X-선 조사에 의한 폐 탄력조직의 초미형태학적 변화

주양구,신현호,곽정식 慶北大學校 醫科大學 1995 慶北醫大誌 Vol.36 No.1

목적 : X-선 조사후 초기에 폐에서 일어나는 탄력섬유의 변화를 전자현미경적으로 검색하여 그 변화의 형태학적 본태와 기전을 규명하고자 본 연구를 시행하였다. 재료 및 방법 : 체중 약 2㎏ 정도의 토끼에 6MV linear accelerator에서 100㎝ 거리 20×20㎝ 넓이의 조건으로 2,000 rad를 15분 동안 가슴을 중심으로 1회 전신조사한 후 1일, 2일 및 4일째에 생존한 토끼를 각각 3마리씩 폐조직을 전자현미경적으로 관찰하였으며 탄력섬유를 검색하기 위해 Kajikawa 염색을 시행하였다. 결과 : X-선 조사후 2일에서 elastin의 분절이 부분적으로 일어났으며 4일후부터 미세섬유를 가진 작은 elastin이 출현하였다. X-선 조사후 폐포내 및 폐포벽에는 대식세포와 호중구가 약간 침윤되었다. 결론 : X-선 조사 후 탄력섬유의 초기의 변화는 분절현상이며 그 이후 곧 신생될 것이라 생각된다. 그리고 X-선 조사에 의한 탄력섬유의 미세구조의 변화는 유리기에 의한 것으로 생각된다. This study was carried out to investigate the early ultratructrual changes of elastic fibers of the lungs after X-ray irradiation and its pathogenesis. The rabbits averaging 2.0㎏ in weight were irradiated 2,000 rad in dose of X-ray for 15 minutes on chest. Irradiation was carried out 100㎝ in distance from 6 MV linear acceleraor with 20×20 ㎠ in covering areas. The lungs were examined 1, 2, and 4 days after irradiation by light and electron microscopy. Kajikawa stain was performed for demonstration of elastic fibers. The results were as follows: On light microscopy, congestion and mild infiltration of alveolar macrophages and neutrophils appeared after irradiation. On electron microscopy, partial fragmentation of elastin was developed after 2 days of irradiation. Small amount of elastin having microfilaments appeared at 4 days after irradiation. And also was infiltration of alveolar macrophages and neutrophils. Thes findings suggest that the earliest change of elastic fibers after irradiation is fragmentation of fibers. Synthesis of elastin is possible in this early period, and damage of elastin is caused by free radical produced by X-ray irradiation.

X-線 照射에 의한 肺彈力組織의 超微形態學的 變化

朱亮求,郭精植,孫泰重 慶北大學校 醫科大學 1988 慶北醫大誌 Vol.29 No.2

This study was carried out to investigate the early ultrastructural changes of elastic fibers of the lungs after X-ray irradiation and its pathogenesis. The rabbits averaging 2.0㎏ in weight were irradiated 2000 rad in dose of X-ray for 15 minutes on the chest. Irradiation was carried out 100 ㎝ in distance from 6 MV linear acceleraor with 20×20㎠ in covering areas. The lungs were examined 1, 2, and 4 days after irradiation by light and electron microscopy. Kajikawa stain was performed for demonstration of the elastic fibers. The results were as follows: On light microscopy, congestion and mild infiltration of alveolar macrophages and neutrophils appeared after irradiation. On electron microscopy, partial fragmentation of elastin was developed after 2 days of irradiation. Small elastin having microfilaments appeared 4 days after irradiation. And also was infiltraion of alveolar macrophages and neutrophils. These findings suggest that the earliest changes of the elastic fibers after irradiation is fragmentation of fibers. Synthesis of elastin is possible in the early period, and damage of elastin is caused by free radicals produced by X-ray irradiation.

