테트라시아노에틸렌과 벤질알코올 사이의 전하이동 착물에 대한 압력 효과

정재봉,이후설,김건,Jae Bong Jung,Hoo Sul Lee,Keon Kim 대한화학회 1985 대한화학회지 Vol.29 No.2

제1형 신경섬유종증에서 세포외 기질과 TGF - β1 유전자의 발현

정재봉,권호준,류영욱,이규석,송준영 ( Jae Bong Jung,Ho June Kwon,Young Wook Rhu,Kyu Suk Lee,June Young Song ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Background: Neurofibroma, the hallmark of neurofibromatosis, is a cutaneous or subcutaneous lesion, with a variable clinical presentation. Histologically, neurofibroma consists of proliferation of nerve derived cellular elements, together with an abundant, collagenous extracellular matrix. Specifically, neurofibroma has been shown to contain 30-50% collagen in its matrix. Objective 5. methods : We examined the expression of extracellular matrix genes(collagen, fibronectin, laminin), TGF-b mRNA and Ha-ras oncogene mRNA by using Northern and slot-blot hybridization and immunoperoxidase stains. Result: In Northern blot analysis, Ha-ras and TGF-b genes revealed respectively, 8.8kb and 2. 5kb sized mRNA transcripts in neurofibroma. These parameters were normal in the control. The expression of these genes were 1.9, 2.0 fold increased in neurofibroma. In slot-blot analysis, expression of type I collagen showed fibronectin genes to be 2,401+210, 540+43, respectively, in neurofibroma. So there were 3.7 fold, 2.1 fold, differences respectively, compared to the normal control. However, there were no significant changes of type IV collagen and laminin Bl mRNA levels between neurofibroma and normal skin tissues. Irnmunoperoxidase staining by rnonoclonal anti type IV collagen antibody in neurofibroma showed type IV collagen to be diffusely and weakly stained in tissue. On staining by monoclonal anti-laminin antibody, laminin was stained in a matrix and around vessels. Conclusion : The increased expression of extracellular matrix genes may suggest that there is a subpopulation of fibroic cells in neurofibroma which are stimulated by TGF-b. Ha-ras genes which might have accumulated with the differentiation of neural tissue may be related to the pathogenesis of neurofibroma tissue formation. Further studies are needed to determine whether the other factors are related to the pathogenesis of neurofibroma. (Kor J Dermatol 1997;35(2): 249-257)

돼지사체의 노출 정도에 따른 곤충상과 사체의 부패 패턴에 대한 연구

Jae Bong Jung(정재봉),Myung Hee Yoon(윤명희) 한국생명과학회 2011 생명과학회지 Vol.21 No.8

본 연구는 유기된 돼지사체의 노출 정도에 따른 곤충상의 변화와 부패 패턴을 이용해서 사체의 사후경과시간 (Post Mortem Interval, PMI)을 추정하기 위한 기초자료를 얻기 위해 수행되었다. 부산 낙동강 주변의 초지에서 완전노출사체, 감은사체, 덮은사체 및 그늘진사체 각각 1구씩을 2010년 8월에 설치하여 총 7목 15과 20종의 곤충들이 관찰되었고 가장 먼저 접근한 곤충은 검정뺨금파리였다. 검정뺨금파리는 모든 사체에서 전 기간에 걸쳐 출현했으며, 꼭지파리과의 1 종, 왕반날개 및 딱정벌레과의 1종은 부패(Ⅲ)~백골화(Ⅴ)단계에 출현하여, 위 4종은 사체의 부패단계를 시사하는 지표곤충으로 유용하다고 생각되었다. 한편, 부패속도는 완전노출사체(7일) > 덮은사체(10일) > 그늘진사체(13일) > 감은사체(15일)의 순으로 빨랐는데, 이는 사체의 노출 정도에 따른 곤충의 접근성 및 큰 비에 의한 사체손실의 정도와 관련이 있는 것으로 생각되었다. 따라서 PMI 추정 시 사체의 노출 정도가 반드시 고려되어야 한다고 생각되었다. This study was carried out to offer forensic entomological evidence to estimate the post mortem interval (PMI) based on the arthropod succession in pig carrions and carrion decomposition patterns varying with the exposed extent of the carrions. Four carrions, exposed, wrapped, covered or shaded, were placed in an open grassland near the Nakdong-river in Busan in August, 2010. It was found that the first visiting insect was Chrysomyia megacephala among a total of 20 species of 15 families belonging to 7 orders of Insecta, and that four species were useful indicators of the decomposition stage of the carrion: C. megacephala for Ⅰ~Ⅴ stages; a species of Sepsidae, Creophilus maxillosus and a species of Carabidae for Ⅲ~Ⅴ stages. It was also found that the more the exposed extent of exposure of carrions, the higher the rate of decomposition of carrions, i. e. the time for decomposition of carrions were 7days for the exposed carrion, 10days for the covered one, 13days for the shaded one, and 15days for the wrapped one. This result seems to be related to the differences in the weight loss of carrions caused by strong rains during the research period and by the accessibility of insects to the carrions; both are strongly affected by the exposed extent of the carrions. Accordingly, it was suggested that the exposed extent of the carrions must be taken into consideration to estimate the PMI.

