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치매유발제인 알루미늄에 대한 Rosmarinic Acid의 보호 효과
정인주 ( In-ju Jung ),서영미 ( Young-mi Seo ),제갈승주 ( Seung-joo Jekal ) 대한임상검사과학회 2017 대한임상검사과학회지(KJCLS) Vol.49 No.1
치매유발제인 AlCl<sub>3</sub>에 대한 rosmarinic acid의 영향을 알아보기 위하여 뇌세포종인 배양 C6 glioma 세포를 배양한 후 세포생존율을 비롯한 전자공여능(electron donating ability, EDA), SOD-유사활성(superoxide dismutase-like activity) 및 지질과산화(lipid peroxidation) 억제능을 조사하였다. 본 연구에서 AlCl<sub>3</sub>는 배양 세포에 농도 의존적으로 세포생존율을 대조군에 비하여 유의하게 감소시킴으로서 세포독성을 나타냈다. 또한, AlCl<sub>3</sub>의 XTT<sub>50</sub>값이 142.2 μM에서 나타남으로 이는 Borenfreund와 Puerner의 독성판정기준에 의하여 중간독성(mid-toxic)인것으로 나타났다. 한편, rosmarinic acid가 AlCl<sub>3</sub>에 미치는 영향에 있어서, 40 μM rosmarinic acid 처리에서는 AlCl<sub>3</sub>만의 처리에 비하여 세포생존율을 유의하게 증가시킴으로서 AlCl<sub>3</sub>의 산화적 손상으로부터 세포손상을 보호하였다. 또한 rosmarinicacid는 전자공여능을 비롯한 SOD-유사활성 및 지질과산화의 억제효과를 보임으로서 항산화능을 나타냈다. 이상의 결과로부터 산화적 손상이 AlCl<sub>3</sub>의 독성에 관여하고 있으며, rosmarinicacid는 항산화능에 의하여 AlCl<sub>3</sub>의 독성을 효과적으로 방어하였다. 따라서, rosmarinic acid와 같은 천연성분은 치매와 같이 산화적 손상과 관련된 병변의 치료적 개선을 위한 천연 소재로서의 가능성을 제시하였다. To examine the protective effect of rosmarinic acid on the aluminum of dementia inducer, cultured C6 glioma cells were treated with various concentrations of aluminum chloride (AlCl<sub>3</sub>) or rosmarinic acid. The cell viability, electron donating ability (EDA), superoxide dismutase (SOD)-like activity, and inhibitory activity of lipid peroxidation were evaluated for the antioxidant effect of rosmarinic acid. In these cultures, AlCl<sub>3</sub> sowed a cytotoxic effect by decreasing the cell viability in a dose-dependent manner; then, the XTT<sub>50</sub> value was measured at 142.2 μM of AlCl<sub>3</sub> after treating the cultured C6 glioma cells with media containing 120∼160 μM AlCl<sub>3</sub>. Therefore, its toxicity was determined as mid-cytotoxic by Borenfreund and Puerner`s toxic criteria; while, vitamin E of antioxidant markedly increased the cell viability on AlCl<sub>3</sub>-induced cytotoxicity in these cultures. This study showed the antioxidant effect of rosmarinic acid via several assays, such as electron donating activity (EDA), superoxide dismutase (SOD)-like activity, and inhibitory activity of lipid peroxidation. From these findings, it is suggested that the oxidative stress is involved in AlCl<sub>3</sub>-induced cytotoxicity, and rosmarinic acid was effective in the protection of AlCl<sub>3</sub>-induced cytotoxicity by antioxidant activity. In conclusion, natural resources, like rosmarinic acid, may be a putative antioxidant agent for the treatment of reactive oxygen species (ROS)-mediated disease, such as dementia.
