http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Design of Mussel-Inspired, Antibacterial Coatings through Non-Biofouling Approach
Woo Kyung Cho(조우경) 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
Bacterial colonies (i.e., biofilm) formed on solid surfaces has been recognized as a main cause for hospital-acquired infections, especially in connection with the use of medical diagnostic devices and therapeutic tools/implants that are contaminated by biofilms. To address the issues caused by hospital-acquired infections, we have developed the antibacterial materials that can work as non-biofouling coatings. Inspired by mussel, catechol-conjugated polysaccharides and functional derivatives of 3-(3,4-dihydroxyphenyl)-L-alanine (L-DOPA) were synthesized. The robust antibacterial coatings were accomplished by using oxidative polymerization and the coordination between catechol groups and iron(III) ions. The DOPA-based non-biofouling approach can also be applied for influenza virus immunoassay. We think that our work can serve as a basis to prepare antibacterial coatings for medical diagnostic devices and therapeutic tools.
조직접착성 소재로서의 갈릭산 함유 글리콜 키토산 유도체의 제조 및 특성 평가
박슬기(Seul Gi Park),이미현(Mei-Xian Li),엄지환(Ji Hwan Eom),서은영(Eun Yeong Suh),조우경(Woo Kyung Cho),정윤기(Yoon Ki Joung),허강무(Kang Moo Huh) 한국고분자학회 2021 폴리머 Vol.45 No.3
본 연구에서는 생체적합성이 우수한 글리콜 키토산에 생기능성 분자인 갈릭산(GA)을 화학적으로 결합하고, 자가-가교(self-crosslinking) 및 자가-치유(self-healing)가 가능한 갈릭산 함유 글리콜 키토산(GA-GC) 하이드로젤을 제조하였으며, 조직접착성 소재로의 응용 가능성을 평가하였다. GA의 반응 몰비를 조절하여 GA 함량이 서로 다른 일련의 GA-GC 유도체들을 합성하고, GA의 파이로갈롤기에 의한 자가-가교 반응을 통해 하이드로젤을 제조하였다. GA-GC 하이드로젤의 자가-치유 능력을 점탄성 분석을 통해 확인하였고, 하이드로젤의 GA 함량이 증가됨에 따라 압축강도와 조직 접착강도가 증가하는 것을 관찰하였다. 생분해성과 낮은 세포독성을 보임으로써 GA-GC 하이드로 젤은 조직접착성 생체재료로 유용하게 응용될 수 있을 것으로 기대된다. In this study, we developed self-crosslinkable and self-healing hydrogels by conjugating biocompatible and biodegradable glycol chitosan (GC) with biofunctional gallic acid (GA) and evaluated their potential application as a new tissue adhesive biomaterial. A series of GA-GC derivatives with different GA content were synthesized by varying the feed molar ratio of GA and their hydrogels were prepared via self-crosslinking reaction between pyrogallol groups of GA. The self-healing ability of GA-GC hydrogels was confirmed by rheological analysis, and their mechanical strength and tissue adhesion strength were observed to increase as the GA content of the hydrogels increased. The GA-GC hydrogels with biodegradability and low cytotoxicity would be useful as new tissue adhesive biomaterials.