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Mohs 미세도식 수술을 이용한 안검부 기저세포암의 준임상적 침윤 유형에 관한 연구
정증태(J . T . Jeong),서수홍(Soo Hong Seo),(McCall MW),김일환(I . H . Kim) 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.7
N/A Background: Systemic corticosteroids can arrest the progression of alopecia areata and lead to hair growth in a significant proportion of patients but may also cause unacceptable side effects. Objective: To minimize the side effects, we tried a new approach using minipulse therapy with betamethasone (CelestoneR). We performed a clinical observation of alopecia areata to understand its therapeutic responses. Method: Forty six patients with alopecia areata were given 3mg betamethasone as a single oral dose on 2 consecutive days per week. Therapeutic effects and side reactions were evaluated by dermatologists every month. Results: The extent of hair regrowth varied in different patients and even in different lesions in the same patient. Effective response, which shows vellus and/or terminal hair growth for more than 1 month, was achieved in 67.4% of the patients (31 cases). The side effects included acne in 14 patients, weight gain in 11 patients, gastrointestinal discomfort in 6 patients and facial flushing or edema in 5 patients; 19 patients had no side effects. Conclusions: Oral minipulse therapy with betamethasone seems to be an effective treatment modality to arrest the progression of alopecia areata and also induces hair regrowth. This modality of treatment had minimal and less severe side effects, compared with currently used pulse therapy with methylprednisolone. It deserves to be tried on a large scale to evaluate its advantages and disadvan-tages over the currently useful methods of treatment. (Korean J Dermatol 2001;39 (7) 775-781)
모공성 홍색 비강진 30예 대한 임상적 및 병리 조직학적 고찰
정증태 ( Jeung Tae Jeong ),계영철 ( Young Chul Kye ),김수남 ( Soo Nam Kim ) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.4
N/A Background : Pityriasis rubra pilaris (PRP)is a rare papulosquamous disorder of unknown etiology. Although the clinical and histapathologic features of PRP are relatively well known in western patients. there are few available studies in Korea. Objective : The purpose of this study was to evaluate the clinical and histopathologic features of pityriasis rubra pilaris(PRP) in Korea Methods : The clinical them, photographies and skin biopsy slides of patients clinically diagnosed s PRP at the initial visit were reviewed. Finally 30 patients were diagnosed as PRP. They were classified into 5 groups according to the Griffiths classfication. And then the evaluation of age at uses, sex distribution, clinical feature of the skin lesion, associated symptoms. clinical course and histapathologic features were conducted. Results : 1) The male to female ratio was 1:1.14. The age of onset was varied from 1 to 65 years with two peaks in first and fifth decades. The average age, of onset in adult type and juvenile type were 40.1 and 5.1 years respectively 2) According to the Griffiths classification, 14(47%) of the patients had type Ⅰ, 4(13%) had type Ⅲ, 7(23%) had type Ⅳ. and 3(10%) had type Ⅴ. However, 2(7%)patients could not be classified under any of these five types due to atypical clinical feature or insufficient follow-up periods 3) The common clinical features during the disease course were follicular hyperkeratosis(83%), knee and/or elbow involvement(83%), palm and/or sole hyperkeratosis(80%). Erythroderma was present in 5 patients(17%) during the disease course 4) There were no specific symptoms in most cases but 9 patients had on .offered from mild itching 5) 3 patients had a positive family history, and were thought to have inherited autosomal dominant trait 6) The frequent histopathologic findings were alternating parakeratosis and orthokeratosis (100%), superficial perivascular infiltration(100%), broad rete ridge(97%), acanthosis(93%), hypergranulosis(87%), follicular plugging(73%). Conclusion : We investigated the clinical and histopathological features of PRP in Korea. In our study, the clinical and histopathological features of PRP were not different from those observed in western patients.