대장내시경적 절제술을 받은 선종성 용종 171개 분석 : 용종 크기와 이형성도와의 관계

정춘식,최규환,박의련,김선한,이동근 대한외과학회 2001 대한외과학회 학술대회 초록집 Vol.2001 No.11

인삼노두 추출물의 위염 및 위궤양에 대한 효과

정춘식,정기화,이은방 德成女子大學校 藥學硏究所 1997 藥學論文誌 Vol.8 No.1

In a preliminary screening of plant extracts for the antigastritic and antiulcer actions in rats. the extracts of head of Panax ginseng Radix showed positive activity in HCI·ethanol-induced gastric lesion. Among the systematic fractions of hexane. chloroform. butanol and water. the most potent butanol fraction reduced significantly HCI ethanol-induced gastric lesion at the oral dose of 500 mg/kg. In pylorus ligated rats. hexane and butanol fraction showed decreases in the volume of gastric secretion and acid output. of which effects were stronger in butanol fraction Further assays with butanol fraction disclosed that in significantly suppressed the aspirin-induced and Shay ulcer. The butanol fraction at the intraduodenal colse of 500 mg/kg showed significant stimulation of mucus secretion.

병식과 식품공업

정춘식 한국식품산업협회 1976 좋은식품 Vol.32 No.-

대장내시경 검사에서 용종의 간과율

정춘식,윤진석,조용걸,차윤정,김경조,박의련,김선한,이동근 대한소화기내시경학회 2004 Clinical Endoscopy Vol.28 No.4

Background/Aim: Colonoscopy has been known as the best diagnostic and therapeutic modality for colorectal polyps. However, it has been difficult to assess its accuracy. Methods: We studied the data from patients who had colonoscopic polypectomy within 30 days after the initial examination. Results: From 218 patients, a total of 362 polyps were found, 51 (14.1%) of which were missed. There were 17 patients with missed polyps among 59 patients who had two or more polyps on the initial examination. According to the location, the missing rates were variable: the splenic and hepatic flexure had the highest missing rates, and the sigmoid colon had the lowest missing rate. In our study, there was no difference of missing rate according to the size and shape. Conclusions: There is a significant colonoscopic missing rate for colorectal polyps in routine clinical practice, especially in patients with multiple colonic polyps and at the site of the colonic flexure. 목적: 대장질환 특히, 용종에 대한 내시경의 가치는 진단뿐만 아니라 치료로서 중요한 위치에 있지만 경우에 따라서는 검사 중 용종을 놓칠 수가 있다. 대장내시경의 논의에서 삽입수기에 화제가 집중되나 내시경의 목적은 삽입수기가 아니라 병변의 발견과 그에 따른 적절한 치료방침을 정하는 것이다. 대장내시경 검사 중 용종을 놓치는 빈도를 알아보고 놓친 용종의 위치, 모양, 크기, 시행한 내시경의사 및 첫 내시경 시 발견된 용종의 수에 따른 빈도의 차이가 있는지 알아보았다. 대상 및 방법: 2001년 7월 1일부터 1년간 본원에서 대장내시경 검사에서 용종이 발견되어 1개월 내 계획된 대장내시경적 용종절제술을 시행한 예 중 용종의 크기가 0.5 cm 이상인 것을 대상으로 후향적으로 조사하였다. 용종의 형태는 Yamada 분류법으로 하였으며 크기는 0.5 cm~1 cm 미만, 1 cm~2 cm 미만, 2 cm 이상으로 구분하였다. 용종의 개수는 첫 내시경 시 단일 용종과 2개 이상의 용종이 발견된 예로 구분하였으며 시술자는 500예 이상의 대장내시경 검사의 경험이 있는 각 2명의 내, 외과 의사로 하였다. 결과: 218예에서 계획된 용종절제술을 시행하였으며 절제된 용종의 개수는 362개였다. 이 중 39예(17.9%)에서 첫 내시경 검사에서 발견 못한 용종이 있었고 개수는 51개(14.1%)였다. 용종의 위치에 따라 놓친 빈도는 간과 비만곡부에서 의미있게 높았고(p=0.039), S상결장에서 낮았으며(p=0.003), 형태 및 내시경 의사에 의한 차이는 없었다. 첫 내시경 검사에서 2개 이상의 용종이 발견된 예에서 빈도가 높았으나(p=0.037) 크기에 따른 차이는 없었다. 놓친 용종의 조직검사에서 증식성 용종 6예, 관상 선종 40예, 관상-융모상 선종 5예였으며 3예에서 고도세포이형성이 관찰되었다. 결론: 대장내시경 검사에서 다발성 용종 환자와 간 및 비만곡부에 대한 세심한 관찰이 요구된다.

