인체 영상용 방사성의약품의 개발

지대윤 한국공업화학회 2003 공업화학 Vol.14 No.3

삼차원적인 방법으로 인체 영상을 통한 진단법이 개발된 후 형태학적 소견 외에 분자수준의 생화학적 정보를 얻을 수 있는 영상진단법이 요구되어 왔으며 이러한 목적에 부합되는 생화학적 영상진단법으로 단일광자방출전산화단층촬영술(single photon emission computed tomography: SPECT) 및 양전자방출단층촬영술(positron emission tomography: PET)이 개발되어 활용되고 있다. SPECI'과 PET 영상진단에 편수적인 요소는 해당 기능을 가진 방사성 동위원소로 표지화된 의약품의 주입이 전제되어야 한다. 이러한 기술을 동하여 인체내의 특정한 장기내의 생화학적 변화를 단백질의 농도 측정을 통해 알 수 있기 때문에 이때 표지화기술과 방사성의약품 개발은 가장 중요한 연구과제가 될 것이다. 이 총설은 방사성의약품을 개발하기 위한 전반적인 개념과 몇가지 실 예를 선명하고자 한다. After the development of techniques to image the human subjects in a three-dimensional direction, two maior techniques-SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) have been used widely for imaging of human body to find the biological changes. The mechanism of these two techniques is to detect a single photon or annihilation photons emitted from the subjects injected with radiopharmaceuticals. It may be very important research project to develop selective methods of labeling with radionuclides and to develop new radiopharmaceuticals, because these two techniques can measure the density of receptors, enzymes and transporters in living human. In this paper, the basic concepts for the development of radiopharmaceuticals will be explained how to develop new radiopharmaceuticals including many examples.

Aromatic Fluorination by Decomposition of Triazenes in Ionic Liquids

지대윤,Chan-Kook Chu,Jong-Hwan Kim,Dong Wook Kim,Kyoo-Hyun Chung,John A. Katzenellenbogen 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.4

The aromatic fluorination method involving the acid-catalyzed decomposition of a triazene in an ionic liquid is a very convenient and efficient way to prepare a variety of aromatic fluorides in a lab-scale. It should be particularly useful for the preparation aryl fluorides substituted with electron withdrawing substituents. Fluorination of triazene 1 (1.0 mmol) and p-toluenesulfonic acid (1.2 mmol) in an ionic liquid, 1-butyl-3-methylimidazolium tetrafluoroborate ([bmim][BF4], 2.5 mL) proceeds very smoothly at 80 oC with or without an external source of fluoride, providing 73% yield in 30 min. Unlike diazonium salts, triazene precursors are stable enough to be stored for a long period of time without a noticeable decomposition.

도파민운반체 방사성추적자 N-(3-[18F]Fluoropropyl)-2 -carbomethoxy-3 -(4-iodophenyl)nortropane 의 합성

지대윤,오승준,이경한,최용,김병태,김상은,최연성 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3

$quot;Purpose: N-(3-[(18)^F]Fluoroporpy)-2β- carbomethoxy-3β-(4-iodophenyl) nortropane ([(18)^F]FP-CIT) has been shown to be very useful for imaging the dopamine transporter. However, synthesis of this radiotracer is some what troublesome. In this study, we used a new method for the preparation of [18F]FP-CIT to increase radiochemical yield and effective specific activity. Materials and Methods: [(18)^F]FP-CIT was prepared by N-alkylation of nor-β-CIT (2 mg) with 3-bromo-l-[18F]fluoropropane in the presence of Et3N (5-6 drops of DMF/CH3CN, 140℃, 20 min). 3-Bromo-l-[(18)^F]fluoropropane was synthesized from 5 μL of 3-bromo-l-trifluoromethanesulfonyloxypropane (3-bromopropyl -l-triflate) and nBu4N18F at 80℃. The final compound was purified by reverse phase HPLC and formulated in 13% ethanol in saline. Results: 3-Bromo-l-[18F]fluoropropane was obtained from 3-bromopropyl-l-triflate and nBu4N18F in 77-80% yield. N-Alkylation of nor-β-CIT with 3-bromo-l-[(18)^F]fluoropropane was carried out at 140℃ using acetonitrile containinl volume of DMF as the solvents. The overall yield of [(18)^F]FP-CIT was 5-10% (decay-corrected) with a radiochemical purity higher than 99% and effective specific activity higher than the one reported in the literature based on their HPLC data. The final [(18)^F]FP-CIT solution had the optimal pH (7.0) and it was pyrogen-free. Conclusion: In this study, 3-bromopropyl-l-triflate was used as the precursor for the [(18)^F]fluorination reaction and new conditions were developed for purification of [(18)^F]FP-CIT by HPLC. We established this new method for the preparation of [(18)^F]FP-CIT, which gave high effective specific activity and relatively good yield.

