폐쇄성 수면 무호흡 환자의 후두개 폐쇄 양상

지영훈,우주영,고태경,구수권 대한이비인후과학회 부산,울산,경남 지부회 2023 임상이비인후과 Vol.34 No.4

Background and Objectives: We evaluated the pattern of epiglottic obstruction in obstructive sleep apnea (OSA) patients, focusing on the results of drug induced sleep endoscopy (DISE), along with a literature review. Materials and Methods: The subjects were 270 Koreans who underwent DISE. Each patient underwent a thorough history taking, physical examination, polysomnography and DISE image evaluated by one otolaryngologist. Results: The prevalence of epiglottic obstruction was 39% (105/270), anterior-posterior complete obstruction was 26% (70/270), and partial obstruction was 13% (35/270). There was no significant correlation between gender, age, body mass index and epiglottis obstruction. The more severe the epiglottic obstruction, the more severe the sleep apnea. The more severe the anterior-posterior obstruction of the tongue base, the more severe the obstruction of the epiglottis (p<0.001). Conclusion: The epiglottis is not well understood compared to other anatomical sites, and it can OSA either alone or simultaneously with other obstructive sites, so researches are needed from a therapeutic point of view.

폐쇄성 수면 무호흡증 환자의 REM(Rapid Eye Movement) 및 NREM(Non- Rapid Eye Movement) 수면에서 코골이 소리의 음향학적 분석

지영훈,권순복,고태경,우주영,최희웅,안진우,고혜정,구수권 대한이비인후과학회 부산,울산,경남 지부회 2023 임상이비인후과 Vol.34 No.3

Background and Objectives: Although there are many stages of sleep, there are few studies on the differences in snoring sounds that occur in each stage of sleep. Acoustic analysis of snoring sounds provides a lot of information, and in this study, we attempted to acoustically analyze and compare snoring sounds generated during rapid eye movement (REM) sleep and non-REM (NREM) sleep. Materials and Methods: Thirteen with obstructive sleep apnea who underwent polysomnography were enrolled. Snoring sounds were analyzed during REM and NREM (N2 stage) sleep using a recorder placed within 30 cm of the shoulders. To eliminate confounding factors associated with sleeping position, the snoring sounds were recorded only in the supine position. In addition, to prevent inter-examiner errors, the recordings were performed by a single person. Snoring sounds were compared between sleep stages for formant frequency (Hz), intensity (dB), and spectrogram. Results: Formant frequency analysis of snoring sounds revealed statistically significant F2 values generated during REM and NREM (N2) sleep in males (p<0.05). The intensity of snoring sounds (dB) was significantly higher in men than in women during REM sleep (p<0.05). A 0.025-narrow-band spectrogram analysis revealed that the intensity waveform of snoring was darker and exhibited higher energy densities in REM sleep than in NREM (N2) sleep. Conclusion: There was an acoustic difference between the snoring sound generated during REM sleep and NREM (N2) sleep, and further studies with more cases should be conducted.

방사선종양학과 전국 통계(2006년)

지영훈,김미숙,류성렬,유대헌,최문식,정해조 대한방사선종양학회 2008 Radiation Oncology Journal Vol.26 No.2

CO-60 감마선에 대한 부정형조사면의 조직공중선량비 (TAR) 계산

지영훈,Ji Young-Hoon 대한방사선치료학회 1989 大韓放射線治療技術學會誌 Vol.3 No.1

In order to calculate the dose on each interest point in five types of irregularly shaped fields used commonly in radiotherapy, the tissue-air ratios (TAR) in these fields for Go-60 gamma radiation were calculated using the newly devised SAR-chart. The TARs calculated from newly method of using the SAR-chart, computer method and approximation method at the interest point were compared to the TARs obtained from measurement. The result are as follows; In case of the interest points on central axis the calculated TARs in irregularly shaped fields by the above mentioned methods were well agreed within the error of $1\%$, whereas for the interest points on off-axis the calculated TARs were resulted in the maximum errors of $2.4\%,\;2.3\%$ and $8.8\%$ respectively. From these results, the accuracy of calculation method of using the SAR-chart was comfirmed.