뇌종양에서의 역동적 자기공명영상의 유용성

주양구,서수지,전석길,우성구,김홍,김정식,이성문,이희정,무쯔마사 다까하시,Joo, Yang-Gu,Seo, Soo-Jhi,Zeon, Seok-Kil,Woo, Sung-Ku,Kim, Hong,Kim, Jung-Sik,Lee, Sung-Moon,Lee, Hee-Jung,Takahashi, Mutsumasa 대한영상의학회 1994 대한영상의학회지 Vol.30 No.4

미만성 축색손상의 자기공명상

주양구 대한영상의학회 1992 대한영상의학회지 Vol.28 No.1

CT has facilitated early recognition and treatment of focal brain injuries in patients with head trauma. However, CT shows relatively low sensitivity in identifying nonhemorrhagic contusion and injuries of white matter. MR is known to be superior to CT in detection of white matter injuries, such as diffuse axonal injury. MR imaging in 14 cases of diffuse axonal injury on 2.0T was studied. The corpus callosum, especially the body portion, was the most commonly involved site. The lesions ranged from 5 to 20mm in size with ovoid to elliptical shape. T2WI was the most sensitive pulse sequence in detecting lesions such as white matter degeneration, hemorrhagic and nonhemorrhagic contusion. The lesions were nonspecific as high and low signal intensities on T2WI and T1WI respectively. CT showed white matter abnormality in only 1 case of 14 cases. We propose MR imaging as the primary imaging procedure for the detection of diffuse axonal injury because of its multiplanar capabilities a d higher sensitivity.

뇌신경절교종이 전산화 단층촬영 및 자기공명영상소견

주양구 대한영상의학회 1995 대한영상의학회지 Vol.33 No.6

간외담관암의 내시경적 역행성 담췌관 조영술 소견

주양구 대한영상의학회 1982 대한영상의학회지 Vol.18 No.4

In the diagnosis of bile duct carcinoma, oral or intraveous cholangiography is of no air in the majority of patients with bile duct carcinoma who are jaundiced. Recently ultrasonography and computed tomography are widely used for evaluation of biliary disease, but dircet visualizing methods of the biliary tract by ERCP and PTC gives more detailed information and exact localization of the lesion. ERCP is less invasive and dangerous and has some more advantages than PTC. We analyzed 33 cases of confirmed extrahepatic bile duct carcinoma who were performed ERCP. The results were as follews: 1. The 7th decade was the predilection age, and the radio of male to female was 3.1:1. 2. The locations of extrahepatic bile duct carcinomas were common bile duct in 45.5%. common hepatic duct in 27.3%, junction of cystic duct and widely extended in 12.1% respectively and junction of hepatic duct in 3.0% in order of frequency. 3. ERCP finding of extrahepatic bile duct carcinomas revealed complete obstruction of bile duct in most cases, and irregular margined protuberant type was more common than smooth margined constricted type at obstruction site. 4. ERCP finding according to the location of lesion showed that protuberant type was relatively frequent in common bile duct and constricted type in common hepatic duct respectively.

고해상력 전산화단층촬영의 측두골 골절소견

주양구 대한영상의학회 1990 대한영상의학회지 Vol.26 No.2

The common serious consequences of trauma to the temporal bone are hearing loss, hemotympanum and facial nerve paralysis. To minimize or prevent these sequelae, accurate radiological evaluation is necessary as soon after injury as possible. High resolution CT of the temporal bone delineate the fine structures of the middle and inner ear including ossicular chain. Excellent resolution of density differences among the soft tissue is the main advantage over conventional tomography. 21 cases of temporal bone fracture were examined at Keimyung university hospital for recent 18months. The results were as follows; 1. The sex distribution of cases were 18 males and 3 females, and most common in the third decade(42.9%). 2. The most common cause was motor vehicle accident(71.4%). 3. The most common type of fracture was longitudinal(81%). 4. clinical symptoms and signs were hearing loss, hemotympanum and facial nerve paralysis in order of frequency. 5. 5 conductive hearing loss were note in 12 hearing loss of 17 longitudinal fractures. 6. The ossicular changes were noted only in longitudinal fracture, such as 3 incudostapedial separation, 2 incudomalleal separation and 1 incus dislocation

