공복 시 Caffeine 투여 후 일회성 운동이 흰쥐의 인슐린 및 골격근의 GLUT-4 발현에 미치는 영향

정일규,오명진,김영표,김종오,윤재석,서태범,윤진환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

This study was done to investigate the effects of caffeine ingestion on the expression of GLUT-4 in rats' skeletal muscle(soleus m) and blood insulin level after 12 hr fasting condition and one hour treadmill running. Total 19 rats(Sprague-Dawley) who were 7week Did were used for experimental subjects and raised for 1week in the room controled the air temperature and relative humudity(22℃ and 50%). They were divided three groups ; 12hr fasting group(F group, n=5), fasting+exercise group(FE, n= 7) and fasting+caffeine+exercise group(FCE group, n=7). FG and FCE group performed treadmill running for one hour and the treadmill speed was 18m/min that was supposed to be moderate exercise to rats. Each Dr rats in FCE group was forced to he given the caffeine solution(5mg/kg, Sigma Chemical co.) through stainless steel tube directly to their stomachs one hour before treadmill exercise. Immediately after treadmill running, we anesthetized them with the mixed solution(Ketamin 80g/kg and Rompun 5ml/kg) to draw 3ml blood from heart four insulin analysis and then obtained the rats' soleus muscle for GLUT-4 expression. We found that FCE group showed significantly higher GLUT - expression then the other groups and FE group showed the lowest GLUT-4 expression. This rusults suggest that the endurance type of exercise in fasting condition inhibit the GLUT-4 expression in working muscle and the caffeine helped to facilitate the GLUT-4 expression during endurance type of exercise. The future studies needed to confirm the action of caffeine to increase the GLUT- 4 and the mechanism.

복와식 장비를 사용한 입체적 정위법에 의한 유방 생검 62예의 분석 : 미세석회화를 동반한 유방 병변을 중심으로

정일규 대한영상의학회 1999 대한영상의학회지 Vol.40 No.2

Purpose : To evaluate the efficacy of stereotaxic breast core biopsy using a prone table system, and theeffects of operator experience, lesion characteristics and number of samples on biopsy results in cases involvingnonpalpable breast lesions. Materials and Methods : We performed stereotaxic core biopsies of 62 nonpalpablemammographic lesions in 61 patients. Subsequent surgical excision was performed in 11 cases withmicrocalcifications and one case with a mass. We equally divided patients with microcalcifications into two groups(early and late periods) and analyzed the mammographic findings. Correlation of the pathologic results of corebiopsy with those of surgical excision were investigated. Results : In two patients, stereotaxic biopsy wasimpossible due to poor visibility of microcalcifications and thinness of the compressed breast. In 59 patients,core biopsy was successfully performed and specimens were adequate for pathologic examination. The average numberof microcalcifications seen on specimen mammography in the two groups was 1.8 (range: 0~8) and 2.5 (range:0~4)respectively. In patients from whom less than five and five or more samples were taken, the average number ofmicrocalcifications seen on specimen mammography was 1.5 (range: 0~6) and 2.6 (range: 0~8), respectively,throughout the whole period. The pathologic findings were fibrocystic change in 50 cases, fibroadenoma in four,ductal carcinoma in situ in four, invasive ductal carcinoma in one, and atypical ductal hyperplasia in one. Theagreement rate of pathologic results between core biopsy and surgical excision was 83% (10/12) for malignancy and75% for histology. In three cases with disagreement between core and surgical pathologic results, the samplingnumber was small (3~4 times) and in two of the three cases, microcalcifications were not visible on mammography.Conclusion : Operator experience and sampling numbers larger than five results in an increased number ofmicrocalcifications in specimens and more reliable core biopsy.