해양심층수 섭취가 STZ로 유발된 제 1형 당뇨 생쥐의 혈당치 및 췌도에 미치는 영향

정재봉(Jae-Bong Jung),정지윤(Ji-Yoon Jung),윤명희(Myung-Hee Yoon) 한국생명과학회 2009 생명과학회지 Vol.19 No.7

STZ(Streptozotocin)를 이용하여 제 1형 당뇨를 유발시킨 생쥐에게 해양심층수를 음용시켜, 혈당치의 변화 및 파괴된 췌도에 미치는 영향에 대하여 연구하였다. 그 결과 수돗물을 음용시킨 생쥐에 비해서 해양심층수를 음용시킨 생쥐의 혈당이 낮아지고, 파괴되었던 췌도의 면적이 넓어졌으며, 췌도 내에 정상적인 β-세포의 수도 많아진 점으로부터, 해양심층수의 음용이 당뇨병의 증상완화에 효과가 있음이 밝혀졌다. 이러한 효과는 해양심층수에 포함된 Mg²?의 효과인 것으로 생각되었다. Effects of deep sea water on blood glucose and the Langerhans' islet in STZ-induced type I diabetic mice were investigated. Results showed that diabetic symptoms in STZ-induced diabetic mice improve with a supplement of deep sea water. That is, the level of blood glucose was lower, the area of the Langerhan' islet was wider, and the number of pancreatic β-cells was larger in the diabetic mice supplied with deep sea water than in the diabetic mice supplied with tap water. Such effects might be related to the high level of Mg²? in the deep sea water.

만성 활동성 간염 환자에서 발생한 미만성 원발성 피부 아스페르길루스증

권호준(Ho June Kwon),정재봉(Jae Bong Jung),이규석(Kyu Suk Lee),송준영(Joon Young Song) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.1

An 41-year-old woman with chronic active hepatitis developed multible asymptomatic erythematous papules, plaques and purpuras on the both lower leg, feet, forearms and hands. Some lesions progressed to ulcers with central black colored necrotic eschars. Biopsies and cultures demorrstrated a fungus, aspergillus fumigatus a the etilogic agent. No evicience of involvement of other organs by aspergillus fumigatus was found. Intravenous amphotericin B therapy was discontinued because of he immediate adverse effects. The patient received treatment with oral itaconazole(200mg/day) and intravenous fluconazole(400mg/day), but skin lesions have been recurring repeatedly. (Kor J Dermatol 1995; 33(1): 172-178)

전신성 백반증 환자 225예에 대한 임상적 고찰

류영욱(Young Wook Ryoo),정재봉(Jae Bong Jung),최윤애(Yoon Ae Choi),노용지(Young Ji Rho),이규석(Kyu Suk Lee),송준영(Joon Young Song) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.5

