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3T3-L1 지방세포 및 제2형 당뇨 마우스 모델에서 건지황 열수 추출물의 항당뇨 효능 연구
조란(Ran Jo),민정란(Jeong-Ran Min),정상희(Sang-Hee Jeong) 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.10
본 연구에서는 대표적인 한의서인 동의보감 및 방약합편에 수재된 농식품 소재 중 당뇨병과 같은 대표증상에 효과가 있는 것으로 소개된 건지황에 대해 3T3-L1 지방세포와 제 2형 당뇨질환모델인 C57BLKsJ-db/db 마우스에서 항당뇨 효과를 조사하였다. 건지황 열수 추출물을 제조하여 3T3-L1 지방세포에서 포도당 흡수능을 관찰한 결과, 3T3-L1 지방세포의 인슐린 감수성을 향상시켜 세포 내로의 포도당 흡수를 대조군 대비 약 2배 증가시켰다. 제2형 당뇨모델인 C57BLKsJ-db/db 마우스에 양성치료약물인 metformin(300 mg/kg bw/d), pioglitazone(20 mg/kg bw/d)과 건지황 열수 추출물(50, 500 mg/kg bw/d)을 4주간 각각 경구 투여한 후 항당뇨 효능을 평가한 결과, 체중감소량의 변화 없이 식이섭취량 및 음수섭취량이 감소하는 경향을 나타내었다. 공복혈당 및 HbA1c 수준은 건지황 열수 추출물을 투여했을 때 당뇨대조군에 비하여 유의적으로 감소시켰지만 경구 내당능은 당뇨대조군에 비하여 유의한 차이는 없었지만 개선하는 경향이 있었다. 혈중 인슐린 및 HOMA-IR 수준은 당뇨대조군에 비해 양성대조군 및 건지황 투여군에서 현저하게 낮은 수치를 나타내었으며, 혈중 중성지방 및 HDL-콜레스테롤 함량은 당뇨대조군에 비해 유의한 변화는 없었지만 총 콜레스테롤 농도는 유의한 감소를 나타내었다. 또한 조직에서 GCK mRNA 및 SLC2A2 mRNA 발현 정도가 유의적으로 증가하였으며, 특히 RG 500 mg/kg bw 투여군에서 제2형 당뇨병의 치료제인 Met 투여군과 비슷한 수준의 GCK 증가 효과가 확인되었다. 이러한 결과로 건지황 열수 추출물은 당뇨 증상 중 음수량, 음수횟수 증가 등을 완화시키고 지질대사 이상을 조절하면서 인슐린저항성을 감소시켜 혈당을 개선하므로 항당뇨 생리활성을 나타내는 식품소재로써 당뇨 개발의 가능성이 있을 것으로 사료되었다. Type 2 diabetes mellitus is characterized by a clinical disorder of sugar and fat metabolism caused by cellular insulin resistance. In our study, the anti-diabetic effects of water extract of Rehmannia glutinosa Libosch (RG) root (40, 200, 1,000 μg/mL) were investigated in mature 3T3-L1 adipocytes. RG root was found to increase glucose uptake under insulin (1 μM)-stimulation conditions but had no effects on glucose uptake without insulin in 3T3-L1 adipocytes. Additionally, the anti-diabetic effects of RG root were studied in a diabetes mellitus animal model (C57BL/KsJ-db/db) by oral ingestion of RG for 4 weeks (50, 500 mg/kg bw/d). During the experimental period, food intake, body weight, and fasting blood glucose level were measured every week. At the end of the treatment, oral glucose tolerance, blood glucose level, HbA1c, plasma insulin level, and blood profile parameters, including AST, ALT, TG, total and HDL-cholesterol levels, were measured. Treatment with RG root resulted in a lower blood glucose level, HbA1c, total cholesterol, ALT, oral glucose tolerance, and serum insulin levels. The mRNA expression of glucokinase (GCK) and solute carrier family 2 (SLC2A2) was significantly increased in liver tissue were reduced by water extract of RG. These results explains the anti-type 2 diabetic effects of water extract of RG.
학령전기 입원 아동의 보호자를 위한 QR 코드를 활용한 스마트폰 기반의 흡입요법 교육 자료 개발
조유리,황희전,조은진,황윤정,현정화,고우리,최소연,이종란,Jo, Yuri,Hwang, Heejeon,Jo, Eunjin,Hwang, Yunjeong,Hyun, Jeonghwa,Ko, U Ri,Choi, So Yeon,Lee, Chong Ran 부모자녀건강학회 2019 부모자녀건강학회지 Vol.22 No.1
Purpose: The purpose of this study is to develop educational material for parents of hospitalized preschool children who receive nebulizer therapy treatment. The educational material is aimed at providing information on the correct use of nebulizer. Methods: The development of educational material was based on the ADDIE model and consists of an A4-sized leaflet and a video. Results: The leaflet included basic information, procedures, and cautionary information for nebulizer therapy, as well as frequently asked questions. The one minute and fifty second video is accessed via QR code and provides step-by-step instruction on nebulizer therapy. Conclusion: This study recommends that the educational leaflet and video developed for nebulizer therapy use be provided to parents of preschool children hospitalized in the pediatric ward.
