MR Findings of the Osteofibrous Dysplasia

정준용,지원희,홍성환,강흥식,정혜원,류경남,김지영,임수아,박정미,성미숙,이연수,홍석주,정찬권,정양국 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.1

Objective: The aim of this study was to describe MR findings of osteofibrous dysplasia. Materials and Methods: MR images of 24 pathologically proven osteofibrous dysplasia cases were retrospectively analyzed for a signal intensity of the lesion, presence of intralesional fat signal, internal hypointense band, multilocular appearance, cortical expansion, intramedullary extension, cystic area, cortical breakage and extraosseous extension, abnormal signal from the adjacent bone marrow and soft tissue and patterns of contrast enhancement. Results: All cases of osteofibrous dysplasia exhibited intermediate signal intensity on T1-weighted images. On T2-weighted images, 20 and 4 cases exhibited heterogeneously intermediate and high signal intensity, respectively. Intralesional fat was identified in 12% of the cases. Internal low-signal bands and multilocular appearance were observed in 91%. Cortical expansion was present in 58%. Intramedullary extension was present in all cases, and an entire intramedullary replacement was observed in 33%. Cortical breakage (n = 3) and extraosseous mass formation (n = 1) were observed in cases with pathologic fractures only. A cystic area was observed in one case. Among 21 cases without a pathologic fracture, abnormalsignal intensity in the surrounding bone marrow and adjacent soft tissue was observed in 43% and 48%, respectively. All cases exhibited diffuse contrast enhancement. Conclusion: Osteofibrous dysplasia exhibited diverse imaging features ranging from lesions confined to the cortex to more aggressive lesions with complete intramedullary involvement or perilesional marrow edema.

다양한 Konus denture의 내관 및 외관의 제작방법

정준용,Chung Jun-Yong 대한치과보철학회 2002 대한치과보철학회지 Vol.40 No.4

The purpose of this article is the consolidation of several methods in fabrication of Konus denture. It is different Konus denture from traditional Clasped removable partial denture in the procedures of construction. There are multiple procedures of fabrications of inner and outer crowns in the construction of Konus denture. It is important to fabricate the inner crown, the outer crown and the denture framework in construction of Konus denture. Each procedure should be performed exactly. However, there are many procedures in fabrications of them, and thus, the operator and technician bear trial and error. This article consolidate the multiple methods of fabrications of components of Konus denture. The first method is completion of inner crown, outer crown and denture after one impression taking. The second method is the procedures of cementation of inner crown, impression taking of edentulous area, and completion of outer crown and denture. The third method is the procedures or pick up impression taking of inner crown and completion of outer crown and denture on the inner crown of working cast. Each method is acceptable, but operater and technician should be accustomed with their own systemic procedures and minimize the errors in the construction of denture.

'몰랐다'가 통용되지 않는 전쟁터

정준용,Jeong, Jun-Yong 한국데이터베이스진흥원 2000 디지털콘텐츠 Vol.2 No.-

이미 우리가 사는 환경의 일부가 되어버린 인터넷. 때문에 새로운 시대를 예고하는 인터넷 문명 속에서 사회의 안정과 균형을 추구하는 추구하는 도구로서의 법의 역할은 장차 우리사회의 변화의 폭과 깊이를 결정짓는 주요한 척도가 될 듯 싶다. 어떻게 활용되고 대비를 해야하는지 살펴봤다.

한국인에서 Lipoprotein lipase gene polymorphism의 빈도와 혈관질환과의 관계

정준용,박소영,김제,성인환,김영건,전은석 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2

Background : Lipoprotein lipase(LPL) is a key enzyme in the metabolism of serum triglycerides(TG) which is utilized in the peripheral tissue as free fatty acid and stored in adipose tissue. LPL gene is consisted of 10 exons which encode 475 amino acids and over 9 LPL gene polymorphisms have been reported. It's polymorphisms are related to the lipid levels and the severity of atherosclerosis in the coronary artery disease. In Korea, LPL polymorphisms has not been reported yet. This study is purposed on the incidences of LPL gene mutations and on it's relationships with blood lipid levels and the severity of atherosclerosis. Methods : Our subjects were consisted of three groups, normal controls(n=50), coronary artery disease(CAD, n=51) and cerebrovascular disease(CVD, n=52). The PCR amplified genomic DNA from peripheral white blood cell were analyzed with restriction fragment length polymorphisms (RFLP by two different restriction enzyme(PVU II, Hind III). Results : Total cholesterol(TC) were higher in CVD than in controls and in CAD (203±60mg/ dl vs 188±37, 167±42, p<0.01). Triglyceride(TG) were also elevated in CAD(166±65mg/dl vs 122±62 in controls, p<0.05). HDL cholesterol(HDL-C) were higher in controls than in CVD and CAD(49±9mg/dl vs 36±10, 44±9, p<0.05). The incidences of Hind III RFLP and PVU II RFLP has no differences among groups. Only HDL-C was elevated in Hind III RFLP(-/-) homozygotes. Conclusions : The LPL gene mutations in intron 6 and 8 have no direct effects on the lipid profiles and the severity of coronary artery disease. Although LPL is a key enzyme in TG metabolism, two mutations in this study could not change the activity of LPL, nor were not a marker of linked other site mutations. The mutation(s) in exon which encode amino acid for enzyme activity should be detected to analyze the pathophysiology of the atherogenesis.