초소수성 특성을 가진 수직관 내부 응축 분석 연구

지대윤(Dae-Yun Ji),김진섭(Jinseop Kim),임휘진(Whijin Lim),이권영(Kwon-Young Lee) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12

Increasing efficiency of the plant cycle is one of the solutions of energy problem. The performances of condensation in heat transfer system have significant effect on efficiency of the plant cycle. At the condensation part, we could increase the condensation heat transfer coefficient by the surface modification. We designed the thermosiphon that can evaluate the condensation heat transfer coefficient of the superhydrophobic aluminum tube. A test sample was the inner-vertical tube that it had out-diameter of 25.4 mm and length of 400 mm. In addition, experimental facility was designed to compare condensation performance of bare and super-hydrophobic tube. The surface modification method was Self Assembled Monolayer (SAM) coating. Variables of the experiments were heat inputs and Reynolds number of coolant. As a result, simulation results about the condensation heat transfer coefficient and saturated pressure were obtained based on designed experimental facility. The simulation result was analyzed compared to previous researches. The experiment will be carried out, and experimental results are going to be compared with simulation results.

초소수성 코팅 튜브에서의 비응축가스 영향에 대한 응축 열전달 연구

지대윤(Dae-Yun Ji),김대호(Daeho Kim),이권영(Kwon-Yeong Lee) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.4

본 연구의 목표는 수평 관외 초소수성 튜브에서 비응축가스(NCG)의 영향을 관찰하고, 이를 일반 알루미늄 튜브의 응축 현상과 비교하는 것이다. 초소수성 튜브 제작을 위해 Self-Assembled Monolayer(SAM) 코팅으로 알루미늄 튜브의 외부를 표면개질 했다. 응축 성능을 나타내기 위해 총합 열전달계수를 사용하였고, 이 값으로 응축 성능을 비교 검토하였다. 본 연구의 주요 변수는 비응축가스 질량 분율로, 0.08에서 0.45의 범위에서 실험을 진행하였다. 응축 실험을 통해 비응축가스 질량 분율이 낮아질수록 응축 성능이 SAM 튜브와 일반 튜브에서 모두 향상되는 것을 확인했다. SAM 튜브에서 적응축 열전달 성능은 일반 튜브 대비하여 평균 약 1.9배에서 2.5배 정도 큰 것을 관찰하였다. SAM 튜브에서 비응축가스 질량 분율이 낮아지면서 응축 성능 상승폭이 감소하게 되는데, 이는 Flooded 응축 현상이 발현되었기 때문이다. 응축이 더 활발하게 진행되면 SAM 튜브에서 막응축이 일어나는 것을 관찰하였고, 이 때 성능은 일반 알루미늄 튜브보다도 저하된 성능을 보였다. SAM 알루미늄 튜브에서 Flooded 응축과 막응축이 일어나는 원인으로 표면에서의 Pinning 효과를 이용하여 설명하였다. 결론적으로, SAM 튜브를 실제 응축기에 적용해 표면개질로 인한 응축 성능 개선 효과를 얻기 위해서는 적응축 또는 Flooded 응축이 일어나는 조건으로 응축기 내 환경 조성을 해야 한다. This purpose of this research is to observe the influence of non-condensable gas (NCG) on a horizontal super-hydrophobic aluminum tube and compare it with a bare aluminum tube. To achieve super-hydrophobic characteristics, an aluminum tube was coated with a Self-Assembled Monolayer (SAM). The overall heat transfer coefficient U was used to represent the condensation performance. The NCG mass fraction was the main variable, and its range was 0.08 to 0.45. The condensation performance of the SAM tube and bare tube increased with decreasing mass fraction of NCG. The SAM tube showed 1.9 to 2.5 times larger dropwise condensation performance than the bare tube. When the mass fraction of NCG decreased in the SAM tube, the rate of increase of the SAM tube was lower because flooded condensation occurred. In addition, filmwise condensation occurred in the SAM tube when more active condensation was generated, and its performance was lower than that of the bare aluminum tube. The flooded and filmwise condensation in the SAM tube is explained by the pinning effect. In conclusion, controlling the condition of the condenser is necessary to improve the condensation performance by surface modification a SAM.

