http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
주현수,한덕재,이재하,이진국 대한결핵및호흡기학회 2018 Tuberculosis and Respiratory Diseases Vol.81 No.4
Background: Roflumilast is the only approved oral phosphodiesterase-4 inhibitor for the treatment of severe chronic obstructive pulmonary disease (COPD) in patients with chronic bronchitis and a history of frequent exacerbations. The purpose of this study was to examine the incidence of adverse effects associated with roflumilast treatment in a real-world setting. Further, we compared the incidence of adverse effects and the discontinuation rate among patients receiving different doses. Methods: We identified all outpatients diagnosed with COPD at Seoul St. Mary’s Hospital between May 2011 and September 2016 and retrospectively reviewed their medical records. Roflumilast was prescribed to patients in doses of 500 mg and 250 mg. Results: A total of 269 COPD patients were prescribed roflumilast in our hospital during the study period. Among them, 178 patients were treated with 500 mg and 91 patients were treated with 250 mg. The incidence of adverse effects was 38.2% in the 500 mg group and 25.3% in the 250 mg group (p=0.034). The discontinuation rate of roflumilast was 41.6% (n=74) in the 500 mg group and 23.1% (n=21) in the 250 mg group (p=0.003). When adjusted by age, sex, smoking status, and lung function, 500 mg dose was significantly associated with the discontinuation of roflumilast (odds ratio, 2.87; p<0.001). Conclusion: There was a lower incidence of adverse effects and discontinuation among patients treated with 250 mg compared with 500 mg dose. Further studies regarding the optimal dose of roflumilast are required.
Characteristics of Asthma-COPD Overlap Syndrome Phenotype Groups
주현수,김세원,이화영,최준영,강지영,김승준,김석찬,이숙영,김영균,이진국 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background : Study of the classification and clinical feature of ACOS has been steadily. We previously proposed 4 phenotypes of ACOS according to eosinophilic inflammation, history of allergic disease, and smoke exposure. Each phenotype has a different underlying pathophysiology. And this approach is easily applicable in clinical practice. According to these phenotypes, we categorized patients and studied about the features. Methods : Patients with ACOS were eligible if their post-bronchodilator FEV1/FVC ratio is less than 0.70 and have positive response of brochondilator. The enrolled patients were divided into four phenotype groups according to blood eosinophil counts and smoke history. Results : In each of the four groups (ACOS phenotype A, B, C, D) it belonged 24, 18, 40, 21 patients. The mean age in each groups were 59±3.05, 62±2.69, 68±1.69, 70±2.66, respectively. And the percentage of male patients were 41.6%, 27.7%, 100%, 95.2%, respectively. There were relatively more female subjects in group A and B, but the majority of subjects in group C and D were male. The mean FEV1(%) in each groups were 67.0%, 58.9%, 62.8%, 61.9%, respectively, while FEV1/FVC were 63.1%, 62.5%, 51.5%, 53.8% respectively. Phenotype C group had the lowest mean FEV1/FVC. ICS+LABA was the most commonly used inhaler in all phenotype groups, while the percentage of LAMA usage was 20.8%, 33.3%, 40.0%, 52.4%, respectively. Conclusions : Our results showed differences in PFT values and medications usage according to ACOS phenotypes, which should be taken into consideration during treatment.
주현수 한양대학교 경제연구소 2017 JOURNAL OF ECONOMIC RESEARCH Vol.22 No.1
During a sudden stop period in developing countries, the subsequent productivity drop is an interesting yet unexplained phenomenon. By assuming different capital levels for production, we show that a lack of capital caused by a sudden stop in developing countries may lead to a drop in output production and productivity. Furthermore, the optimal level of international reserves under an economy with indivisible technology increases more than the level under a benchmark economy with divisible technology because the cost of a sudden stop is larger.
주현수,김성호,이우범 한국환경생물학회 2002 환경생물 : 환경생물학회지 Vol.20 No.2
강진만 해역의 6개 조사정점을 대상으로 1998년 2월부터 1998년 10월까지 계절별로 이화학적 환경요인과 일차생산력을 측정하였다. 일차생산력은 NaH^14CO_3을 이용한 배양방법을 사용하였고, 조사결과 2.78㎎Cm^-3Hr^-1의 범위를 나타났으며, 계절별 일차생산력의 변화는 하계, 동계, 추계의 순으로 나타났다. 조사정점별로는 강진만의 상류수역에 해당되는 정점 1과 2에 비해 3,4,5 및 6의 조사결과가 크게 나타났다. Chlorophyll a의 분포는 평균 5.16~17.90㎎m^-3를 나타났으며 계절별로는 하계에, 정점별로는 정점4에서 높게 나타났다. 일차 생산력과 Chlorophyll a 의 분포, 수중광도와는 정상관을, 부유물질과는 역상관을 보였으며 강진만의 일차생산력의 변화는 상류수역인 탐진강으로부터 유입되는 담수에 의해 크게 영향을 받고 있는 것으로 생각된다. The primary productivity and physicochemical factors were surveyed seasonally in Gangjin bay from February to October in 1998. The determination of the primary productivity was performed in situ be isotope-method using NaH^14CO_3. The range of primary productivity was 2.78 ㎎C m^-3 hr^-1∼4.92 ㎎C m^-3hr^-1 according to seasons. The primary productivity showed the highest value in summer, followed by those of winter, autumn and spring. The primary productivities of station 1, 2 which are located the upper area, were lower than those of station 3, 4, 5 and 6. The correlations showed that the primary productivity correlated with chlorophyll a, underwater light intensity but reversely correlated with suspended solids. These results suggested that the primary productivity in Gangjin Bay was mainly influenced by the inflow of freshwater from Tamjin River.