엔도톡신에 의한 혈전증에 미치는 프로폴리스의 효과

정춘식,정주희,정기화 한국양봉협회 2003 양봉협회보 Vol.275 No.-

질감 근사화 및 반복적 병합을 이용한 율왜곡 기반 영상 분할

정춘식,임채환,김남철 한국통신학회 2000 韓國通信學會論文誌 Vol.25 No.1

본 논문에서는 반복적 병합의 율왜곡 기반 비용을 계산할 때 일반화된 질감 근사화 과정을 도입함으로써 질감 특성이 고려된 율왜곡 기반 영상 분할 기법을 제시하였다. 이때 영역 내부의 질감은 SA-DCT를 적용한 후, 양자화 간격이 고정된 두 개의 균일 양자화기에 의해 DC 성분 및 AC 성분을 각각 근사화하여 율왜곡 기반 비용을 구하고, 이러한 율왜곡 기반 비용에 근거하여 반복적 병합을 이용한 영상 분할을 수행하였다. 256$\times$256 Lena에 대하여 실험한 결과, 제안한 분할법에 의한 영역기반 부호화는 DC 성분만으로 근사화하여 율왜곡 기반 영상분할에 의한 것과 JPEG에 비하여 각각 0.8~1.0 ㏈, 1.2~1.5㏈ 정도의 PSNR 성능 개선이 있는 것으로 나타났다. A rate-distortion based segmentation using recursive merging is presented, which considers texture as a homogeneity by adopting the procedure of a generalized texture approximation. The texture in a region is approximated by SA-DCT and a set of two uniform quantizers with fixed step sizes, one for DC and another for AC. Using the approximated texture, we calculated the rate-distortion based cost. The segmentation using recursive merging is performed by using the rate-distortion based cost. Experimental results for 256$\times$256 Lena show that the region-based coding using the proposed segmentation yields the PSNR improvements of 0.8~ 1.0 dB and 1.2~1.5 dB over that using the rate-distortion based segmentation with DC approximation only and JPEG, respectively.

흰주 위조직에 대한 노두 추출물 및 분획물의 항지질과산화작용

정춘식 德成女子大學校 藥學硏究所 1996 藥學論文誌 Vol.7 No.1

In a preliminary screening of plant extracts for the antigastric and antiulcer action in rats, the extracts of Panax ginseng Radix showed positive activity in HCl·ethanol-induced gastric lesion. Panax ginseng Radix was extracted with methanol and fractionated systemically with hexane, chloroform and butanol. The chloroform and butanol fraction reduced significantly HCl·ethanol-induced gastric lesion at the dose of 150 and 500㎎/㎏, p.o, respectively. On the gastric secretion in pylorus ligated rats, hexane and butanol fraction decreased the volume of gastric secretion and acid output. It also significantly suppressed the aspirin-induced and Shay's ulcer. The butanol fraction at the i.d. dose of 500㎎/㎏ showed significant inhibition in absolute ethanol induced gastric lesion which was more potent than 150㎎/㎏ of cimetidine and had significant stimulation of mucus secretion. These results might suggest that the butanol fraction of Panax ginseng Radix had inhibitory action in gastric lesion and ulceration through inhibition of gastric acid secretion and stimulation of mucin secretion in the stomach of rats.

크론병에 합병된 직장질루의 임상경과

정춘식,이동근,Bruce D. George,Neil J. Mortensen 대한대장항문학회 2007 Annals of Coloproctolgy Vol.23 No.1

Purpose:The aim of this study is to analyze the outcome of a variety of treatments, including local surgical treatments, diverting stoma, and combined medical therapy, for patients with a rectovaginal fistula complicating Crohn's disease. Methods: Between 1994 and 2003, twenty-one patients with a rectovaginal fistula complicating Crohn's disease from a prospectively compiled 422-patient Crohn's disease database were reviewed. Results: All three patients treated by seton and fibrin glue recurred despite having relatively long tracts. Of six patients with infliximab treatment combined with a seton procedure, five patients had an improvement of their symptoms, but were not cured. Of eight patients with a transanal or endovaginal advancement flap techniques, three had successful closure, three eventually required a proctectomy, and two had a recurrent fistula without symptoms. Four (2 without any local treatments, and 2 with seton placement) of 16 patients who had a diverting stoma during treatment had successful closure. All proctectomy patients (n=8) had rectal involvement of Crohn's disease. Two patients who underwent a proctectomy with a presumptive diagnosis of ulcerative colitis and indeterminate colitis turned out to have Crohn's disease. Overall, except for the proctectomy patients, seven patients (54%) had successful closure, but six (four without symptoms, and two with symptoms) following a wide spectrum of treatments had recurrence after a mean follow-up of 44 months. Conclusions: Combining different treatments for a rectovaginal fistula in Crohn's disease can be successful in a reasonable number of cases. The presence of uncontrolled perianal sepsis and/or complicated anorectal problems is likely to lead to a proctectomy.

두릅나무 根皮抽出物의 藥理學的 硏究

정춘식,김재완 德成女子大學校 藥學硏究所 1991 藥學論文誌 Vol.2 No.1

The plant of Aralia elata (Araliaceae) is described to be used for treatment of diabetes, gastritis, neuralgegia and rheumatoid arthritis in oriental medicinal books. This study is concerned with the effect on the gastritis and ulcer in rats and some general pharmacological action in rats. It was observed that the methanol extract of the rootbark of Aralia elata showed effectiveness in gastritis and pain in rats. From the result obtained that the methanol extract exhibited antigastritic activity. Thus, It was fractionated into hexane, chloroform, ethylacetate and butanol, and further bioassays for the fractions resulted in potent activity in the butanol fraction. The fraction elicited analgesic effect by inhibition of writhing syndrome induced by acetic acid and by increment of pain-threshold in inflamed tail of mice. The fraction showed inhibition of HCl · ethanol and absolute ethanol induced gastritis and inhibition of Shay ulcer in rats. It also exhibited inhibition of gastric secretion in rats. The fraction showed low acute toxicity, i.e., the minimum lethal dose was more than 5000 ㎎/㎏ in oral administration in rats and LD_50 was 740 ㎎/㎏ given subcutaneous by in rats.

서혜부 탈장으로 의심된 자궁 원인대 낭종

정춘식,유상화,이정은,정규영,김승한,조용걸,이동근 대한외과학회 2010 대한외과학회 학술대회 초록집 Vol.2010 No.11