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정인경,Da Hee Oh,Seung-Joon Park,Ja-Heon Kang,Sunshin Kim,Myung-Shik Lee,Myung-Jun Kim,Yoo-Chul Hwang,Kyu Jeong Ahn,Ho-Yeon Chung,Min-Kyung Chae,유형준 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.12
Recent epidemiologic studies clearly showed that early intensive glucose control has a legacy effect for preventing diabetic macrovascular complications. However, the cellular and molecular processes by which high glucose leads to macrovascular complications are poorly understood. Vascular smooth muscle cell (VSMC) dysfunction due to high glucose is a characteristic of diabetic vascular complications. Activation of nuclear factor-κB (NF-κB) may play a key role in the regulation of inflammation and proliferation of VSMCs. We examined whether VSMC proliferation and plasminogen activator inhibitor-1 (PAI-1) expression induced by high glucose were mediated by NF-κB activation. Also, we determined whether selective inhibition of NF-κB would inhibit proliferation and PAI-1 expression in VSMCs. VSMCs of the aorta of male SD rats were treated with various concentrations of glucose (5.6,11.1, 16.7, and 22.2 mM) with or without an inhibitor of NF-κB or expression of a recombinant adenovirus vector encoding an IκB-α mutant (Ad-IκBαM). VSMC proliferation was examined using an MTT assay. PAI-1 expression was assayed by real-time PCR and PAI-1 protein in the media was measured by ELISA. NF-κB activation was determined by immunohistochemical staining, NF-κB reporter assay, and immunoblotting. We found that glucose stimulated VSMC proliferation and PAI-1 expression in a dose-dependent manner up to 22.2 mM. High glucose (22.2 mM) alone induced an increase in NF-κB activity. Treatment with inhibitors of NF-κB such as MG132, PDTC or expression of Ad-IκB-αM in VSMCs prevented VSMC proliferation and PAI-1 expression induced by high glucose. In conclusion,inhibition of NF-κB activity prevented high glucose-induced VSMC proliferation and PAI-1expression.
정인경 ( In Kyung Jeong ) 대한내과학회 2015 대한내과학회지 Vol.89 No.4
Glucagon like peptide-1 (GLP-1) is an intestinal L cell derived incretin hormone which stimulates insulin secretion of beta cell and inhibits glucagon secretion of alpha cell of pancreatic islets. GLP-1 receptors are located in pancreas as well as in a wide variety of tissue such as gastrointestinal tract, heart, blood vessel, lung, brain, kidney, and bone. Therefore GLP-1 and GLP-1 based treatment have multiple extrapancreatic effects which are inhibition of gastrointestinal motility, reduction of appetite, weight loss, increase of cardiac output, cardiovascular protection, neuroprotection, renoprotection, and increase of bone mineral density. Recently, besides GLP-1 receptor dependent pathway, GLP-1 receptor independent pathway has been identified in the extrapancreatic effect of GLP-1 in liver, adipose tissue, muscle, cardiovascular system. This review provides an overview of the pleiotropic effect of GLP-1 in the extrapancreatic organ through review of animal and clinical research. (Korean J Med 2015;89: 404-412)
지속적 외래 복막투석환자에서 투석 연결방법에 따른 복막염의 양상
정인경(In Kyung Jeong),홍성표(Seung Pyo Hong),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim),안재형(Jae Hyung Ahn) 대한내과학회 1998 대한내과학회지 Vol.54 No.1
N/A Objectives : The purpose of the present study was to compare the general conditon of peritonitis through a study of three connector systems : The Straight transfer set with Spike-and-Pork system (SPS), The Straight transfer set with Luer-Lock system(SLS), and The Y-set with Two Bag system(YS). Methods: We reviewed our experience with 134 patients from 1988.1 to 1995.12. According to various kinds of connector system, we divided cases into 3 groups: The SPS(1988. 1-1991. 3) was used on 55 patients(mean age 47±12, M:F=30:25); The SLS (1991.4-1993.8) on 45 patients(mean age 55±11, M:F=30:15); and The YS(1993.9-1995.12) on 34 patients(mean age 49±15, M:F=15:19). Results: 1) Total CAPD duration was 1.22 patient ·year in SPS, 1.08 in SLS, and 0.96 in YS. The incidence of peritonitis is 1.71 episodes per patient ·year in SPS, 1.03 in SLS, and 0.61 in YS. 2) Among the causative organisms of peritonitis, coagulase negative Staphylococcus was most common in the three groups(SPS:10.4%, SLS:10%, YS: 20%). In SPS and SLS, S. aureus(7.7%, 8%), Pseudomonas(6.5%, 8%), E.coli(5.2%, 6%) were present in decreasing order. In YS, Pseudomonas (15%), S.aureus(15%), Ecoli(10%) were present in decreasing order. There were no growth of organisms in 55.9% of SPS, 38% of SLS, and 30% of YS. 3) The probability of experiencing the first peritonitis at 1, 3, 6, and 12 months was 21.4%, 21.4%, 21.4%, and 23.9% respectively in SPS, 3.4%, 34.5%, 34.5%, and 10.3% respectively in SLS, and 0%, 28.5%, 35.7%, and 28.5% respectively in YS. 4) In the response to the treatment of peritonitis, 59.7% of the peritonitis episodes in SPS, 72% in SLS, and 85% in YS were cured with antibiotics. In 37.7% of the peritonitis episodes in SPS, 24% in SLS, and 10% in YS, the catheter was removed due to fungal, tuberculous, recurrent, or peritonitis not responding to antibiotics. 2 patients in SPS, 2 patients in SLS, and 1 patient in YS died due to peritonitis. 5) The catheter survival rate at 3, 6, 12 months was 72%, 63.6%, and 40% respectively in SPS, 89%, 78.3%, and 46.7% respectively in SLS, and 94%, 85.3%, and 76.6% respectively in YS. Conclusion: Our study suggests that there is a relationship between the development of connector system and a decrease of peritonitis in CAPD.
