재생근관치료의 성공에 영향을 미치는 결정 요인에 대한 후향적 연구

정화경,이난영,이상호,Jeong, Hwakyong,Lee, Nanyoung,Lee, Sangho 대한소아치과학회 2017 大韓小兒齒科學會誌 Vol.44 No.1

본 연구의 목적은 괴사된 미성숙 영구치의 재생근관치료 시 성공에 영향을 미치는 결정적 인자를 평가하고자 함에 있다. 미성숙 영구치의 치수괴사로 진단된 환자 중 재생근관치료를 시행하고 1년 이상 경과 관찰한 증례로서 46개 치아가 선택되었다. 이를 대상으로 성공률과 관련된 변수로서 나이, 성별, 초진 시 치근발육단계, 치수괴사 원인, 치료과정, 임상 및 방사선학적 결과를 조사하고 관련성을 통계 분석하였다. 분석 결과, 치근발육단계는 재생근관치료의 성공률에 영향을 미치지 않았으나, 치수괴사 원인은 치외치, 우식, 외상 순으로 성공률이 높았으며 유의한 차이가 있었다. 근관내 멸균 시 국소적 항생제를 적용했을 때 높은 성공률을 보이며 통계학적 유의차를 보였으며, double과 triple antibiotic paste간에는 유의차가 없었다. 재생근관치료의 성공률을 높이기 위해 치수 괴사 원인, 특히 외상 증례에 있어 신중한 적응증 판단이 선행되어야 하며, 적절한 항생제 적용이 필요하다. This study evaluated critical factors influencing the success of regenerative endodontic treatment for necrotic immature permanent teeth. The study enrolled patients who had regenerative endodontic treatment in a necrotic immature permanent tooth through 1-year follow-up. Possible explanatory variables related to the success rates for 46 teeth were age, gender, dental stage at the initial appointment, etiology, treatment information, and clinical and radiographic outcomes. The dental stage at the time of regenerative endodontic treatment did not influence the success rate. The success rate was significantly related to the etiology of the necrotic immature tooth. The success rate according to etiology decreased in the following order: dens evaginatus, caries, and trauma. There was also a significant difference according to the type of antimicrobial. The success rate was influenced by appropriate disinfection of the root canal system, provision of a scaffold, and coronal sealing. Above all, careful case selection is necessary for treating a necrotic immature permanent tooth, especially in cases of trauma.

대장암에서 폐색이 예후에 미치는 영향

정화경,정상훈,김재황,심민철 대한대장항문학회 2008 Annals of Coloproctolgy Vol.24 No.6

Purpose: An obstructed colorectal cancer (OB) has a poorer survival than a non-obstructed cancer (NOB). This study examined the prognostic impact of bowel obstruction on colorectal cancer. Methods: From December 1999 to December 2005, patients undergoing single stage operation for OB were examined prospectively. OB (n= 193) was compared with a NOB (n=444) used in a primary tumor resection during the same period. 637 colorectal cancers were examined in this study. Results: The overall operative mortality was 21 (3.3%) and the postoperative mortality was significantly higher in the OB (OB: 16, 8.3%) group than in the NOB (NOB: 5, 1.1%) group. The proportion of OB was higher in the left-colon (52.8%) than in the right colon (16.0%) and rectum (31.1%, P<0.001). However, OB was associated with an older age (P=0.013). The proportion of advanced tumor stage was higher in OB (II: 35.8%, III: 39.5%, IV: 24.7%) than in NOB (II: 53.2%, III: 35.8%, IV: 11.0%, P<0.001). The 5-year cancer-related survival for OB was worse than NOB (OB: 77.3%, NOB: 57.8%, P<0.05). However, in the cases of a colorectal cancer performed curative resection (stage II and III), the survival for OB was not worse than NOB: stage II (OB: 82.8%, NOB: 92.2%, P=0.24), stage III (OB: 65.2%, NOB: 56.9%, P=0.43). Conclusions: OB has older and more advanced disease characteristics. However, if an oncologically curative resection is performed, the survival for OB is similar to that of a NOB. Purpose: An obstructed colorectal cancer (OB) has a poorer survival than a non-obstructed cancer (NOB). This study examined the prognostic impact of bowel obstruction on colorectal cancer. Methods: From December 1999 to December 2005, patients undergoing single stage operation for OB were examined prospectively. OB (n= 193) was compared with a NOB (n=444) used in a primary tumor resection during the same period. 637 colorectal cancers were examined in this study. Results: The overall operative mortality was 21 (3.3%) and the postoperative mortality was significantly higher in the OB (OB: 16, 8.3%) group than in the NOB (NOB: 5, 1.1%) group. The proportion of OB was higher in the left-colon (52.8%) than in the right colon (16.0%) and rectum (31.1%, P<0.001). However, OB was associated with an older age (P=0.013). The proportion of advanced tumor stage was higher in OB (II: 35.8%, III: 39.5%, IV: 24.7%) than in NOB (II: 53.2%, III: 35.8%, IV: 11.0%, P<0.001). The 5-year cancer-related survival for OB was worse than NOB (OB: 77.3%, NOB: 57.8%, P<0.05). However, in the cases of a colorectal cancer performed curative resection (stage II and III), the survival for OB was not worse than NOB: stage II (OB: 82.8%, NOB: 92.2%, P=0.24), stage III (OB: 65.2%, NOB: 56.9%, P=0.43). Conclusions: OB has older and more advanced disease characteristics. However, if an oncologically curative resection is performed, the survival for OB is similar to that of a NOB.