속중성자선의 선량분포에 관한 연구

지영훈,이동한,류성렬,권수일,신동오,박성용 한국의학물리학회 1997 의학물리 Vol.8 No.2

속중성자선을 임상에 이용하기 위해서는 속중성자선의 선량 및 선량분포를 정확히 측정하는 것이 매우 중요하다. 현재 속중성자선의 측정법은 크게 나누어 American Associations of Physicists in Medicine, European Clinical Neutron Dosimetry Group 및 International Commission on Radiation Units and Measurements에 의하여 제시되고 있으나 측정의 복잡함으로 인하여 서로 약간씩 다른 방법을 제시하고 있다. 따라서 본 연구에서는 중성자 치료장치에서 방출되는 속중성자선의 방출선량 및 물질 내 선량분포 등의 측정을 통하여 독자적인 측정기술을 확보하고, 우리 실정에 알맞은 표준측정법을 개발하고자 하였다. 속중성자선의 선량 및 물질 내 선량 분포 측정에는 조직등가물질인 A-150 플라스틱으로 제작된 IC-17 및 IC-18 이온함, 마그네슘으로 제작된 IC-17M 이온함, TE 기체, Ar 기체 및 RDM 2A electrometer 등을 사용하였다. 연구 결과 중성자선에 혼합되어 있는 ${\gamma}$선의 오염도는 기준조사면 깊이 5cm에서 약 13% 로 나타났으며, 깊이가 깊어질수록 증가하였다. 기준 조사면에 대하여 중심축선상의 최대 선량 깊이는 1.32cm 이었으며, 50% 선량 깊이는 14.8cm로 나타났다. 표면선량율은 전 조사면에 걸쳐서 41.6%~54.1%이었으며 조사면가 커질수록 증가하였다. Beam profile 은 2.5cm 깊이에서 7.5% 정도 horne effect가 나타났으며 10cm 깊이에서 가장 평탄하였다. It is mandatory to measure accurately the dose distribution and the total absorbed dose of fast neutron for putting it to the clinical use. At present the methods of measurement of fast neutron are proposed largely by American Associations of Physicists in Medicine, European Clinical Neutron Dosimetry Group, and International Commission on Radiation Units and Measurements. The complexity of measurement, however, induces the methodological differences between them. In our study, therefore, we tried to establish a unique technique of measurement by means of measuring the emitted doses and the dose distribution of fast neutron beam from neutron therapy machine, and to invent a standard method of measurement adequate to our situation. For measuring the absorbed doses and the dose distribution of fast neutron beam, we used IC-17 and IC-18 ion chambers manufactured by A-150 plastic(tissue-equivalent material), IC-17M ion chamber manufactured by magnesium, TE gas and Ar gas, and RDM 2A electrometer. The magnitude of gamma-contamination intermingled with fast neutron beam was about 13% at 5cm depth of standard irradiated field, and increased as the depth was increased. At the central axis the maximum dose depth and 50% dose depth were 1.32cm and 14.8cm, respectively. The surface dose rate was 41.6-54.1% throughout the entire irradiated fields and increased as the irradiated fields were increased. Beam profile was that the horn effect of about 7.5% appeared at 2.5cm depth and the flattest at 10cm depth.

면역 저하 환자에서 발생한 접형동 진균성 부비동염에 의한 안와 첨부 증후군 1예

지영훈,구수권,이화선,조규섭 대한이비인후과학회 부산,울산,경남 지부회 2023 임상이비인후과 Vol.34 No.4

Orbital apex syndrome (OAS) is a very rare syndrome caused by damage to the superior orbital fissure and optic canal. This syndrome is characterized by loss of vision, extraocular muscle paralysis, blepharoptosis, and hypoesthesia of the forehead due to damage to the optic nerve, pupillary nerve, trochlear nerve, abducens nerve, and trigeminal nerve branches. Various causes have been reported, including bacterial, viral and fungal infections, inflammation due to immunosuppressed conditions, tumors, and trauma. The authors report a case of OAS, which occurred as a complication of chronic invasive fungal infection with fungal ball of the isolated sphenoid sinus in an immunocompromised patient with multiple myeloma and diabetes, with a literature review.