도파민과 세로토닌 운반체 및 수용체 영상을 위한 방사선리간드

지대윤(Dae Yoon Chi) 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.3

In the 1980s, techniques to image the human subjects in a rhree-dimensiona1 direction were developed, Two major techniques are SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) which allow the detector to detect a single photon or annihilation photons emitted from the subjects injected with radiopharmaceuticals. Since the latter two techniques can measure the density of receptors, enzymes and transporters in living human, it may be very important project to develop selective methods of labeling with radionuclides and to develop new radiopharmaceuticals. There has been a considerable interest in developing new compounds which specifically bind to dopamine and serotonin receptor and transporters, and it will be thus very useful to label those compounds with radionuclides in order to gain a better understanding in biochemical and pharmacological interactions in living human. This review rnentions the characteristics of radioligands for the imaging of dopamine and serotonin receptors and transporters. Although significant progress has been achieved in the development of new PET and SPECT ligands for in vivo imaging of those receptors and transporters, there are continuous needs of new diagnostic radioligands, (Korean J Nucl Med 2000;34:159-68)

소규모 사이펀 차단기에 대한 실험적 연구

지대윤(Dae-Yun Ji),김성훈(Sung hoon Kim),이권영(Kwon-Yeong Lee) 한국산학기술학회 2018 한국산학기술학회논문지 Vol.19 No.5

본 연구는 Siphon Breaker Simulation Program(SBSP)을 이용하여 소규모 사이펀 차단기 실험장치를 설계 및 제작하고, 실험 수행 후 그 결과를 이용하여 다양한 규모의 사이펀 차단기에 대한 SBSP의 적용 가능성을 평가하기 위해 진행되었다. 실험장치 설계를 위하여 C factor와 Chisholm B 계수, Undershooting Height(UH)에 대한 시뮬레이션 결과값을 SBSP로 도출하였다. 실험장치의 중요파트는 upper tank, lower tank, downcomer, Siphon Breaker Line(SBL) 등이며, upper tank는 넓이 0.09-㎡, 높이 0.65-m의 크기로 제작되었고, downcomer 높이는 1.6-m로 제작되었다. 실험결과 분석을 위하여 압력계, 차압계, 전자저울이 사용되어 압력과 차압, 유량에 대한 정보를 도출하였다. 실험에서 사용된 실험변수는 Loss Of Coolant Accident(LOCA) 크기와 SBL 크기이며, LOCA는 30-mm와 38-mm에 대해서, SBL은 6/16-inch와 8/16-inch에 대해서 실험이 진행되었다. 실험의 결과로 유량과 압력, 그리고 UH를 도출하였으며, 실험결과를 SBSP의 시뮬레이션 결과와 비교, 분석하였다. UH 측면에서 SBSP가 수조의 총 높이 대비 2.5 %의 오차로 실험결과를 잘 예측하는 것을 관찰하였다. 그러므로 SBSP를 이용한 다양한 규모의 사이펀 차단기 설계가 가능한 것을 확인하였다. In this study, a small-scale siphon breaker experimental facility was designed to examine the validity of the Siphon Breaker Simulation Program (SBSP). To design the experimental facility, the simulation results of the C factor, Chisholm B coefficient, and Undershooting Height (UH) were obtained by SBSP. The major parts of the experimental facility were the upper tank, lower tank, downcomer, and Siphon Breaker Line (SBL). The area of the Upper tank was 0.09-㎡ with a height of 0.65-m. The height of the downcomer was 1.6-m. Pressure transmitters and an electronic scale were used to obtain the experimental results. The experimental variables were the sizes of Loss of Coolant Accident (LOCA) and SBL. The experimental results were analyzed by UH. The SBSP well predicted the UH with an error of 2.5%. Overall, it is possible to design siphon breakers with various scales using SBSP.

Novel Homo - and Heterodimeric Bis - bidentate (NS)2 Technetium (Ⅴ) Complexes . An Approach to Metal Complexes that Mimic Steroid Hormones

지대윤 ( Dae Yoon Chi ) 한국공업화학회 1995 한국공업화학회 연구논문 초록집 Vol.1990 No.3

F - 18 이온과 F - 18 fluorodeoxyglucose 복합투여 양전자방출단층촬영 (PET) 에 의한 뼈 . 연조직의 동시영상

김병태,지대윤,최용,양정현,김상은 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.2

양전자방출단층촬영 (PET) 에서 회전 핀선원과 투과 및 방출 동시영상방법을 이용한 감쇠 보정방법 특성에 관한 고찰

김병태,지대윤,최용,신승애,이정림,김상은 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.2