啓明大學敎 醫科大學 放射線科學敎室

金洪,徐修之,李珍雨,朱亮求 啓明大學校 醫科大學 1988 계명의대학술지 Vol.7 No.2

It is important to determine the normal range of the spinal cord dimension for screening or localizing spinal pathologic processes which could change the size of cord, such as intramedullary tumor, syringomyelia, radiation and trauma. Although CT has been used extensively for the evaluation of spinal disease, the spinal cord cannot be defined from th subarachnoid space and dura without intrathecal injection of a contrast medium. A few studies have been reported that determined the dimensions of normal spinal cord and subarachnoid space, and moreover, a cross-sectional area of the thoracic cord has not yet been known. CT measurements of coronal and sagittal diameters including the coss-sectional area in the thoracic spines were obtained in 31 cases of normal Korean adults who were undergoing the contrast (Isovist) myelography without any pathology in the thoracic spines. The results were as follows: 1. The transverse diameters of the thoracic cord were 9.1mm(SD 1.1) in level (T1), 7.9mm(SD 0.8) in level 2(T5) and 7.3mm(SD 0.7) in level 3(T9). The sagittal diameters were 7.0mm(SD 0.9) in level 1, 6.1mm(SD 0.8) in level 2, and 6.3mm(SD 0.7) in level 3. 2. The transeverse diameters of the thorthratic subarachnoid space were 15.8mm(SD 1.4) in level 1, 14.3mm(SD 1.6) in level 2, and 13.9mm(SD 1.3) in level 3. The sagittal diameters were 12.9mm(SD 1.5), 12.3mm(SD 1.6) and 11.6mm(SD 1.5) in order of the levels. 3. The cross-sectional areas of the thoracic cord and the subarachnoid space were 58.0㎟(SD 7.5) and 165.4㎟ (SD 27.5) in level 1, 46.4㎟(SD 6.2) and 147.1㎟(SD 27.3) in level 3 separately. 4. The shape of the thoracic cord was elliptical in the upper thoracic spines, then became more round in the lower thoracic levels. The cross-sectional area of the thoracic cord is relatively smaller in the midthoracic spines than those of the upper and lower thoracic spines.

경추의 퇴행성 변화와 추간판 탈출증에 의한 이차적 소견의 자기공명 영상

주양구,우영훈 啓明大學校 醫科大學 1991 계명의대학술지 Vol.10 No.4

Magnetic resonance(MR) images of the cervical spine show anatomic detail and pathologic changes unlike any other imging modality. The authors reviewed MR images of 140 patients referred for cervical spondylosis. Fatty marrow changes were identified in 582 cervical spines(69%). The changes were independent of age and sex distribution and other degenerative changes. Disc herniations referring to extrusion of disc material beyond the posterior vertebral line were identified in 216 levels. Cord compressions referring to a concave defect in the spinal cord adjacent to a site of lesion were identified on T1 weighted image in 152 levels. Cord signal changes referring to a high signal intensity within the spinal cord on T2 weighted image were observed in 27 patients 51 levels. MR images can provide sharply defined anatomic delineation and tissue characterization of the cervical spine, and then evidence of degenerative change of cervical spine and secondary effect of cervical disc herniation may be regarded.

간질환자들의 자기공명영상소견

주양구,손철호 啓明大學校 醫科大學 1995 계명의대학술지 Vol.14 No.4

To evaluate the causes of the epileptic seizure and the usefulness of the MR imagings for detection, localization, and differentiation of structural epileptogenic abnormalities. We retrospectively reviewed 101 patients who had seizure episodes and had undergone brain MRI for recent 1 years. The causes of the seizure were classified into brain atrophy, traumatic or post-operative lesions, congenital or developmental anomaly, tumor, vascular malformation, white matter disease, infectious disease and others. The location of the lesions were classified onto diffuse, frontal, parietal, temporal, occipital and others. Fourty-two of the 101 patients had brain atrophy, 23 patients had lesions secondary to trauma or surgery, 12 had congenital or developmental anomaly, seven had tumor, six had vascular malfomation, four had white matter disease, two had infectious disease, and five others had two arachnoid cysts, one hydrocephalus, one eclampsia, and one tuberous sclerosis. The lesions were located at the parietal lobe in 17 patients, frontal lobe in 15, temporal lobe in 21, and occipital lobe in four. MR imaging is the technique of choice when examining a patient who is having seizures. Detection, localization, and differentiation of structural epileptogenic abnormalities are much better with MR imaging than other diagnostic method.