Clinical Characteristics of Radiation Oncology in Korea during Past 10 Years

지영훈,유성열,조철구,김미숙,정해조 대한의학회 2009 Journal of Korean medical science Vol.24 No.6

To understand trends in the clinical characteristics of radiation oncology over the last 10 yr in Korea, annual survey questionnaires were sent to all of Korean radiation oncology facilities since 1990. Questionnaires addressed basic radiation therapy facilities and the clinical information. Responses were obtained from all facilities, and data collected from 1997 to 2006 was analyzed. The numbers of new patients that have undergone radiation therapy and the numbers of hospitals with a department of radiation oncology have steadily increased over the past 10 yr, and totaled 37,215 patients and 60 hospitals, respectively, in 2006. However, the proportion of patients irradiated among total cancer patients has remained below 30% over the last 10 yr. The numbers of prostate cancer, breast cancer, and hepatoma have increased by more than 3 fold over the past 10 yr. Moreover, the percentage of irradiated patients treated by brachytherapy was 10.3% in 1997, but this gradually fell to only 4.2% in 2006. The information collected described the role played by radiation oncology in Korea. Continuous surveys are required to enable trends to be detected.

비중격만곡증과 이관기능의 연관성에 대한 연구

지영훈,우주영,정남윤,고태경,구수권 대한이비인후과학회 부산,울산,경남 지부회 2023 임상이비인후과 Vol.34 No.3

Background and Objectives: This study is designed to examine the correlation of the direction of the nasal septum deviation (NSD) and Eustachian tube dysfunction (ETD). Since the Eustachian tube lies between the middle ear and the nasopharynx, we presumed that the direction of the NSD causes narrowing of certain parts of the nasal cavity and can cause the ETD. Materials and Methods: We recruited 50 NSD patients who were in need of septoplasty. We run the test of nasal endoscopy, oto-endoscopy, computed tomography, and Eustachian function test and looked into the correlation of the direction of the NSD and ETD. Results: There were no correlation between the direction of NSD and the side effected by ETD. Conclusion: Narrowed nasal cavity due to NSD is thought to take effect to the pathogenesis of ETD. However, this study has several shortcomings such as small number of enrolled patients and lack of diversity in measuring of Eustachian tube function. Further studies with more patients and detailed considerations are needed, and we plan to design a study that might yield different results.

Co-60 감마선에 대한 부정형조사면의 조직공중선량비(TAR) 계산

이수용,김채옥,김필수,지영훈 漢陽大學校 基礎科學硏究所 1988 基礎科學論文集 Vol.7 No.-

방사선치료에 사용되는 대표적인 부정형조사면 다섯가지에 대한 각 관심점에서의 선량계산을 위하여 새로 고안한 도표를 사용하여 Co-60감마선에 대한 부정형조사면의 조직공중선량비(TAR)를 계산하였다. 도표를 이용한 계산과 기존의 계산법인 컴퓨터계산법 및 근사법으로 구한 TAR를 측정에 의한 TAR에 비교하여 다음과 같은 결과를 얻었다. 관심점이 방사선속의 중심축상에 있을 때 부정형조사면에서 이들 방법으로 구한 TAR의 대부분은 오차가 1% 이내에서 잘 일치되어 있으며, 축으로부터 벗어난 경우에는 최대 오차가 각각 2.4%,2.3%, 및 8.8% 이었다. 이들 결과로부터 새로 고안한 도표를 이용한 계산법의 정확성을 확인하였다. In order to calculate the dose on each interest point in five types of irregularly shaped fields used commonly in radiotherapy, the tissue-air ratios (TAR) in these fields for Co-60 gamma radiation were calcnlated using the newly devised SAR-chart. The TARS calculated from newly method of using the SAR-chart. computer method and approximation method at the interest point were compared to the TARs obtained from measurement. The result are as follows: In case of the interest points on central axis the calculated TARs in irregularly shaped fields by the above metioned methods were well agreed within the error of 1%, whereas for the interest points on off-axis the calculated TARs were resulted in the maximum errors of 2.4%, 2.3% and 8.8% respectively. From these results, the accuracy of calculation method of using the SAR-chart was comfirmed.

노약자 보행지원을 위한 착용형 로봇 알고리즘 연구

지영훈(Y. H. Ji),한창수(C. S. Han),한정수(J. S. Han),장혜연( H. Y. Jang),이재영 (J. Y. Lee),임동환 (D. H. Lim),신찬수(C. S. Shin) 한국정밀공학회 2013 한국정밀공학회 학술발표대회 논문집 Vol.2013 No.5월