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조장희 대한의용생체공학회 1986 의공학회지 Vol.7 No.2
Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined.p was also examined.
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조장희,김남범,배성봉,지제근,오가와세이지,박찬웅,김영보 대한의학회 2014 Journal of Korean medical science Vol.29 No.10
The two basic scripts of the Korean writing system, Hanja (the logography of the traditionalKorean character) and Hangul (the more newer Korean alphabet), have been used togethersince the 14th century. While Hanja character has its own morphemic base, Hangul beingpurely phonemic without morphemic base. These two, therefore, have substantiallydifferent outcomes as a language as well as different neural responses. Based on theselinguistic differences between Hanja and Hangul, we have launched two studies; first wasto find differences in cortical activation when it is stimulated by Hanja and Hangul readingto support the much discussed dual-route hypothesis of logographic and phonologicalroutes in the brain by fMRI (Experiment 1). The second objective was to evaluate howHanja and Hangul affect comprehension, therefore, recognition memory, specifically theeffects of semantic transparency and morphemic clarity on memory consolidation andthen related cortical activations, using functional magnetic resonance imaging (fMRI)(Experiment 2). The first fMRI experiment indicated relatively large areas of the brain areactivated by Hanja reading compared to Hangul reading. The second experiment, therecognition memory study, revealed two findings, that is there is only a small difference inrecognition memory for semantic transparency, while for the morphemic clarity was muchlarger between Hanja and Hangul. That is the morphemic clarity has significantly moreeffect than semantic transparency on recognition memory when studies by fMRI incorrelation with behavioral study.
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조장희,최돈승,이태희 한국경영컨설팅학회 2018 경영컨설팅연구 Vol.18 No.2
본 연구는 제주 관광 수요의 시계열 자료를 사용하여 통계적 특성을 확인하고 관광 수요 예측에 적합한 모형을 도출한다. 이를 위해 본 연구는 선행연구에서는 주로 다루고 있는 ARMA 모형과 주기성 변수의 비선형적 특성을 반영하는 GAM을 고려하여 두 결과를 비교한다. 제주 관광객 수의 시계열 자료는 단위근 검정 결과 안정적인 시계열로 나타나 차분을 할 필요가 없어 ARIMA 모형이 아닌 ARMA 모형을 사용한다. 또한 각 모형을 통해 예측한 2017년 동안의 제주 관광 수요의 RMSE 값을 통해 모형의 예측력을 비교한다. 분석 결과에 의하면 선형적인 특성을 보이고 있는 내국인 관광객 수요를 예측할 때는 ARMA 모형의 예측력이 좋았지만, 일정한 추세를 확인하기 어려운 외국인 관광객 수요를 예측할 때는 비선형적 특성을 고려하는 GAM의 예측력이 더 좋은 것으로 나타났다. 이 결과는 제주 관광 특성에 의거하여 중국인을 비롯한 외국인 관광객의 중요성이 강조됨에 따라 정책적 의미를 갖는다. 또한 방법론의 적용 측면에서도 시계열 자료를 이용하여 수요를 예측할 경우 자료를 구성하고 있는 변수를 세분화하여 각각의 시계열 특성을 반영한 모형을 별도로 고려할 필요가 있음을 시사한다. This study forecast the tourism demand of Jeju island using the monthly time series data for the number of tourists(domestic and foreign), and compare the forecasting results and real work using two models, ARMA(or ARIMA) and GAM. The ARMA(or ARIMA) is a more popular to forecast time series data in previous studies, however we consider the non-parametric model(GAM) for adjusting nonlinear characteristics of periodic series, such as a world unobservable trend. We use a ARMA as a reference model, because the number of tourists in Jeju shows a stable time series after the unit root test. We also forecast using GAM, and compare the predictive power of the model through the RMSE value of tourist demand for 2017 in Jeju. The results show that the ARMA model has a good predictive power for forecasting the domestic demand, but the predictive power of the GAM is better when forecasting the foreign demand. And it give a important political implication about changing foreign tourism policy in a bid for Chinese tourists. Also, in terms of applying the methodology, it imply a separate consideration of the model that reflects the characteristics of each time series data.
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조장희,서성채,김귀연,김병기 한국정보처리학회 2005 한국정보처리학회 학술대회논문집 Vol.12 No.1
소프트웨어 개발에서 요구사항 분석에 대한 관리는 품질과 생산성에 중요한 역할을 한다. 기존 연구는 요구사항 분석단계에서 기능 중심으로 문제분석을 시도하고, 시험 및 구현단계에서 품질문제를 고려하고 있다. 본 논문에서는 요구사항을 추출하고 분석하는 단계에서 품질속성을 고려하는 요구분석 모델을 제안한다. 품질평가모형인 ISO/IEC 9126 품질속성으로 분석된 요구사항을 개발시스템의 이해와 사용자의 요구사항에 대한 만족도를 높일 수 있도록 카노(Kano)의 이원적 품질이론을 통해서 재분류함으로써 새로운 요구분석 방법을 제안한다.
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침의 치료기전에 대한 신경기반 및 신경기능 가설 -침자극과 관계된 신경기반 및 체액성 반응, 신경적 반응, 면역반응-
조장희,황선출,손영돈,강창기,박태석,배선준,성강경,Cho, Z.H,Hwang, S.C,Wong, E.K.,Son, Y.D,Kang, C.K,Park, T.S,Bai, S.J,Sung, K.K 대한침구의학회 2003 대한침구의학회지 Vol.20 No.5
Acupuncture therapy has demonstrated efficacy in several clinical areas, and of these areas the understanding of pain has progressed immensely in the last two decades. The underlying mechanisms of acupuncture in general and the analgesic effect in particular are still not clearly delineated. The leading hypothesis include the effects of local stimulation, neuronal gating, release of endogenous opiates, and the placebo effect. Accumulating evidence suggests that the central nervous system(CNS) is essential for the processing of these effects, via its modulation of the autonomic nervous system, neuro-immune system, and hormonal regulation. These processes tap into basic survival mechanisms. As such, understanding the effects of acupuncture within a neuroscience-based framework becomes vital. We propose a model which incorporates the stress-induced hypothalamus-pituitary-adrenal axis(HPA-axis) model of Akil et al., the cholinergic anti-inflamatory observations of Tracey et al., and Petrovic et al.
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