수처리 적용을 위한 PVdF/GO 나노섬유 분리막의 제조 및 특성 분석

정화경,장원기,윤재한,변홍식 한국막학회 2015 한국막학회 총회 및 학술발표회 Vol.2015 No.05

본 연구에서는 Hummers 법으로 제조된 산화그래핀(GO)를 활용하여 Poly(vinylidene fluoride)(PVdF) 나노섬유 분리막을 제조하고 수처리 적용을 위한 특성평가를 진행하였다. PVdF/GO 나노섬유 분리막의 제조는 나노섬유 지지막에 다양한 농도로 분산된 GO용액을 스프레이건을 이용하여 코팅하는 방법과 고분자 용액에 GO를 도입하여 혼합 방사하는 방법을 적용하였으며, 기공크기 제어 및 기계적 물성을 향상시키기 위해 후처리공정을 진행하였다. 도입방법에 따른 수투과 특성 및 접촉각 등 특성변화를 비교 분석하였다.

Tricalcium Silicate-Based 치수복조재에 대한 수 종 수복재의 전단결합강도 비교

정화경,이난영,이상호 대한소아치과학회 2017 大韓小兒齒科學會誌 Vol.44 No.2

본 연구의 목적은 Tricalcium silicate를 기반으로 한 3종의 치수복조재(Theracal LC™, Biodentine™, ProRoot™ white MTA)와 임상에서 통상적으로 사용되는 수복재인 복합레진, 레진강화형 글래스아이오노머 시멘트, 그리고 전통적인 글래스아이오노머 시멘트 간의전단결합강도를 비교 평가하는 것이다. 이를 위해 중심구를 가진 아크릴 레진 블록 90개를 제작하고 각각 30개씩 3종의 치수복조재로중심구 안에 채운 다음, 다시 무작위로 10개씩 하위 군을 나누어 치수복조재 상방에 복합레진, 레진강화형 글래스아이오노머 시멘트, 전통적인 글래스아이오노머 시멘트를 적용하여 총 9개 군으로 이루어진 시편을 제작하였다. Universal testing machine을 이용해 전단결합강도를 측정한 뒤, 입체현미경을 사용해 파절양상을 분석하였다. 연구 결과, Theracal LC™-복합레진 군이 가장 높은 전단결합강도를, Theracal LC™-전통적인 글래스아이오노머 시멘트 군이 가장 낮은 전단결합강도를 나타냈다. 복합레진이 수복재로 선택된 군들이다른 수복재 군에 비해 높은 전단결합강도를 보였다. 전통적인 글래스아이오노머 시멘트가 수복재인 경우 Biodentine™이 다른 치수복조재 군들에 비해 높은 전단결합강도를 나타냈다. The aim of this study was to evaluate the shear bond strength (SBS) of three typical restorative materials - glass ionomer cement (GIC), resin-modified glass ionomer (RMGIC) and composite resin (CR) - to different pulp capping materials, i.e., Theracal LC™ (TLC), Biodentine™ (BD), and ProRoot™ white MTA (WMTA). 90 acrylic blocks with a center hole were prepared. The holes were completely filled with three pulp capping materials (TLC, BD, and WMTA), with 30 specimens per capping material. The samples were then randomly divided into 3 subgroups of 10 specimens each and were overlaid with GIC, RMGIC, or CR. A total 9 specimen groups were prepared. The SBS was assessed using a universal testing machine. Kruskal-Wallis test and Mann-Whitney’s test were performed to compare the SBS among the subgroups (p < 0.05). After the SBS test, the fractured surfaces were examined under a stereomicroscope at a magnification of 25×. The highest and lowest SBS values were recorded for TLC-CR and TLC-GIC, respectively. With regard to the SBS to the three pulp capping materials, CR was found to be superior to RMGIC and GIC. BD showed a higher SBS compared to TLC and WMTA when used with GIC.

