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Sunitinib에 의해 발생한 수족증후군과 수포성 고정약진 1예
정택조 ( Taek Jo Jeong ),이은주 ( Eun Ju Lee ),정기헌 ( Ki Heon Jeong ),신민경 ( Min Kyung Shin ),김낙인 ( Nack In Kim ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.6
Sunitinib is multitargeted tyrosine kinase inhibitor, and this drug was approved for use to treat gastrointestinal stromal tumor and advanced renal cell carcinoma. It has also been shown to be efficacious in treating neuroendocrine, colon and breast cancer. Sunitinib therapy is often complicated by cutaneous adverse effects such as hand-foot syndrome, hair depigmentation, subungal splinter hemorrhage, xerosis, alopecia and seborrheic dermatitis-like reactions. But there have been no reports on patients presenting with a bullous fixed drug eruption associated with sunitinib administration. We report here on a case of a bullous fixed drug eruption and hand-foot syndrome, and these maladies were caused by this agent. (Korean J Dermatol 2009;47(6):739∼742)
결절성 병변과 반피부위축증양 병변을 함께 보인 융기피부섬유육종
정택조 ( Taek Jo Jeong ),신민경 ( Min Kyung Shin ),이무형 ( Mu Hyoung Lee ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.3
Atrophic dermatofibrosarcoma protuberans (DFSP) is an uncommon clinical variant, which clinically mimics other atrophic dermatological conditions. Given the typical `protuberant` morphology of DFSP, such atrophic lesions may be difficult to diagnose clinically. We report a 44-year-old man who presented with an 8-month history of an asymptomatic, depressed, anetoderma-like plaque on the right subclavicular area. He also presented with a 1-year history of a 1.5×1.5 cm, asymptomatic, firm, erythematous nodule above an atrophic lesion. Biopsy specimens were taken from each lesion. These specimens, along with histochemical staining for CD34, established the diagnosis of dermatofibrosarcoma protuberans. (Korean J Dermatol 2009;47(3):361∼364)
High Sensitivity C-reactive Protein을 이용하여 분석한 전신 염증과 단기간 저용량 Cyclosporine의 건선 치료효과의 상관관계
정택조 ( Taek Jo Jeong ),신민경 ( Min Kyung Shin ),김낙인 ( Nack In Kim ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.3
Background: Cyclosporine is an immunosuppressant that acts on T-cells and cytokines. Although the efficacy of systemic cyclosporine in the treatment of psoriasis has been established, the relationship between response to cyclosporine and systemic inflammation using the high sensitivity C-reactive protein (hs-CRP) immunoassay is still unclear. Objective: The aim of this study is to investigate whether systemic inflammation with clinical and laboratory findings indicate a response after 8 weeks of oral 3 mg/kg cyclosporine therapy in patients with psoriasis. Methods: Thirty-five patients with psoriasis were treated with oral cyclosporine for 8 weeks. The clinical response to oral cyclosporine was determined using the PASI score. The correlation between hs-CRP and the treatment response to cyclosporine was analyzed. Also, descriptive characteristics of psoriatic patients with psoriatic arthritis, metabolic syndrome, and high BMI (BMI≥25) were investigated. Results: Hs-CRP levels and PASI scores were significantly reduced after 8 weeks of oral cyclosporine treatment. Eight patients showed excellent response, fifteen a good response, and twelve a moderate response. The baseline hs-CRP levels in excellent and good response groups (1.35±0.59 mg/L and 1.32±0.86 mg/L, respectively) to oral cyclosporine were significantly higher than the moderate response group (0.51±0.20 mg/L, p=0.004). Psoriatic patients with psoriatic arthritis, metabolic syndrome, and high BMI demonstrated higher levels of baseline hs-CRP. Patients with psoriatic arthritis and metabolic syndrome showed greater response to cyclosporine treatment. Conclusion: Patients with greater inflammatory burden, as demonstrated by elevated baseline hs-CRP, have better treatment responses to cyclosporine compared to patients with lesser inflammation. (Korean J Dermatol 2010; 48(3):171~178)
INTEGRATED APPROACH TO AN OPTIMAL AUTOMOTIVE TIMING CHAIN SYSTEM DESIGN
정택수,박영식,김영진,조종두 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.6
Ensuring engine efficiency is a crucial issue for automotive manufacturers. Several manufacturers focus on reducing the time taken to develop and introduce brand new vehicles to the market. Thus, a synergic approach including various simulations is generally adopted to achieve a development schedule and to reduce the cost of physical tests. This study involved proposing a design process that is very useful in the preliminary development stage through effective support from simulations. This type of simulation-based design process is effective in developing timing chain drives; the use of this process, based on results from multiple trials, showed improvements in performance including low friction and vibration, improved durability, and cost-effective part design when compared to conventional processes. This study proposes an integrated approach to the preliminary design of an automotive timing chain system. The approach involves structural and dynamic analyses. The details of the design process are described by using the case of a virtual engine. This study conducted and summarized a dynamic and structural analysis as well as topological optimization to describe a process to obtain optimal results. The results of this study indicated the following improvements in overall performance factors: 12.1 % improvement in transmission error, 10.1 % reduction in chain tension, 46 % reduction in tensioner arm weight, and 11 % reduction in transversal displacement.
Expression of Ca2+-dependent Synaptotagmin Isoforms in Mouse and Rat Parotid Acinar Cells
조해,변해미,김종훈,김민석,김승회,홍정희,서정택,이승일,신동민,손흥규 연세대학교의과대학 2006 Yonsei medical journal Vol.47 No.1
Synaptotagmin is a Ca2+ sensing protein, which triggers a fusion of synaptic vesicles in neuronal transmission. Little is known regarding the expression of Ca2+-dependent synaptotagmin isoforms and their contribution to the release of secretory vesicles in mouse and rat parotid acinar cells. We investigated a type of Ca2+-dependent synaptotagmin and Ca2+ signaling in both rat and mouse parotid acinar cells using RT-PCR, microfluorometry, and amylase assay. Mouse parotid acinar cells exhibited much more sensitive amylase release in response to muscarinic stimulation than did rat parotid acinar cells. However, transient [Ca2+]i increases and Ca2+ influx in response to muscarinic stimulation in both cells were identical, suggesting that the expression or activity of the Ca2+ sensing proteins is different. Seven Ca2+-dependent synaptotagmins, from 1 to 7, were expressed in the mouse parotid acinar cells. However, in the rat parotid acinar cells, only synaptotagmins 1, 3, 4 and 7 were expressed. These results indicate that the expression of Ca2+-dependent synaptotagmins may contribute to the release of secretory vesicles in parotid acinar cells.