Background : Vitiligo is a relatively common acquired depigmentating disorder that affects at least 1 % of the population. The mode of transmission has not been clearly,stablished, but either polygenic or autosomal dominant with incomplete penetrance and variable expresion has been proposed. Objective : Our purpose was to evaluate the causative factor, variable clinical features and current teratment of generalized vitiligo patients. Method : This clinical in vestigation was made with 225 outpatiens of generalized type vitiligo who had visited the Department of Dermatology, Keirnyung Universitv Hospital from January 1987 till December 1991. Results & Conclusion : 1. There were 125 female, (55.5%) and 100 males(44.4%). 2. The mean age of onset was 21.4 years(male . 24.3, female: 19.1). 3. The mean age at the first visit was 27.5 years (male : 28.8, female : 26.5). 4. The mean duration of the disease was 10.7 years(male : 9.9, female : 10.9). 5. The mean interval between onset and visiting was 6.1 years (male : 4.5, female : 7.4). 6. The most common sites of involvernent at the first visit was tie face 11.7% (male : 11.4%, female : 11.8%). 7. The most common precipitating factor was trauma(8.8%). 8. The most common previous treatment was sunlight irradiaion after application of topical oxoralene(33.2%). 9. The most common degree of depigmented lesion was 5-10%(64.4%). 10. The most common occupations of the patients were students mals, and housewife females. (Kor J Dermatol 1993;31(6):684-671)

파리유충을 이용한 사후경과시간의 추정

김애경(Kim, Ae-Gyung),황영길(Hwang, Young-Gil),유경진(Yu, Gywong-Jin),정재봉(Jung, Jae-Bong) 경찰대학 범죄수사연구원 2015 범죄수사학연구 Vol.1 No.1

변사자의 혈액채취와 증거물 유효성

송예은 ( Song Ye-eun ),고준채 ( Ko Jun-chae ),유경진 ( Yu Gyeong-jin ),정재봉 ( Jung Jae-bong ),박현도 ( Park Hyun-do ) 미래융합통섭학회 2023 현대사회와 안전문화 Vol.6 No.1

연구목적 본 연구는 변사자로부터 채취한 혈액이 증거로서의 가치를 확인하고 채혈자 조사를 통하여 검안의사를 포함한 비의료인에 의한 채혈과 이때 수집된 증거물의 연계성에 대해 검토하고자 하였다. 연구방법 표본으로 선정된 2개의 시와 2개의 도에서 2017년 한 해 동안 SCAS에 입력된 변사사건 11,176건 중 변사자로부터 채혈한 사건은 455건(2.5%)으로 확인되었다. 결과 변사건수는 A 지역이 4,578건으로 가장 많았으며, 채혈건수는 B 지역이 172건으로 가장 많았다. 채혈이 이루어진 455건 중 검안의사에 의한 채혈이 330건으로(72%) 가장 많았으며, 경찰에 의한 채혈도 111건(25%)으로 나타났고, 이를 제외한 채혈은 14건(3%)이었다. 특히, D 지역은 1,875건의 변사사건 중 19건(1.0%)밖에 채혈이 이루어지지 않았으며, 연구표본 지역 중 가장 낮은 비율을 보였다. 이는 변사사건 현장에서 채혈을 해야 할 필요성을 인식하지 못하였거나 채혈을 기피하는 것으로 생각되며, 이후 현장에서 채혈이 필요한 경우가 발생하더라도 이를 외면할 가능성이 존재한다. 더욱이 변사사건에서 혈액은 사건의 중요한 단서가 될 수 있어 수집된 혈액을 자세하게 기록함으로서 증거물 연계성을 지켜야 할 것이다. 결론 검안의사는 의료행위에 대한 전문지식과 기술을 가지고 경찰의 요청에 의해 현장임장 및 검시를 하므로, 변사자로부터 채혈을 진행함에 법적으로 문제가 되지 않는다고 생각된다. 그러나 검시조사관 또는 과학수사요원은 감식과 분석 임무를 수행하고 있지만, 채혈에 대한 자격이나 권한은 없다. 따라서 채혈에 대한 증거물 연계성을 높이기 위해서는 검안의사를 확충하여 그들에 의해 채혈이 이루어질 수 있도록 해야 할 것이다. 하지만 검안의사가 임장할 수 없는 경우가 발생할 수 있으므로 검시조사관 또는 과학수사요원의 채혈에 대해 법적 뒷받침을 마련하고 이에 대한 교육이 필요하다고 생각된다. PURPOSE The purpose of this study is to confirm the value of blood collected as proof and review the relationship between the blood collecting by non-medical personnel and the evidence collected through the blood sampler investigation. METHOD Among the 11,176 incident cases put into the SCAS during the year 2017, 455 cases (2.5%) were identified to be from unnatural death in the two selected cities and two provinces for the year 2017. RESULT The number of the unnatural death was the highest in A area (4,578 cases) while the number of blood collection was the highest in B area (172 cases). Among the 455 cases of blood collection, 330 cases (72%) were collected by postmortem doctor, and 111 cases (25%) were collected by the police and the others were 14 cases(3%). In particular, in the D region, only 19 out of 1,875 cases (1.0%) accompanied blood collection, showing the lowest rate among the study sample areas. This is because there was no recognition that there is a need to collect blood at the scene of a criminal case or people avoided blood collection. Therefore there is a possibility that notwithstanding a need to collect blood in the field, it may be ignored. Moreover, in the case of unnatural death, blood can be an important clue, and the evidence linkage should be protected by recording the detail of collected blood. CONCLUSION since postmortem doctor has expert knowledge and skills on medical practice and performs on-site examination and autopsy at the request of the police, it is not legally problematic to conduct blood collection from unnatural death. However, although the coroner or scientific investigator performs the identification and analysis but does not have the qualification or authority to collect blood. Therefore, in order to increase the linkage of evidence for blood collection, it is necessary to increase the number of postmortem doctor so that blood collection can be done by them. However, since postmortem doctor may not be able to attend, it is necessary to provide legal support for the blood sampling by the coroner or scientific investigator.