8km 달리기 경기 후 적혈구 용혈의 혈중 지표와 적혈구의 형태적 변화

정일규,윤진환,변재종,김종오,김영표,정경훈 한국발육발달학회 2004 한국발육발달학회지 Vol.12 No.1

본 연구는 8km 달리기 경주 후에 나타나는 혈액 구성분과 혈중 암모니아, LDH, CPK 그리고 적혈구 침강속도의 변화와 함께 적혈구의 형태학적 변화를 고찰하였다. 이러한 변인들에 대한 분석을 통해 달리기 운동 중에 나타날 수 있는 적혈구 용혈(erythrocyte hemolysis)에 대한 증거를 발견하는데 본 연구의 목적이 있다.본 연구의 대상자들은 교내 마라톤 대회에 참가한 15명의 대학생(18.53±0.51 yrs)으로서 이들의 주정중피 정맥으로부터 약 10㎖의 정맥혈을 경기직전, 경기를 마친 후 5분과 60분의 회복기에 채혈하였다. 채혈한 혈액은 적혈구수, Hematocrit, Hemoglobin 농도, 혈중 암모니아, CPK 그리도 LDH 농도를 분석하는데 이용하였으며, 적혈구 침강속도 역시 측정하였다. 또한 채혈한 혈액 중 일부는 Wright's의 염색법을 이용하여 광학현미경을 통해 형태학적으로 이상 적혈구의 수를 분석하는데 이용하였다. 이상 적혈구는 광학현미경을 통해 동일 단위면적 중에서 총적혈구 중 형태학상으로 변형된 적혈구 수의 비율(%)로 하였다.본 연구에서 8km의 달리기 경주 직후 및 회복기 60분 동안 혈중 ammonia, CPK 그리고 LDH는 경기 전에 비해 매우 유의하게 높은 상태를 유지하였다(p<.05~.01). 그러나 적혈구 침강속도는 달리기 후에도 변화없이 비교적 안정된 상태를 보였다. 또한 이상 적혈구의 출현비율은 안정시 .28±.10%에서 운동 후 6.56±2.18%로 매우 유의하게 증가된 현상을 보였다(p<.01).이러한 결과는 건강한 대학생에 있어서도 8km 정도의 경쟁적인 장거리 달리기는 가벼운 적혈구 용혈을 초래할 수 있는 것으로 나타났다.

수평 거치 기판을 위한 마하-젠더 레이저 간섭 리소그래피 장치

정일규,김종석,강경대,한재원,이성호 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.5-4

군운용 환경에 적합한 GPS 센서기반 주행궤적 측정 및 분석 기술

정일규,류치영,김상영 한국군사과학기술학회 2017 한국군사과학기술학회지 Vol.20 No.6

The techniques for driving trajectory calculation and driving trajectory distribution calculation are proposed to analyze the durability of ground vehicles effectively. To achieve this aim, the driving trajectory of a vehicle and the driving trajectory distribution of that are needed, in addition to road profile. The road profiles can be measured by a profilometer but a driving trajectory of a vehicle cannot be acquired effectively due to a large position error from a conventional GPS sensor. Therefore two techniques are proposed to reduce the position error of a vehicle and achieve the distribution of driving trajectory of that. The driving trajectory calculation technique produces relative positions by using the velocity, time and heading of a vehicle. The driving trajectory distribution calculation technique produces distributions of the driving trajectory by using axis transformation, estimating reference line, dividing sectors and plotting a histogram of the sectors. As a results of this study, we can achieve the considerably accurate driving trajectory and driving trajectory distribution of a vehicle.

레이저 간섭 리소그래피를 이용한 대면적 나노 구조체 제작

정일규,이성호,김종석,한재원 한국반도체디스플레이기술학회 2012 반도체디스플레이기술학회지 Vol.11 No.1

One dimensional and two dimensional nano patterns were fabricated on a 4-inch substrate by Laser Interference Lithography (LIL). Mach-Zehnder interferometer was setup to obtain the interference patterns and adjusted the pattern sizes with change of incident angle. We could obtain a periodic structure with a period of 440nm using 266nm laser, and demonstrated a pattern size with 293±25nm over a 4-inch substrate.

The Environmental Factors of Physical Education Influencing the Healthy Life Style of Children