김유정(Kim Yu-Jeong),오수진(O Soo-Jin),정인경(Jung In-Kyung) 한국가정과교육학회 2007 한국가정과교육학회지 Vol.19 No.2
본 연구는 중학교 기술 · 가정 교과를 통한 우리나라 전통 식생활 교육의 활성화 방안을 모색해 보고자 중학생들을 대상으로 학교 교육과정에서의 전통 식생활 교육의 실태와 인식 및 내용별 요구도를 알아보기 위하여 실시되었다. 본 조사대상 중학생은 학교에서 주로 기술 · 가정 교과를 통해 전통식생활 교육을 받고 있었으며, 학교 교육과정에서의 전통식생활 교육은 필요하며, 실생활에 도움이 많이 되는 것으로 인식하고 있었다. 전통식생활 교육의 교수 · 학습방법에 대한 조사결과, 현재 전통식생활 교육은 주로 강의식 설명위주로 진행되는 경우가 가장 많았으나 학생들은 좀 더 실천적인 교수 · 학습방법을 원하는 것으로 나타났다. 또한 내용에 있어서도 실생활에 도움이 될 수 있는 내용의 교육이 이루어지질 바라고 있었다. 따라서 학교 교육과정을 통한 전통식생활 교육이 효과적으로 이루어지기 위해서는 현재 중학교 기술 · 가정교과 내 전통식생활 관련 내용 및 교수 · 학습방법이 실생활에 도움이 될 수 있는 내용과 학습자의 요구를 반영한 교수 · 학습 방법으로 수정 · 보완되어져야 할 것이다. The purpose of this study was to find out the way to activate the Education of Korean Traditional foods and culture from middle school subject, Technology and Home Economics Education. We investigated the middle school students perception and needs for the Education of Korean Traditional foods and culture in their educational curriculum. This study was carried out by using a self-administered questionnaire and 600 middle school students in Gyeonggi province were participated. Most of subjects took the Education of Korean Traditional foods and culture as a part of Technology and Home Economics Education. They recognized that this lecture is necessary and effective, since it is of great help to their life. However, lecture was descriptively given by teacher and not actively participated by students. Therefore, students requested for more practical methods of teaching and learning. They also desired that the education should comprise what will be helpful in a real life. These results suggested that current teaching and learning methods should be corrected and complemented in such a way as to reflect relevant contents and learners demands which are useful in a real life, so that the Education of Korean Traditional foods and culture may be conducted through middle school subjects of Technology and Home Economics Education in an effective way at school.
말단비대증 환자의 혈중 프롤락틴 수치와 면역조직화학염색과의 상관관계
강보현 ( Bo Hyun Kang ),정인경 ( In Kyung Jeong ),조덕신 ( Duck Shin Cho ),강한욱 ( Han Wook Kang ),김형훈 ( Hyung Hoon Kim ),김범진 ( Beom Jin Kim ),민태훈 ( Tae Hoon Min ),손준성 ( Jun Seong Son ),홍성노 ( Sung No Hong ),이춘영 대한내과학회 2003 대한내과학회지 Vol.64 No.2
목적: 말단비대증은 대부분 성장호르몬 분비 뇌하수체 선종에 의한 것으로 35%에서 고프롤락틴혈증이 동반된다고 알려져 있다. 저자들은 말단비대증 환자의 뇌하수체 조직의 면역조직화학염색 소견과 혈중 호르몬 수치를 비교하여 이들간에 어떠한 관계가 있는지 알아보고자 하였다. 방법: 1998년 8월부터 2001년 5월까지 말단비대증 진단 하에 뇌하수체 종양 제거수술을 받은 환자 28명(남자:여자=18:10, 평균연령: 41세)을 대상으로 하였다. 혈중 기저 성장 Background: Acromegaly occurs by excessive secretion of growth hormone and more than 99% of cases are caused by a growth hormone-secreting pituitary adenoma. Pituitary adenomas expressing multiple immunoreactivities are common. We assumed that the pituita