두개내에서 분리된 동맥류 클립의 척추관으로의 이동: 증례 보고

정준용,유원종,임연수,정명희,성미숙,임현욱,윤회수,이해규 대한영상의학회 2004 대한영상의학회지 Vol.51 No.2

매우 드물게 두개강내의 동맥류 결찰에 사용되는 동맥류 클립이 분리되어 뇌척수액을 따라 척추관으로 이동하고 이동된 클립에 의한 신경근의 압박이나 염증에 의해 요통이나 신경근병증등을 일으키기도 한다. 하지만 증상이 없을 경우, 혹은 증상이 있다 하더라도 단순 추간판 탈출로 오인하여 간과하기 쉽다. 최근 분리된 뇌동맥류 클립이 척추관으로 이동한 증례를 경험하여 이를 보고한다. Very rarely, clips used for the ligation of intracranial aneurysms become detached and subsequently migrate into the spinal canal, causing lumbar pain or radiculopathy by compressing nerve roots or inducing inflammatory processes in their newly established location. However, it is easy to overlook the migration of the clip, because there may be either no noticeable symptoms, or a herniated disk may be mistakenly diagnosed as being the source of the present symptoms. Herein, the authors report a case in which an aneurysmal clip migrated into the spinal cord.

조리과정에 따른 콩나물 중의 수은잔유량

정준용,박정덕,정규철,Chung, Jun-Yong,Park, Jung-Duck,Chung, Kyou-Chull 대한예방의학회 1986 Journal of Preventive Medicine and Public Health Vol.19 No.2

This study was carried out in order to estimate the residual amount of mercury in soy-bean sprouts in each steps of cooking. Samples were taken at markets and also cultured at home without applying the mercury containing pesticides as control. Mercury was determined by dithizone method. It was disclosed that soy-bean sprouts purchased at markets contained $1.32{\pm}0.274ppm$, 13 times as high as the maximal allowable concentration of mercury in food recommeded by Ministry of Health and Social Affairs. Mercury contents, however, dropped off steadily by steps of cooking: rinsed with distilled water and boiled in distilled water showing concentrations of $0.11{\pm}0.025ppm$ in boiled sprouts and $0.03{\pm}0.022ppm$ in sprout-soup. These values were not statistically different from those in control samples, and not exceeded the maximal allowabled levels of mercury in food. It can be concluded that the use of mercury containing pesticides in the cultivation of soy-bean sprouts is not so serious problem as it has been suspected in respect of food contamination, but careful attention must be paid to indiscriminate use of mercury containing pesticides as they may contaminate air, water and soil and secondarily bring harm to human health through food chains.

Electro-optic polyimides containing disulfide group with improved poling property

정준용,서해민,가재원,임종선,김동균,김경옥,이미혜 한국고분자학회 2018 한국고분자학회 학술대회 연구논문 초록집 Vol.43 No.1

췌십이지장 절제술후의 가성동맥류: 혈관조영술을 이용한 진단과 색전술

정준용,이상현,김삼수,한헌,정혜원,한준구,최병인,정진욱,박재형,Jeong, Jun-Yong,Lee, Sang-Hyeon,Kim, Sam-Su,Han, Heon,Jeong, Hye-Won,Han, Jun-Gu,Choe, Byeong-In,Jeong, Jin-Uk,Park, Jae-Hyeong 대한영상의학회 2002 대한영상의학회지 Vol.47 No.2