비전형적인 임상 양상을 보인 미만성 피부전이암

신문석 ( Moon Seok Sihn ),권호준 ( Ho June Kwon ),류영욱 ( Young Wook Ryoo ),정재봉 ( Jae Bong Jung ),김병천 ( Byung Chun Kim ),이규석 ( Kyu Suk Lee ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.5

Cutaneous metastases from Internal carcinomas are relatively rare. We report a case of cutaneous metastasis believed t.o originate from primary lung carcinoma in a 69-year-old male patient. The patient presented with localized well defined multiple variable sized, hard eryt,hematous papules, nodules and pustules on the right chest, back and upper arm. Biopsy specimens from the nodules upper chest revealed scatt,ered islands of tumor cells and fi brosis of the dermis. To evaluate the role of p53 protein in the development of skin tumors, we examed p53 expres sion at protein level by imnunoperoxidase stain using monoclonal antimouse human p53 antibody on paraffin embeded tissues The patient died after four months from the appearance of cutaneous lesions. (Kor J Dermatol 1995;33(5): 956-960)

피부이식술을 시도한 유아 지지 섬유종증

손보성 ( Bo Sung Sohn ),류영욱 ( Young Wook Ryoo ),정재봉 ( Jae Bong Jung ),김병천 ( Byung Chun Kim ),이규석 ( Kyu Suk Lee ),송준영 ( Joon Young Song ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.5

Infantile digital fibromatosis is a rare benign tumor on the fingers and toes of infants and childhood which is characterized by fibroblastic proliferation. Usually the lesions occur singly or severally on the dorsal or lateral aspects of the distal phalanges of the toes and fingers. The thumb and great toe are usually spared. These asymptomatic, firm, red, smooth nodules, some lcm diameter, occur during the first year of life. Forty-seven percent occur in the first month of life. This disease can occur after trauma. The lesions do not metastasize. Occasionally, spontaneous regression has been reported. After excision, recurrence can be possible. A 2 years old female infant had three large bean sized erythematous masses on the left 2,3,4th fingers. The erythematous aacule was developed at 6 months old and grew slowly. We could find inclusion body stained bright red with Massons trichrome and purple with PTAH in cytoplasm of fibroblast. The patient was treated with a simple excision followed by a skin graft. During 5 rnonths after operation, recurrence was not occurred. (Kor J Dermatol 1995;33(5): 978-982)