정일규,김명화 한국사회체육학회 2015 한국사회체육학회지 Vol.0 No.59

오늘날 여러 나라에서 어른들의 높은 비만률과 성인병 증가현상은 어린 시기에 적절한 체육교육의 부재와 신체활동의 결핍에 그 근원을 두고 있다는 것은 많은 연구를 통해 입증되고 있다. 특히 한국의 경우 어린이와 청소년의높은 자살률과 학교폭력 등의 문제는 학교의 테두리를 벗어나 사회적으로 심각한 문제로 대두되어 왔다. 어린 시기에 경험하는 체육교육, 쉬는 시간, 교내체육활동프로그램, 학교대항스포츠, 방과 후 학교시설의 이용용이성, 방과 후 신체활동프로그램의 제공 등은 추후 일생을 통해 생활체육으로서의 습관을 형성하는 매우 소중한 기회가된다. 그러므로 본 연구는 1) 여러 나라에서 어린이의 건강생활을 촉진하기 위한 체육교육의 정책, 법령과 규칙, 체육관련 기구나 조직으로부터 제정된 권장사항 등을 비교검토하고, 2) 학령기 청소년의 건강을 위한 전략이나 연구프로젝트 등을 조사하여 소개하며 3) 학교 안이나 학교 밖에서 어린이의 신체활동과 체력수준에 영향을 미치는여러 요인들을 조사하고 4) 한국에서 건강교육의 측면에서 어린이의 신체활동을 촉진하기 위한 정책적 노력이나움직임에 대하여 소개하였다. 지난 수십 년 간 학업중시의 교육풍토로 인해 어린이와 청소년의 신체활동이 제한되어 왔음은 영국을 비롯한유럽, 미국, 호주와 같은 선진국에서도 큰 문제점으로 지적되어 왔으며, 이에 따라 정부나 민간차원의 체육법령이나 규정의 제정노력이 있어 왔다. 중국, 베네수엘라, 파키스탄과 같은 나라에서도 도시, 농촌 간, 성별간의 체육활동에 따른 차별의 문제가 제기되어 왔다. 어린이와 청소년의 체육활동과 건강생활을 증진시키기 위한 전략을 수립하기 위해서는 이에 영향을 미치는 여러 환경적 요인에 대한 분석이 필요하다. 어린이와 청소년의 신체활동에 영향을 미치는 요인으로는 1)학교의 정책(쉬는 시간, 점심시간, 주당 체육시간, 방과 후 체육프로그램의 제공 등) 2)사회적 환경(선생의 태도, 가족의 지지 등) 3) 물리적 환경(시설, 장비, 놀이터의 마킹, 캠퍼스 크기 등)을 들 수 있다. 이러한 환경조건의 개선을 위한 여러 나라의 전략과 방법 등을 비교ㆍ공유하고, 무엇보다 학생자신, 부모, 선생, 교육관료와 학자들로부터 피드백을 통해서 이들의 건강한 생활과 신체활동수준을 높이기 위한 방법이 수립되어야 한다.

소아기 비만관리와 운동 프로그램

정일규 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

These days the children obesity rate increase precipitously in Korea suggesting the need of education authorties" effort and proper measure to prevent the spread of this disease. The role of physical education teachers in school is getting more important to prevent children obesity and cope with this disease. However, there is no reliable measuring presedure to determine the children obesity and no highly reliable standard for children obesity that has been established through the research for the wide range of population so far in Korea. The children obesity has been characterized by the difficulty to treat and maintain the obtained effect even if the state of obesity has been improved due to the hyperplasia (the increase of the number of adipocytes). Because the childhood is the most important time period throughout the lifetime to prevent and treat the obesity, the increased role of elementary teacher as a health counsellor has to be requested. The guidline of exercise program or prescription for adult must not be simply applied to the obese children who has much different physiological and psychological characteristics from adults. The exercise proram for children obesity must have the primary purpose to help the children to foam the sound habit throughout their lifetime and contain the recreational activities to prevent the dropout from the program rather than sticking to the short-term target to decrease a certain weight.

지면 미끄럼 이동운동이 심박수, 산소 소비수준 및 하체 적분 근전도에 미치는 영향

정일규,김진희 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

The purpose of this study was to investigate the effects of Ground Sliding Board Exercise on the cardio-respiratory response and energy consumption and Integrated Electromyograph. That board was specially designed for one to firstly stand on it and make it slide on the ground to forward and backward by one's knee and hip extension and flexion movement. All ten healthy collegiate male students were asked to perform the treadmill exercise(Bruce Protocol) and ground sliding board exercise, The interval of two tests was arranged to be one week for each subject and the order of experiments was randomly determined. All subjects were learned about how to make them move on the board before ground sliding board exercise test, They were asked to stand on the board and make a sliding movement per second with the rhythm of metronome by their knee and hip extension end flexion. They were also asked to move themselves on the board forward and backward two times each for fifteen minutes, During both exercises, the HR, Oxygen Consumption. iEMG of vastus lateralis and medials etc. were measured. The results of this study was as follows. 1. The mean percentage of heart rate and oxygen consumption were 73.8-85.1%HRmax and 61.7-71.9%VO₂max, during the stead state of ground sliding board exercise. 2. The heart rate and oxygen consumption during ground sliding board exercise reached significant higher level than second stage of treadmill exercise(Bruce protocol) after 3 minutes and maintained the level corresponding to the heart rate appeared at fourth stage of treadmill running(16% grade, 4.2mph). 3. Although the iEMG of sliding board exercise had no significant difference with the iEMG at 4 stage of treadmill running showing the similar level of oxygen consumption, the more muscle activation during ground sliding board exercise was found at vastus lateralis than at vastus menials.

이중에너지 방사선 흡수계측법을 이용한 Cycling 운동수행 노인의 골밀도 측정

정일규 최신의학사 1995 最新醫學 Vol.38 No.11