Electrochemical separation of Cs using a nickel hexacyanoferrate/graphene oxide composite film

정화경,최동철,박태홍,배상은 한국공업화학회 2020 한국공업화학회 연구논문 초록집 Vol.2020 No.-

We investigated the electrochemical behavior of a nickel hexacyanoferrate/graphene oxide (NiPB/GO) composite coated on electrode. NiPB/GO composite showed electrochemically switched ion exchange capability, and selectivity for Cs over other alkali cations. In experiments to evaluate the stability of NiPB/GO composites, we found that the repeated potential cycling rather improved its cation uptake capacity. In particular, this electrochemical treatment such as potential cycling as well as constant potential method, significantly enhanced Cs uptake compared to that of NiPB/GO and still retained the ion selectivity of NiPB. The electrochemically treated NiPB/GO composite can be applied to the electrochemical separation of radioactive Cs for nuclear wastewater treatment.

수면장애의 통합적 치료를 위한 수면센터의 역할

정화경,최희연,김진우,김선종,이승신,배정호,임원정,이향운 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.2

The prevalence of sleep disorder is about 30% of the population. Common sleep disorders are insomnia, obstructive sleep apnea, narcolepsy, restless legs syndrome, rapid eye movement sleep behavior disorder and parasomnia. These sleep disorders lead various medical and mental complications. However, most sleep disorders are underdiagnosed and not treated appropriately. Sleep medicine is important for treating these sleep disorders and maintaining general healthy conditions. Specialized and comprehensive treatments for sleep disorder are important in sleep medicine.

BSCL2유전자의 N88S돌연변이가 확인된 제5형 원위유전운동신경병증(dHMN-V)

정화경,정기화,박진모,구혜수,최경규,박기덕,최병옥 대한신경과학회 2012 대한신경과학회지 Vol.30 No.4

Berardinelli-Seip congenital lipodystrophy 2 (BSCL2) gene is known to be associated with different clinical phenotypes;Silver syndrome, Charcot-Marie-Tooth type 2 with a dominant hand involvement and distal hereditary motor neuropathy type V (dHMN-V). Up to now, only two heterozygous mutations (N88S and S90L) in BSCL2 have been reported. We identified a N88S BSCL2 mutation in a dHMN-V family with a spastic gait by whole-exome sequencing. To our knowledge, this is the first report of a N88S BSCL2 mutation in Korean patient.

PVdF/GO 나노섬유 분리막의 제조 및 중금속 제거

정화경,장원기,변홍식 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0

본 연구에서는 Hummers법으로 제조된 산화그래핀(GO)를 기질 고분자인PVdF(polyvinylidene fluoride)에 도입하여 전기방사법을 이용하여 나노섬유형태의 막을 제조하고, 제조된 PVdF/GO막에 대한 중금속(납, 카드뮴) 제거 실험을 진행하였다. 먼저 GO의 중금속 제거 실험에서 납 이온의 경우 97%, 카드뮴 이온의 경우 100%까지 GO에 대한 중금속 제거 성능이 있는 것으로 확인되었으며, PVdF/GO 막의 경우에도 GO의 함량이 높을수록 납과 카드뮴의 중금속제거가 100%까지 확인되었다. 제조된 막은 후처리공정을 통해 기공크기 및 기계적 물성을 제어하였으며, 도입방법에 따른 접촉각 및 수투과도 분석 등 특성평가를 진행하여 수처리용 막으로의 활용가능성도 조사하였다.

부릅뜬 눈 외 1편

정화경 고요아침 2021 열린시학 Vol.26 No.4

[당선작] 재활 병원

정화경 고요아침 2022 시조시학 Vol.82 No.-