목적: 췌십이지장 절제술후 합병증으로 출혈을 보인 환자에서 혈관조영술을 이용한 가성동맥류의 진단 및 색전술을 통한 지혈의 효과를 알아보고자 하였다. 대상과 방법: 총 51개월 동안 췌십이지장 절제술을 시행 받은 298명의 환자 중 임상적으로 의미 있는 출혈로 혈관조영술을 시행한 19명(6.4%)의 환자에서 가성동맥류가 발견된 9명(3.0%)을 대상으로 출혈 전후의 임상소견, 혈관조영술 소견 및 색전술의 지혈효과를 후향적으로 분석하였다. 결과: 총 9명의 환자에서 혈관조영술로 가성동맥류를 진단하였다(총간동맥 4명, 위십이지장동맥 3명, 고유간동맥 1명, 좌위대망막동맥 1명). 크기는 0.3 cm에서 6.5 cm로 평균 1.9 cm이었고 조영제의 혈관외유출은 5명(55.6%)에서 보였다. 혈관조영술을 시행받은 나머지 10명의 환자에서는 혈관조영에서 출혈의 증거를 찾을 수 없었다. 수술 2주일 이내와 이후의 조기 또는 지연출혈에 동반된 경우는 각각 5명, 4명이었다. 가성동맥류를 진단받은 9명 환자 중 대량 출혈이전에 문합부 유출로 인한 복강내의 체액 또는 농양 배출을 위해 경피적배액술을 시행받은 환자는 7명(77.8%)이었으며 9명 모두에서 소량의 예기출혈을 보였다. 혈관조영술로 정확한 가성동맥류 위치를 파악하여 환자는 8명에서 코일을, 나머지 한명에서는 gelfoam을 이용하여 색전술을 시행하였고 모두에서 지혈에 성공하였다. 색전술과 연관된 주요 합병증을 경험한 환자와 추적기간 중(72-1336일,평균 640일)재출혈을 보인 환자는 없었다. 결론: 췌십이지장 절제술후 가성동맥류는 드물지만 출혈의 원인으로 중요하며 혈관조영술 및색전술로 가성동맥류의 조기 진단 및 성공적인 지혈을 하여 위험이 높은 응급수술을 최소화할수있다. Purpose: To evaluate the efficacy of angiography in the diagnosis and treatment of pseudoaneurysm manifesting arterial hemorrhage as a significant complication following pancreatoduodenectomy. Materials and Methods: For 51 months, of a total of 298 patients who had undergone pancreatoduodenectomy, 19 patients (6.4%) developed clinically significant hemorrhage and nine patients proved to have a pseudoaneurysm on angiography. These nine patients (3.0%) were managed by transcatheter arterial embolization. We analyzed clinical feature, angiographic findings and hemostatic effect of embolization retrospectively. Results: In nine patients (3.0%), pseudoaneurysm was diagnosed on angiography (common hepatic artery in four, gastroduodenal artery in three, proper hepatic artery in one, and left gastroepoploic artery in one patient). The size ranged from 0.3 cm to 6.5 cm (mean 1.9 cm). And extravasation was noted in five patients (55.6%). The remained ten patients showed no evidence of bleeding on angiography. Those who manifested as early bleeding (within two weeks) or delayed bleeding (later than two weeks) were five and four patients respectively. Before the onset of major bleeding, among the nine pseudoaneurysm patients, seven patients (77.8%) had experienced percutaneous drainage due to intra-abdominal fluid collection with or without abscess resulting from anastomotic leak, and all nine patients had had preliminary minor bleeding. The angiogram demonstrated an exact site of bleeding as a pseudoaneurysm followed by transcatheter arterial embolization (microcoil in eight patients, gelfoam in one) and achieved complete hemostasis yielding a success rate of 100%. Overall, no patients experienced complications related directly to the transcatheter arterial embolization technique. During the follow-up period (72-1,336days, mean 640), no recurrence of bleeding was noted. Conclusion: Although pseudoaneurysm is a rare complication, it is important as a cause of hemorrhage after pancreatoduodenectomy. Angiography followed by transcatheter arterial embolization allows early diagnosis and hemostasis of pseudoaneurysm and minimizes the need for high-risk emergency surgery.

Real-Time RT-PCR 기법을 이용한 사이토카인 유전자 발현의 정량분석

정준용 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

The analysis of cytokine profiles plays a central part in the characterization of disease-related inflammatory pathways and the identification of functional properties of immune cells, both for research and for clinical diagnosis. Because tissue biopsy samples are too small to allow the detection of cytokine protein, the detection of mRNA expression level by reverse transcription-polymerase chain reaction (RT-PCR) analysis is often used to investigate the cytokine profiles in inflammatory lesions. RT-PCR itself is a qualitative method, indicating the presence or absence of specific mRNA. The most widely accepted method is qualitative competitive RT-PCR, based on internal shortened standards. Recently, real-time RT-PCR has been introduced for quantitative analysis of cytokine expression profiles. The real-time RT-PCR is becoming widely used to quantify cytokines from cells, tissues, tissue biopsies or body fluids. Being a very powerful and sensitive method it can be used to quantify mRNA expression levels of cytokines, which are often very low in the tissues under investigation. The method allows for the direct detection of PCR product during the exponential phases of the reaction, combining amplification and detection in one single step. In the review, I discussed the principle of real-time RT-PCR, the different methodologies and chemistries available, the assets, and some of pitfalls. Also, validation for a large panel of human cytokines and other factors playing a role in the immune system is discussed in detail. In summary, the real-time RT-PCR technique is very accurate and sensitive, allows a high throughput, and can be performed on very small samples.

변이형 협심증에서 추적 관상동맥 조영술을 통한관상동맥 연축에 대한 연구

정준용,임대승,강정아,이민수,김정희,송인관,최시완,정진옥,성인환 대한심장학회 2002 Korean Circulation Journal Vol.32 No.9