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정혜신 한국생화학분자생물학회 1992 생화학분자생물학회 소식 Vol.12 No.1
Recent studies of molecular dynamics on protein and nucleic acids are given after the introductory section explaning the basis of MD calculation for the general reader.
정혜신,조중명 ( Hye - Shin Chung Park,Joong Myung Cho ) 생화학분자생물학회 1991 BMB Reports Vol.24 No.3
Native monellin, an intensely sweet protein from a tropical plant, consists of two chains, A and B chains. The crystal structure of native monellin has been solved at low resolution. Single chain monellin, PS1 has been produced by genetic method. We have done 100 ps molecular dynamics studies of the two chain protein in order to obtain initial coordinates for the B-A fused monellin, PS1. Fifteen sets of coordinates from the dynamics trajectory were picked. Two chains were connected by a peptide bond and minimized each. One of fifteen minimized PS1 contains cis-peptide in the fusion loop. In addition, loop search to find the protein fragments from the well-defined structures which fit the C alpha atomic positions of nearby beta-strands results in several fragments containing cis-Pro. The informations from the present studies are useful in designing the fusion loop of monellin to increase the themostability.
이성훈,허균,정혜신 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.4
Authors reported a case of rapid cycling affective disorder(RCAD) developed after the damage of temporal lobe by traffic accident. Patient showed sharp transients on bilateral temporal area of nasopharyngeal EEG and a significant decrease of blood flow of left temporal area on SPECT. The kindling desensitization in the temporal lobe and limbic system has been accepted as the most probable hypothesis in development of RCAD. In our case, same pathophysiology was thought to play a causative role in development of RCAD.