치매유발제인 알루미늄으로 손상된 배양 C6 Glioma 세포에 대한 금은화 추출물의 보호 효과
정재윤,정인주,제갈승주,Jung, Jai-Yun,Jung, In-Ju,Jekal, Seung-Joo 대한임상검사과학회 2017 대한임상검사과학회지(KJCLS) Vol.49 No.3
This study was performed to evaluate the cytotoxicity of aluminum chloride ($AlCl_3$), and the protective effect of Lonicerae flos (LF) extract on $AlCl_3-induced$ cytotoxicity in the cultured C6 glioma cells. Here, the cell viability and antioxidative effects, such as DPPH-radical scavenging activity, superoxide anion scavenging activity, and lipid peroxidation (LP), were assessed. $AlCl_3$ significantly decreased the cell viability in a dose-dependent manner; the $XTT_{50}$ value was measured at $128.8{\mu}M$ of $AlCl_3$. The cytotoxicity of $AlCl_3$ was determined as highly toxic the y Borenfreund and Puerner's toxic criteria. The butylated hydroxytoluene (BHT) and antioxidant both significantly increased the cell viability, which was damaged by $AlCl_3-induced$ cytotoxicity in these cultures. In the protective effect of LF extract on $AlCl_3-induced$ cytotoxicity, the LF extract significantly increased the superoxide anion scavenging activity and inhibitory activity of LP, as well as the DPPH-radical scavenging activity. From these results, it is suggested that the oxidative stress may have been involved in the cytotoxicity of $AlCl_3$, and LP extract effectively protected $AlCl_3-induced$ cytotoxicity through the antioxidative effects. Conclusively, the natural resources, like LP extract, may be a putative therapeutic agent for the treatment of dementia induced by allergen like aluminum correlated with the oxidative stress.
과도안정도와 미소신호안정도 관점에서 국내 전력계통의 임계관성계수 평가
백종오(Jong-Oh Baek),정인주(In-Joo Jeong),하정민(Jung-Min Ha),맹창엽(Chang-Yeop Maeng),권오근(Oh-Geun Kwon),이배근(Bae-Geun Lee),김수배(Soobae Kim) 대한전기학회 2019 전기학회논문지 Vol.68 No.9
The increase of inverter-based renewable energy sources reduces inertia constant of power systems and the loss of the system inertia may cause power system stability problems. To ensure a secure energy delivery system, these problems should be analyzed thoroughly from various perspectives about power system stability. This paper presents the estimation of the critical inertia of Korean power systems, which is the minimum amount of inertia required to maintain power system dynamic securities. The estimation has been made by gradually reducing the system inertia of Korean power systems and then by analyzing the change of dynamic securities in terms of transient and small signal stabilities. In the transient stability aspect, the decrease of critical clearing time(CCT) has been analyzed with four different reduced inertial models of Korean power systems. With the small signal stability perspective, the change of the system damping ratio has been studied. Based on the results from the stability studies, the critical inertia has been determined and it can be considered as the indirect limit of renewable energy shares in Korean power systems.
보문 : DNCB에 의해 발생되는 세포독성에 대한 오이풀 추출물의 방어 효과
박승택 ( Seung Taeck Park ),강민정 ( Min Jung Kwang ),제갈승주 ( Seung Joo Jekal ),이재형 ( Jae Hyoung Lee ),윤미영 ( Mi Young Yoon ),표애자 ( Ae Ja Pyo ),임요섭 ( Yo Sup Rim ),정인주 ( In Ju Jung ) 대한미용학회(구 대한미용과학회) 2013 대한미용학회지 Vol.9 No.2
The protective effect of Sanguisorba officinalis L. (SO) extract against 1-chloro-2, 4-dinitrobenzene (DNCB)-induced cytotoxicity was performed in cultured human skin fibroblasts (Detroit 551 cells). The DNCB remarkably lowered cellviability in a dose-dependent manner, and its XTT50 value was measured at 48.4 μM. Whereas, 20 and 30 μM pretreatment of catalase for 2 hours before 48.4 μM treatment of DNCB significantly raised the cell viability. And also, 70 and 90μg/mL pretreatment of SO extract for 2 hours before 48.4 μM treatment of DNCB significantly raised the cell viability. The SO extract had a considerable DPPH-radical scavenging activity and SOD-like activity. From these results, it is suggested that the cytotoxicity of DNCB may be correlated with oxidative stress, and also, SO extract effectively prevented DNCB-in duced cytotoxicity by antioxidative effect. Conclusively, the natural plant extract such as SO may be a putative resource for the prevention of the cytotoxicity induced by skin decoloric agent such as DNCB.