어떤 다발성 외상환자가 중환자실에 오래 있게 되는가?: Injury severity score와 손상부위 수의 비교
조무진 ( Mu Jin Jo ),이성화 ( Seong Hwa Lee ),조석주 ( Seok Ju Cho ),염석란 ( Seok Ran Yeom ),한상균 ( Sang Kyoon Han ),박성욱 ( Sung Wook Park ),이대섭 ( Dae Seop Lee ) 대한외상학회 2013 大韓外傷學會誌 Vol.26 No.2
Purpose: Injury severity score (ISS), a widely used scoring system, is used to define the severity of trauma in multiple-trauma patients. Nevertheless, ISS cut-off value for predicting the outcome of multiple-trauma patients has not been confirmed. Thus, this study was performed to determine the more useful method for predicting the outcome for multiple-trauma patients: the ISS or the number of anatomical Abbreviated injury scale (AIS) injury regions. Methods: for 195 consecutive patients who a regional emergency medical center, we analyzed the ISS and the number of anatomical AIS injury region. The patients were divided into four groups based on the ISS and the number of anatomical AIS regions. We compared intensive-care-unit (ICU) admission days and hospitalization days and ICU stay ratio (ICU admission days/hospitalization days) between the four groups. Results: In the groups with an ISS more than 17, the results were not significantly different statistically the group with 2 anatomical AIS injury regions and more than 3 anatomical AIS injury regions. Also, in the group with an ISS of 17 or less, the results were the same as those for patients with an ISS more than 17 (p>0.05). Among the patients with 2 anatomical AIS injury regions, patients with an ISS more than 17 patients had more ICU admission days and a higher ICU stay ratio than patients with an ISS 17 or less. Also, Among the patients with 3 anatomical AIS injury regions, the results were the same as those for patients with 2 anatomical AIS injury regions. Conclusion: Patients with high ISS, regardless of the number of anatomical AIS injury regions had significantly longer ICU stays and higher ICU admission ratio. Thus, the ISS may be a better method than the number of anatomical AIS injury regions for predicting the outcomes for multiple-trauma patients.
BIM 체계를 적용한 현대 한옥건축 모델러 개발에 관한 연구
조연준,조길환,Cho, Yeon-Jun,Jo, Gi-Ran 한국주거학회 2008 한국주거학회 논문집 Vol.19 No.6
In the construction field, there has been a recent and unprecedented increase in the research and development of modernized Korean traditional buildings, This is because, in today's modern society, the basic needs for survival have already been met and more people are now recognizing the importance of the identity of our unique culture. It is therefore timeous to consider not just how to preserve and use Korean traditional buildings, but also how to develop them into more industrialized and modernized buildings in a practical way. Recently, the direction has been focused on the industrialization of modernized Korean traditional buildings, including their evolution, and development, as well as on the numerous cases where construction has been delayed. In order to industrialize modernized Korean traditional buildings, we need to standardize their form and actively introduce current IT (Information Technology). In order to achieve this, it is absolutely necessary to change from the CADD (Computer Aided Design and Drafting) system to the BIM (Building Information Modeling) system, which reflects the concept of Virtual Architecture. Therefore, the aim of this study is to discuss the possibilities of using BIM system for industrialization of modernized Korean traditional buildings, extend the foundation of the form library, and develop an intelligent modeler. It is also necessary to exemplify a case model for modernized Korean traditional buildings to which BIM is applied.
근로자의 산업보건관리에 대한 지식, 태도, 실천 조사연구 -경인지역을 중심으로-
안태성,조동란,김명순,이복희,고봉련,Ahn, Tae-Sung,Jo, Dong-Ran,Kim, Myung-Soon,Lee, Bok-Hee,Ko, Bong-Ryeon 한국지역사회간호학회 1993 지역사회간호학회지 Vol.4 No.2
The purpose of this study was to examine industrial workers ; Knowledge, Attitude and Practice of occupational health management and service. The data was collected from Dec 4. 1993 to Jan 21, 1993. The data was collected from 352 industrial workers from 37 companies located in Kyng Ki Province and In cheon city. The measurement tool used in this study was a structured questionnaire developed by the community Nursing academy. The major findings attained from this study are summarized as follows : 1. The level of Knowledge, Attitude and Practice of industrial workers of occupational health management and service, were as follows : The total mean score was 72 out of 100. The total mean score of Knowledge was 22.5, out of 30. The mean score of Attitude was 39.2, out of 55. The mean score of Practice was 10. 6, out of 15. 2. The level of Knowledge, Attitude, and Practice of industrial workers of health management and service according to workers' general characteristics. The significant perceptions of health management as a whole that impact on the Knowledge score were occupational factors such as, age, income, number of workers, educational status, sex, and marital status. The significant factor of Practice which impact on the score was age, number of workers, sex, and marital status.