 대전광역시에 소재한 Y유치원 만 4세 2학급 유아 50명을 실험집단과 비교집단에 각각 25명씩 배치하였다. 실험집단은 그림책 읽기방법으로 화법교육을 실시하고, 비교집단은 이야기나누기 방법으로 화법교육을 실시하였다. 연구결과 유아의 또래 상호작용 능력에서는 두 집단 간에 유의미한 차이가 나타나지 않았으나, 유아의 자기조절력에서는 그림책 읽기를 실시한 집단의 사후 자기조절력 점수가 이야기나누기를 실시한 집단의 사후 자기조절력 점수보다 통계적으로 유의미한 수준에서 높은 것으로 나타났다. 이러한 결과는 그림책 읽기가 유아의 자기조절력을 향상시키는 데 효과적인 화법교수방법임을 시사한다. The purpose of this study focused on analyzing the effects on children’s peer interaction and self-regulation by implementing speaking education adapting teaching method, which are picture book reading and large-group discussion. For this study, 50 children attending Y Kindergarten located in Dae-jeon were selected and were divided into experiment group(N=25) and a control group(N=25). The experiment group participated in speaking education based on picture book reading and the control group participated in speaking education through large-group discussion. The results of this research were summarized as follows. First, there are no significant differences in peer interaction between two groups. Second, speaking education based on picture book reading was more effective on self-regulation than the large-group discussion. These results suggest that picture book reading was an effective teaching method of speaking education improving self-regulation.

기억성 경도인지장애와 알츠하이머병의시계 그리기 검사의 수행양상

정하나,진주희,김희진,서상원,나덕렬 한국임상심리학회 2018 한국심리학회지: 임상심리 연구와 실제 Vol.4 No.1

The clock drawing test (CDT) has been consistently used as part of neuropsychological assessment, specifically as a screening tool for dementia. This study compared the quantitative and qualitative performance on the CDT among patients with amnestic mild cognitive impairment (aMCI), very mild Alzheimer's disease (AD) with a clinical dementia rating (CDR) of 0.5, and mild AD with a CDR of 1. Ninety-seven subjects with aMCI, 37 subjects with AD-CDR 0.5, and 50 subjects with AD-CDR 1, who visited the Memory Disorders Clinic in the Department of Neurology at the general hospital located in Seoul, underwent CDT and standardized neuropsychological battery tests. Although significant differences were found in the total quantitative scores among the three patient groups, there were no significant differences between aMCI and AD-CDR 0.5 patients. However, the qualitative error analysis revealed differences between the two groups in several areas: misrepresentation of clock (conceptual deficit error), deficit in spatial layout of numbers without any specific pattern (spatial disorganization), and moderate graphic difficulty. In correlational analysis between the CDT and other neuropsychological measures, the CDT was significantly correlated with the Korean-Boston Naming Test, Rey-Osterrieth Complex Figure copying test, verbal/visual memory tests, and frontal/executive function tests. Therefore, the findings of this study suggested that the characteristics of qualitative errors in the CDT can help identify cognitive changes in the early stage of AD; however, the quantitative scores of the CDT revealed limited information about these changes. Additionally, our results indicated that performance in the CDT was associated with semantic knowledge, visuospatial function, and executive function 시계 그리기 검사(Clock Drawing Test: CDT)는 치매 선별검사로, 임상 장면에서 많이 사용되는 신경심리검사 중 하나이다. 본 연구에서는 기억성 경도인지장애(amnestic Mild Cognitive Impairment, aMCI)와 임상치매평가척도(Clinical Dementia Rating scale: CDR)에 따라 CDR 0.5로 분류된 알츠하이머병 치매(Alzheimer's disease, AD), 그리고 CDR 1로 분류된 AD 환자를 대상으로 시계 그리기 검사(CDT)의 수행을 양적 및 질적 오류 분석을 통해 비교하고자 하였다. 서울 소재 한 종합병원 신경과를 방문한 환자 중 aMCI 환자 97명, AD-CDR 0.5 환자 37명, AD-CDR 1 환자 50명을 대상으로 CDT와 종합적인 신경심리평가가 시행되었다. 연구 결과, CDT의 양적 점수는 유의한 차이가 있었으나 사후분석에서 aMCI와 AD-CDR 0.5 간의 유의한 차이는 보이지 않았다. 그러나 질적 오류 분석에서, <개념적 결함> 오류 중 <잘못된 표상: 시계>, <공간과 계획 결함> 오류 중 <불특정형태 오류>, 그리고 <그리기 어려움: 중도>에서 aMCI와 AD-CDR 0.5 간의 유의한 차이를 확인할 수 있었다. 다른 신경심리평가와 CDT의 상관관계를 분석한 결과, 한국판 보스톤 이름 대기 검사, 레이 복합 도형 검사: 모사, 언어적/시각적 기억 과제 및 전두엽/집행기능 과제들과 유의한 상관관계를 보였다. 따라서 본 연구 결과는 CDT 수행의 양적 점수만으로는 AD 초기 인지 변화를 살펴보는데 제한이 있으나 질적 오류 특성이 AD 초기 인지 변화를 살펴보는데 유용할 것이라는 점과 CDT를 수행하는데 의미적 지식, 시공간 구성 능력 및 집행기능이 영향을 미친다는 점을 시사한다.

Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): A Useful Tool for Assessing and Monitoring Cognitive Impairments in Dementia Patients

안현정,진주희,박아람,이병화,서미경,서상원,나덕렬 대한의학회 2010 Journal of Korean medical science Vol.25 No.7

The Seoul Neuropsychological Screening Battery (SNSB) is one of the standardized neuropsychological test batteries widely used in Korea. However, it may be a bit too lengthy for patients with decreased attention span; and it does not provide the score of global cognitive function (GCF), which is useful for monitoring patients longitudinally. We sought to validate a dementia version of SNSB (SNSB-D) that was shorter than the original SNSB and contained only scorable tests with a GCF score of 300. We administered SNSB-D to patients with mild cognitive impairment (MCI) (n=43) and Alzheimer’s disease (AD) (n=93),and normal controls (NC) (n=77). MCI and AD groups had GCF scores significantly different from NC group, and GCF scores were able to distinguish patients with Clinical Dementia Rating of 0.5 and 1. Test-retest reliability was high, with a correlation coefficient of 0.918for AD, 0.999 for MCI, and 0.960 for NC. The GCF score significantly correlated with the Mini-Mental State Examination (MMSE). Through ROC-curve analysis, GCF scores were found to yield more accurate diagnoses than the MMSE. The SNSB-D is a valid, reliable tool for assessing the overall cognitive function, and can be used to monitor cognitive changes in patients with dementia.