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정의배,Jeong, Ui-Bae 대한수의사회 2011 대한수의사회지 Vol.47 No.3
최근의 연구에 의하면 자연계 또는 인류가 합성한 수많은 화합물질들이 내분비계를 교란하여 야생 도물, 조류, 어류 및 인체에 부작용을 일으킨다고 보고되고 있다. 이들 내분비계를 교란시키는 물질들을 과학자들은 "내분비계 장애물질 (endocrine disruptors, 언론에서는 환경호르몬으로 소개됨)"이라고 부른다. 이들 내분비계 장애물질은 일상 생활에서 우리 주변에서 흔히 볼 수 있는 것으로서 플라스틱, 캔, 세제, 내연제, 음식, 완구, 화장품, 살충제, 약품 등에 광범위하게 분포되어 있다. 우리는 음식물, 음료수, 약품, 화장품 등에 포함된 내분비계장애물질을 구강 또는 피부로 이들 물질을 섭취하고 있다. 아직까지 이들 화합물질에 대한 정확한 부작용이 규명되지 않고 있는 문제점이 있음에도 불구하고 동물과 사람은 다양한 이들 화합물에 노출되고 있다.
랫트의 실험적 동맥경화증에 대한 $\beta$-Glucan의 예방 효과
정의배,이영순 한국식품위생안전성학회 1986 한국식품위생안전성학회지 Vol.1 No.1
The present studies were undertaken in attempt to investigate the preventive effect of $\beta$-glucan from barley ad diltiazem on cholesterol and vitamin D2 induced-atherosclerotic rat. The results obtained were summerized as follows. 1.The group, fed only the mixture of cholesterol and vitamin D2, showed significant increase of calcium, inorganic phosphorus, total cholesterol, lipid LDL-cholesterol and phospholipid in serum, and total lipid in the liver (p<0.05) as comparing with normal group. The aorta showed severe damage of disorganization, necrosis and lipid deposition in the elastic membrane. 2. The group fed mixture of cholesterol and vitamin D2 plus diltiazem simultaneously, showed significant increase of total cholesterol, total lipid and phospholipid in serum, and total lipid and triglyceride n the liver (p<0.05) as comparing with normal group, but the significant decrease of calcium and inorganic phosphorus in serum(p<0.05) as comparing with the atherogenic control group. The aorta showed slight damage of elastic membrane and lipid deposition as comparing with the atherogenic control group. 3.The group, fed mixture of cholesterol and vitamin D2 puls $\beta$-glucan simultaneously, showed significant decrease of total cholesterol, LDL and VLDL-cholesterol, total lipid, phospholipid and triglyceride in serum, and total lipid in the liver as comparing with the atherogenic control group(p<0.05), but the significant increase of calcium in serum as comparing with the normal group(p<0.05). The aorta showed no changes in elastic fiber and no lipid deposition in comparing with the atherogenic control group.
Uterine expression of tight junctions in the Canine uterus
정의배 충북대학교 동물의학연구소 2015 Journal of Biomedical and Translational Research Vol.16 No.3
Tight junctions (TJs) form continuous intercellular contacts in intercellular junctions. TJs involve integral proteins such as occludin (OCLN) and claudins (CLDNs) as well as peripheral proteins such as zona occludens-1 (ZO-1) and junctional adhesion molecules (JAMs). TJs control paracellular transportation across cell-to-cell junctions. Although TJs have been studied for several decades, comparison of the transcriptional-translational levels of these molecules in canine organs has not yet been performed. In this study, we examined uterine expression of CLDNs, OCLN, junction adhesion molecule-A, and ZO-1 in canine. Expression levels of canine uterine TJ proteins, including CLDN1, 2, 4, 5, JAM-A, ZO-1, and OCLN, were measured using reverse transcription PCR, real-time PCR, and Western blotting, whereas TJs distribution was determined by immunohistochemistry. The mRNA and protein expression levels of OCLN, CLDN-1, 4, JAM-1, and ZO-1 were identified in the uterus. Immunohistochemistry demonstrated that TJs were localized to the endometrium and/or myometrium of the uterus. Our results show that canine TJ proteins, including CLDNs, OCLN, JAM-A, and ZO-1, were expressed in the canine uterus. Taken together, these proteins may perform unique physiological roles in the uterus. Therefore, these findings may serve as a basis for further studies on TJ proteins and their roles in the physiological or pathological condition of the canine uterus.
Toxicological Mechanism of Endocrine Disrupting Chemicals: Is Estrogen Receptor Involved?
정의배,최경철 한국독성학회 2010 Toxicological Research Vol.26 No.4
Endocrine disrupting chemicals (EDCs) have been shown to interfere with physiological systems, i.e., adversely affecting hormone balance (endocrine system), or disrupting normal function, in the female and male reproductive organs. Although endocrine disruption is a global concern for human health, its impact and significance and the screening strategy for detecting these synthetic or man-made chemicals are not clearly understood in female and male reproductive functions. Thus, in this review, we summarize the interference of environmental EDCs on reproductive development and function, and toxicological mechanism(s) of EDCs in in vitro and in vivo models of male and female reproductive system. In addition, this review highlights the effect of exposure to multiple EDCs on reproductive functions, and brings attention to their toxicological mechanism(s) through estrogen receptors.